1 line
994 KiB
JSON
1 line
994 KiB
JSON
{"R-SCE-114516": ["r", "Disinhibition of SNARE formation"], "R-DDI-1257604": ["r", "PIP3 activates AKT signaling"], "R-SPO-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-DRE-5625740": ["r", "RHO GTPases activate PKNs"], "R-XTR-111995": ["r", "phospho-PLA2 pathway"], "R-HSA-2142753": ["r", "Arachidonate metabolism"], "R-DRE-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-HSA-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-DRE-1482922": ["r", "Acyl chain remodelling of PI"], "R-MMU-1169408": ["r", "ISG15 antiviral mechanism"], "R-HSA-186763": ["r", "Downstream signal transduction"], "R-BTA-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-HSA-111995": ["r", "phospho-PLA2 pathway"], "R-DME-3000170": ["r", "Syndecan interactions"], "R-RNO-2424491": ["r", "DAP12 signaling"], "R-RNO-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-SCE-114508": ["r", "Effects of PIP2 hydrolysis"], "R-BTA-9020702": ["r", "Interleukin-1 signaling"], "R-HSA-9692916": ["r", "SARS-CoV-1 activates/modulates innate immune responses"], "R-BTA-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-MMU-3928662": ["r", "EPHB-mediated forward signaling"], "R-CEL-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-HSA-9013406": ["r", "RHOQ GTPase cycle"], "R-BTA-418217": ["r", "G beta:gamma signalling through PLC beta"], "R-HSA-202424": ["r", "Downstream TCR signaling"], "R-DME-9013423": ["r", "RAC3 GTPase cycle"], "R-RNO-2871837": ["r", "FCERI mediated NF-kB activation"], "R-MMU-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-XTR-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-SCE-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-HSA-9020702": ["r", "Interleukin-1 signaling"], "R-RNO-8948751": ["r", "Regulation of PTEN stability and activity"], "R-DRE-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-HSA-168638": ["r", "NOD1/2 Signaling Pathway"], "R-MMU-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-RNO-111995": ["r", "phospho-PLA2 pathway"], "R-MMU-114604": ["r", "GPVI-mediated activation cascade"], "R-CEL-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-DME-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-HSA-167021": ["r", "PLC-gamma1 signalling"], "R-DME-5658442": ["r", "Regulation of RAS by GAPs"], "R-RNO-202433": ["r", "Generation of second messenger molecules"], "R-CEL-114516": ["r", "Disinhibition of SNARE formation"], "R-DDI-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-MMU-9020702": ["r", "Interleukin-1 signaling"], "R-MMU-9013409": ["r", "RHOJ GTPase cycle"], "R-MMU-3000170": ["r", "Syndecan interactions"], "R-DME-9013148": ["r", "CDC42 GTPase cycle"], "R-XTR-114516": ["r", "Disinhibition of SNARE formation"], "R-RNO-210990": ["r", "PECAM1 interactions"], "R-DME-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-MMU-1489509": ["r", "DAG and IP3 signaling"], "R-SPO-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-HSA-114604": ["r", "GPVI-mediated activation cascade"], "R-DME-1433559": ["r", "Regulation of KIT signaling"], "R-HSA-1474228": ["r", "Degradation of the extracellular matrix"], "R-DME-9013149": ["r", "RAC1 GTPase cycle"], "R-CEL-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-HSA-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-GGA-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-GGA-1483115": ["r", "Hydrolysis of LPC"], "R-DME-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-MMU-1482839": ["r", "Acyl chain remodelling of PE"], "R-RNO-112043": ["r", "PLC beta mediated events"], "R-MMU-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-DDI-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-MMU-9013423": ["r", "RAC3 GTPase cycle"], "R-DRE-1483166": ["r", "Synthesis of PA"], "R-HSA-1433559": ["r", "Regulation of KIT signaling"], "R-CEL-418597": ["r", "G alpha (z) signalling events"], "R-HSA-418597": ["r", "G alpha (z) signalling events"], "R-BTA-2142753": ["r", "Arachidonate metabolism"], "R-DRE-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-HSA-9648002": ["r", "RAS processing"], "R-RNO-6798695": ["r", "Neutrophil degranulation"], "R-HSA-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-HSA-1482788": ["r", "Acyl chain remodelling of PC"], "R-CEL-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-SCE-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-RNO-9035034": ["r", "RHOF GTPase cycle"], "R-DDI-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-GGA-1482798": ["r", "Acyl chain remodeling of CL"], "R-HSA-2672351": ["r", "Stimuli-sensing channels"], "R-HSA-9665348": ["r", "Signaling by ERBB2 ECD mutants"], "R-BTA-9013148": ["r", "CDC42 GTPase cycle"], "R-DME-5625740": ["r", "RHO GTPases activate PKNs"], "R-HSA-1483166": ["r", "Synthesis of PA"], "R-RNO-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-BTA-9013423": ["r", "RAC3 GTPase cycle"], "R-SPO-9013406": ["r", "RHOQ GTPase cycle"], "R-HSA-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-GGA-111995": ["r", "phospho-PLA2 pathway"], "R-MMU-9013507": ["r", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "R-CEL-111933": ["r", "Calmodulin induced events"], "R-RNO-1482925": ["r", "Acyl chain remodelling of PG"], "R-GGA-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-MMU-111465": ["r", "Apoptotic cleavage of cellular proteins"], "R-BTA-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-DRE-114516": ["r", "Disinhibition of SNARE formation"], "R-CEL-9013423": ["r", "RAC3 GTPase cycle"], "R-HSA-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-HSA-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-HSA-418217": ["r", "G beta:gamma signalling through PLC beta"], "R-SPO-114508": ["r", "Effects of PIP2 hydrolysis"], "R-RNO-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-SPO-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-SCE-9013106": ["r", "RHOC GTPase cycle"], "R-HSA-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-SCE-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-RNO-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-BTA-9013404": ["r", "RAC2 GTPase cycle"], "R-HSA-877300": ["r", "Interferon gamma signaling"], "R-CEL-9013420": ["r", "RHOU GTPase cycle"], "R-RNO-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-HSA-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-MMU-9013149": ["r", "RAC1 GTPase cycle"], "R-RNO-3000170": ["r", "Syndecan interactions"], "R-MMU-373752": ["r", "Netrin-1 signaling"], "R-DME-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-XTR-1482925": ["r", "Acyl chain remodelling of PG"], "R-DDI-2028269": ["r", "Signaling by Hippo"], "R-DME-9013420": ["r", "RHOU GTPase cycle"], "R-RNO-1482798": ["r", "Acyl chain remodeling of CL"], "R-GGA-1482839": ["r", "Acyl chain remodelling of PE"], "R-DRE-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-CEL-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-SCE-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-HSA-432142": ["r", "Platelet sensitization by LDL"], "R-RNO-9013149": ["r", "RAC1 GTPase cycle"], "R-HSA-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-DRE-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-MMU-9013404": ["r", "RAC2 GTPase cycle"], "R-HSA-3928662": ["r", "EPHB-mediated forward signaling"], "R-CEL-9035034": ["r", "RHOF GTPase cycle"], "R-MMU-2871796": ["r", "FCERI mediated MAPK activation"], "R-RNO-1482788": ["r", "Acyl chain remodelling of PC"], "R-DME-9035034": ["r", "RHOF GTPase cycle"], "R-RNO-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-RNO-5625740": ["r", "RHO GTPases activate PKNs"], "R-RNO-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-RNO-9026527": ["r", "Activated NTRK2 signals through PLCG1"], "R-HSA-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-HSA-9664565": ["r", "Signaling by ERBB2 KD Mutants"], "R-CEL-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-DRE-9013106": ["r", "RHOC GTPase cycle"], "R-DME-8980692": ["r", "RHOA GTPase cycle"], "R-DME-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-HSA-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-DRE-432142": ["r", "Platelet sensitization by LDL"], "R-DDI-5658442": ["r", "Regulation of RAS by GAPs"], "R-BTA-432142": ["r", "Platelet sensitization by LDL"], "R-HSA-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-MMU-8853659": ["r", "RET signaling"], "R-CEL-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-MMU-450520": ["r", "HuR (ELAVL1) binds and stabilizes mRNA"], "R-BTA-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-DRE-1482788": ["r", "Acyl chain remodelling of PC"], "R-BTA-111995": ["r", "phospho-PLA2 pathway"], "R-HSA-9013404": ["r", "RAC2 GTPase cycle"], "R-MMU-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-MMU-2871837": ["r", "FCERI mediated NF-kB activation"], "R-RNO-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-BTA-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-HSA-5250958": ["r", "Toxicity of botulinum toxin type B (botB)"], "R-SCE-203615": ["r", "eNOS activation"], "R-RNO-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-SPO-8948751": ["r", "Regulation of PTEN stability and activity"], "R-RNO-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-HSA-9679504": ["r", "Translation of Replicase and Assembly of the Replication Transcription Complex"], "R-MMU-2028269": ["r", "Signaling by Hippo"], "R-HSA-114516": ["r", "Disinhibition of SNARE formation"], "R-DME-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-DME-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-GGA-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-MMU-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-MMU-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-RNO-111933": ["r", "Calmodulin induced events"], "R-DDI-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-DDI-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-HSA-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "R-BTA-114516": ["r", "Disinhibition of SNARE formation"], "R-HSA-1169408": ["r", "ISG15 antiviral mechanism"], "R-HSA-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-CEL-9013149": ["r", "RAC1 GTPase cycle"], "R-DME-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-XTR-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-SCE-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-HSA-112043": ["r", "PLC beta mediated events"], "R-SCE-9013406": ["r", "RHOQ GTPase cycle"], "R-BTA-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-DRE-1482839": ["r", "Acyl chain remodelling of PE"], "R-RNO-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-SPO-114604": ["r", "GPVI-mediated activation cascade"], "R-SPO-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-DDI-389513": ["r", "Co-inhibition by CTLA4"], "R-MMU-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-RNO-373752": ["r", "Netrin-1 signaling"], "R-MMU-1482925": ["r", "Acyl chain remodelling of PG"], "R-RNO-9648002": ["r", "RAS processing"], "R-MMU-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-DDI-1169408": ["r", "ISG15 antiviral mechanism"], "R-XTR-1482839": ["r", "Acyl chain remodelling of PE"], "R-DME-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-DRE-5689880": ["r", "Ub-specific processing proteases"], "R-HSA-9013420": ["r", "RHOU GTPase cycle"], "R-HSA-9013508": ["r", "NOTCH3 Intracellular Domain Regulates Transcription"], "R-HSA-9679191": ["r", "Potential therapeutics for SARS"], "R-MMU-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-HSA-1433557": ["r", "Signaling by SCF-KIT"], "R-MMU-877300": ["r", "Interferon gamma signaling"], "R-CEL-418594": ["r", "G alpha (i) signalling events"], "R-SPO-203615": ["r", "eNOS activation"], "R-RNO-114604": ["r", "GPVI-mediated activation cascade"], "R-HSA-418594": ["r", "G alpha (i) signalling events"], "R-BTA-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-GGA-2142753": ["r", "Arachidonate metabolism"], "R-MMU-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-RNO-5658442": ["r", "Regulation of RAS by GAPs"], "R-MMU-9013026": ["r", "RHOB GTPase cycle"], "R-DDI-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-MMU-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-DDI-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-MMU-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-RNO-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-RNO-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-DRE-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-MMU-9026527": ["r", "Activated NTRK2 signals through PLCG1"], "R-MMU-8856828": ["r", "Clathrin-mediated endocytosis"], "R-RNO-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-DDI-114516": ["r", "Disinhibition of SNARE formation"], "R-BTA-1483115": ["r", "Hydrolysis of LPC"], "R-BTA-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-CEL-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-RNO-9013409": ["r", "RHOJ GTPase cycle"], "R-MMU-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-GGA-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-SCE-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-MMU-8948751": ["r", "Regulation of PTEN stability and activity"], "R-DME-8948751": ["r", "Regulation of PTEN stability and activity"], "R-DRE-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-SCE-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-DDI-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-XTR-1483115": ["r", "Hydrolysis of LPC"], "R-BTA-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-DDI-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-DDI-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-DME-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-HSA-9013507": ["r", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "R-RNO-193648": ["r", "NRAGE signals death through JNK"], "R-MMU-186763": ["r", "Downstream signal transduction"], "R-DDI-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-MMU-9035034": ["r", "RHOF GTPase cycle"], "R-HSA-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-BTA-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-DME-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-MMU-8948747": ["r", "Regulation of PTEN localization"], "R-RNO-9013148": ["r", "CDC42 GTPase cycle"], "R-SCE-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-CEL-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-XTR-1482798": ["r", "Acyl chain remodeling of CL"], "R-MMU-4641258": ["r", "Degradation of DVL"], "R-BTA-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-DDI-5674135": ["r", "MAP2K and MAPK activation"], "R-MMU-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-SPO-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-HSA-1482839": ["r", "Acyl chain remodelling of PE"], "R-HSA-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-MMU-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-DRE-9013026": ["r", "RHOB GTPase cycle"], "R-BTA-8980692": ["r", "RHOA GTPase cycle"], "R-CEL-8948751": ["r", "Regulation of PTEN stability and activity"], "R-HSA-9680350": ["r", "Signaling by CSF1 (M-CSF) in myeloid cells"], "R-MMU-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-SCE-114604": ["r", "GPVI-mediated activation cascade"], "R-DDI-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-RNO-8980692": ["r", "RHOA GTPase cycle"], "R-HSA-5625740": ["r", "RHO GTPases activate PKNs"], "R-DRE-4641257": ["r", "Degradation of AXIN"], "R-CEL-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-RNO-1489509": ["r", "DAG and IP3 signaling"], "R-HSA-1482925": ["r", "Acyl chain remodelling of PG"], "R-HSA-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-SPO-5625740": ["r", "RHO GTPases activate PKNs"], "R-DRE-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-BTA-4086398": ["r", "Ca2+ pathway"], "R-RNO-416482": ["r", "G alpha (12/13) signalling events"], "R-HSA-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-BTA-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-RNO-3928662": ["r", "EPHB-mediated forward signaling"], "R-MMU-201451": ["r", "Signaling by BMP"], "R-BTA-1483166": ["r", "Synthesis of PA"], "R-CEL-9013406": ["r", "RHOQ GTPase cycle"], "R-HSA-1483115": ["r", "Hydrolysis of LPC"], "R-SPO-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-SCE-9031628": ["r", "NGF-stimulated transcription"], "R-MMU-114508": ["r", "Effects of PIP2 hydrolysis"], "R-GGA-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-CEL-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-3000170": ["r", "Syndecan interactions"], "R-HSA-5655332": ["r", "Signaling by FGFR3 in disease"], "R-GGA-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-SPO-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-RNO-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-SCE-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-HSA-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-BTA-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-HSA-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-DDI-112043": ["r", "PLC beta mediated events"], "R-DME-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-DME-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-DDI-9648002": ["r", "RAS processing"], "R-DDI-5675221": ["r", "Negative regulation of MAPK pathway"], "R-CEL-2672351": ["r", "Stimuli-sensing channels"], "R-HSA-9725371": ["r", "Nuclear events stimulated by ALK signaling in cancer"], "R-HSA-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-DDI-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-RNO-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-RNO-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-RNO-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-SCE-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-CEL-114604": ["r", "GPVI-mediated activation cascade"], "R-HSA-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-RNO-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-DME-5689880": ["r", "Ub-specific processing proteases"], "R-MMU-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-XTR-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-RNO-877300": ["r", "Interferon gamma signaling"], "R-MMU-1433559": ["r", "Regulation of KIT signaling"], "R-MMU-111995": ["r", "phospho-PLA2 pathway"], "R-RNO-1483166": ["r", "Synthesis of PA"], "R-MMU-9013106": ["r", "RHOC GTPase cycle"], "R-HSA-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-RNO-5621480": ["r", "Dectin-2 family"], "R-MMU-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-CEL-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-HSA-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-CEL-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-CEL-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-MMU-5625740": ["r", "RHO GTPases activate PKNs"], "R-MMU-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-SPO-202424": ["r", "Downstream TCR signaling"], "R-DDI-6804757": ["r", "Regulation of TP53 Degradation"], "R-CEL-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-XTR-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-DRE-6798695": ["r", "Neutrophil degranulation"], "R-CEL-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-HSA-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-MMU-1482798": ["r", "Acyl chain remodeling of CL"], "R-DDI-9013423": ["r", "RAC3 GTPase cycle"], "R-RNO-9013408": ["r", "RHOG GTPase cycle"], "R-DRE-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-DME-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-GGA-1482922": ["r", "Acyl chain remodelling of PI"], "R-DRE-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-GGA-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-MMU-1433557": ["r", "Signaling by SCF-KIT"], "R-DRE-1482798": ["r", "Acyl chain remodeling of CL"], "R-SPO-165158": ["r", "Activation of AKT2"], "R-DRE-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-HSA-9034793": ["r", "Activated NTRK3 signals through PLCG1"], "R-HSA-450520": ["r", "HuR (ELAVL1) binds and stabilizes mRNA"], "R-HSA-5250989": ["r", "Toxicity of botulinum toxin type G (botG)"], "R-BTA-1482925": ["r", "Acyl chain remodelling of PG"], "R-SPO-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-HSA-4641258": ["r", "Degradation of DVL"], "R-DDI-203615": ["r", "eNOS activation"], "R-XTR-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-HSA-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-SPO-8980692": ["r", "RHOA GTPase cycle"], "R-BTA-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-HSA-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-HSA-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-MMU-4641257": ["r", "Degradation of AXIN"], "R-MMU-9013406": ["r", "RHOQ GTPase cycle"], "R-MMU-6798695": ["r", "Neutrophil degranulation"], "R-CEL-186763": ["r", "Downstream signal transduction"], "R-DDI-9031628": ["r", "NGF-stimulated transcription"], "R-MMU-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-DDI-1489509": ["r", "DAG and IP3 signaling"], "R-MMU-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-RNO-432142": ["r", "Platelet sensitization by LDL"], "R-MMU-114608": ["r", "Platelet degranulation"], "R-MMU-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-HSA-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-BTA-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-SCE-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-XTR-1482922": ["r", "Acyl chain remodelling of PI"], "R-GGA-1482801": ["r", "Acyl chain remodelling of PS"], "R-BTA-1482788": ["r", "Acyl chain remodelling of PC"], "R-DDI-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-SPO-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-RNO-450520": ["r", "HuR (ELAVL1) binds and stabilizes mRNA"], "R-XTR-1483166": ["r", "Synthesis of PA"], "R-HSA-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-RNO-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-DME-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-GGA-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-RNO-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-HSA-2871837": ["r", "FCERI mediated NF-kB activation"], "R-HSA-210990": ["r", "PECAM1 interactions"], "R-RNO-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-HSA-5610787": ["r", "Hedgehog 'off' state"], "R-DME-9013406": ["r", "RHOQ GTPase cycle"], "R-DRE-9013149": ["r", "RAC1 GTPase cycle"], "R-DRE-2142753": ["r", "Arachidonate metabolism"], "R-CEL-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-RNO-114508": ["r", "Effects of PIP2 hydrolysis"], "R-HSA-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-DDI-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-HSA-445355": ["r", "Smooth Muscle Contraction"], "R-HSA-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-MMU-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-RNO-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-HSA-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-RNO-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-HSA-5632684": ["r", "Hedgehog 'on' state"], "R-HSA-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-HSA-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-HSA-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-MMU-1482922": ["r", "Acyl chain remodelling of PI"], "R-CEL-1169408": ["r", "ISG15 antiviral mechanism"], "R-RNO-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-SPO-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-HSA-9845576": ["r", "Glycosphingolipid transport"], "R-MMU-416482": ["r", "G alpha (12/13) signalling events"], "R-DME-114516": ["r", "Disinhibition of SNARE formation"], "R-RNO-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-MMU-1482801": ["r", "Acyl chain remodelling of PS"], "R-SCE-202424": ["r", "Downstream TCR signaling"], "R-HSA-9013409": ["r", "RHOJ GTPase cycle"], "R-SPO-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-BTA-112043": ["r", "PLC beta mediated events"], "R-HSA-5689880": ["r", "Ub-specific processing proteases"], "R-RNO-1474228": ["r", "Degradation of the extracellular matrix"], "R-MMU-4086398": ["r", "Ca2+ pathway"], "R-SPO-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-HSA-1489509": ["r", "DAG and IP3 signaling"], "R-MMU-9013408": ["r", "RHOG GTPase cycle"], "R-MMU-210990": ["r", "PECAM1 interactions"], "R-DDI-416476": ["r", "G alpha (q) signalling events"], "R-RNO-1433559": ["r", "Regulation of KIT signaling"], "R-DME-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-MMU-8854214": ["r", "TBC/RABGAPs"], "R-CEL-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-RNO-111465": ["r", "Apoptotic cleavage of cellular proteins"], "R-DDI-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-SCE-6804757": ["r", "Regulation of TP53 Degradation"], "R-HSA-8853659": ["r", "RET signaling"], "R-MMU-9013420": ["r", "RHOU GTPase cycle"], "R-SPO-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-DDI-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-MMU-1482788": ["r", "Acyl chain remodelling of PC"], "R-DDI-5673000": ["r", "RAF activation"], "R-CEL-3000170": ["r", "Syndecan interactions"], "R-MMU-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-HSA-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-SPO-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-RNO-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-BTA-5625740": ["r", "RHO GTPases activate PKNs"], "R-HSA-9026527": ["r", "Activated NTRK2 signals through PLCG1"], "R-BTA-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-HSA-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-SPO-9031628": ["r", "NGF-stimulated transcription"], "R-HSA-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-RNO-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-HSA-2424491": ["r", "DAP12 signaling"], "R-HSA-416482": ["r", "G alpha (12/13) signalling events"], "R-BTA-1482839": ["r", "Acyl chain remodelling of PE"], "R-HSA-5637810": ["r", "Constitutive Signaling by EGFRvIII"], "R-HSA-9696264": ["r", "RND3 GTPase cycle"], "R-RNO-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-MMU-1483166": ["r", "Synthesis of PA"], "R-HSA-1445148": ["r", "Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "R-HSA-111933": ["r", "Calmodulin induced events"], "R-MMU-193648": ["r", "NRAGE signals death through JNK"], "R-CEL-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-HSA-9013026": ["r", "RHOB GTPase cycle"], "R-DDI-202433": ["r", "Generation of second messenger molecules"], "R-XTR-9020702": ["r", "Interleukin-1 signaling"], "R-DME-201451": ["r", "Signaling by BMP"], "R-CEL-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-HSA-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-HSA-9664323": ["r", "FCGR3A-mediated IL10 synthesis"], "R-HSA-1839117": ["r", "Signaling by cytosolic FGFR1 fusion mutants"], "R-DME-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-HSA-5655253": ["r", "Signaling by FGFR2 in disease"], "R-DDI-165159": ["r", "MTOR signalling"], "R-GGA-1482788": ["r", "Acyl chain remodelling of PC"], "R-HSA-8854214": ["r", "TBC/RABGAPs"], "R-MMU-8980692": ["r", "RHOA GTPase cycle"], "R-CEL-1489509": ["r", "DAG and IP3 signaling"], "R-RNO-1169408": ["r", "ISG15 antiviral mechanism"], "R-SCE-6798695": ["r", "Neutrophil degranulation"], "R-XTR-432142": ["r", "Platelet sensitization by LDL"], "R-HSA-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-HSA-9013106": ["r", "RHOC GTPase cycle"], "R-DME-114508": ["r", "Effects of PIP2 hydrolysis"], "R-SPO-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-GGA-1482925": ["r", "Acyl chain remodelling of PG"], "R-CEL-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-CEL-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-RNO-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-SCE-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-MMU-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-HSA-9013423": ["r", "RAC3 GTPase cycle"], "R-MMU-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-DRE-1483115": ["r", "Hydrolysis of LPC"], "R-DME-416476": ["r", "G alpha (q) signalling events"], "R-SPO-9013420": ["r", "RHOU GTPase cycle"], "R-HSA-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-HSA-4086398": ["r", "Ca2+ pathway"], "R-SPO-6804757": ["r", "Regulation of TP53 Degradation"], "R-SPO-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-MMU-202424": ["r", "Downstream TCR signaling"], "R-SCE-5625740": ["r", "RHO GTPases activate PKNs"], "R-BTA-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-381038": ["r", "XBP1(S) activates chaperone genes"], "R-RNO-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-HSA-5655291": ["r", "Signaling by FGFR4 in disease"], "R-MMU-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-MMU-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-MMU-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-HSA-1482801": ["r", "Acyl chain remodelling of PS"], "R-RNO-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-SCE-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-HSA-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-MMU-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-HSA-201556": ["r", "Signaling by ALK"], "R-SPO-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-HSA-111465": ["r", "Apoptotic cleavage of cellular proteins"], "R-HSA-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-SCE-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-HSA-422356": ["r", "Regulation of insulin secretion"], "R-MMU-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-XTR-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-DDI-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-SCE-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-HSA-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-SPO-9013106": ["r", "RHOC GTPase cycle"], "R-SCE-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-CEL-114508": ["r", "Effects of PIP2 hydrolysis"], "R-CEL-1433559": ["r", "Regulation of KIT signaling"], "R-HSA-4641257": ["r", "Degradation of AXIN"], "R-MMU-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-RNO-202424": ["r", "Downstream TCR signaling"], "R-MMU-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-SCE-9013420": ["r", "RHOU GTPase cycle"], "R-BTA-1482798": ["r", "Acyl chain remodeling of CL"], "R-RNO-9013406": ["r", "RHOQ GTPase cycle"], "R-HSA-5621480": ["r", "Dectin-2 family"], "R-CEL-9013148": ["r", "CDC42 GTPase cycle"], "R-HSA-5655302": ["r", "Signaling by FGFR1 in disease"], "R-SCE-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-RNO-201556": ["r", "Signaling by ALK"], "R-HSA-9665686": ["r", "Signaling by ERBB2 TMD/JMD mutants"], "R-SPO-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-RNO-8853659": ["r", "RET signaling"], "R-MMU-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-RNO-1483115": ["r", "Hydrolysis of LPC"], "R-DME-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-HSA-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-DME-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-MMU-111933": ["r", "Calmodulin induced events"], "R-MMU-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-BTA-416476": ["r", "G alpha (q) signalling events"], "R-DME-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-HSA-9013149": ["r", "RAC1 GTPase cycle"], "R-BTA-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-HSA-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-HSA-8980692": ["r", "RHOA GTPase cycle"], "R-HSA-5658442": ["r", "Regulation of RAS by GAPs"], "R-SPO-389513": ["r", "Co-inhibition by CTLA4"], "R-DME-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-HSA-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-HSA-8948751": ["r", "Regulation of PTEN stability and activity"], "R-HSA-418890": ["r", "Role of second messengers in netrin-1 signaling"], "R-RNO-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-SPO-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-BTA-9013106": ["r", "RHOC GTPase cycle"], "R-SCE-202433": ["r", "Generation of second messenger molecules"], "R-SPO-1489509": ["r", "DAG and IP3 signaling"], "R-HSA-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-HSA-416476": ["r", "G alpha (q) signalling events"], "R-MMU-9845576": ["r", "Glycosphingolipid transport"], "R-MMU-1483115": ["r", "Hydrolysis of LPC"], "R-DDI-9013149": ["r", "RAC1 GTPase cycle"], "R-SCE-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-SCE-8948751": ["r", "Regulation of PTEN stability and activity"], "R-HSA-1236382": ["r", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants"], "R-RNO-9845576": ["r", "Glycosphingolipid transport"], "R-SCE-1257604": ["r", "PIP3 activates AKT signaling"], "R-DME-8856828": ["r", "Clathrin-mediated endocytosis"], "R-MMU-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-RNO-9013106": ["r", "RHOC GTPase cycle"], "R-DRE-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-DME-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-RNO-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-SPO-1257604": ["r", "PIP3 activates AKT signaling"], "R-HSA-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-HSA-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-DME-1489509": ["r", "DAG and IP3 signaling"], "R-MMU-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-DME-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-RNO-8948747": ["r", "Regulation of PTEN localization"], "R-MMU-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-HSA-193648": ["r", "NRAGE signals death through JNK"], "R-GGA-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-MMU-202433": ["r", "Generation of second messenger molecules"], "R-SSC-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-MMU-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-GGA-432142": ["r", "Platelet sensitization by LDL"], "R-DME-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-MMU-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-RNO-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-XTR-1482788": ["r", "Acyl chain remodelling of PC"], "R-DME-5632684": ["r", "Hedgehog 'on' state"], "R-DDI-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-CEL-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-DDI-114508": ["r", "Effects of PIP2 hydrolysis"], "R-DRE-1482801": ["r", "Acyl chain remodelling of PS"], "R-MMU-2424491": ["r", "DAP12 signaling"], "R-SCE-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-HSA-8939246": ["r", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "R-RNO-186763": ["r", "Downstream signal transduction"], "R-HSA-2028269": ["r", "Signaling by Hippo"], "R-HSA-9696273": ["r", "RND1 GTPase cycle"], "R-SCE-2871837": ["r", "FCERI mediated NF-kB activation"], "R-XTR-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-DME-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-DME-209155": ["r", "Phosphorylation of AXN and APC"], "R-RNO-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-DME-432553": ["r", "Phosphorylation of PER and TIM"], "R-CEL-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DME-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-DDI-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-DME-69231": ["r", "Cyclin D associated events in G1"], "R-HSA-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-SPO-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-HSA-69231": ["r", "Cyclin D associated events in G1"], "R-DME-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-RNO-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-DME-209214": ["r", "Phosphorylation of SMO"], "R-SCE-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DME-209396": ["r", "Phosphorylation of ARM"], "R-SPO-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-CEL-69231": ["r", "Cyclin D associated events in G1"], "R-MMU-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-DME-209413": ["r", "Assembly of the 'destruction complex'"], "R-SCE-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-CEL-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-RNO-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DME-209190": ["r", "Phosphorylation of CI"], "R-DME-209360": ["r", "Ubiquitination and proteolysis of phosphorylated CI"], "R-CEL-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-DDI-69231": ["r", "Cyclin D associated events in G1"], "R-DME-209461": ["r", "Ubiquitination and degradation of phosphorylated ARM"], "R-HSA-186797": ["r", "Signaling by PDGF"], "R-HSA-6798695": ["r", "Neutrophil degranulation"], "R-MMU-416476": ["r", "G alpha (q) signalling events"], "R-HSA-8874081": ["r", "MET activates PTK2 signaling"], "R-HSA-8875555": ["r", "MET activates RAP1 and RAC1"], "R-HSA-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-MMU-159740": ["r", "Gamma-carboxylation of protein precursors"], "R-MMU-76009": ["r", "Platelet Aggregation (Plug Formation)"], "R-MMU-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-HSA-140837": ["r", "Intrinsic Pathway of Fibrin Clot Formation"], "R-RNO-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-BTA-6798695": ["r", "Neutrophil degranulation"], "R-MMU-8875791": ["r", "MET activates STAT3"], "R-MMU-375276": ["r", "Peptide ligand-binding receptors"], "R-RNO-3772470": ["r", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "R-CFA-9734091": ["r", "Drug-mediated inhibition of MET activation"], "R-MMU-8865999": ["r", "MET activates PTPN11"], "R-CFA-114608": ["r", "Platelet degranulation"], "R-HSA-6806942": ["r", "MET Receptor Activation"], "R-RNO-140837": ["r", "Intrinsic Pathway of Fibrin Clot Formation"], "R-RNO-977606": ["r", "Regulation of Complement cascade"], "R-CFA-1257604": ["r", "PIP3 activates AKT signaling"], "R-MMU-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-CFA-8851805": ["r", "MET activates RAS signaling"], "R-RNO-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-MMU-8851805": ["r", "MET activates RAS signaling"], "R-RNO-202733": ["r", "Cell surface interactions at the vascular wall"], "R-CFA-6807004": ["r", "Negative regulation of MET activity"], "R-MMU-202733": ["r", "Cell surface interactions at the vascular wall"], "R-CFA-5673001": ["r", "RAF/MAP kinase cascade"], "R-HSA-9672391": ["r", "Defective F8 cleavage by thrombin"], "R-HSA-8875513": ["r", "MET interacts with TNS proteins"], "R-CFA-186797": ["r", "Signaling by PDGF"], "R-HSA-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-CFA-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-RNO-8865999": ["r", "MET activates PTPN11"], "R-HSA-75205": ["r", "Dissolution of Fibrin Clot"], "R-HSA-1266695": ["r", "Interleukin-7 signaling"], "R-HSA-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-RNO-5673001": ["r", "RAF/MAP kinase cascade"], "R-RNO-159740": ["r", "Gamma-carboxylation of protein precursors"], "R-RNO-416476": ["r", "G alpha (q) signalling events"], "R-MMU-5673001": ["r", "RAF/MAP kinase cascade"], "R-RNO-6806942": ["r", "MET Receptor Activation"], "R-MMU-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-CFA-8874081": ["r", "MET activates PTK2 signaling"], "R-HSA-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-DME-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-RNO-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-MMU-140837": ["r", "Intrinsic Pathway of Fibrin Clot Formation"], "R-CFA-8875513": ["r", "MET interacts with TNS proteins"], "R-HSA-2219530": ["r", "Constitutive Signaling by Aberrant PI3K in Cancer"], "R-HSA-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-MMU-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-GGA-6798695": ["r", "Neutrophil degranulation"], "R-HSA-5673001": ["r", "RAF/MAP kinase cascade"], "R-HSA-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-RNO-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-HSA-159740": ["r", "Gamma-carboxylation of protein precursors"], "R-RNO-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-MMU-8875555": ["r", "MET activates RAP1 and RAC1"], "R-CFA-8875555": ["r", "MET activates RAP1 and RAC1"], "R-RNO-8875656": ["r", "MET receptor recycling"], "R-RNO-8851805": ["r", "MET activates RAS signaling"], "R-CFA-6806942": ["r", "MET Receptor Activation"], "R-CFA-8875656": ["r", "MET receptor recycling"], "R-MMU-8875513": ["r", "MET interacts with TNS proteins"], "R-RNO-8875555": ["r", "MET activates RAP1 and RAC1"], "R-HSA-1257604": ["r", "PIP3 activates AKT signaling"], "R-MMU-186797": ["r", "Signaling by PDGF"], "R-HSA-8865999": ["r", "MET activates PTPN11"], "R-RNO-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-CFA-8875791": ["r", "MET activates STAT3"], "R-HSA-9657688": ["r", "Defective factor XII causes hereditary angioedema"], "R-HSA-201681": ["r", "TCF dependent signaling in response to WNT"], "R-MMU-3772470": ["r", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "R-HSA-9657689": ["r", "Defective SERPING1 causes hereditary angioedema"], "R-HSA-375276": ["r", "Peptide ligand-binding receptors"], "R-RNO-1257604": ["r", "PIP3 activates AKT signaling"], "R-RNO-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-RNO-9734091": ["r", "Drug-mediated inhibition of MET activation"], "R-RNO-114608": ["r", "Platelet degranulation"], "R-RNO-8874081": ["r", "MET activates PTK2 signaling"], "R-RNO-8875513": ["r", "MET interacts with TNS proteins"], "R-HSA-114608": ["r", "Platelet degranulation"], "R-HSA-76009": ["r", "Platelet Aggregation (Plug Formation)"], "R-MMU-8852405": ["r", "Signaling by MST1"], "R-MMU-8874081": ["r", "MET activates PTK2 signaling"], "R-CEL-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-HSA-977606": ["r", "Regulation of Complement cascade"], "R-HSA-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-CFA-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-MMU-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-RNO-75205": ["r", "Dissolution of Fibrin Clot"], "R-HSA-8851805": ["r", "MET activates RAS signaling"], "R-HSA-9918481": ["r", "Dengue Virus-Host Interactions"], "R-MMU-9734091": ["r", "Drug-mediated inhibition of MET activation"], "R-HSA-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-HSA-9734091": ["r", "Drug-mediated inhibition of MET activation"], "R-HSA-3772470": ["r", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "R-HSA-8875791": ["r", "MET activates STAT3"], "R-HSA-8852405": ["r", "Signaling by MST1"], "R-CFA-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-MMU-977606": ["r", "Regulation of Complement cascade"], "R-RNO-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-RNO-8875791": ["r", "MET activates STAT3"], "R-HSA-5339717": ["r", "Signaling by LRP5 mutants"], "R-HSA-4086400": ["r", "PCP/CE pathway"], "R-RNO-186797": ["r", "Signaling by PDGF"], "R-MMU-75205": ["r", "Dissolution of Fibrin Clot"], "R-HSA-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-HSA-6807004": ["r", "Negative regulation of MET activity"], "R-MMU-1257604": ["r", "PIP3 activates AKT signaling"], "R-SSC-75205": ["r", "Dissolution of Fibrin Clot"], "R-HSA-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-HSA-8964041": ["r", "LDL remodeling"], "R-MMU-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-RNO-6807004": ["r", "Negative regulation of MET activity"], "R-MMU-6806942": ["r", "MET Receptor Activation"], "R-CFA-8865999": ["r", "MET activates PTPN11"], "R-RNO-375276": ["r", "Peptide ligand-binding receptors"], "R-MMU-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-MMU-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-CFA-75205": ["r", "Dissolution of Fibrin Clot"], "R-BTA-75205": ["r", "Dissolution of Fibrin Clot"], "R-MMU-8875656": ["r", "MET receptor recycling"], "R-MMU-6807004": ["r", "Negative regulation of MET activity"], "R-HSA-8875656": ["r", "MET receptor recycling"], "R-HSA-202733": ["r", "Cell surface interactions at the vascular wall"], "R-SSC-186797": ["r", "Signaling by PDGF"], "R-HSA-1989781": ["r", "PPARA activates gene expression"], "R-RNO-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DRE-211976": ["r", "Endogenous sterols"], "R-DRE-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DRE-192105": ["r", "Synthesis of bile acids and bile salts"], "R-HSA-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-BTA-5362517": ["r", "Signaling by Retinoic Acid"], "R-DRE-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-CEL-383280": ["r", "Nuclear Receptor transcription pathway"], "R-HSA-1368108": ["r", "BMAL1:CLOCK,NPAS2 activates circadian expression"], "R-HSA-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-DME-9623433": ["r", "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"], "R-MMU-159418": ["r", "Recycling of bile acids and salts"], "R-HSA-9844594": ["r", "Transcriptional regulation of brown and beige adipocyte differentiation by EBF2"], "R-SSC-383280": ["r", "Nuclear Receptor transcription pathway"], "R-HSA-9933387": ["r", "RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression"], "R-HSA-9707564": ["r", "Cytoprotection by HMOX1"], "R-DME-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-HSA-4090294": ["r", "SUMOylation of intracellular receptors"], "R-HSA-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-DME-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-RNO-4090294": ["r", "SUMOylation of intracellular receptors"], "R-RNO-383280": ["r", "Nuclear Receptor transcription pathway"], "R-DRE-381340": ["r", "Transcriptional regulation of white adipocyte differentiation"], "R-DRE-200425": ["r", "Carnitine shuttle"], "R-DME-383280": ["r", "Nuclear Receptor transcription pathway"], "R-MMU-200425": ["r", "Carnitine shuttle"], "R-MMU-192105": ["r", "Synthesis of bile acids and bile salts"], "R-HSA-192105": ["r", "Synthesis of bile acids and bile salts"], "R-DRE-5362517": ["r", "Signaling by Retinoic Acid"], "R-DRE-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-HSA-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DRE-159418": ["r", "Recycling of bile acids and salts"], "R-MMU-381340": ["r", "Transcriptional regulation of white adipocyte differentiation"], "R-MMU-211976": ["r", "Endogenous sterols"], "R-RNO-381340": ["r", "Transcriptional regulation of white adipocyte differentiation"], "R-RNO-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-HSA-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-RNO-211976": ["r", "Endogenous sterols"], "R-RNO-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-DRE-9707564": ["r", "Cytoprotection by HMOX1"], "R-MMU-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-DRE-383280": ["r", "Nuclear Receptor transcription pathway"], "R-RNO-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-HSA-211976": ["r", "Endogenous sterols"], "R-MMU-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-HSA-5617472": ["r", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "R-HSA-9623433": ["r", "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"], "R-MMU-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-RNO-5362517": ["r", "Signaling by Retinoic Acid"], "R-HSA-9029558": ["r", "NR1H2 & NR1H3 regulate gene expression linked to lipogenesis"], "R-DME-200425": ["r", "Carnitine shuttle"], "R-DRE-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-HSA-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-DRE-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-RNO-9029569": ["r", "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "R-DRE-9623433": ["r", "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"], "R-DRE-9029569": ["r", "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "R-RNO-192105": ["r", "Synthesis of bile acids and bile salts"], "R-MMU-383280": ["r", "Nuclear Receptor transcription pathway"], "R-RNO-159418": ["r", "Recycling of bile acids and salts"], "R-RNO-200425": ["r", "Carnitine shuttle"], "R-MMU-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-MMU-4090294": ["r", "SUMOylation of intracellular receptors"], "R-HSA-9029569": ["r", "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "R-HSA-5362517": ["r", "Signaling by Retinoic Acid"], "R-MMU-9029569": ["r", "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "R-HSA-9931509": ["r", "Expression of BMAL (ARNTL), CLOCK, and NPAS2"], "R-DME-159418": ["r", "Recycling of bile acids and salts"], "R-RNO-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-HSA-9839394": ["r", "TGFBR3 expression"], "R-MMU-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-MMU-9623433": ["r", "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"], "R-DME-9707564": ["r", "Cytoprotection by HMOX1"], "R-HSA-9031525": ["r", "NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake"], "R-HSA-381340": ["r", "Transcriptional regulation of white adipocyte differentiation"], "R-HSA-9632974": ["r", "NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis"], "R-HSA-9707616": ["r", "Heme signaling"], "R-RNO-9707564": ["r", "Cytoprotection by HMOX1"], "R-RNO-9623433": ["r", "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"], "R-HSA-383280": ["r", "Nuclear Receptor transcription pathway"], "R-BTA-383280": ["r", "Nuclear Receptor transcription pathway"], "R-DRE-4090294": ["r", "SUMOylation of intracellular receptors"], "R-HSA-200425": ["r", "Carnitine shuttle"], "R-DME-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-MMU-5362517": ["r", "Signaling by Retinoic Acid"], "R-HSA-159418": ["r", "Recycling of bile acids and salts"], "R-DME-381340": ["r", "Transcriptional regulation of white adipocyte differentiation"], "R-HSA-9031528": ["r", "NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose"], "R-DME-9029569": ["r", "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "R-HSA-2426168": ["r", "Activation of gene expression by SREBF (SREBP)"], "R-DME-5362517": ["r", "Signaling by Retinoic Acid"], "R-MMU-9707564": ["r", "Cytoprotection by HMOX1"], "R-RNO-5661231": ["r", "Metallothioneins bind metals"], "R-SSC-5661231": ["r", "Metallothioneins bind metals"], "R-HSA-5661231": ["r", "Metallothioneins bind metals"], "R-GGA-5661231": ["r", "Metallothioneins bind metals"], "R-MMU-5661231": ["r", "Metallothioneins bind metals"], "R-DRE-5661231": ["r", "Metallothioneins bind metals"], "R-BTA-5661231": ["r", "Metallothioneins bind metals"], "R-MMU-8951664": ["r", "Neddylation"], "R-CEL-5610787": ["r", "Hedgehog 'off' state"], "R-MMU-5610787": ["r", "Hedgehog 'off' state"], "R-HSA-8951664": ["r", "Neddylation"], "R-RNO-9013026": ["r", "RHOB GTPase cycle"], "R-HSA-9013405": ["r", "RHOD GTPase cycle"], "R-DDI-114604": ["r", "GPVI-mediated activation cascade"], "R-XTR-1482801": ["r", "Acyl chain remodelling of PS"], "R-HSA-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-HSA-2871796": ["r", "FCERI mediated MAPK activation"], "R-BTA-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-MMU-1632852": ["r", "Macroautophagy"], "R-MMU-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-SPO-165181": ["r", "Inhibition of TSC complex formation by PKB"], "R-HSA-9010642": ["r", "ROBO receptors bind AKAP5"], "R-CEL-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-RNO-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-HSA-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-MMU-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-DDI-202424": ["r", "Downstream TCR signaling"], "R-MMU-5689880": ["r", "Ub-specific processing proteases"], "R-MMU-201556": ["r", "Signaling by ALK"], "R-HSA-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-HSA-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-SCE-8980692": ["r", "RHOA GTPase cycle"], "R-HSA-9662360": ["r", "Sensory processing of sound by inner hair cells of the cochlea"], "R-DRE-201451": ["r", "Signaling by BMP"], "R-SCE-165158": ["r", "Activation of AKT2"], "R-SCE-9696273": ["r", "RND1 GTPase cycle"], "R-DDI-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-DDI-6798695": ["r", "Neutrophil degranulation"], "R-DME-4641257": ["r", "Degradation of AXIN"], "R-SPO-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-MMU-112043": ["r", "PLC beta mediated events"], "R-HSA-373752": ["r", "Netrin-1 signaling"], "R-HSA-162588": ["r", "Budding and maturation of HIV virion"], "R-GGA-1483166": ["r", "Synthesis of PA"], "R-BTA-500657": ["r", "Presynaptic function of Kainate receptors"], "R-SCE-1489509": ["r", "DAG and IP3 signaling"], "R-CEL-112043": ["r", "PLC beta mediated events"], "R-DME-112043": ["r", "PLC beta mediated events"], "R-RNO-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-DRE-8980692": ["r", "RHOA GTPase cycle"], "R-XTR-2142753": ["r", "Arachidonate metabolism"], "R-SCE-389513": ["r", "Co-inhibition by CTLA4"], "R-MMU-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-RNO-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-RNO-2871796": ["r", "FCERI mediated MAPK activation"], "R-HSA-202433": ["r", "Generation of second messenger molecules"], "R-MMU-2142753": ["r", "Arachidonate metabolism"], "R-HSA-201451": ["r", "Signaling by BMP"], "R-CEL-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-DME-111933": ["r", "Calmodulin induced events"], "R-XTR-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-CEL-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-SCE-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-DME-2028269": ["r", "Signaling by Hippo"], "R-MMU-9034793": ["r", "Activated NTRK3 signals through PLCG1"], "R-SPO-114516": ["r", "Disinhibition of SNARE formation"], "R-HSA-500657": ["r", "Presynaptic function of Kainate receptors"], "R-MMU-2672351": ["r", "Stimuli-sensing channels"], "R-CEL-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-HSA-9013148": ["r", "CDC42 GTPase cycle"], "R-RNO-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-SCE-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-MMU-5621480": ["r", "Dectin-2 family"], "R-RNO-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-HSA-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-DDI-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-DDI-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-MMU-114516": ["r", "Disinhibition of SNARE formation"], "R-DME-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-DRE-111995": ["r", "phospho-PLA2 pathway"], "R-MMU-5675482": ["r", "Regulation of necroptotic cell death"], "R-DRE-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-MMU-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-HSA-1482798": ["r", "Acyl chain remodeling of CL"], "R-BTA-416482": ["r", "G alpha (12/13) signalling events"], "R-RNO-9013423": ["r", "RAC3 GTPase cycle"], "R-GGA-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-HSA-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-SPO-2871837": ["r", "FCERI mediated NF-kB activation"], "R-DDI-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-CEL-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-HSA-9027277": ["r", "Erythropoietin activates Phospholipase C gamma (PLCG)"], "R-BTA-1482922": ["r", "Acyl chain remodelling of PI"], "R-BTA-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-HSA-9725370": ["r", "Signaling by ALK fusions and activated point mutants"], "R-DRE-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-HSA-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-SPO-202433": ["r", "Generation of second messenger molecules"], "R-CEL-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-DDI-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-MMU-5632684": ["r", "Hedgehog 'on' state"], "R-RNO-9020702": ["r", "Interleukin-1 signaling"], "R-MMU-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-CEL-6798695": ["r", "Neutrophil degranulation"], "R-MMU-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-BTA-1482801": ["r", "Acyl chain remodelling of PS"], "R-CEL-9013409": ["r", "RHOJ GTPase cycle"], "R-SCE-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-SPO-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-SPO-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-SPO-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-MMU-432142": ["r", "Platelet sensitization by LDL"], "R-SCE-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-DDI-5675482": ["r", "Regulation of necroptotic cell death"], "R-RNO-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-SPO-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-DDI-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-DME-8948747": ["r", "Regulation of PTEN localization"], "R-MMU-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-RNO-9013404": ["r", "RAC2 GTPase cycle"], "R-CEL-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-HSA-9013408": ["r", "RHOG GTPase cycle"], "R-MMU-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-HSA-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-RNO-1482839": ["r", "Acyl chain remodelling of PE"], "R-RNO-1482801": ["r", "Acyl chain remodelling of PS"], "R-DRE-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-MMU-1474228": ["r", "Degradation of the extracellular matrix"], "R-DDI-8948751": ["r", "Regulation of PTEN stability and activity"], "R-HSA-5675482": ["r", "Regulation of necroptotic cell death"], "R-RNO-1482922": ["r", "Acyl chain remodelling of PI"], "R-HSA-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-DRE-1482925": ["r", "Acyl chain remodelling of PG"], "R-DME-450520": ["r", "HuR (ELAVL1) binds and stabilizes mRNA"], "R-XTR-6798695": ["r", "Neutrophil degranulation"], "R-HSA-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-RNO-1433557": ["r", "Signaling by SCF-KIT"], "R-CEL-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-MMU-418217": ["r", "G beta:gamma signalling through PLC beta"], "R-DDI-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-DME-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-MMU-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-DDI-5625740": ["r", "RHO GTPases activate PKNs"], "R-HSA-1632852": ["r", "Macroautophagy"], "R-DME-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-RNO-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-DME-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-SPO-6798695": ["r", "Neutrophil degranulation"], "R-MMU-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-DME-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-RNO-114516": ["r", "Disinhibition of SNARE formation"], "R-MMU-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-MMU-9648002": ["r", "RAS processing"], "R-BTA-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-DDI-2871837": ["r", "FCERI mediated NF-kB activation"], "R-MMU-9013148": ["r", "CDC42 GTPase cycle"], "R-HSA-1251932": ["r", "PLCG1 events in ERBB2 signaling"], "R-CEL-416476": ["r", "G alpha (q) signalling events"], "R-XTR-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-HSA-6794361": ["r", "Neurexins and neuroligins"], "R-DDI-76005": ["r", "Response to elevated platelet cytosolic Ca2+"], "R-HSA-9754560": ["r", "SARS-CoV-2 modulates autophagy"], "R-HSA-1482922": ["r", "Acyl chain remodelling of PI"], "R-HSA-114508": ["r", "Effects of PIP2 hydrolysis"], "R-DDI-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-MMU-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-HSA-9035034": ["r", "RHOF GTPase cycle"], "R-DME-9013409": ["r", "RHOJ GTPase cycle"], "R-MMU-5658442": ["r", "Regulation of RAS by GAPs"], "R-MMU-168638": ["r", "NOD1/2 Signaling Pathway"], "R-SCE-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-MMU-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-MMU-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-SPO-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-HSA-9694676": ["r", "Translation of Replicase and Assembly of the Replication Transcription Complex"], "R-CEL-202433": ["r", "Generation of second messenger molecules"], "R-RNO-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-DDI-3295583": ["r", "TRP channels"], "R-RNO-9034793": ["r", "Activated NTRK3 signals through PLCG1"], "R-MMU-500657": ["r", "Presynaptic function of Kainate receptors"], "R-BTA-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-RNO-2142753": ["r", "Arachidonate metabolism"], "R-SSC-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-BTA-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-HSA-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-DDI-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-SPO-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-SCE-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-DME-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-DDI-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-CFA-72689": ["r", "Formation of a pool of free 40S subunits"], "R-SCE-72689": ["r", "Formation of a pool of free 40S subunits"], "R-MMU-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-CFA-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-SCE-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-DME-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-BTA-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-CEL-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-SSC-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-MMU-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DME-72689": ["r", "Formation of a pool of free 40S subunits"], "R-HSA-156902": ["r", "Peptide chain elongation"], "R-HSA-72689": ["r", "Formation of a pool of free 40S subunits"], "R-HSA-72764": ["r", "Eukaryotic Translation Termination"], "R-SCE-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-SSC-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-MMU-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-BTA-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-BTA-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-HSA-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DME-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-CFA-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-BTA-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-BTA-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-SSC-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-DDI-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-DDI-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DDI-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-DME-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DDI-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-RNO-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-RNO-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-HSA-9633012": ["r", "Response of EIF2AK4 (GCN2) to amino acid deficiency"], "R-HSA-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-MMU-8941326": ["r", "RUNX2 regulates bone development"], "R-HSA-8939256": ["r", "RUNX1 regulates transcription of genes involved in WNT signaling"], "R-HSA-9942503": ["r", "Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)"], "R-CEL-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-MMU-8939246": ["r", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "R-MMU-8939247": ["r", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "R-RNO-9018519": ["r", "Estrogen-dependent gene expression"], "R-MMU-8939245": ["r", "RUNX1 regulates transcription of genes involved in BCR signaling"], "R-RNO-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-RNO-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-DME-8939246": ["r", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "R-HSA-8941333": ["r", "RUNX2 regulates genes involved in differentiation of myeloid cells"], "R-DME-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-HSA-8939245": ["r", "RUNX1 regulates transcription of genes involved in BCR signaling"], "R-HSA-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-DME-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-HSA-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-RNO-8939247": ["r", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "R-HSA-9018519": ["r", "Estrogen-dependent gene expression"], "R-HSA-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-DME-8939245": ["r", "RUNX1 regulates transcription of genes involved in BCR signaling"], "R-MMU-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-DME-8877330": ["r", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "R-MMU-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-HSA-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-DME-9018519": ["r", "Estrogen-dependent gene expression"], "R-HSA-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-HSA-8949275": ["r", "RUNX3 Regulates Immune Response and Cell Migration"], "R-HSA-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-MMU-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-DME-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-CEL-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-MMU-9018519": ["r", "Estrogen-dependent gene expression"], "R-HSA-8941332": ["r", "RUNX2 regulates genes involved in cell migration"], "R-RNO-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-HSA-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-HSA-8935964": ["r", "RUNX1 regulates expression of components of tight junctions"], "R-RNO-8877330": ["r", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "R-CEL-8939246": ["r", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "R-CEL-549127": ["r", "SLC-mediated transport of organic cations"], "R-DME-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-HSA-549127": ["r", "SLC-mediated transport of organic cations"], "R-DME-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-HSA-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-HSA-8940973": ["r", "RUNX2 regulates osteoblast differentiation"], "R-HSA-8941284": ["r", "RUNX2 regulates chondrocyte maturation"], "R-DME-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-CEL-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-DME-8940973": ["r", "RUNX2 regulates osteoblast differentiation"], "R-DME-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-DME-549127": ["r", "SLC-mediated transport of organic cations"], "R-HSA-8941856": ["r", "RUNX3 regulates NOTCH signaling"], "R-HSA-8951430": ["r", "RUNX3 regulates WNT signaling"], "R-CEL-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-MMU-8940973": ["r", "RUNX2 regulates osteoblast differentiation"], "R-RNO-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-DME-8939247": ["r", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "R-MMU-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-CEL-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-CEL-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-MMU-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-HSA-8951911": ["r", "RUNX3 regulates RUNX1-mediated transcription"], "R-HSA-8952158": ["r", "RUNX3 regulates BCL2L11 (BIM) transcription"], "R-RNO-8939246": ["r", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "R-HSA-1912408": ["r", "Pre-NOTCH Transcription and Translation"], "R-HSA-8877330": ["r", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "R-RNO-8939245": ["r", "RUNX1 regulates transcription of genes involved in BCR signaling"], "R-CEL-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-MMU-8951430": ["r", "RUNX3 regulates WNT signaling"], "R-MMU-8877330": ["r", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "R-HSA-8941326": ["r", "RUNX2 regulates bone development"], "R-MMU-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-CEL-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-DME-8951430": ["r", "RUNX3 regulates WNT signaling"], "R-HSA-8939247": ["r", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "R-DME-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-MMU-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-RNO-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-CEL-8941326": ["r", "RUNX2 regulates bone development"], "R-CEL-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-MMU-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-CEL-8939247": ["r", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "R-CEL-8939245": ["r", "RUNX1 regulates transcription of genes involved in BCR signaling"], "R-DME-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-MMU-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-MMU-8941856": ["r", "RUNX3 regulates NOTCH signaling"], "R-DME-8941326": ["r", "RUNX2 regulates bone development"], "R-CEL-8951430": ["r", "RUNX3 regulates WNT signaling"], "R-HSA-4411364": ["r", "Binding of TCF/LEF:CTNNB1 to target gene promoters"], "R-MMU-549127": ["r", "SLC-mediated transport of organic cations"], "R-CEL-8877330": ["r", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "R-RNO-549127": ["r", "SLC-mediated transport of organic cations"], "R-CEL-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "PWY-5041": ["t", "S-adenosyl-L-methionine salvage II"], "R-CEL-156581": ["r", "Methylation"], "R-RNO-1614635": ["r", "Sulfur amino acid metabolism"], "R-HSA-5607763": ["r", "CLEC7A (Dectin-1) induces NFAT activation"], "R-MMU-425381": ["r", "Bicarbonate transporters"], "R-HSA-5578997": ["r", "Defective AHCY causes HMAHCHD"], "R-DME-156581": ["r", "Methylation"], "R-SCE-156581": ["r", "Methylation"], "R-SCE-1614635": ["r", "Sulfur amino acid metabolism"], "R-HSA-1614635": ["r", "Sulfur amino acid metabolism"], "R-HSA-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-SPO-156581": ["r", "Methylation"], "R-SPO-1614635": ["r", "Sulfur amino acid metabolism"], "R-BTA-1614635": ["r", "Sulfur amino acid metabolism"], "R-RNO-156581": ["r", "Methylation"], "R-MMU-1614635": ["r", "Sulfur amino acid metabolism"], "R-HSA-5578775": ["r", "Ion homeostasis"], "R-DME-425381": ["r", "Bicarbonate transporters"], "R-DDI-156581": ["r", "Methylation"], "R-BTA-425381": ["r", "Bicarbonate transporters"], "R-HSA-425381": ["r", "Bicarbonate transporters"], "R-DME-5578775": ["r", "Ion homeostasis"], "R-RNO-5578775": ["r", "Ion homeostasis"], "R-CEL-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-HSA-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-RNO-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-RNO-69231": ["r", "Cyclin D associated events in G1"], "R-DME-432620": ["r", "Dephosphorylation of PER"], "R-HSA-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-DME-209440": ["r", "Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM"], "R-HSA-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-MMU-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-MMU-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-MMU-69231": ["r", "Cyclin D associated events in G1"], "R-SSC-6798695": ["r", "Neutrophil degranulation"], "R-HSA-6809371": ["r", "Formation of the cornified envelope"], "R-HSA-977225": ["r", "Amyloid fiber formation"], "R-MMU-8957275": ["r", "Post-translational protein phosphorylation"], "R-RNO-418594": ["r", "G alpha (i) signalling events"], "R-BTA-8957275": ["r", "Post-translational protein phosphorylation"], "R-BTA-114608": ["r", "Platelet degranulation"], "R-MMU-6809371": ["r", "Formation of the cornified envelope"], "R-RNO-8957275": ["r", "Post-translational protein phosphorylation"], "R-MMU-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-CEL-8957275": ["r", "Post-translational protein phosphorylation"], "R-CEL-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-BTA-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-SSC-6809371": ["r", "Formation of the cornified envelope"], "R-HSA-8957275": ["r", "Post-translational protein phosphorylation"], "R-BTA-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-MMU-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-HSA-168928": ["r", "DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "R-HSA-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-DRE-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-HSA-9918485": ["r", "Dengue Virus Attachment and Entry"], "R-RNO-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-MMU-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-HSA-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-SPO-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-HSA-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-DDI-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-HSA-5656169": ["r", "Termination of translesion DNA synthesis"], "R-MMU-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-BTA-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-SPO-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-RNO-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-DDI-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "R-MMU-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-BTA-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-MMU-5656169": ["r", "Termination of translesion DNA synthesis"], "R-DDI-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-DRE-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-DDI-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-DDI-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-HSA-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-BTA-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-RNO-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-DDI-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-HSA-180910": ["r", "Vpr-mediated nuclear import of PICs"], "R-HSA-162592": ["r", "Integration of provirus"], "R-HSA-177539": ["r", "Autointegration results in viral DNA circles"], "R-HSA-164516": ["r", "Minus-strand DNA synthesis"], "R-HSA-175567": ["r", "Integration of viral DNA into host genomic DNA"], "R-HSA-175474": ["r", "Assembly Of The HIV Virion"], "R-HSA-164525": ["r", "Plus-strand DNA synthesis"], "R-HSA-162585": ["r", "Uncoating of the HIV Virion"], "R-HSA-180897": ["r", "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization"], "R-HSA-180689": ["r", "APOBEC3G mediated resistance to HIV-1 infection"], "R-HSA-164843": ["r", "2-LTR circle formation"], "R-HSA-173107": ["r", "Binding and entry of HIV virion"], "R-HSA-162594": ["r", "Early Phase of HIV Life Cycle"], "R-DME-1296072": ["r", "Voltage gated Potassium channels"], "R-CEL-211945": ["r", "Phase I - Functionalization of compounds"], "R-CEL-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-HSA-9931530": ["r", "Phosphorylation and nuclear translocation of the CRY:PER:kinase complex"], "R-RNO-8857538": ["r", "PTK6 promotes HIF1A stabilization"], "R-HSA-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-HSA-2122947": ["r", "NOTCH1 Intracellular Domain Regulates Transcription"], "R-HSA-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-DME-432524": ["r", "Degradation of PER"], "R-DME-538898": ["r", "Dephosphorylation of TIM"], "R-MMU-9932298": ["r", "Degradation of CRY and PER proteins"], "R-HSA-418555": ["r", "G alpha (s) signalling events"], "R-HSA-9931521": ["r", "The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex"], "R-HSA-452723": ["r", "Transcriptional regulation of pluripotent stem cells"], "R-MMU-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-RNO-5689880": ["r", "Ub-specific processing proteases"], "R-RNO-211945": ["r", "Phase I - Functionalization of compounds"], "R-DME-432408": ["r", "Transcription regulation of cwo gene"], "R-RNO-8951664": ["r", "Neddylation"], "R-SPO-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-DME-211945": ["r", "Phase I - Functionalization of compounds"], "R-DME-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-HSA-9931529": ["r", "Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK"], "R-MMU-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-HSA-9664873": ["r", "Pexophagy"], "R-HSA-8857538": ["r", "PTK6 promotes HIF1A stabilization"], "R-HSA-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-MMU-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-RNO-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-DRE-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-RNO-9932298": ["r", "Degradation of CRY and PER proteins"], "R-DME-418555": ["r", "G alpha (s) signalling events"], "R-HSA-211945": ["r", "Phase I - Functionalization of compounds"], "R-HSA-1234174": ["r", "Cellular response to hypoxia"], "R-MMU-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-DME-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-DME-432490": ["r", "Nuclear import of PER and TIM"], "R-DME-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-DME-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-MMU-3214847": ["r", "HATs acetylate histones"], "R-DRE-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-MMU-3899300": ["r", "SUMOylation of transcription cofactors"], "R-DME-432626": ["r", "Circadian Clock pathway"], "R-CEL-5689880": ["r", "Ub-specific processing proteases"], "R-HSA-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-RNO-3214847": ["r", "HATs acetylate histones"], "R-DME-9932298": ["r", "Degradation of CRY and PER proteins"], "R-HSA-1296072": ["r", "Voltage gated Potassium channels"], "R-DRE-211945": ["r", "Phase I - Functionalization of compounds"], "R-HSA-3214847": ["r", "HATs acetylate histones"], "R-MMU-418555": ["r", "G alpha (s) signalling events"], "R-CEL-8951664": ["r", "Neddylation"], "R-SSC-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-HSA-211981": ["r", "Xenobiotics"], "R-MMU-1234174": ["r", "Cellular response to hypoxia"], "R-CFA-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-HSA-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-DME-8951664": ["r", "Neddylation"], "R-HSA-9932298": ["r", "Degradation of CRY and PER proteins"], "R-RNO-211981": ["r", "Xenobiotics"], "R-SSC-1296072": ["r", "Voltage gated Potassium channels"], "R-MMU-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-DRE-3214847": ["r", "HATs acetylate histones"], "R-DRE-211981": ["r", "Xenobiotics"], "R-RNO-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-DRE-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-RNO-1234174": ["r", "Cellular response to hypoxia"], "R-HSA-9768778": ["r", "Regulation of NPAS4 mRNA translation"], "R-MMU-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-CEL-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-MMU-211945": ["r", "Phase I - Functionalization of compounds"], "R-RNO-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-BTA-1296072": ["r", "Voltage gated Potassium channels"], "R-DME-432560": ["r", "Transcription activation by CLK:CYC and repression by VRI"], "R-MMU-211981": ["r", "Xenobiotics"], "R-MMU-8857538": ["r", "PTK6 promotes HIF1A stabilization"], "R-HSA-8849473": ["r", "PTK6 Expression"], "R-HSA-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-MMU-1296072": ["r", "Voltage gated Potassium channels"], "R-CEL-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-RNO-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-CFA-1296072": ["r", "Voltage gated Potassium channels"], "R-RNO-1296072": ["r", "Voltage gated Potassium channels"], "R-HSA-9931510": ["r", "Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes"], "R-HSA-9931512": ["r", "Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters"], "R-HSA-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-DME-432395": ["r", "Degradation of TIM"], "R-RNO-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-HSA-3899300": ["r", "SUMOylation of transcription cofactors"], "R-CEL-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-DME-432501": ["r", "Transcription repression by PER and activation by PDP1"], "R-HSA-417957": ["r", "P2Y receptors"], "R-MMU-417957": ["r", "P2Y receptors"], "R-RNO-417957": ["r", "P2Y receptors"], "R-MMU-418594": ["r", "G alpha (i) signalling events"], "R-RNO-166663": ["r", "Initial triggering of complement"], "R-HSA-9920588": ["r", "Dengue virus activates/modulates innate and adaptive immune responses"], "R-BTA-173736": ["r", "Alternative complement activation"], "R-MMU-166663": ["r", "Initial triggering of complement"], "R-CEL-1566948": ["r", "Elastic fibre formation"], "R-MMU-166665": ["r", "Terminal pathway of complement"], "R-CEL-1474228": ["r", "Degradation of the extracellular matrix"], "R-BTA-418594": ["r", "G alpha (i) signalling events"], "R-CEL-2129379": ["r", "Molecules associated with elastic fibres"], "R-HSA-166665": ["r", "Terminal pathway of complement"], "R-MMU-174577": ["r", "Activation of C3 and C5"], "R-HSA-174577": ["r", "Activation of C3 and C5"], "R-HSA-166663": ["r", "Initial triggering of complement"], "R-BTA-977606": ["r", "Regulation of Complement cascade"], "R-CEL-216083": ["r", "Integrin cell surface interactions"], "R-HSA-2129379": ["r", "Molecules associated with elastic fibres"], "R-BTA-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-RNO-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-HSA-9660826": ["r", "Purinergic signaling in leishmaniasis infection"], "R-BTA-375276": ["r", "Peptide ligand-binding receptors"], "R-BTA-174577": ["r", "Activation of C3 and C5"], "R-RNO-174577": ["r", "Activation of C3 and C5"], "R-MMU-173736": ["r", "Alternative complement activation"], "R-MMU-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-RNO-166665": ["r", "Terminal pathway of complement"], "R-HSA-173736": ["r", "Alternative complement activation"], "R-RNO-173736": ["r", "Alternative complement activation"], "R-HSA-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-CEL-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-MMU-2129379": ["r", "Molecules associated with elastic fibres"], "PWY-5484": ["t", "glycolysis II (from fructose 6-phosphate)"], "PWY-1861": ["t", "formaldehyde assimilation II (assimilatory RuMP Cycle)"], "PWY-1042": ["t", "glycolysis IV"], "PWY-7385": ["t", "1,3-propanediol biosynthesis (engineered)"], "R-MMU-70171": ["r", "Glycolysis"], "R-SCE-70171": ["r", "Glycolysis"], "R-DME-6798695": ["r", "Neutrophil degranulation"], "R-BTA-70171": ["r", "Glycolysis"], "R-DME-70171": ["r", "Glycolysis"], "R-CEL-70171": ["r", "Glycolysis"], "R-RNO-70171": ["r", "Glycolysis"], "R-HSA-70171": ["r", "Glycolysis"], "R-SPO-70171": ["r", "Glycolysis"], "R-DRE-418594": ["r", "G alpha (i) signalling events"], "R-RNO-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-GGA-418594": ["r", "G alpha (i) signalling events"], "R-GGA-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-HSA-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-DRE-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-MMU-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-HSA-9636249": ["r", "Inhibition of nitric oxide production"], "R-RNO-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-MMU-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-CEL-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-HSA-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-DME-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-GGA-419140": ["r", "De novo synthesis of IMP"], "R-MMU-182971": ["r", "EGFR downregulation"], "R-MMU-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-MMU-180336": ["r", "SHC1 events in EGFR signaling"], "R-BTA-8964026": ["r", "Chylomicron clearance"], "R-MMU-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-HSA-180292": ["r", "GAB1 signalosome"], "R-MMU-8964046": ["r", "VLDL clearance"], "R-HSA-3000178": ["r", "ECM proteoglycans"], "R-RNO-8866376": ["r", "Reelin signalling pathway"], "R-HSA-2168880": ["r", "Scavenging of heme from plasma"], "R-RNO-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-RNO-3000157": ["r", "Laminin interactions"], "R-MMU-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-RNO-8964026": ["r", "Chylomicron clearance"], "R-HSA-9927418": ["r", "Developmental Lineage of Mammary Gland Luminal Epithelial Cells"], "R-GGA-8866376": ["r", "Reelin signalling pathway"], "R-RNO-8964038": ["r", "LDL clearance"], "R-RNO-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-MMU-975634": ["r", "Retinoid metabolism and transport"], "R-RNO-9758890": ["r", "Transport of RCbl within the body"], "R-HSA-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-HSA-9818030": ["r", "NFE2L2 regulating tumorigenic genes"], "R-RNO-8847993": ["r", "ERBB2 Activates PTK6 Signaling"], "R-RNO-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-HSA-177929": ["r", "Signaling by EGFR"], "R-MMU-1236394": ["r", "Signaling by ERBB4"], "R-RNO-8964046": ["r", "VLDL clearance"], "R-RNO-8866427": ["r", "VLDLR internalisation and degradation"], "R-MMU-2168880": ["r", "Scavenging of heme from plasma"], "R-RNO-179812": ["r", "GRB2 events in EGFR signaling"], "R-DME-1227986": ["r", "Signaling by ERBB2"], "R-HSA-182971": ["r", "EGFR downregulation"], "R-MMU-180292": ["r", "GAB1 signalosome"], "R-DME-1236394": ["r", "Signaling by ERBB4"], "R-HSA-8847993": ["r", "ERBB2 Activates PTK6 Signaling"], "R-RNO-2168880": ["r", "Scavenging of heme from plasma"], "R-DME-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-DME-114608": ["r", "Platelet degranulation"], "R-RNO-9013507": ["r", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "R-DME-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-RNO-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-MMU-8866427": ["r", "VLDLR internalisation and degradation"], "R-MMU-9758890": ["r", "Transport of RCbl within the body"], "R-MMU-179812": ["r", "GRB2 events in EGFR signaling"], "R-MMU-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-MMU-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-DME-1257604": ["r", "PIP3 activates AKT signaling"], "R-DME-182971": ["r", "EGFR downregulation"], "R-HSA-179812": ["r", "GRB2 events in EGFR signaling"], "R-DME-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-MMU-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-HSA-5638303": ["r", "Inhibition of Signaling by Overexpressed EGFR"], "R-DME-180336": ["r", "SHC1 events in EGFR signaling"], "R-RNO-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-HSA-9725554": ["r", "Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin"], "R-DME-5673001": ["r", "RAF/MAP kinase cascade"], "R-HSA-3000157": ["r", "Laminin interactions"], "R-HSA-8964046": ["r", "VLDL clearance"], "R-DME-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-HSA-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-MMU-8847993": ["r", "ERBB2 Activates PTK6 Signaling"], "R-MMU-8964038": ["r", "LDL clearance"], "R-HSA-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-HSA-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-HSA-5340588": ["r", "Signaling by RNF43 mutants"], "R-RNO-975634": ["r", "Retinoid metabolism and transport"], "R-RNO-177929": ["r", "Signaling by EGFR"], "R-DME-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-HSA-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-DME-180292": ["r", "GAB1 signalosome"], "R-MMU-3000157": ["r", "Laminin interactions"], "R-HSA-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-HSA-8964026": ["r", "Chylomicron clearance"], "R-MMU-1227986": ["r", "Signaling by ERBB2"], "R-RNO-1227986": ["r", "Signaling by ERBB2"], "R-HSA-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-HSA-9927432": ["r", "Developmental Lineage of Mammary Gland Myoepithelial Cells"], "R-HSA-1227986": ["r", "Signaling by ERBB2"], "R-HSA-9937080": ["r", "Developmental Lineage of Multipotent Pancreatic Progenitor Cells"], "R-MMU-8964026": ["r", "Chylomicron clearance"], "R-RNO-180292": ["r", "GAB1 signalosome"], "R-HSA-9758890": ["r", "Transport of RCbl within the body"], "R-HSA-9634638": ["r", "Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "R-DME-177929": ["r", "Signaling by EGFR"], "R-HSA-180336": ["r", "SHC1 events in EGFR signaling"], "R-HSA-1236394": ["r", "Signaling by ERBB4"], "R-DME-1474228": ["r", "Degradation of the extracellular matrix"], "R-HSA-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-HSA-8866427": ["r", "VLDLR internalisation and degradation"], "R-GGA-8866427": ["r", "VLDLR internalisation and degradation"], "R-BTA-8964038": ["r", "LDL clearance"], "R-MMU-8866376": ["r", "Reelin signalling pathway"], "R-RNO-180336": ["r", "SHC1 events in EGFR signaling"], "R-RNO-1236394": ["r", "Signaling by ERBB4"], "R-RNO-182971": ["r", "EGFR downregulation"], "R-HSA-8866376": ["r", "Reelin signalling pathway"], "R-DME-179812": ["r", "GRB2 events in EGFR signaling"], "R-HSA-8964038": ["r", "LDL clearance"], "R-HSA-975634": ["r", "Retinoid metabolism and transport"], "R-MMU-177929": ["r", "Signaling by EGFR"], "R-HSA-3560783": ["r", "Defective B4GALT7 causes EDS, progeroid type"], "R-HSA-9619665": ["r", "EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "R-HSA-9856532": ["r", "Mechanical load activates signaling by PIEZO1 and integrins in osteocytes"], "R-HSA-3656237": ["r", "Defective EXT2 causes exostoses 2"], "R-HSA-373760": ["r", "L1CAM interactions"], "R-HSA-9638630": ["r", "Attachment of bacteria to epithelial cells"], "R-HSA-3656253": ["r", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS"], "R-HSA-2024096": ["r", "HS-GAG degradation"], "R-HSA-2022928": ["r", "HS-GAG biosynthesis"], "R-HSA-9833110": ["r", "RSV-host interactions"], "R-HSA-446107": ["r", "Type I hemidesmosome assembly"], "R-HSA-9925563": ["r", "Developmental Lineage of Pancreatic Ductal Cells"], "R-HSA-2214320": ["r", "Anchoring fibril formation"], "R-HSA-216083": ["r", "Integrin cell surface interactions"], "R-HSA-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-HSA-3000171": ["r", "Non-integrin membrane-ECM interactions"], "R-HSA-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-HSA-9694614": ["r", "Attachment and Entry"], "R-HSA-3560801": ["r", "Defective B3GAT3 causes JDSSDHD"], "R-HSA-9820960": ["r", "Respiratory syncytial virus (RSV) attachment and entry"], "R-HSA-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-HSA-4420332": ["r", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "R-BTA-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-HSA-9010553": ["r", "Regulation of expression of SLITs and ROBOs"], "R-SPO-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-CFA-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-SCE-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-RNO-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-DME-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-DME-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-BTA-72689": ["r", "Formation of a pool of free 40S subunits"], "R-MMU-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-HSA-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-CEL-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-MMU-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-RNO-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-CFA-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-DDI-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-CEL-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-CFA-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-CEL-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-CEL-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-SSC-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-HSA-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-MMU-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-HSA-2408557": ["r", "Selenocysteine synthesis"], "R-SPO-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-SPO-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-BTA-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-RNO-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-MMU-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-SPO-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-BTA-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-SCE-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-CEL-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-SSC-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-HSA-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-CFA-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-CEL-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-CFA-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-RNO-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-SSC-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-SSC-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-HSA-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-RNO-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-RNO-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-SSC-72689": ["r", "Formation of a pool of free 40S subunits"], "R-SPO-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-HSA-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-CEL-72689": ["r", "Formation of a pool of free 40S subunits"], "R-SPO-72689": ["r", "Formation of a pool of free 40S subunits"], "R-MMU-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-CFA-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-DDI-72689": ["r", "Formation of a pool of free 40S subunits"], "R-DDI-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-HSA-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-CFA-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DME-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-DME-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-SCE-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-MMU-72689": ["r", "Formation of a pool of free 40S subunits"], "R-HSA-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-RNO-72689": ["r", "Formation of a pool of free 40S subunits"], "R-MMU-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-HSA-192823": ["r", "Viral mRNA Translation"], "R-SSC-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-HSA-9018682": ["r", "Biosynthesis of maresins"], "R-BTA-426048": ["r", "Arachidonate production from DAG"], "R-SSC-2142670": ["r", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "R-SCE-426048": ["r", "Arachidonate production from DAG"], "R-MMU-8963888": ["r", "Chylomicron assembly"], "R-HSA-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-GGA-3000471": ["r", "Scavenging by Class B Receptors"], "R-GGA-975634": ["r", "Retinoid metabolism and transport"], "R-BTA-8963896": ["r", "HDL assembly"], "R-HSA-8963901": ["r", "Chylomicron remodeling"], "R-HSA-8864260": ["r", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "R-BTA-8963888": ["r", "Chylomicron assembly"], "R-HSA-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-RNO-3000471": ["r", "Scavenging by Class B Receptors"], "R-MMU-9707616": ["r", "Heme signaling"], "R-GGA-8964011": ["r", "HDL clearance"], "R-GGA-8957275": ["r", "Post-translational protein phosphorylation"], "R-MMU-8964011": ["r", "HDL clearance"], "R-MMU-8964058": ["r", "HDL remodeling"], "R-DRE-8963896": ["r", "HDL assembly"], "R-DRE-3000480": ["r", "Scavenging by Class A Receptors"], "R-HSA-9918432": ["r", "Maturation of DENV proteins"], "R-BTA-8963901": ["r", "Chylomicron remodeling"], "R-DRE-8964011": ["r", "HDL clearance"], "R-BTA-9707616": ["r", "Heme signaling"], "R-BTA-975634": ["r", "Retinoid metabolism and transport"], "R-RNO-8964011": ["r", "HDL clearance"], "R-MMU-8963901": ["r", "Chylomicron remodeling"], "R-RNO-8963888": ["r", "Chylomicron assembly"], "R-DRE-8964058": ["r", "HDL remodeling"], "R-RNO-8963896": ["r", "HDL assembly"], "R-GGA-8963896": ["r", "HDL assembly"], "R-DRE-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-DRE-3000471": ["r", "Scavenging by Class B Receptors"], "R-RNO-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-GGA-8963888": ["r", "Chylomicron assembly"], "R-HSA-8964011": ["r", "HDL clearance"], "R-DRE-114608": ["r", "Platelet degranulation"], "R-RNO-8963901": ["r", "Chylomicron remodeling"], "R-HSA-3000480": ["r", "Scavenging by Class A Receptors"], "R-HSA-1251985": ["r", "Nuclear signaling by ERBB4"], "R-MMU-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-MMU-3000480": ["r", "Scavenging by Class A Receptors"], "R-HSA-3000471": ["r", "Scavenging by Class B Receptors"], "R-RNO-9707616": ["r", "Heme signaling"], "R-GGA-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-RNO-8964058": ["r", "HDL remodeling"], "R-GGA-9707616": ["r", "Heme signaling"], "R-DRE-8957275": ["r", "Post-translational protein phosphorylation"], "R-BTA-8964058": ["r", "HDL remodeling"], "R-BTA-3000471": ["r", "Scavenging by Class B Receptors"], "R-GGA-8964058": ["r", "HDL remodeling"], "R-GGA-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-HSA-8963896": ["r", "HDL assembly"], "R-MMU-3000471": ["r", "Scavenging by Class B Receptors"], "R-HSA-8964058": ["r", "HDL remodeling"], "R-GGA-2168880": ["r", "Scavenging of heme from plasma"], "R-GGA-114608": ["r", "Platelet degranulation"], "R-HSA-8963888": ["r", "Chylomicron assembly"], "R-HSA-5682113": ["r", "Defective ABCA1 causes TGD"], "R-MMU-8963896": ["r", "HDL assembly"], "R-RNO-3000480": ["r", "Scavenging by Class A Receptors"], "R-BTA-8964011": ["r", "HDL clearance"], "R-HSA-5619039": ["r", "Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"], "R-MMU-426117": ["r", "Cation-coupled Chloride cotransporters"], "R-RNO-426117": ["r", "Cation-coupled Chloride cotransporters"], "R-HSA-426117": ["r", "Cation-coupled Chloride cotransporters"], "R-GGA-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-GGA-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-GGA-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-GGA-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-GGA-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-GGA-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-GGA-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-MMU-5578775": ["r", "Ion homeostasis"], "R-MMU-156581": ["r", "Methylation"], "R-CEL-1614635": ["r", "Sulfur amino acid metabolism"], "R-BTA-156581": ["r", "Methylation"], "R-DDI-1614635": ["r", "Sulfur amino acid metabolism"], "R-HSA-156581": ["r", "Methylation"], "R-DME-1614635": ["r", "Sulfur amino acid metabolism"], "PWY-7045": ["t", "mithramycin biosynthesis"], "PWY-7161": ["t", "polymethylated quercetin biosynthesis"], "PWY-7751": ["t", "shinorine biosynthesis"], "PWY-8426": ["t", "(2R)-methoxymalonyl-[acp] biosynthesis"], "PWY-8238": ["t", "24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"], "PWY-7743": ["t", "dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"], "PWY-7689": ["t", "8-O-methylfusarubin biosynthesis"], "PWY-7100": ["t", "spinosyn biosynthesis"], "PWY-5665": ["t", "vanillin biosynthesis I"], "PWY-8364": ["t", "7,8-dimethylmenaquinone biosynthesis"], "PWY-7151": ["t", "polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"], "PWY-3542": ["t", "choline biosynthesis II"], "PWY-8381": ["t", "sulfazecin biosynthesis"], "PWY-7717": ["t", "3-hydroxy-4-methyl-anthranilate biosynthesis I"], "PWY-7517": ["t", "brassicicene C biosynthesis"], "PWY-7440": ["t", "dTDP-beta-L-4-epi-vancosamine biosynthesis"], "PWY-8437": ["t", "furaquinocin biosynthesis"], "PWY-6310": ["t", "aloenin biosynthesis"], "PWY-7692": ["t", "bikaverin biosynthesis"], "PWY-7498": ["t", "phenylpropanoids methylation (ice plant)"], "PWY-6148": ["t", "tetrahydromethanopterin biosynthesis"], "PWY-8077": ["t", "ginkgotoxin biosynthesis"], "PWY-8380": ["t", "dTDP-sibirosamine biosynthesis"], "PWY-6739": ["t", "pinitol biosynthesis II"], "PWY-6427": ["t", "rot-2'-enonate biosynthesis"], "PWY-7135": ["t", "emetine biosynthesis"], "PWY-7485": ["t", "tetracenomycin C biosynthesis"], "PWY-7659": ["t", "viridicatumtoxin biosynthesis"], "PWY-7150": ["t", "polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"], "PWY-7667": ["t", "apicidin biosynthesis"], "PWY-7643": ["t", "coniferyl alcohol 9-methyl ether biosynthesis"], "PWY-6835": ["t", "6-gingerol biosynthesis"], "PWY-8076": ["t", "8-O-methylated benzoxazinoid glucoside biosynthesis"], "PWY-5479": ["t", "6-methoxypodophyllotoxin biosynthesis"], "PWY-8424": ["t", "ascomycin biosynthesis"], "PWY-2083": ["t", "isoflavonoid biosynthesis II"], "PWY-8361": ["t", "apratoxin A biosynthesis"], "PWY-4021": ["t", "beta-alanine betaine biosynthesis"], "PWY-8100": ["t", "crotonosine biosynthesis"], "PWY-7745": ["t", "p-HBAD biosynthesis"], "PWY-8463": ["t", "5,6-dehydrokavain biosynthesis (engineered)"], "PWY-5305": ["t", "bixin biosynthesis"], "PWY-7977": ["t", "L-methionine biosynthesis IV"], "PWY-7629": ["t", "yatein biosynthesis II"], "PWY-7055": ["t", "daphnetin modification"], "PWY-7607": ["t", "meleagrin biosynthesis"], "PWY-7163": ["t", "polymethylated kaempferol biosynthesis"], "PWY-5059": ["t", "pinobanksin biosynthesis"], "PWY-6736": ["t", "sulfur volatiles biosynthesis"], "PWY-8368": ["t", "clorobiocin biosynthesis"], "PWY-8122": ["t", "mycofactocin biosynthesis"], "PWY-7547": ["t", "prodigiosin biosynthesis"], "PWY-5301": ["t", "ajmaline and sarpagine biosynthesis"], "PWY-8172": ["t", "10-methylstearate biosynthesis"], "PWY-5729": ["t", "vestitol and sativan biosynthesis"], "PWY-5773": ["t", "gossypol biosynthesis"], "PWY-7155": ["t", "7-dehydroporiferasterol biosynthesis"], "PWY-7076": ["t", "3,5-dimethoxytoluene biosynthesis"], "PWY-7737": ["t", "thiocoraline biosynthesis"], "PWY-6682": ["t", "dehydrophos biosynthesis"], "PWY-8104": ["t", "yangonin biosynthesis"], "PWY-6045": ["t", "methylthiopropanonate degradation II (demethylation)"], "PWY-7608": ["t", "neoxaline biosynthesis"], "PWY-7439": ["t", "dTDP-beta-L-evernitrose biosynthesis"], "PWY-8379": ["t", "sibiromycin biosynthesis"], "PWY-7668": ["t", "apicidin F biosynthesis"], "PWY-7564": ["t", "bacimethrin and bacimethrin pyrophosphate biosynthesis"], "PWY-8047": ["t", "bryostatin biosynthesis"], "PWY-7104": ["t", "dTDP-beta-L-megosamine biosynthesis"], "PWY-7569": ["t", "arginomycin biosynthesis"], "PWY-7534": ["t", "gliotoxin inactivation"], "PWY-1061": ["t", "homogalacturonan biosynthesis"], "PWY-7811": ["t", "6-methylpretetramide biosynthesis"], "PWY-7673": ["t", "fusarin C biosynthesis"], "PWY-7655": ["t", "dechlorogriseofulvin biosynthesis"], "PWY-6339": ["t", "syringate degradation"], "PWY-8326": ["t", "grayanate biosynthesis"], "PWY-5748": ["t", "gamma-coniciene and coniine biosynthesis"], "PWY-7285": ["t", "methylwyosine biosynthesis"], "PWY-8040": ["t", "ansatrienin biosynthesis"], "PWY-7735": ["t", "echinomycin and triostin A biosynthesis"], "PWY-8103": ["t", "kavain biosynthesis"], "PWY-6286": ["t", "spheroidene and spheroidenone biosynthesis"], "PWY-4202": ["t", "arsenic detoxification (mammals)"], "PWY-6581": ["t", "spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis"], "PWY-7186": ["t", "superpathway of scopolin and esculin biosynthesis"], "PWY-7705": ["t", "quinolinone B biosynthesis"], "PWY-8036": ["t", "chaxamycin biosynthesis"], "PWY-5975": ["t", "furaneol and mesifurane biosynthesis"], "PWY-6795": ["t", "diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis"], "PWY-7301": ["t", "dTDP-4-O-demethyl-beta-L-noviose biosynthesis"], "PWY-7669": ["t", "equisetin biosynthesis"], "PWY-8367": ["t", "hygromycin B biosynthesis"], "PWY-8212": ["t", "Escherichia coli serotype O:8 O antigen biosynthesis"], "PWY-7325": ["t", "salvigenin biosynthesis"], "PWY-7739": ["t", "aucuparin biosynthesis"], "PWY-6955": ["t", "lincomycin A biosynthesis"], "PWY-7483": ["t", "elloramycin biosynthesis"], "PWY-8257": ["t", "Escherichia coli serotype O:52 O antigen biosynthesis"], "PWY-6973": ["t", "dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"], "PWYG-321": ["t", "mycolate biosynthesis"], "PWY-5883": ["t", "ephedrine biosynthesis"], "PWY-5105": ["t", "hesperitin glycoside biosynthesis"], "PWY-7742": ["t", "phenolphthiocerol biosynthesis"], "PWY-6477": ["t", "gibberellin inactivation II (methylation)"], "PWY-7826": ["t", "Amaryllidacea alkaloids biosynthesis"], "PWY-7298": ["t", "nevadensin biosynthesis"], "PWY-8035": ["t", "streptovaricin biosynthesis"], "PWY-7157": ["t", "eupatolitin 3-O-glucoside biosynthesis"], "PWY-7533": ["t", "gliotoxin biosynthesis"], "PWY-7160": ["t", "polymethylated myricetin biosynthesis (tomato)"], "PWY-8210": ["t", "pyrrolomycin biosynthesis"], "PWY-7072": ["t", "hopanoid biosynthesis (bacteria)"], "PWY-7729": ["t", "5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"], "PWY-7695": ["t", "aurofusarin biosynthesis"], "PWY-5765": ["t", "1,3,5-trimethoxybenzene biosynthesis"], "PWY-7765": ["t", "3-hydroxy-4-methyl-anthranilate biosynthesis II"], "PWY-8438": ["t", "corallopyronin A biosynthesis"], "PWY-7614": ["t", "methiin metabolism"], "PWY-8031": ["t", "epiberberine biosynthesis"], "PWY-6978": ["t", "plastoquinol-9 biosynthesis II"], "PWY-8327": ["t", "atranorin biosynthesis"], "PWY-6976": ["t", "dTDP-beta-L-mycarose biosynthesis"], "PWY-7025": ["t", "gentamicin biosynthesis"], "PWY-8096": ["t", "5-methoxybenzimidazole biosynthesis (anaerobic)"], "PWY-8095": ["t", "5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)"], "PWY-6153": ["t", "autoinducer AI-2 biosynthesis I"], "PWY-5846": ["t", "colchicine biosynthesis"], "PWY-7671": ["t", "saframycin A biosynthesis"], "PWY-7058": ["t", "esculetin modification"], "PWY-7691": ["t", "10,13-epoxy-11-methyl-octadecadienoate biosynthesis"], "PWY-7653": ["t", "griseofulvin biosynthesis"], "PWY-6154": ["t", "autoinducer AI-2 biosynthesis II (Vibrio)"], "PWY-601": ["t", "glucosinolate biosynthesis from tryptophan"], "PWY-4161": ["t", "superpathway of benzoxazinoid glucosides biosynthesis"], "PWY-7591": ["t", "okenone biosynthesis"], "PWY-7363": ["t", "papaverine biosynthesis"], "PWY-6346": ["t", "staurosporine biosynthesis"], "PWY-7570": ["t", "blasticidin S biosynthesis"], "PWY-7079": ["t", "geodin biosynthesis"], "PWY-7661": ["t", "protein N-glycosylation (Haloferax volcanii)"], "PWY-7741": ["t", "phthiocerol biosynthesis"], "PWY-6442": ["t", "spermidine hydroxycinnamic acid conjugates biosynthesis"], "PWY-7631": ["t", "arctigenin and isoarctigenin biosynthesis"], "PWY-5987": ["t", "sorgoleone biosynthesis"], "R-HSA-380095": ["r", "Tachykinin receptors bind tachykinins"], "R-CFA-8856828": ["r", "Clathrin-mediated endocytosis"], "R-CFA-416476": ["r", "G alpha (q) signalling events"], "R-CFA-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-CFA-380095": ["r", "Tachykinin receptors bind tachykinins"], "R-MMU-380095": ["r", "Tachykinin receptors bind tachykinins"], "R-RNO-380095": ["r", "Tachykinin receptors bind tachykinins"], "R-HSA-9819196": ["r", "Zygotic genome activation (ZGA)"], "R-MMU-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-DME-3214847": ["r", "HATs acetylate histones"], "R-HSA-9830364": ["r", "Formation of the nephric duct"], "R-HSA-210747": ["r", "Regulation of gene expression in early pancreatic precursor cells"], "R-CEL-8853884": ["r", "Transcriptional Regulation by VENTX"], "R-HSA-9938206": ["r", "Developmental Lineage of Mammary Stem Cells"], "R-HSA-9925561": ["r", "Developmental Lineage of Pancreatic Acinar Cells"], "R-HSA-210745": ["r", "Regulation of gene expression in beta cells"], "R-HSA-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-HSA-9834899": ["r", "Specification of the neural plate border"], "R-DME-8853884": ["r", "Transcriptional Regulation by VENTX"], "R-HSA-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-HSA-5674135": ["r", "MAP2K and MAPK activation"], "R-HSA-6802952": ["r", "Signaling by BRAF and RAF1 fusions"], "R-HSA-264876": ["r", "Insulin processing"], "R-CEL-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-HSA-9013424": ["r", "RHOV GTPase cycle"], "R-DME-445355": ["r", "Smooth Muscle Contraction"], "R-HSA-9649948": ["r", "Signaling downstream of RAS mutants"], "R-DME-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-RNO-9013424": ["r", "RHOV GTPase cycle"], "R-SCE-9013425": ["r", "RHOT1 GTPase cycle"], "R-BTA-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-HSA-6802955": ["r", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "R-HSA-5635838": ["r", "Activation of SMO"], "R-SPO-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-HSA-373753": ["r", "Nephrin family interactions"], "R-MMU-9013419": ["r", "RHOT2 GTPase cycle"], "R-MMU-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-HSA-6802948": ["r", "Signaling by high-kinase activity BRAF mutants"], "R-RNO-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-MMU-390522": ["r", "Striated Muscle Contraction"], "R-MMU-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-HSA-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-GGA-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-MMU-373753": ["r", "Nephrin family interactions"], "R-HSA-9620244": ["r", "Long-term potentiation"], "R-HSA-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-SPO-190873": ["r", "Gap junction degradation"], "R-SPO-9013424": ["r", "RHOV GTPase cycle"], "R-MMU-5627123": ["r", "RHO GTPases activate PAKs"], "R-DDI-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-HSA-9656223": ["r", "Signaling by RAF1 mutants"], "R-HSA-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-HSA-5625900": ["r", "RHO GTPases activate CIT"], "R-MMU-5674135": ["r", "MAP2K and MAPK activation"], "R-HSA-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-HSA-9662834": ["r", "CD163 mediating an anti-inflammatory response"], "R-HSA-445095": ["r", "Interaction between L1 and Ankyrins"], "R-RNO-373760": ["r", "L1CAM interactions"], "R-DDI-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-RNO-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-HSA-5576892": ["r", "Phase 0 - rapid depolarisation"], "R-BTA-5627123": ["r", "RHO GTPases activate PAKs"], "R-SCE-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-HSA-6802946": ["r", "Signaling by moderate kinase activity BRAF mutants"], "R-MMU-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-BTA-373760": ["r", "L1CAM interactions"], "R-MMU-9013425": ["r", "RHOT1 GTPase cycle"], "R-RNO-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-SCE-190873": ["r", "Gap junction degradation"], "R-SCE-9013424": ["r", "RHOV GTPase cycle"], "R-RNO-390522": ["r", "Striated Muscle Contraction"], "R-MMU-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-SPO-9013419": ["r", "RHOT2 GTPase cycle"], "R-DRE-9013424": ["r", "RHOV GTPase cycle"], "R-SPO-9013425": ["r", "RHOT1 GTPase cycle"], "R-HSA-9662361": ["r", "Sensory processing of sound by outer hair cells of the cochlea"], "R-MMU-9013424": ["r", "RHOV GTPase cycle"], "R-RNO-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-DME-350480": ["r", "Activation of non-muscle Myosin II"], "R-MMU-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-MMU-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-HSA-9703465": ["r", "Signaling by FLT3 fusion proteins"], "R-HSA-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-HSA-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-HSA-5627123": ["r", "RHO GTPases activate PAKs"], "R-XTR-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-SCE-9013419": ["r", "RHOT2 GTPase cycle"], "R-HSA-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-RNO-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-HSA-9664422": ["r", "FCGR3A-mediated phagocytosis"], "R-MMU-373760": ["r", "L1CAM interactions"], "R-HSA-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-HSA-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-SSC-611105": ["r", "Respiratory electron transport"], "R-RNO-611105": ["r", "Respiratory electron transport"], "R-HSA-611105": ["r", "Respiratory electron transport"], "R-HSA-8876725": ["r", "Protein methylation"], "R-DDI-611105": ["r", "Respiratory electron transport"], "R-SSC-8876725": ["r", "Protein methylation"], "R-RNO-8876725": ["r", "Protein methylation"], "R-MMU-611105": ["r", "Respiratory electron transport"], "R-SPO-611105": ["r", "Respiratory electron transport"], "R-SCE-611105": ["r", "Respiratory electron transport"], "R-DME-611105": ["r", "Respiratory electron transport"], "R-MMU-8876725": ["r", "Protein methylation"], "PWY-7181": ["t", "pyrimidine deoxyribonucleosides degradation"], "R-RNO-73621": ["r", "Pyrimidine catabolism"], "R-MMU-73614": ["r", "Pyrimidine salvage"], "R-HSA-73621": ["r", "Pyrimidine catabolism"], "R-HSA-73614": ["r", "Pyrimidine salvage"], "R-MMU-73621": ["r", "Pyrimidine catabolism"], "R-RNO-73614": ["r", "Pyrimidine salvage"], "PWY-8178": ["t", "pentose phosphate pathway (non-oxidative branch) II"], "PWY-5723": ["t", "Rubisco shunt"], "R-MMU-71336": ["r", "Pentose phosphate pathway"], "R-HSA-71336": ["r", "Pentose phosphate pathway"], "R-SPO-71336": ["r", "Pentose phosphate pathway"], "R-SCE-71336": ["r", "Pentose phosphate pathway"], "R-HSA-380108": ["r", "Chemokine receptors bind chemokines"], "R-MMU-380108": ["r", "Chemokine receptors bind chemokines"], "R-RNO-380108": ["r", "Chemokine receptors bind chemokines"], "R-BTA-9033241": ["r", "Peroxisomal protein import"], "R-RNO-9033241": ["r", "Peroxisomal protein import"], "R-HSA-9033241": ["r", "Peroxisomal protein import"], "R-MMU-9033241": ["r", "Peroxisomal protein import"], "PWY-7821": ["t", "tunicamycin biosynthesis"], "PWY-7419": ["t", "FR-900098 and FR-33289 antibiotics biosynthesis"], "PWY-6383": ["t", "mono-trans, poly-cis decaprenyl phosphate biosynthesis"], "PWY-5757": ["t", "fosfomycin biosynthesis"], "PWY-6147": ["t", "6-hydroxymethyl-dihydropterin diphosphate biosynthesis I"], "PWY-6797": ["t", "6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)"], "PWY-7539": ["t", "6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"], "PWY-7719": ["t", "CMP-diacetamido-8-epilegionaminic acid biosynthesis"], "PWY-8289": ["t", "dZTP biosynthesis"], "PWY-7206": ["t", "pyrimidine deoxyribonucleotides dephosphorylation"], "R-HSA-390918": ["r", "Peroxisomal lipid metabolism"], "R-SPO-9033241": ["r", "Peroxisomal protein import"], "R-SCE-9033241": ["r", "Peroxisomal protein import"], "R-SPO-9770562": ["r", "mRNA Polyadenylation"], "R-HSA-72163": ["r", "mRNA Splicing - Major Pathway"], "R-HSA-9770562": ["r", "mRNA Polyadenylation"], "R-MMU-9770562": ["r", "mRNA Polyadenylation"], "R-MMU-72163": ["r", "mRNA Splicing - Major Pathway"], "R-RNO-9770562": ["r", "mRNA Polyadenylation"], "R-BTA-9770562": ["r", "mRNA Polyadenylation"], "R-DDI-9770562": ["r", "mRNA Polyadenylation"], "R-BTA-72163": ["r", "mRNA Splicing - Major Pathway"], "R-MMU-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-RNO-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-MMU-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-RNO-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-HSA-2586552": ["r", "Signaling by Leptin"], "R-HSA-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-DRE-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-BTA-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-RNO-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-MMU-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-HSA-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-SSC-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-RNO-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-SSC-416476": ["r", "G alpha (q) signalling events"], "R-MMU-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-SSC-418594": ["r", "G alpha (i) signalling events"], "R-DRE-416476": ["r", "G alpha (q) signalling events"], "PWY-7185": ["t", "UTP and CTP dephosphorylation I"], "PWY-7198": ["t", "pyrimidine deoxyribonucleotides de novo biosynthesis IV"], "PWY-6545": ["t", "pyrimidine deoxyribonucleotides de novo biosynthesis III"], "PWY-7375": ["t", "mRNA capping I"], "PWY-7184": ["t", "pyrimidine deoxyribonucleotides de novo biosynthesis I"], "PWY-7210": ["t", "pyrimidine deoxyribonucleotides biosynthesis from CTP"], "PWY-7379": ["t", "mRNA capping II"], "R-HSA-9918487": ["r", "Dengue Virus Genome Translation and Replication"], "R-HSA-9920951": ["r", "Dengue virus modulates apoptosis"], "R-HSA-9918476": ["r", "Assembly and Release of Dengue Virus Virions"], "PWY-7246": ["t", "pectin degradation I"], "PWY-7248": ["t", "pectin degradation II"], "R-HSA-174490": ["r", "Membrane binding and targetting of GAG proteins"], "R-HSA-174495": ["r", "Synthesis And Processing Of GAG, GAGPOL Polyproteins"], "R-BTA-5673001": ["r", "RAF/MAP kinase cascade"], "R-MMU-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-HSA-194313": ["r", "VEGF ligand-receptor interactions"], "R-HSA-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-BTA-186763": ["r", "Downstream signal transduction"], "R-GGA-186797": ["r", "Signaling by PDGF"], "R-BTA-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-BTA-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-HSA-8866910": ["r", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "R-BTA-186797": ["r", "Signaling by PDGF"], "R-BTA-195399": ["r", "VEGF binds to VEGFR leading to receptor dimerization"], "R-HSA-195399": ["r", "VEGF binds to VEGFR leading to receptor dimerization"], "R-DRE-195399": ["r", "VEGF binds to VEGFR leading to receptor dimerization"], "R-MMU-194313": ["r", "VEGF ligand-receptor interactions"], "R-BTA-194313": ["r", "VEGF ligand-receptor interactions"], "R-DRE-194313": ["r", "VEGF ligand-receptor interactions"], "R-RNO-195399": ["r", "VEGF binds to VEGFR leading to receptor dimerization"], "R-MMU-195399": ["r", "VEGF binds to VEGFR leading to receptor dimerization"], "R-BTA-1257604": ["r", "PIP3 activates AKT signaling"], "R-DRE-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-HSA-194138": ["r", "Signaling by VEGF"], "R-RNO-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-RNO-194313": ["r", "VEGF ligand-receptor interactions"], "R-HSA-156588": ["r", "Glucuronidation"], "R-XTR-426048": ["r", "Arachidonate production from DAG"], "R-SSC-9033241": ["r", "Peroxisomal protein import"], "R-HSA-426048": ["r", "Arachidonate production from DAG"], "R-BTA-156588": ["r", "Glucuronidation"], "R-RNO-426048": ["r", "Arachidonate production from DAG"], "R-RNO-156588": ["r", "Glucuronidation"], "R-MMU-1483191": ["r", "Synthesis of PC"], "R-BTA-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-SPO-1482839": ["r", "Acyl chain remodelling of PE"], "R-MMU-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-RNO-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-SPO-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-CEL-1483191": ["r", "Synthesis of PC"], "R-DRE-426048": ["r", "Arachidonate production from DAG"], "R-HSA-192456": ["r", "Digestion of dietary lipid"], "R-SCE-1482839": ["r", "Acyl chain remodelling of PE"], "R-MMU-9018682": ["r", "Biosynthesis of maresins"], "R-RNO-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-HSA-2142670": ["r", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "R-BTA-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-DDI-1483191": ["r", "Synthesis of PC"], "R-CEL-1482839": ["r", "Acyl chain remodelling of PE"], "R-MMU-156588": ["r", "Glucuronidation"], "R-MMU-2142670": ["r", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "R-HSA-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-MMU-426048": ["r", "Arachidonate production from DAG"], "R-HSA-163560": ["r", "Triglyceride catabolism"], "R-RNO-9018682": ["r", "Biosynthesis of maresins"], "R-HSA-1483191": ["r", "Synthesis of PC"], "R-MMU-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-SPO-426048": ["r", "Arachidonate production from DAG"], "R-SSC-9018682": ["r", "Biosynthesis of maresins"], "R-HSA-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-RNO-2142670": ["r", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "R-SCE-1483191": ["r", "Synthesis of PC"], "R-BTA-1483191": ["r", "Synthesis of PC"], "R-CFA-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-HSA-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-MMU-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-DRE-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-RNO-110331": ["r", "Cleavage of the damaged purine"], "R-BTA-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-HSA-196807": ["r", "Nicotinate metabolism"], "R-MMU-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-SSC-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-MMU-9969896": ["r", "Lanosterol biosynthesis"], "R-RNO-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-CEL-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-MMU-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-HSA-9748787": ["r", "Azathioprine ADME"], "R-MMU-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-HSA-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-HSA-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-MMU-196807": ["r", "Nicotinate metabolism"], "R-MMU-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-SPO-196807": ["r", "Nicotinate metabolism"], "R-GGA-390918": ["r", "Peroxisomal lipid metabolism"], "R-CEL-390918": ["r", "Peroxisomal lipid metabolism"], "R-HSA-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-BTA-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-RNO-390918": ["r", "Peroxisomal lipid metabolism"], "R-MMU-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-RNO-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-HSA-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-RNO-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-MMU-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-HSA-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-DRE-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-CEL-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-BTA-196807": ["r", "Nicotinate metabolism"], "R-RNO-3295583": ["r", "TRP channels"], "R-SPO-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-BTA-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-DRE-9770562": ["r", "mRNA Polyadenylation"], "R-DRE-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-HSA-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-CEL-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-GGA-9033241": ["r", "Peroxisomal protein import"], "R-BTA-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-HSA-9969896": ["r", "Lanosterol biosynthesis"], "R-SPO-9969896": ["r", "Lanosterol biosynthesis"], "R-HSA-9608287": ["r", "Defective MUTYH substrate binding"], "R-SCE-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-SCE-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-SCE-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-HSA-9608290": ["r", "Defective MUTYH substrate processing"], "R-CEL-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-MMU-390918": ["r", "Peroxisomal lipid metabolism"], "R-HSA-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-RNO-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-MMU-72187": ["r", "mRNA 3'-end processing"], "R-MMU-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-SPO-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-HSA-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-HSA-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-DDI-9969896": ["r", "Lanosterol biosynthesis"], "R-MMU-3295583": ["r", "TRP channels"], "R-RNO-9969896": ["r", "Lanosterol biosynthesis"], "R-HSA-3295583": ["r", "TRP channels"], "R-DDI-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-HSA-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-RNO-9857492": ["r", "Protein lipoylation"], "R-MMU-70263": ["r", "Gluconeogenesis"], "R-DDI-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-CEL-9013407": ["r", "RHOH GTPase cycle"], "R-HSA-70263": ["r", "Gluconeogenesis"], "R-RNO-70268": ["r", "Pyruvate metabolism"], "R-BTA-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-MMU-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-BTA-6783984": ["r", "Glycine degradation"], "R-DME-9857492": ["r", "Protein lipoylation"], "R-BTA-9859138": ["r", "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV"], "R-BTA-9837999": ["r", "Mitochondrial protein degradation"], "R-SPO-200425": ["r", "Carnitine shuttle"], "R-HSA-71032": ["r", "Propionyl-CoA catabolism"], "R-DME-6783984": ["r", "Glycine degradation"], "R-HSA-9912481": ["r", "Branched-chain ketoacid dehydrogenase kinase deficiency"], "R-CEL-9859138": ["r", "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV"], "R-SCE-200425": ["r", "Carnitine shuttle"], "R-BTA-9013407": ["r", "RHOH GTPase cycle"], "R-BTA-70895": ["r", "Branched-chain amino acid catabolism"], "R-MMU-9013407": ["r", "RHOH GTPase cycle"], "R-CEL-9837999": ["r", "Mitochondrial protein degradation"], "R-MMU-9857492": ["r", "Protein lipoylation"], "R-SCE-9857492": ["r", "Protein lipoylation"], "R-BTA-9857492": ["r", "Protein lipoylation"], "R-HSA-9907570": ["r", "Loss-of-function mutations in DLD cause MSUD3/DLDD"], "R-HSA-70895": ["r", "Branched-chain amino acid catabolism"], "R-GGA-9857492": ["r", "Protein lipoylation"], "R-BTA-196780": ["r", "Biotin transport and metabolism"], "R-MMU-196780": ["r", "Biotin transport and metabolism"], "R-HSA-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-RNO-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-RNO-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-BTA-70268": ["r", "Pyruvate metabolism"], "R-SPO-9857492": ["r", "Protein lipoylation"], "R-CEL-9857492": ["r", "Protein lipoylation"], "R-MMU-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-MMU-9859138": ["r", "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV"], "R-BTA-70263": ["r", "Gluconeogenesis"], "R-HSA-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-HSA-9909438": ["r", "3-Methylcrotonyl-CoA carboxylase deficiency"], "R-SCE-196780": ["r", "Biotin transport and metabolism"], "R-MMU-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-HSA-9912529": ["r", "H139Hfs13* PPM1K causes a mild variant of MSUD"], "R-HSA-9013407": ["r", "RHOH GTPase cycle"], "R-SCE-70268": ["r", "Pyruvate metabolism"], "R-SCE-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-MMU-9837999": ["r", "Mitochondrial protein degradation"], "R-CEL-71032": ["r", "Propionyl-CoA catabolism"], "R-SPO-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-SPO-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-SPO-70268": ["r", "Pyruvate metabolism"], "R-DDI-70895": ["r", "Branched-chain amino acid catabolism"], "R-HSA-196780": ["r", "Biotin transport and metabolism"], "R-GGA-6783984": ["r", "Glycine degradation"], "R-RNO-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-DDI-9857492": ["r", "Protein lipoylation"], "R-DDI-200425": ["r", "Carnitine shuttle"], "R-HSA-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-RNO-196780": ["r", "Biotin transport and metabolism"], "R-DDI-196780": ["r", "Biotin transport and metabolism"], "R-MMU-70895": ["r", "Branched-chain amino acid catabolism"], "R-SPO-70263": ["r", "Gluconeogenesis"], "R-HSA-1222541": ["r", "Cell redox homeostasis"], "R-DDI-6783984": ["r", "Glycine degradation"], "R-RNO-71032": ["r", "Propionyl-CoA catabolism"], "R-HSA-9837999": ["r", "Mitochondrial protein degradation"], "R-SPO-6783984": ["r", "Glycine degradation"], "R-MMU-71032": ["r", "Propionyl-CoA catabolism"], "R-MMU-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-HSA-9859138": ["r", "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV"], "R-RNO-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-HSA-163765": ["r", "ChREBP activates metabolic gene expression"], "R-CEL-196780": ["r", "Biotin transport and metabolism"], "R-MMU-70268": ["r", "Pyruvate metabolism"], "R-HSA-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-SPO-5362517": ["r", "Signaling by Retinoic Acid"], "R-SCE-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-MMU-6783984": ["r", "Glycine degradation"], "R-RNO-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-SPO-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-BTA-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-HSA-9865125": ["r", "Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD"], "R-SCE-6783984": ["r", "Glycine degradation"], "R-HSA-3371599": ["r", "Defective HLCS causes multiple carboxylase deficiency"], "R-MMU-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-HSA-9857492": ["r", "Protein lipoylation"], "R-HSA-70268": ["r", "Pyruvate metabolism"], "R-RNO-70895": ["r", "Branched-chain amino acid catabolism"], "R-RNO-6783984": ["r", "Glycine degradation"], "R-SPO-196780": ["r", "Biotin transport and metabolism"], "R-CEL-70268": ["r", "Pyruvate metabolism"], "R-DDI-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-CEL-70263": ["r", "Gluconeogenesis"], "R-SCE-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-HSA-6783984": ["r", "Glycine degradation"], "R-SCE-70263": ["r", "Gluconeogenesis"], "R-HSA-9865113": ["r", "Loss-of-function mutations in DBT cause MSUD2"], "R-DDI-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-SPO-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-RNO-70263": ["r", "Gluconeogenesis"], "R-HSA-9022692": ["r", "Regulation of MECP2 expression and activity"], "R-SPO-2142789": ["r", "Ubiquinol biosynthesis"], "R-SCE-9969896": ["r", "Lanosterol biosynthesis"], "R-SCE-2142789": ["r", "Ubiquinol biosynthesis"], "R-DDI-2142789": ["r", "Ubiquinol biosynthesis"], "R-HSA-2142789": ["r", "Ubiquinol biosynthesis"], "R-BTA-9969896": ["r", "Lanosterol biosynthesis"], "R-RNO-2142789": ["r", "Ubiquinol biosynthesis"], "R-MMU-2142789": ["r", "Ubiquinol biosynthesis"], "R-HSA-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-CEL-3928664": ["r", "Ephrin signaling"], "R-BTA-3928662": ["r", "EPHB-mediated forward signaling"], "R-RNO-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-CEL-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-MMU-445355": ["r", "Smooth Muscle Contraction"], "R-RNO-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-DDI-389359": ["r", "CD28 dependent Vav1 pathway"], "R-RNO-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-HSA-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-BTA-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-HSA-389359": ["r", "CD28 dependent Vav1 pathway"], "R-DME-3928664": ["r", "Ephrin signaling"], "R-SPO-389359": ["r", "CD28 dependent Vav1 pathway"], "R-DDI-445144": ["r", "Signal transduction by L1"], "R-CEL-389359": ["r", "CD28 dependent Vav1 pathway"], "R-HSA-203641": ["r", "NOSTRIN mediated eNOS trafficking"], "R-HSA-211733": ["r", "Regulation of activated PAK-2p34 by proteasome mediated degradation"], "R-SPO-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-RNO-445144": ["r", "Signal transduction by L1"], "R-RNO-9013407": ["r", "RHOH GTPase cycle"], "R-DME-5627123": ["r", "RHO GTPases activate PAKs"], "R-DME-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-DME-389359": ["r", "CD28 dependent Vav1 pathway"], "R-HSA-211728": ["r", "Regulation of PAK-2p34 activity by PS-GAP/RHG10"], "R-HSA-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-SPO-5627123": ["r", "RHO GTPases activate PAKs"], "R-BTA-203641": ["r", "NOSTRIN mediated eNOS trafficking"], "R-HSA-445144": ["r", "Signal transduction by L1"], "R-RNO-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-RNO-9013420": ["r", "RHOU GTPase cycle"], "R-BTA-202433": ["r", "Generation of second messenger molecules"], "R-BTA-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-CEL-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-BTA-9013406": ["r", "RHOQ GTPase cycle"], "R-BTA-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-MMU-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-SCE-3928662": ["r", "EPHB-mediated forward signaling"], "R-RNO-389359": ["r", "CD28 dependent Vav1 pathway"], "R-RNO-445355": ["r", "Smooth Muscle Contraction"], "R-MMU-3928664": ["r", "Ephrin signaling"], "R-DDI-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-DDI-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-BTA-3928664": ["r", "Ephrin signaling"], "R-BTA-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-BTA-418885": ["r", "DCC mediated attractive signaling"], "R-RNO-3928664": ["r", "Ephrin signaling"], "R-DDI-3928662": ["r", "EPHB-mediated forward signaling"], "R-HSA-428540": ["r", "Activation of RAC1"], "R-SCE-389359": ["r", "CD28 dependent Vav1 pathway"], "R-DDI-9013404": ["r", "RAC2 GTPase cycle"], "R-RNO-5627123": ["r", "RHO GTPases activate PAKs"], "R-MMU-389359": ["r", "CD28 dependent Vav1 pathway"], "R-BTA-9013424": ["r", "RHOV GTPase cycle"], "R-BTA-373753": ["r", "Nephrin family interactions"], "R-DME-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-CEL-9013424": ["r", "RHOV GTPase cycle"], "R-DME-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-BTA-389359": ["r", "CD28 dependent Vav1 pathway"], "R-DME-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-MMU-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-CEL-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-HSA-164944": ["r", "Nef and signal transduction"], "R-CEL-3928662": ["r", "EPHB-mediated forward signaling"], "R-MMU-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-HSA-3928664": ["r", "Ephrin signaling"], "R-BTA-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-DME-3928662": ["r", "EPHB-mediated forward signaling"], "R-HSA-8950505": ["r", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "R-MMU-445144": ["r", "Signal transduction by L1"], "R-RNO-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-DME-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-BTA-445355": ["r", "Smooth Muscle Contraction"], "R-DME-2871796": ["r", "FCERI mediated MAPK activation"], "R-CEL-5627123": ["r", "RHO GTPases activate PAKs"], "R-DME-445144": ["r", "Signal transduction by L1"], "R-SCE-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-SCE-445144": ["r", "Signal transduction by L1"], "R-DDI-5627123": ["r", "RHO GTPases activate PAKs"], "R-SCE-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-SPO-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-SCE-5627123": ["r", "RHO GTPases activate PAKs"], "R-HSA-418885": ["r", "DCC mediated attractive signaling"], "R-DME-9013424": ["r", "RHOV GTPase cycle"], "R-HSA-211736": ["r", "Stimulation of the cell death response by PAK-2p34"], "R-BTA-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-HSA-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-BTA-2871796": ["r", "FCERI mediated MAPK activation"], "R-DME-9013407": ["r", "RHOH GTPase cycle"], "R-BTA-9013420": ["r", "RHOU GTPase cycle"], "R-MMU-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-CEL-445144": ["r", "Signal transduction by L1"], "R-HSA-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-CEL-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-DDI-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-BTA-9013408": ["r", "RHOG GTPase cycle"], "R-DRE-9013148": ["r", "CDC42 GTPase cycle"], "R-CEL-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-CEL-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-HSA-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-HSA-444473": ["r", "Formyl peptide receptors bind formyl peptides and many other ligands"], "R-HSA-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-HSA-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-MMU-6783783": ["r", "Interleukin-10 signaling"], "R-GGA-6783783": ["r", "Interleukin-10 signaling"], "R-SSC-6783783": ["r", "Interleukin-10 signaling"], "R-HSA-6783783": ["r", "Interleukin-10 signaling"], "R-RNO-6783783": ["r", "Interleukin-10 signaling"], "PWY-8301": ["t", "S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis"], "PWY-5826": ["t", "hypoglycin biosynthesis"], "PWY-8001": ["t", "felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis"], "PWY-7559": ["t", "glutathione degradation (DUG pathway)"], "PWY-4061": ["t", "glutathione-mediated detoxification I"], "PWY-6842": ["t", "glutathione-mediated detoxification II"], "PWY-7112": ["t", "4-hydroxy-2-nonenal detoxification"], "PWY-4041": ["t", "gamma-glutamyl cycle"], "PWY-8355": ["t", "peptido-conjugates in tissue regeneration biosynthesis"], "R-HSA-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-SPO-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-MMU-9753281": ["r", "Paracetamol ADME"], "R-RNO-174403": ["r", "Glutathione synthesis and recycling"], "R-RNO-9753281": ["r", "Paracetamol ADME"], "R-SPO-5423646": ["r", "Aflatoxin activation and detoxification"], "R-RNO-5423646": ["r", "Aflatoxin activation and detoxification"], "R-HSA-5423646": ["r", "Aflatoxin activation and detoxification"], "R-HSA-9753281": ["r", "Paracetamol ADME"], "R-SCE-174403": ["r", "Glutathione synthesis and recycling"], "R-MMU-5423646": ["r", "Aflatoxin activation and detoxification"], "R-SCE-5423646": ["r", "Aflatoxin activation and detoxification"], "R-RNO-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-HSA-5579022": ["r", "Defective GGT1 causes GLUTH"], "R-BTA-5423646": ["r", "Aflatoxin activation and detoxification"], "R-BTA-174403": ["r", "Glutathione synthesis and recycling"], "R-MMU-174403": ["r", "Glutathione synthesis and recycling"], "R-SPO-174403": ["r", "Glutathione synthesis and recycling"], "R-SCE-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-MMU-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-HSA-9664535": ["r", "LTC4-CYSLTR mediated IL4 production"], "R-SPO-9753281": ["r", "Paracetamol ADME"], "R-HSA-9035968": ["r", "Defective GGT1 in aflatoxin detoxification causes GLUTH"], "R-SCE-9753281": ["r", "Paracetamol ADME"], "R-HSA-174403": ["r", "Glutathione synthesis and recycling"], "R-BTA-9753281": ["r", "Paracetamol ADME"], "R-HSA-111885": ["r", "Opioid Signalling"], "R-MMU-202040": ["r", "G-protein activation"], "R-RNO-111885": ["r", "Opioid Signalling"], "R-RNO-202040": ["r", "G-protein activation"], "R-HSA-202040": ["r", "G-protein activation"], "R-HSA-9022699": ["r", "MECP2 regulates neuronal receptors and channels"], "R-MMU-111885": ["r", "Opioid Signalling"], "R-HSA-9860276": ["r", "SLC15A4:TASL-dependent IRF5 activation"], "R-SCE-427975": ["r", "Proton/oligopeptide cotransporters"], "R-RNO-9860276": ["r", "SLC15A4:TASL-dependent IRF5 activation"], "R-DME-427975": ["r", "Proton/oligopeptide cotransporters"], "R-SPO-427975": ["r", "Proton/oligopeptide cotransporters"], "R-MMU-427975": ["r", "Proton/oligopeptide cotransporters"], "R-CEL-427975": ["r", "Proton/oligopeptide cotransporters"], "R-BTA-9860276": ["r", "SLC15A4:TASL-dependent IRF5 activation"], "R-BTA-427975": ["r", "Proton/oligopeptide cotransporters"], "R-HSA-427975": ["r", "Proton/oligopeptide cotransporters"], "R-MMU-9860276": ["r", "SLC15A4:TASL-dependent IRF5 activation"], "R-RNO-427975": ["r", "Proton/oligopeptide cotransporters"], "PWY-6527": ["t", "stachyose degradation"], "R-MMU-9840310": ["r", "Glycosphingolipid catabolism"], "R-HSA-9840310": ["r", "Glycosphingolipid catabolism"], "R-BTA-5389840": ["r", "Mitochondrial translation elongation"], "R-HSA-5419276": ["r", "Mitochondrial translation termination"], "R-MMU-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-HSA-5083632": ["r", "Defective C1GALT1C1 causes TNPS"], "R-MMU-2024096": ["r", "HS-GAG degradation"], "R-RNO-2024096": ["r", "HS-GAG degradation"], "R-MMU-3000178": ["r", "ECM proteoglycans"], "R-HSA-5083625": ["r", "Defective GALNT3 causes HFTC"], "R-RNO-913709": ["r", "O-linked glycosylation of mucins"], "R-RNO-3000178": ["r", "ECM proteoglycans"], "R-RNO-9696273": ["r", "RND1 GTPase cycle"], "R-HSA-419037": ["r", "NCAM1 interactions"], "R-MMU-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-HSA-5683826": ["r", "Surfactant metabolism"], "R-RNO-9696264": ["r", "RND3 GTPase cycle"], "R-MMU-9696264": ["r", "RND3 GTPase cycle"], "R-HSA-977068": ["r", "Termination of O-glycan biosynthesis"], "R-RNO-9696270": ["r", "RND2 GTPase cycle"], "R-MMU-913709": ["r", "O-linked glycosylation of mucins"], "R-RNO-977068": ["r", "Termination of O-glycan biosynthesis"], "R-HSA-913709": ["r", "O-linked glycosylation of mucins"], "R-MMU-2022928": ["r", "HS-GAG biosynthesis"], "R-MMU-977068": ["r", "Termination of O-glycan biosynthesis"], "R-MMU-5683826": ["r", "Surfactant metabolism"], "R-HSA-1442490": ["r", "Collagen degradation"], "R-HSA-5083636": ["r", "Defective GALNT12 causes CRCS1"], "R-HSA-9696270": ["r", "RND2 GTPase cycle"], "R-RNO-5683826": ["r", "Surfactant metabolism"], "R-RNO-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-RNO-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-RNO-2022928": ["r", "HS-GAG biosynthesis"], "R-MMU-9696273": ["r", "RND1 GTPase cycle"], "R-MMU-9696270": ["r", "RND2 GTPase cycle"], "R-MMU-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-MMU-1442490": ["r", "Collagen degradation"], "R-HSA-9927426": ["r", "Developmental Lineage of Mammary Gland Alveolar Cells"], "R-HSA-9700645": ["r", "ALK mutants bind TKIs"], "R-RNO-372708": ["r", "p130Cas linkage to MAPK signaling for integrins"], "R-GGA-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-GGA-354192": ["r", "Integrin signaling"], "R-RNO-9634597": ["r", "GPER1 signaling"], "R-GGA-3000170": ["r", "Syndecan interactions"], "R-RNO-1566977": ["r", "Fibronectin matrix formation"], "R-GGA-216083": ["r", "Integrin cell surface interactions"], "R-GGA-2129379": ["r", "Molecules associated with elastic fibres"], "R-MMU-9634597": ["r", "GPER1 signaling"], "R-GGA-202733": ["r", "Cell surface interactions at the vascular wall"], "R-GGA-5674135": ["r", "MAP2K and MAPK activation"], "R-MMU-216083": ["r", "Integrin cell surface interactions"], "R-HSA-372708": ["r", "p130Cas linkage to MAPK signaling for integrins"], "R-GGA-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-MMU-354192": ["r", "Integrin signaling"], "R-GGA-9634597": ["r", "GPER1 signaling"], "R-HSA-9634597": ["r", "GPER1 signaling"], "R-GGA-3000178": ["r", "ECM proteoglycans"], "R-RNO-216083": ["r", "Integrin cell surface interactions"], "R-GGA-1474228": ["r", "Degradation of the extracellular matrix"], "R-RNO-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-RNO-2129379": ["r", "Molecules associated with elastic fibres"], "R-MMU-372708": ["r", "p130Cas linkage to MAPK signaling for integrins"], "R-RNO-354192": ["r", "Integrin signaling"], "R-RNO-5674135": ["r", "MAP2K and MAPK activation"], "R-HSA-354192": ["r", "Integrin signaling"], "R-MMU-1566977": ["r", "Fibronectin matrix formation"], "R-HSA-1566977": ["r", "Fibronectin matrix formation"], "R-HSA-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-MMU-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-GGA-1566977": ["r", "Fibronectin matrix formation"], "R-GGA-372708": ["r", "p130Cas linkage to MAPK signaling for integrins"], "R-MMU-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-HSA-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-CEL-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-SCE-196807": ["r", "Nicotinate metabolism"], "R-HSA-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-BTA-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-HSA-72187": ["r", "mRNA 3'-end processing"], "R-HSA-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-RNO-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-MMU-110331": ["r", "Cleavage of the damaged purine"], "R-RNO-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-HSA-110331": ["r", "Cleavage of the damaged purine"], "R-HSA-380994": ["r", "ATF4 activates genes in response to endoplasmic reticulum stress"], "R-SSC-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-MMU-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-SPO-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-BTA-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-CEL-196807": ["r", "Nicotinate metabolism"], "R-MMU-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-SCE-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-MMU-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-HSA-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-MMU-9748787": ["r", "Azathioprine ADME"], "R-DME-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-RNO-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-DME-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-RNO-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-RNO-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-HSA-5663220": ["r", "RHO GTPases Activate Formins"], "R-HSA-180746": ["r", "Nuclear import of Rev protein"], "R-SSC-1679131": ["r", "Trafficking and processing of endosomal TLR"], "R-BTA-166166": ["r", "MyD88-independent TLR4 cascade"], "R-MMU-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-MMU-9014843": ["r", "Interleukin-33 signaling"], "R-SSC-109704": ["r", "PI3K Cascade"], "R-MMU-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-XTR-209543": ["r", "p75NTR recruits signalling complexes"], "R-HSA-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-HSA-168927": ["r", "TICAM1, RIP1-mediated IKK complex recruitment"], "R-DME-214869": ["r", "Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"], "R-MMU-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-HSA-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-DME-214842": ["r", "DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"], "R-BTA-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-GGA-517856": ["r", "TLR2 subfamily cascade"], "R-HSA-5602415": ["r", "UNC93B1 deficiency - HSE"], "R-MMU-1679131": ["r", "Trafficking and processing of endosomal TLR"], "R-RNO-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-HSA-168138": ["r", "Toll Like Receptor 9 (TLR9) Cascade"], "R-MMU-9007892": ["r", "Interleukin-38 signaling"], "R-RNO-2562578": ["r", "TRIF-mediated programmed cell death"], "R-BTA-168142": ["r", "Toll Like Receptor 10 (TLR10) Cascade"], "R-GGA-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-DME-214862": ["r", "Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"], "R-RNO-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-HSA-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-RNO-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-MMU-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-HSA-5602680": ["r", "MyD88 deficiency (TLR5)"], "R-RNO-209543": ["r", "p75NTR recruits signalling complexes"], "R-HSA-9008059": ["r", "Interleukin-37 signaling"], "R-DME-214874": ["r", "PLL kinase binds to TUB in the TL receptor 'signalling complex'"], "R-RNO-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-HSA-1236974": ["r", "ER-Phagosome pathway"], "R-DME-9010553": ["r", "Regulation of expression of SLITs and ROBOs"], "R-HSA-168164": ["r", "Toll Like Receptor 3 (TLR3) Cascade"], "R-HSA-9705671": ["r", "SARS-CoV-2 activates/modulates innate and adaptive immune responses"], "R-RNO-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-SSC-168138": ["r", "Toll Like Receptor 9 (TLR9) Cascade"], "R-HSA-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-DME-214863": ["r", "Adaptor protein complex binds to TL receptor at the plasma membrane"], "R-HSA-168179": ["r", "Toll Like Receptor TLR1:TLR2 Cascade"], "R-RNO-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-MMU-166166": ["r", "MyD88-independent TLR4 cascade"], "R-MMU-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-GGA-451514": ["r", "MyD88:TIRAP-dependent cascade initiated on plasma membrane"], "R-HSA-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-HSA-9824856": ["r", "Defective regulation of TLR7 by endogenous ligand"], "R-HSA-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-DME-376176": ["r", "Signaling by ROBO receptors"], "R-MMU-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-MMU-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-RNO-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-DDI-9833482": ["r", "PKR-mediated signaling"], "R-HSA-975871": ["r", "MyD88 cascade initiated on plasma membrane"], "R-MMU-109704": ["r", "PI3K Cascade"], "R-HSA-109704": ["r", "PI3K Cascade"], "R-HSA-5602566": ["r", "TICAM1 deficiency - HSE"], "R-HSA-168142": ["r", "Toll Like Receptor 10 (TLR10) Cascade"], "R-RNO-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-HSA-5603037": ["r", "IRAK4 deficiency (TLR5)"], "R-HSA-9014843": ["r", "Interleukin-33 signaling"], "R-HSA-5602498": ["r", "MyD88 deficiency (TLR2/4)"], "R-MMU-2562578": ["r", "TRIF-mediated programmed cell death"], "R-HSA-140534": ["r", "Caspase activation via Death Receptors in the presence of ligand"], "R-MMU-168138": ["r", "Toll Like Receptor 9 (TLR9) Cascade"], "R-MMU-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-BTA-2562578": ["r", "TRIF-mediated programmed cell death"], "R-GGA-433822": ["r", "NFkB and MAPK activation mediated by TRAF6"], "R-HSA-9828211": ["r", "Regulation of TBK1, IKKEpsilon-mediated activation of IRF3, IRF7 upon TLR3 ligation"], "R-MMU-9012546": ["r", "Interleukin-18 signaling"], "R-RNO-9014843": ["r", "Interleukin-33 signaling"], "R-BTA-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-BTA-140534": ["r", "Caspase activation via Death Receptors in the presence of ligand"], "R-HSA-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-BTA-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-RNO-140534": ["r", "Caspase activation via Death Receptors in the presence of ligand"], "R-HSA-9007892": ["r", "Interleukin-38 signaling"], "R-MMU-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-HSA-168176": ["r", "Toll Like Receptor 5 (TLR5) Cascade"], "R-DME-214844": ["r", "DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"], "R-HSA-1461957": ["r", "Beta defensins"], "R-MMU-140534": ["r", "Caspase activation via Death Receptors in the presence of ligand"], "R-HSA-166058": ["r", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "R-RNO-9014826": ["r", "Interleukin-36 pathway"], "R-DRE-9007892": ["r", "Interleukin-38 signaling"], "R-MMU-209543": ["r", "p75NTR recruits signalling complexes"], "R-GGA-1461957": ["r", "Beta defensins"], "R-MMU-1461957": ["r", "Beta defensins"], "R-CFA-168138": ["r", "Toll Like Receptor 9 (TLR9) Cascade"], "R-BTA-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-HSA-9014826": ["r", "Interleukin-36 pathway"], "R-DRE-209543": ["r", "p75NTR recruits signalling complexes"], "R-HSA-9012546": ["r", "Interleukin-18 signaling"], "R-HSA-5603041": ["r", "IRAK4 deficiency (TLR2/4)"], "R-HSA-975110": ["r", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"], "R-HSA-9013957": ["r", "TLR3-mediated TICAM1-dependent programmed cell death"], "R-HSA-168188": ["r", "Toll Like Receptor TLR6:TLR2 Cascade"], "R-GGA-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-HSA-975138": ["r", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"], "R-HSA-5602571": ["r", "TRAF3 deficiency - HSE"], "R-GGA-573298": ["r", "NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation"], "R-HSA-209543": ["r", "p75NTR recruits signalling complexes"], "R-XTR-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-BTA-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-RNO-166166": ["r", "MyD88-independent TLR4 cascade"], "R-HSA-5602410": ["r", "TLR3 deficiency - HSE"], "R-HSA-168181": ["r", "Toll Like Receptor 7/8 (TLR7/8) Cascade"], "R-MMU-9014826": ["r", "Interleukin-36 pathway"], "R-GGA-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-MMU-168181": ["r", "Toll Like Receptor 7/8 (TLR7/8) Cascade"], "R-GGA-451477": ["r", "MyD88-dependent cascade initiated on endosome membrane"], "R-DME-428890": ["r", "Role of ABL in ROBO-SLIT signaling"], "R-HSA-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-RNO-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-GGA-1257604": ["r", "PIP3 activates AKT signaling"], "R-HSA-9013973": ["r", "TICAM1-dependent activation of IRF3/IRF7"], "R-MMU-166058": ["r", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "R-CFA-109704": ["r", "PI3K Cascade"], "R-HSA-166166": ["r", "MyD88-independent TLR4 cascade"], "R-HSA-975155": ["r", "MyD88 dependent cascade initiated on endosome"], "R-HSA-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-HSA-1679131": ["r", "Trafficking and processing of endosomal TLR"], "R-RNO-9007892": ["r", "Interleukin-38 signaling"], "R-HSA-2562578": ["r", "TRIF-mediated programmed cell death"], "R-CFA-1679131": ["r", "Trafficking and processing of endosomal TLR"], "R-GGA-977240": ["r", "MyD88 cascade initiated on plasma membrane"], "R-HSA-9014325": ["r", "TICAM1,TRAF6-dependent induction of TAK1 complex"], "R-BTA-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-HSA-9637628": ["r", "Modulation by Mtb of host immune system"], "R-DME-209442": ["r", "Formation of the trans-membrane 'signalling complex'"], "R-HSA-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-HSA-9607240": ["r", "FLT3 Signaling"], "R-RNO-1306955": ["r", "GRB7 events in ERBB2 signaling"], "R-MMU-9607240": ["r", "FLT3 Signaling"], "R-DRE-5674135": ["r", "MAP2K and MAPK activation"], "R-BTA-9696273": ["r", "RND1 GTPase cycle"], "R-SSC-9607240": ["r", "FLT3 Signaling"], "R-MMU-1306955": ["r", "GRB7 events in ERBB2 signaling"], "R-SPO-5223345": ["r", "Miscellaneous transport and binding events"], "R-CEL-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-RNO-9607240": ["r", "FLT3 Signaling"], "R-RNO-74749": ["r", "Signal attenuation"], "R-MMU-210993": ["r", "Tie2 Signaling"], "R-HSA-1306955": ["r", "GRB7 events in ERBB2 signaling"], "R-CEL-5673001": ["r", "RAF/MAP kinase cascade"], "R-DRE-5673001": ["r", "RAF/MAP kinase cascade"], "R-HSA-418990": ["r", "Adherens junctions interactions"], "R-BTA-8853659": ["r", "RET signaling"], "R-MMU-74751": ["r", "Insulin receptor signalling cascade"], "R-RNO-5419276": ["r", "Mitochondrial translation termination"], "R-HSA-5368286": ["r", "Mitochondrial translation initiation"], "R-MMU-5419276": ["r", "Mitochondrial translation termination"], "R-BTA-5419276": ["r", "Mitochondrial translation termination"], "R-HSA-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-RNO-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-MMU-5389840": ["r", "Mitochondrial translation elongation"], "R-HSA-5389840": ["r", "Mitochondrial translation elongation"], "R-BTA-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-RNO-5389840": ["r", "Mitochondrial translation elongation"], "PWY-6122": ["t", "5-aminoimidazole ribonucleotide biosynthesis II"], "PWY-6121": ["t", "5-aminoimidazole ribonucleotide biosynthesis I"], "PWY-6277": ["t", "superpathway of 5-aminoimidazole ribonucleotide biosynthesis"], "R-SPO-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-SCE-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-BTA-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-DDI-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-CFA-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-HSA-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-RNO-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-MMU-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-HSA-5223345": ["r", "Miscellaneous transport and binding events"], "R-RNO-5223345": ["r", "Miscellaneous transport and binding events"], "R-MMU-5223345": ["r", "Miscellaneous transport and binding events"], "R-SSC-5223345": ["r", "Miscellaneous transport and binding events"], "PWY-6724": ["t", "starch degradation II"], "PWY-842": ["t", "starch degradation I"], "R-GGA-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-GGA-4090294": ["r", "SUMOylation of intracellular receptors"], "R-RNO-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-HSA-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-GGA-9018519": ["r", "Estrogen-dependent gene expression"], "R-GGA-383280": ["r", "Nuclear Receptor transcription pathway"], "R-MMU-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-DDI-9837999": ["r", "Mitochondrial protein degradation"], "R-BTA-8949613": ["r", "Cristae formation"], "R-SPO-9837999": ["r", "Mitochondrial protein degradation"], "R-HSA-8949613": ["r", "Cristae formation"], "R-DME-9837999": ["r", "Mitochondrial protein degradation"], "R-SCE-9837999": ["r", "Mitochondrial protein degradation"], "R-MMU-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-DME-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-BTA-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-RNO-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-RNO-8949613": ["r", "Cristae formation"], "R-RNO-9837999": ["r", "Mitochondrial protein degradation"], "R-MMU-8949613": ["r", "Cristae formation"], "R-DME-8949613": ["r", "Cristae formation"], "R-HSA-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-SPO-6807878": ["r", "COPI-mediated anterograde transport"], "R-SCE-6807878": ["r", "COPI-mediated anterograde transport"], "R-RNO-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-SCE-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-RNO-6807878": ["r", "COPI-mediated anterograde transport"], "R-XTR-6807878": ["r", "COPI-mediated anterograde transport"], "R-HSA-6807878": ["r", "COPI-mediated anterograde transport"], "R-CEL-6807878": ["r", "COPI-mediated anterograde transport"], "R-MMU-6807878": ["r", "COPI-mediated anterograde transport"], "R-DDI-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-PFA-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-CEL-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-DME-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-BTA-6807878": ["r", "COPI-mediated anterograde transport"], "R-HSA-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-XTR-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-DRE-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-DDI-6807878": ["r", "COPI-mediated anterograde transport"], "R-SPO-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-DRE-6807878": ["r", "COPI-mediated anterograde transport"], "R-DME-6807878": ["r", "COPI-mediated anterograde transport"], "R-BTA-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-MMU-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "PWY-5074": ["t", "mevalonate degradation"], "R-HSA-77111": ["r", "Synthesis of Ketone Bodies"], "R-MMU-77111": ["r", "Synthesis of Ketone Bodies"], "R-BTA-77111": ["r", "Synthesis of Ketone Bodies"], "R-RNO-77111": ["r", "Synthesis of Ketone Bodies"], "R-HSA-391908": ["r", "Prostanoid ligand receptors"], "R-MMU-391908": ["r", "Prostanoid ligand receptors"], "R-RNO-391908": ["r", "Prostanoid ligand receptors"], "R-GGA-416476": ["r", "G alpha (q) signalling events"], "R-GGA-417957": ["r", "P2Y receptors"], "R-BTA-417957": ["r", "P2Y receptors"], "R-SSC-70263": ["r", "Gluconeogenesis"], "R-DDI-70263": ["r", "Gluconeogenesis"], "R-HSA-168255": ["r", "Influenza Infection"], "R-HSA-168302": ["r", "Budding"], "R-HSA-168288": ["r", "Fusion of the Influenza Virion to the Host Cell Endosome"], "R-HSA-168275": ["r", "Entry of Influenza Virion into Host Cell via Endocytosis"], "R-HSA-168316": ["r", "Assembly of Viral Components at the Budding Site"], "R-HSA-168298": ["r", "Release"], "R-HSA-168874": ["r", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus"], "R-HSA-168336": ["r", "Uncoating of the Influenza Virion"], "R-HSA-168303": ["r", "Packaging of Eight RNA Segments"], "R-MMU-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-GGA-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-HSA-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-RNO-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-SSC-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-RNO-2022923": ["r", "DS-GAG biosynthesis"], "R-HSA-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-HSA-9604323": ["r", "Negative regulation of NOTCH4 signaling"], "R-HSA-9673202": ["r", "Defective F9 variant does not activate FX"], "R-GGA-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-HSA-209968": ["r", "Thyroxine biosynthesis"], "R-MMU-1912420": ["r", "Pre-NOTCH Processing in Golgi"], "R-RNO-1912420": ["r", "Pre-NOTCH Processing in Golgi"], "R-DRE-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-HSA-2691232": ["r", "Constitutive Signaling by NOTCH1 HD Domain Mutants"], "R-HSA-2022870": ["r", "CS-GAG biosynthesis"], "R-CEL-2979096": ["r", "NOTCH2 Activation and Transmission of Signal to the Nucleus"], "R-DRE-2979096": ["r", "NOTCH2 Activation and Transmission of Signal to the Nucleus"], "R-XTR-9013507": ["r", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "R-HSA-2660826": ["r", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"], "R-MMU-209968": ["r", "Thyroxine biosynthesis"], "R-HSA-140834": ["r", "Extrinsic Pathway of Fibrin Clot Formation"], "R-MMU-140834": ["r", "Extrinsic Pathway of Fibrin Clot Formation"], "R-XTR-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-MMU-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-HSA-9824272": ["r", "Somitogenesis"], "R-BTA-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-CFA-159740": ["r", "Gamma-carboxylation of protein precursors"], "R-RNO-140834": ["r", "Extrinsic Pathway of Fibrin Clot Formation"], "R-BTA-2129379": ["r", "Molecules associated with elastic fibres"], "R-RNO-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-RNO-2022870": ["r", "CS-GAG biosynthesis"], "R-HSA-1912420": ["r", "Pre-NOTCH Processing in Golgi"], "R-GGA-140834": ["r", "Extrinsic Pathway of Fibrin Clot Formation"], "R-MMU-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-BTA-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-HSA-210744": ["r", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"], "R-DME-2243919": ["r", "Crosslinking of collagen fibrils"], "R-HSA-166662": ["r", "Lectin pathway of complement activation"], "R-HSA-428890": ["r", "Role of ABL in ROBO-SLIT signaling"], "R-BTA-216083": ["r", "Integrin cell surface interactions"], "R-HSA-3595174": ["r", "Defective CHST14 causes EDS, musculocontractural type"], "R-DME-9604323": ["r", "Negative regulation of NOTCH4 signaling"], "R-XTR-2979096": ["r", "NOTCH2 Activation and Transmission of Signal to the Nucleus"], "R-HSA-173623": ["r", "Classical antibody-mediated complement activation"], "R-BTA-140837": ["r", "Intrinsic Pathway of Fibrin Clot Formation"], "R-HSA-2855086": ["r", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "R-RNO-350054": ["r", "Notch-HLH transcription pathway"], "R-HSA-9673240": ["r", "Defective gamma-carboxylation of F9"], "R-BTA-2022870": ["r", "CS-GAG biosynthesis"], "R-MMU-2022923": ["r", "DS-GAG biosynthesis"], "R-MMU-9013700": ["r", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "R-MMU-446203": ["r", "Asparagine N-linked glycosylation"], "R-DME-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-RNO-1566948": ["r", "Elastic fibre formation"], "R-HSA-9013695": ["r", "NOTCH4 Intracellular Domain Regulates Transcription"], "R-RNO-6794361": ["r", "Neurexins and neuroligins"], "R-BTA-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-XTR-9017802": ["r", "Noncanonical activation of NOTCH3"], "R-CEL-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-HSA-9672383": ["r", "Defective factor IX causes thrombophilia"], "R-DRE-9013423": ["r", "RAC3 GTPase cycle"], "R-BTA-3000178": ["r", "ECM proteoglycans"], "R-HSA-1566948": ["r", "Elastic fibre formation"], "R-XTR-2197563": ["r", "NOTCH2 intracellular domain regulates transcription"], "R-RNO-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-RNO-2024101": ["r", "CS/DS degradation"], "R-CFA-8957275": ["r", "Post-translational protein phosphorylation"], "R-BTA-2024101": ["r", "CS/DS degradation"], "R-BTA-159740": ["r", "Gamma-carboxylation of protein precursors"], "R-RNO-209968": ["r", "Thyroxine biosynthesis"], "R-MMU-428890": ["r", "Role of ABL in ROBO-SLIT signaling"], "R-HSA-2894862": ["r", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"], "R-GGA-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-HSA-2197563": ["r", "NOTCH2 intracellular domain regulates transcription"], "R-CEL-376176": ["r", "Signaling by ROBO receptors"], "R-HSA-2243919": ["r", "Crosslinking of collagen fibrils"], "R-HSA-9672396": ["r", "Defective cofactor function of FVIIIa variant"], "R-DME-1912420": ["r", "Pre-NOTCH Processing in Golgi"], "R-HSA-5083630": ["r", "Defective LFNG causes SCDO3"], "R-HSA-2979096": ["r", "NOTCH2 Activation and Transmission of Signal to the Nucleus"], "R-HSA-3359462": ["r", "Defective AMN causes MGA1"], "R-MMU-1566948": ["r", "Elastic fibre formation"], "R-BTA-140834": ["r", "Extrinsic Pathway of Fibrin Clot Formation"], "R-BTA-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-BTA-1566948": ["r", "Elastic fibre formation"], "R-CEL-2214320": ["r", "Anchoring fibril formation"], "R-CFA-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-BTA-1474228": ["r", "Degradation of the extracellular matrix"], "R-HSA-5173105": ["r", "O-linked glycosylation"], "R-DRE-5362798": ["r", "Release of Hh-Np from the secreting cell"], "R-MMU-376176": ["r", "Signaling by ROBO receptors"], "R-HSA-2022923": ["r", "DS-GAG biosynthesis"], "R-MMU-350054": ["r", "Notch-HLH transcription pathway"], "R-HSA-9793380": ["r", "Formation of paraxial mesoderm"], "R-DME-9013700": ["r", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "R-MMU-2024101": ["r", "CS/DS degradation"], "R-HSA-2644606": ["r", "Constitutive Signaling by NOTCH1 PEST Domain Mutants"], "R-RNO-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-CFA-202733": ["r", "Cell surface interactions at the vascular wall"], "R-MMU-2122947": ["r", "NOTCH1 Intracellular Domain Regulates Transcription"], "R-HSA-3595172": ["r", "Defective CHST3 causes SEDCJD"], "R-XTR-8941856": ["r", "RUNX3 regulates NOTCH signaling"], "R-XTR-1912420": ["r", "Pre-NOTCH Processing in Golgi"], "R-CEL-9010553": ["r", "Regulation of expression of SLITs and ROBOs"], "R-HSA-9013700": ["r", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "R-HSA-3359463": ["r", "Defective CUBN causes MGA1"], "R-HSA-3595177": ["r", "Defective CHSY1 causes TPBS"], "R-HSA-8985801": ["r", "Regulation of cortical dendrite branching"], "R-HSA-376176": ["r", "Signaling by ROBO receptors"], "R-DME-446107": ["r", "Type I hemidesmosome assembly"], "R-MMU-9017802": ["r", "Noncanonical activation of NOTCH3"], "R-HSA-350054": ["r", "Notch-HLH transcription pathway"], "R-MMU-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-MMU-5362798": ["r", "Release of Hh-Np from the secreting cell"], "R-HSA-1912399": ["r", "Pre-NOTCH Processing in the Endoplasmic Reticulum"], "R-HSA-9673218": ["r", "Defective F9 secretion"], "R-CFA-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-HSA-9022702": ["r", "MECP2 regulates transcription of neuronal ligands"], "R-GGA-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-HSA-9818749": ["r", "Regulation of NFE2L2 gene expression"], "R-BTA-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-HSA-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-MMU-2243919": ["r", "Crosslinking of collagen fibrils"], "R-MMU-2214320": ["r", "Anchoring fibril formation"], "R-DME-2214320": ["r", "Anchoring fibril formation"], "R-HSA-9926550": ["r", "Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition"], "R-DME-2979096": ["r", "NOTCH2 Activation and Transmission of Signal to the Nucleus"], "R-HSA-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-HSA-9629569": ["r", "Protein hydroxylation"], "R-CFA-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-HSA-2024101": ["r", "CS/DS degradation"], "R-RNO-446203": ["r", "Asparagine N-linked glycosylation"], "R-MMU-9604323": ["r", "Negative regulation of NOTCH4 signaling"], "R-HSA-9673221": ["r", "Defective F9 activation"], "R-HSA-2644607": ["r", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"], "R-HSA-9911233": ["r", "Expression of NOTCH2NL genes"], "R-HSA-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-MMU-2022870": ["r", "CS-GAG biosynthesis"], "R-DRE-2243919": ["r", "Crosslinking of collagen fibrils"], "R-RNO-9017802": ["r", "Noncanonical activation of NOTCH3"], "R-MMU-9010553": ["r", "Regulation of expression of SLITs and ROBOs"], "R-BTA-202733": ["r", "Cell surface interactions at the vascular wall"], "R-HSA-9017802": ["r", "Noncanonical activation of NOTCH3"], "R-HSA-5362798": ["r", "Release of Hh-Np from the secreting cell"], "R-CFA-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-HSA-446203": ["r", "Asparagine N-linked glycosylation"], "R-HSA-428542": ["r", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "R-MMU-6794361": ["r", "Neurexins and neuroligins"], "R-HSA-9830674": ["r", "Formation of the ureteric bud"], "R-HSA-428543": ["r", "Inactivation of CDC42 and RAC1"], "R-HSA-9831926": ["r", "Nephron development"], "R-BTA-2022923": ["r", "DS-GAG biosynthesis"], "R-SSC-375276": ["r", "Peptide ligand-binding receptors"], "R-DRE-375276": ["r", "Peptide ligand-binding receptors"], "R-BTA-418555": ["r", "G alpha (s) signalling events"], "R-HSA-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-MMU-2467813": ["r", "Separation of Sister Chromatids"], "R-RNO-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-MMU-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-DME-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-RNO-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-HSA-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-MMU-68877": ["r", "Mitotic Prometaphase"], "R-MMU-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-HSA-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-RNO-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-MMU-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-RNO-191859": ["r", "snRNP Assembly"], "R-HSA-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-DME-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-HSA-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-SPO-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-HSA-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-HSA-9610379": ["r", "HCMV Late Events"], "R-DME-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-MMU-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-SPO-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-HSA-6784531": ["r", "tRNA processing in the nucleus"], "R-MMU-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-HSA-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-DME-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-HSA-168325": ["r", "Viral Messenger RNA Synthesis"], "R-HSA-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-MMU-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-HSA-9609690": ["r", "HCMV Early Events"], "R-MMU-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-HSA-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-HSA-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-HSA-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-MMU-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-RNO-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-SPO-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-RNO-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-HSA-5619107": ["r", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"], "R-RNO-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-HSA-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-MMU-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-MMU-5663220": ["r", "RHO GTPases Activate Formins"], "R-RNO-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-SPO-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-RNO-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-HSA-191859": ["r", "snRNP Assembly"], "R-HSA-2467813": ["r", "Separation of Sister Chromatids"], "R-HSA-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-SPO-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-SPO-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-MMU-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-DME-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-DME-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-MMU-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-HSA-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-HSA-168333": ["r", "NEP/NS2 Interacts with the Cellular Export Machinery"], "R-MMU-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-HSA-68877": ["r", "Mitotic Prometaphase"], "R-HSA-165054": ["r", "Rev-mediated nuclear export of HIV RNA"], "R-RNO-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-HSA-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-MMU-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-MMU-191859": ["r", "snRNP Assembly"], "R-DME-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-MMU-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-MMU-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-MMU-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-HSA-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-HSA-168276": ["r", "NS1 Mediated Effects on Host Pathways"], "R-HSA-168271": ["r", "Transport of Ribonucleoproteins into the Host Nucleus"], "R-SPO-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-DME-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-HSA-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-RNO-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-MMU-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-MMU-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-SPO-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-MMU-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-HSA-9617629": ["r", "Regulation of FOXO transcriptional activity by acetylation"], "R-CEL-351200": ["r", "Interconversion of polyamines"], "R-DDI-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-HSA-70635": ["r", "Urea cycle"], "R-SCE-351200": ["r", "Interconversion of polyamines"], "R-HSA-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-HSA-9636569": ["r", "Suppression of autophagy"], "R-DDI-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-SCE-9018519": ["r", "Estrogen-dependent gene expression"], "R-HSA-9733709": ["r", "Cardiogenesis"], "R-RNO-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-DME-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-CEL-351143": ["r", "Agmatine biosynthesis"], "R-HSA-351143": ["r", "Agmatine biosynthesis"], "R-SPO-351143": ["r", "Agmatine biosynthesis"], "R-SPO-351202": ["r", "Metabolism of polyamines"], "R-DME-351143": ["r", "Agmatine biosynthesis"], "R-CEL-351202": ["r", "Metabolism of polyamines"], "R-SPO-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-MMU-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-RNO-351143": ["r", "Agmatine biosynthesis"], "R-BTA-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-DME-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-HSA-351202": ["r", "Metabolism of polyamines"], "R-DME-351202": ["r", "Metabolism of polyamines"], "R-RNO-351202": ["r", "Metabolism of polyamines"], "R-RNO-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-DDI-351202": ["r", "Metabolism of polyamines"], "R-MMU-351143": ["r", "Agmatine biosynthesis"], "R-SCE-351143": ["r", "Agmatine biosynthesis"], "R-DDI-351143": ["r", "Agmatine biosynthesis"], "R-MMU-351202": ["r", "Metabolism of polyamines"], "R-SCE-351202": ["r", "Metabolism of polyamines"], "R-CEL-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-HSA-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-BTA-351202": ["r", "Metabolism of polyamines"], "R-XTR-9013404": ["r", "RAC2 GTPase cycle"], "R-HSA-1268020": ["r", "Mitochondrial protein import"], "R-HSA-9760173": ["r", "Secretion of toxins"], "R-DRE-9013404": ["r", "RAC2 GTPase cycle"], "R-HSA-9636383": ["r", "Prevention of phagosomal-lysosomal fusion"], "R-HSA-1222387": ["r", "Tolerance of reactive oxygen produced by macrophages"], "R-MMU-912526": ["r", "Interleukin receptor SHC signaling"], "R-SSC-5673001": ["r", "RAF/MAP kinase cascade"], "R-CFA-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-CFA-912526": ["r", "Interleukin receptor SHC signaling"], "R-BTA-912526": ["r", "Interleukin receptor SHC signaling"], "R-HSA-912526": ["r", "Interleukin receptor SHC signaling"], "R-RNO-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-MMU-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-HSA-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-SSC-912526": ["r", "Interleukin receptor SHC signaling"], "R-SSC-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-BTA-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-RNO-912526": ["r", "Interleukin receptor SHC signaling"], "R-BTA-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-SSC-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-GGA-375276": ["r", "Peptide ligand-binding receptors"], "R-SSC-8856828": ["r", "Clathrin-mediated endocytosis"], "R-SSC-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-HSA-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-BTA-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-DDI-977347": ["r", "Serine metabolism"], "R-XTR-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-RNO-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-CEL-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-HSA-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-MMU-9865881": ["r", "Complex III assembly"], "R-SPO-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-DME-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-MMU-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-DDI-9865881": ["r", "Complex III assembly"], "R-PFA-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-MMU-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-MMU-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-MMU-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-SCE-977347": ["r", "Serine metabolism"], "R-SCE-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-DDI-9033241": ["r", "Peroxisomal protein import"], "R-DME-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-DME-9865881": ["r", "Complex III assembly"], "R-HSA-9865881": ["r", "Complex III assembly"], "R-HSA-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-MMU-977347": ["r", "Serine metabolism"], "R-DME-977347": ["r", "Serine metabolism"], "R-SCE-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-RNO-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-SPO-977347": ["r", "Serine metabolism"], "R-DME-9033241": ["r", "Peroxisomal protein import"], "R-MMU-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-DDI-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-RNO-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-DDI-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-SCE-9865881": ["r", "Complex III assembly"], "R-RNO-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-HSA-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-DDI-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-HSA-977347": ["r", "Serine metabolism"], "R-SPO-9865881": ["r", "Complex III assembly"], "R-PFA-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-DME-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-DRE-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-RNO-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-RNO-9865881": ["r", "Complex III assembly"], "R-CEL-977347": ["r", "Serine metabolism"], "R-SPO-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-BTA-947581": ["r", "Molybdenum cofactor biosynthesis"], "PWY-7980": ["t", "ATP biosynthesis"], "R-MMU-1222556": ["r", "ROS and RNS production in phagocytes"], "R-CEL-1222556": ["r", "ROS and RNS production in phagocytes"], "R-DDI-77387": ["r", "Insulin receptor recycling"], "R-DME-1222556": ["r", "ROS and RNS production in phagocytes"], "R-HSA-77387": ["r", "Insulin receptor recycling"], "R-CFA-1268020": ["r", "Mitochondrial protein import"], "R-MMU-9639288": ["r", "Amino acids regulate mTORC1"], "R-SPO-9639288": ["r", "Amino acids regulate mTORC1"], "R-HSA-9639288": ["r", "Amino acids regulate mTORC1"], "R-CFA-8949613": ["r", "Cristae formation"], "R-RNO-983712": ["r", "Ion channel transport"], "R-SPO-917977": ["r", "Transferrin endocytosis and recycling"], "R-MMU-1268020": ["r", "Mitochondrial protein import"], "R-CEL-9639288": ["r", "Amino acids regulate mTORC1"], "R-SPO-1222556": ["r", "ROS and RNS production in phagocytes"], "R-RNO-917977": ["r", "Transferrin endocytosis and recycling"], "R-CFA-9837999": ["r", "Mitochondrial protein degradation"], "R-SSC-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-SCE-1222556": ["r", "ROS and RNS production in phagocytes"], "R-SCE-917977": ["r", "Transferrin endocytosis and recycling"], "R-MMU-77387": ["r", "Insulin receptor recycling"], "R-BTA-1222556": ["r", "ROS and RNS production in phagocytes"], "R-SCE-77387": ["r", "Insulin receptor recycling"], "R-SSC-8949613": ["r", "Cristae formation"], "R-RNO-77387": ["r", "Insulin receptor recycling"], "R-DME-983712": ["r", "Ion channel transport"], "R-MMU-917977": ["r", "Transferrin endocytosis and recycling"], "R-SPO-77387": ["r", "Insulin receptor recycling"], "R-RNO-9639288": ["r", "Amino acids regulate mTORC1"], "R-HSA-917977": ["r", "Transferrin endocytosis and recycling"], "R-CEL-1268020": ["r", "Mitochondrial protein import"], "R-DDI-983712": ["r", "Ion channel transport"], "R-BTA-77387": ["r", "Insulin receptor recycling"], "R-DME-1268020": ["r", "Mitochondrial protein import"], "R-DDI-917977": ["r", "Transferrin endocytosis and recycling"], "R-SCE-9639288": ["r", "Amino acids regulate mTORC1"], "R-CEL-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-HSA-9857377": ["r", "Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy"], "R-RNO-1222556": ["r", "ROS and RNS production in phagocytes"], "R-PFA-917977": ["r", "Transferrin endocytosis and recycling"], "R-HSA-1222556": ["r", "ROS and RNS production in phagocytes"], "R-DDI-1222556": ["r", "ROS and RNS production in phagocytes"], "R-RNO-1268020": ["r", "Mitochondrial protein import"], "R-DDI-9639288": ["r", "Amino acids regulate mTORC1"], "R-DDI-1268020": ["r", "Mitochondrial protein import"], "R-DME-917977": ["r", "Transferrin endocytosis and recycling"], "R-BTA-983712": ["r", "Ion channel transport"], "R-SSC-74749": ["r", "Signal attenuation"], "R-RNO-210993": ["r", "Tie2 Signaling"], "R-HSA-74713": ["r", "IRS activation"], "R-HSA-210993": ["r", "Tie2 Signaling"], "R-HSA-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-CEL-5674135": ["r", "MAP2K and MAPK activation"], "R-DRE-354192": ["r", "Integrin signaling"], "R-SPO-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-HSA-9648895": ["r", "Response of EIF2AK1 (HRI) to heme deficiency"], "R-MMU-171007": ["r", "p38MAPK events"], "R-MMU-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-DRE-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-SSC-1433557": ["r", "Signaling by SCF-KIT"], "R-HSA-74751": ["r", "Insulin receptor signalling cascade"], "R-RNO-418990": ["r", "Adherens junctions interactions"], "R-RNO-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-CEL-354192": ["r", "Integrin signaling"], "R-SSC-8853659": ["r", "RET signaling"], "R-SPO-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-HSA-171007": ["r", "p38MAPK events"], "R-BTA-1433557": ["r", "Signaling by SCF-KIT"], "R-BTA-1306955": ["r", "GRB7 events in ERBB2 signaling"], "R-MMU-74713": ["r", "IRS activation"], "R-RNO-171007": ["r", "p38MAPK events"], "R-MMU-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-DME-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-HSA-74749": ["r", "Signal attenuation"], "R-DDI-264876": ["r", "Insulin processing"], "R-RNO-74713": ["r", "IRS activation"], "R-MMU-418990": ["r", "Adherens junctions interactions"], "R-RNO-74751": ["r", "Insulin receptor signalling cascade"], "R-SSC-74713": ["r", "IRS activation"], "R-BTA-210993": ["r", "Tie2 Signaling"], "R-SSC-74751": ["r", "Insulin receptor signalling cascade"], "R-MMU-74749": ["r", "Signal attenuation"], "R-RNO-388479": ["r", "Vasopressin-like receptors"], "R-HSA-388479": ["r", "Vasopressin-like receptors"], "R-MMU-388479": ["r", "Vasopressin-like receptors"], "R-BTA-388479": ["r", "Vasopressin-like receptors"], "R-BTA-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-HSA-9036092": ["r", "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)"], "R-DME-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-DME-418594": ["r", "G alpha (i) signalling events"], "R-CEL-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-RNO-5673000": ["r", "RAF activation"], "R-HSA-9840373": ["r", "Cellular response to mitochondrial stress"], "R-BTA-8949664": ["r", "Processing of SMDT1"], "R-MMU-5673000": ["r", "RAF activation"], "R-GGA-8949664": ["r", "Processing of SMDT1"], "R-RNO-9840373": ["r", "Cellular response to mitochondrial stress"], "R-CEL-5673000": ["r", "RAF activation"], "R-RNO-8949664": ["r", "Processing of SMDT1"], "R-MMU-8949664": ["r", "Processing of SMDT1"], "R-HSA-5673000": ["r", "RAF activation"], "R-DME-8949664": ["r", "Processing of SMDT1"], "R-CEL-8949664": ["r", "Processing of SMDT1"], "R-HSA-8949664": ["r", "Processing of SMDT1"], "R-BTA-5673000": ["r", "RAF activation"], "R-GGA-5673000": ["r", "RAF activation"], "R-DME-5673000": ["r", "RAF activation"], "R-MMU-9840373": ["r", "Cellular response to mitochondrial stress"], "R-BTA-9840373": ["r", "Cellular response to mitochondrial stress"], "R-HSA-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-BTA-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-HSA-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-MMU-1266695": ["r", "Interleukin-7 signaling"], "R-GGA-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-HSA-427413": ["r", "NoRC negatively regulates rRNA expression"], "R-MMU-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-BTA-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-HSA-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-BTA-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-BTA-3247509": ["r", "Chromatin modifying enzymes"], "R-BTA-3214841": ["r", "PKMTs methylate histone lysines"], "R-SSC-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-BTA-9018519": ["r", "Estrogen-dependent gene expression"], "R-RNO-3214842": ["r", "HDMs demethylate histones"], "R-SSC-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-HSA-427359": ["r", "SIRT1 negatively regulates rRNA expression"], "R-RNO-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-DME-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-GGA-1266695": ["r", "Interleukin-7 signaling"], "R-SSC-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-DME-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-MMU-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-MMU-3214841": ["r", "PKMTs methylate histone lysines"], "R-GGA-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-HSA-69473": ["r", "G2/M DNA damage checkpoint"], "R-HSA-3247509": ["r", "Chromatin modifying enzymes"], "R-BTA-3214847": ["r", "HATs acetylate histones"], "R-HSA-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-BTA-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-HSA-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-SSC-9018519": ["r", "Estrogen-dependent gene expression"], "R-RNO-3214841": ["r", "PKMTs methylate histone lysines"], "R-HSA-9710421": ["r", "Defective pyroptosis"], "R-GGA-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-HSA-212300": ["r", "PRC2 methylates histones and DNA"], "R-RNO-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-BTA-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-HSA-9670095": ["r", "Inhibition of DNA recombination at telomere"], "R-BTA-110331": ["r", "Cleavage of the damaged purine"], "R-DME-3247509": ["r", "Chromatin modifying enzymes"], "R-SSC-9843970": ["r", "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "R-SSC-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-BTA-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-GGA-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-BTA-9843970": ["r", "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "R-GGA-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-BTA-427359": ["r", "SIRT1 negatively regulates rRNA expression"], "R-SSC-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-HSA-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-SSC-212300": ["r", "PRC2 methylates histones and DNA"], "R-DME-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-BTA-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-DME-427359": ["r", "SIRT1 negatively regulates rRNA expression"], "R-BTA-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-BTA-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-HSA-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-BTA-1266695": ["r", "Interleukin-7 signaling"], "R-GGA-212300": ["r", "PRC2 methylates histones and DNA"], "R-HSA-9843970": ["r", "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "R-HSA-912446": ["r", "Meiotic recombination"], "R-GGA-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-BTA-9670095": ["r", "Inhibition of DNA recombination at telomere"], "R-RNO-427359": ["r", "SIRT1 negatively regulates rRNA expression"], "R-HSA-3214842": ["r", "HDMs demethylate histones"], "R-SSC-427359": ["r", "SIRT1 negatively regulates rRNA expression"], "R-GGA-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-MMU-3214858": ["r", "RMTs methylate histone arginines"], "R-HSA-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-HSA-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-DME-427413": ["r", "NoRC negatively regulates rRNA expression"], "R-MMU-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-MMU-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-GGA-3247509": ["r", "Chromatin modifying enzymes"], "R-HSA-9821002": ["r", "Chromatin modifications during the maternal to zygotic transition (MZT)"], "R-SSC-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-HSA-427389": ["r", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"], "R-BTA-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-RNO-427413": ["r", "NoRC negatively regulates rRNA expression"], "R-RNO-3247509": ["r", "Chromatin modifying enzymes"], "R-CEL-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-HSA-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-BTA-3214815": ["r", "HDACs deacetylate histones"], "R-BTA-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-RNO-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-RNO-3214858": ["r", "RMTs methylate histone arginines"], "R-BTA-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-HSA-5693607": ["r", "Processing of DNA double-strand break ends"], "R-RNO-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-DME-1266695": ["r", "Interleukin-7 signaling"], "R-MMU-3247509": ["r", "Chromatin modifying enzymes"], "R-SSC-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-RNO-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-BTA-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-BTA-5693607": ["r", "Processing of DNA double-strand break ends"], "R-HSA-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-SSC-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-BTA-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-DME-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-HSA-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-HSA-9821993": ["r", "Replacement of protamines by nucleosomes in the male pronucleus"], "R-SSC-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-BTA-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-BTA-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-BTA-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-BTA-171306": ["r", "Packaging Of Telomere Ends"], "R-GGA-3214847": ["r", "HATs acetylate histones"], "R-HSA-3214815": ["r", "HDACs deacetylate histones"], "R-DME-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-GGA-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-RNO-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-DME-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-BTA-427413": ["r", "NoRC negatively regulates rRNA expression"], "R-RNO-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-BTA-3214842": ["r", "HDMs demethylate histones"], "R-GGA-9843970": ["r", "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "R-HSA-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-SSC-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-BTA-69473": ["r", "G2/M DNA damage checkpoint"], "R-HSA-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-MMU-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-MMU-212300": ["r", "PRC2 methylates histones and DNA"], "R-HSA-1221632": ["r", "Meiotic synapsis"], "R-HSA-3214858": ["r", "RMTs methylate histone arginines"], "R-SSC-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-GGA-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-MMU-9670095": ["r", "Inhibition of DNA recombination at telomere"], "R-DME-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-BTA-3214858": ["r", "RMTs methylate histone arginines"], "R-RNO-3214815": ["r", "HDACs deacetylate histones"], "R-RNO-212300": ["r", "PRC2 methylates histones and DNA"], "R-HSA-3214841": ["r", "PKMTs methylate histone lysines"], "R-MMU-3214842": ["r", "HDMs demethylate histones"], "R-HSA-9845323": ["r", "Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)"], "R-DME-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-HSA-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-CEL-3214842": ["r", "HDMs demethylate histones"], "R-CEL-3214847": ["r", "HATs acetylate histones"], "R-HSA-5334118": ["r", "DNA methylation"], "R-BTA-212300": ["r", "PRC2 methylates histones and DNA"], "R-RNO-1266695": ["r", "Interleukin-7 signaling"], "R-RNO-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-HSA-171306": ["r", "Packaging Of Telomere Ends"], "R-SSC-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-BTA-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-DME-212300": ["r", "PRC2 methylates histones and DNA"], "R-GGA-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-HSA-110328": ["r", "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"], "R-CEL-3214841": ["r", "PKMTs methylate histone lysines"], "R-SSC-9670095": ["r", "Inhibition of DNA recombination at telomere"], "R-SSC-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-MMU-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-SSC-5625886": ["r", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "R-GGA-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-RNO-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-CEL-3214858": ["r", "RMTs methylate histone arginines"], "R-HSA-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-RNO-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-SSC-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-DME-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-RNO-9843970": ["r", "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "R-SSC-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-GGA-427413": ["r", "NoRC negatively regulates rRNA expression"], "PWY-5941": ["t", "glycogen degradation II"], "R-BTA-1679131": ["r", "Trafficking and processing of endosomal TLR"], "R-MMU-204005": ["r", "COPII-mediated vesicle transport"], "R-CFA-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-RNO-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-MMU-5694530": ["r", "Cargo concentration in the ER"], "R-HSA-9766229": ["r", "Degradation of CDH1"], "R-BTA-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-DDI-114608": ["r", "Platelet degranulation"], "R-CEL-2132295": ["r", "MHC class II antigen presentation"], "R-SSC-1474228": ["r", "Degradation of the extracellular matrix"], "R-HSA-5694530": ["r", "Cargo concentration in the ER"], "R-RNO-1679131": ["r", "Trafficking and processing of endosomal TLR"], "R-SSC-2132295": ["r", "MHC class II antigen presentation"], "R-HSA-9678110": ["r", "Attachment and Entry"], "R-PFA-2132295": ["r", "MHC class II antigen presentation"], "R-CFA-2132295": ["r", "MHC class II antigen presentation"], "R-DDI-5683826": ["r", "Surfactant metabolism"], "R-SSC-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-RNO-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-DME-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-CEL-5683826": ["r", "Surfactant metabolism"], "R-HSA-204005": ["r", "COPII-mediated vesicle transport"], "R-BTA-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-CFA-1474228": ["r", "Degradation of the extracellular matrix"], "R-DME-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-CFA-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-MMU-9766229": ["r", "Degradation of CDH1"], "R-GGA-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-HSA-2132295": ["r", "MHC class II antigen presentation"], "R-CFA-9768919": ["r", "NPAS4 regulates expression of target genes"], "R-BTA-1442490": ["r", "Collagen degradation"], "R-HSA-8862803": ["r", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "R-MMU-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-CFA-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-MMU-2132295": ["r", "MHC class II antigen presentation"], "R-SSC-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-SSC-1442490": ["r", "Collagen degradation"], "R-BTA-2132295": ["r", "MHC class II antigen presentation"], "R-CFA-211976": ["r", "Endogenous sterols"], "R-DME-2024096": ["r", "HS-GAG degradation"], "R-RNO-2132295": ["r", "MHC class II antigen presentation"], "R-RNO-5694530": ["r", "Cargo concentration in the ER"], "R-DME-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-RNO-1442490": ["r", "Collagen degradation"], "R-HSA-1236977": ["r", "Endosomal/Vacuolar pathway"], "R-RNO-204005": ["r", "COPII-mediated vesicle transport"], "R-MMU-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-BTA-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-PFA-114608": ["r", "Platelet degranulation"], "R-CFA-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-DME-1442490": ["r", "Collagen degradation"], "R-RNO-9766229": ["r", "Degradation of CDH1"], "R-DME-2132295": ["r", "MHC class II antigen presentation"], "R-PFA-6798695": ["r", "Neutrophil degranulation"], "R-BTA-5683826": ["r", "Surfactant metabolism"], "R-SSC-5683826": ["r", "Surfactant metabolism"], "R-BTA-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-DDI-2132295": ["r", "MHC class II antigen presentation"], "R-RNO-6798163": ["r", "Choline catabolism"], "R-HSA-6798163": ["r", "Choline catabolism"], "R-MMU-6798163": ["r", "Choline catabolism"], "R-HSA-380615": ["r", "Serotonin clearance from the synaptic cleft"], "R-HSA-71288": ["r", "Creatine metabolism"], "R-MMU-888593": ["r", "Reuptake of GABA"], "R-CEL-352230": ["r", "Amino acid transport across the plasma membrane"], "R-HSA-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-CFA-71288": ["r", "Creatine metabolism"], "R-MMU-380615": ["r", "Serotonin clearance from the synaptic cleft"], "R-HSA-5619094": ["r", "Variant SLC6A14 may confer susceptibility towards obesity"], "R-CEL-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-HSA-5619101": ["r", "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)"], "R-BTA-352230": ["r", "Amino acid transport across the plasma membrane"], "R-MMU-352230": ["r", "Amino acid transport across the plasma membrane"], "R-HSA-888593": ["r", "Reuptake of GABA"], "R-RNO-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-HSA-352230": ["r", "Amino acid transport across the plasma membrane"], "R-RNO-352230": ["r", "Amino acid transport across the plasma membrane"], "R-MMU-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-DME-380615": ["r", "Serotonin clearance from the synaptic cleft"], "R-DME-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-HSA-5659735": ["r", "Defective SLC6A19 causes Hartnup disorder (HND)"], "R-HSA-5660686": ["r", "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)"], "R-HSA-5619089": ["r", "Defective SLC6A5 causes hyperekplexia 3 (HKPX3)"], "R-RNO-380615": ["r", "Serotonin clearance from the synaptic cleft"], "R-DME-352230": ["r", "Amino acid transport across the plasma membrane"], "R-BTA-380615": ["r", "Serotonin clearance from the synaptic cleft"], "R-HSA-5619081": ["r", "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)"], "R-MMU-379401": ["r", "Dopamine clearance from the synaptic cleft"], "R-CFA-888593": ["r", "Reuptake of GABA"], "R-RNO-379401": ["r", "Dopamine clearance from the synaptic cleft"], "R-BTA-71288": ["r", "Creatine metabolism"], "R-RNO-888593": ["r", "Reuptake of GABA"], "R-HSA-5619044": ["r", "Defective SLC6A19 causes Hartnup disorder (HND)"], "R-HSA-5619109": ["r", "Defective SLC6A2 causes orthostatic intolerance (OI)"], "R-BTA-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-MMU-71288": ["r", "Creatine metabolism"], "R-HSA-379401": ["r", "Dopamine clearance from the synaptic cleft"], "R-RNO-71288": ["r", "Creatine metabolism"], "R-BTA-888593": ["r", "Reuptake of GABA"], "R-CFA-352230": ["r", "Amino acid transport across the plasma membrane"], "R-HSA-5660724": ["r", "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)"], "PWY-8397": ["t", "arachidonate metabolites biosynthesis"], "R-SSC-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-BTA-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-SSC-5423646": ["r", "Aflatoxin activation and detoxification"], "R-CEL-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-MMU-5689901": ["r", "Metalloprotease DUBs"], "R-SCE-3214847": ["r", "HATs acetylate histones"], "R-MMU-351200": ["r", "Interconversion of polyamines"], "R-GGA-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-BTA-351200": ["r", "Interconversion of polyamines"], "R-HSA-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-SPO-351200": ["r", "Interconversion of polyamines"], "R-HSA-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-XTR-8963693": ["r", "Aspartate and asparagine metabolism"], "R-DDI-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-DRE-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-DRE-9018519": ["r", "Estrogen-dependent gene expression"], "R-MTU-879299": ["r", "Mycothiol biosynthesis"], "R-DRE-5689901": ["r", "Metalloprotease DUBs"], "R-GGA-351200": ["r", "Interconversion of polyamines"], "R-HSA-9955693": ["r", "NAGS variants cause NAGS deficiency"], "R-SPO-9018519": ["r", "Estrogen-dependent gene expression"], "R-HSA-351200": ["r", "Interconversion of polyamines"], "R-RNO-8963693": ["r", "Aspartate and asparagine metabolism"], "R-HSA-8963693": ["r", "Aspartate and asparagine metabolism"], "R-SCE-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-DRE-5250924": ["r", "B-WICH complex positively regulates rRNA expression"], "R-MMU-70635": ["r", "Urea cycle"], "R-SCE-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-MMU-8963693": ["r", "Aspartate and asparagine metabolism"], "R-MMU-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-DDI-381042": ["r", "PERK regulates gene expression"], "R-DRE-9617629": ["r", "Regulation of FOXO transcriptional activity by acetylation"], "R-DRE-8963693": ["r", "Aspartate and asparagine metabolism"], "R-HSA-5689901": ["r", "Metalloprotease DUBs"], "R-HSA-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-DRE-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-DDI-176187": ["r", "Activation of ATR in response to replication stress"], "R-SPO-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-SPO-3214847": ["r", "HATs acetylate histones"], "R-HSA-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-DDI-3214847": ["r", "HATs acetylate histones"], "R-MMU-9617629": ["r", "Regulation of FOXO transcriptional activity by acetylation"], "R-HSA-6790901": ["r", "rRNA modification in the nucleus and cytosol"], "R-DME-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-HSA-5578768": ["r", "Physiological factors"], "R-DDI-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-HSA-198203": ["r", "PI3K/AKT activation"], "R-RNO-430116": ["r", "GP1b-IX-V activation signalling"], "R-SCE-9013423": ["r", "RAC3 GTPase cycle"], "R-CFA-9013404": ["r", "RAC2 GTPase cycle"], "R-HSA-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-DDI-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-XTR-9696264": ["r", "RND3 GTPase cycle"], "R-XTR-9013423": ["r", "RAC3 GTPase cycle"], "R-SPO-9013409": ["r", "RHOJ GTPase cycle"], "R-DME-350407": ["r", "RHO1 GTPase cycle"], "R-DDI-171007": ["r", "p38MAPK events"], "R-BTA-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-CFA-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-XTR-9035034": ["r", "RHOF GTPase cycle"], "R-MMU-112399": ["r", "IRS-mediated signalling"], "R-BTA-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-RNO-5654720": ["r", "PI-3K cascade:FGFR4"], "R-DME-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-DME-350379": ["r", "Homo-/heterophilic binding of transmembrane components"], "R-DRE-9619665": ["r", "EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "R-MMU-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-CEL-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-CEL-9619665": ["r", "EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "R-DME-9619665": ["r", "EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "R-DME-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-DME-350368": ["r", "Activation of RHO1 by FZ:DSH complex"], "R-DME-350376": ["r", "Activation of RAC1:GTP by FZ:DSH complex"], "R-HSA-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-DME-350411": ["r", "Formation and asymmetric localisation of transmembrane complexes"], "R-MMU-9619665": ["r", "EGR2 and SOX10-mediated initiation of Schwann cell myelination"], "R-DME-450728": ["r", "Inhibition of actin polymerization"], "R-BTA-389397": ["r", "Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "R-CFA-389397": ["r", "Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "R-RNO-389397": ["r", "Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "R-MMU-389397": ["r", "Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "R-SSC-389397": ["r", "Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "R-HSA-389397": ["r", "Orexin and neuropeptides FF and QRFP bind to their respective receptors"], "R-MMU-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-HSA-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-RNO-418597": ["r", "G alpha (z) signalling events"], "R-RNO-390696": ["r", "Adrenoceptors"], "R-MMU-418597": ["r", "G alpha (z) signalling events"], "R-RNO-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-MMU-390696": ["r", "Adrenoceptors"], "R-HSA-390696": ["r", "Adrenoceptors"], "PWY-7884": ["t", "lipoprotein posttranslational modification (Gram-negative bacteria)"], "R-CEL-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-DME-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-DDI-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-HSA-171286": ["r", "Synthesis and processing of ENV and VPU"], "R-RNO-381033": ["r", "ATF6 (ATF6-alpha) activates chaperones"], "R-HSA-9828806": ["r", "Maturation of hRSV A proteins"], "R-DDI-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-RNO-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-HSA-5210891": ["r", "Uptake and function of anthrax toxins"], "R-MMU-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "R-RNO-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-HSA-209952": ["r", "Peptide hormone biosynthesis"], "R-MMU-381033": ["r", "ATF6 (ATF6-alpha) activates chaperones"], "R-MMU-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-CEL-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-RNO-8874211": ["r", "CREB3 factors activate genes"], "R-HSA-381033": ["r", "ATF6 (ATF6-alpha) activates chaperones"], "R-SPO-8866427": ["r", "VLDLR internalisation and degradation"], "R-HSA-167060": ["r", "NGF processing"], "R-SCE-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-HSA-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-SCE-8866427": ["r", "VLDLR internalisation and degradation"], "R-MMU-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-RNO-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-DDI-382556": ["r", "ABC-family proteins mediated transport"], "R-SPO-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-RNO-8874177": ["r", "ATF6B (ATF6-beta) activates chaperones"], "R-HSA-8874211": ["r", "CREB3 factors activate genes"], "R-MMU-8874211": ["r", "CREB3 factors activate genes"], "R-DDI-9757110": ["r", "Prednisone ADME"], "R-DME-77387": ["r", "Insulin receptor recycling"], "R-CEL-8949613": ["r", "Cristae formation"], "R-CFA-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-CEL-77387": ["r", "Insulin receptor recycling"], "R-BTA-917977": ["r", "Transferrin endocytosis and recycling"], "R-HSA-983712": ["r", "Ion channel transport"], "R-PFA-1222556": ["r", "ROS and RNS production in phagocytes"], "R-CEL-983712": ["r", "Ion channel transport"], "R-CEL-917977": ["r", "Transferrin endocytosis and recycling"], "R-SSC-9837999": ["r", "Mitochondrial protein degradation"], "R-MMU-983712": ["r", "Ion channel transport"], "R-PFA-77387": ["r", "Insulin receptor recycling"], "R-BTA-9639288": ["r", "Amino acids regulate mTORC1"], "R-DME-9639288": ["r", "Amino acids regulate mTORC1"], "R-RNO-8854214": ["r", "TBC/RABGAPs"], "R-DDI-8854214": ["r", "TBC/RABGAPs"], "R-SCE-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-DME-8854214": ["r", "TBC/RABGAPs"], "R-XTR-8854214": ["r", "TBC/RABGAPs"], "R-SPO-8854214": ["r", "TBC/RABGAPs"], "R-SCE-204005": ["r", "COPII-mediated vesicle transport"], "R-SPO-204005": ["r", "COPII-mediated vesicle transport"], "R-SPO-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-SCE-8854214": ["r", "TBC/RABGAPs"], "R-CEL-8854214": ["r", "TBC/RABGAPs"], "R-MMU-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-BTA-8854214": ["r", "TBC/RABGAPs"], "R-BTA-204005": ["r", "COPII-mediated vesicle transport"], "R-DRE-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-DRE-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-DRE-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-DRE-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-DRE-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-DRE-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DRE-72689": ["r", "Formation of a pool of free 40S subunits"], "R-DRE-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-DRE-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-RNO-933541": ["r", "TRAF6 mediated IRF7 activation"], "R-CEL-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-CEL-9617629": ["r", "Regulation of FOXO transcriptional activity by acetylation"], "R-HSA-9614657": ["r", "FOXO-mediated transcription of cell death genes"], "R-MMU-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-HSA-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-RNO-9759194": ["r", "Nuclear events mediated by NFE2L2"], "R-MMU-3371568": ["r", "Attenuation phase"], "R-HSA-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-MMU-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-HSA-9031628": ["r", "NGF-stimulated transcription"], "R-HSA-9833109": ["r", "Evasion by RSV of host interferon responses"], "R-HSA-9735871": ["r", "SARS-CoV-1 targets host intracellular signalling and regulatory pathways"], "R-CEL-3899300": ["r", "SUMOylation of transcription cofactors"], "R-MMU-9759194": ["r", "Nuclear events mediated by NFE2L2"], "R-HSA-3371568": ["r", "Attenuation phase"], "R-HSA-9818028": ["r", "NFE2L2 regulates pentose phosphate pathway genes"], "R-RNO-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-HSA-156711": ["r", "Polo-like kinase mediated events"], "R-MMU-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-MMU-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-HSA-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-HSA-933541": ["r", "TRAF6 mediated IRF7 activation"], "R-RNO-8941856": ["r", "RUNX3 regulates NOTCH signaling"], "R-RNO-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-CEL-9018519": ["r", "Estrogen-dependent gene expression"], "R-RNO-9617629": ["r", "Regulation of FOXO transcriptional activity by acetylation"], "R-MMU-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-MMU-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-CEL-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-RNO-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-MMU-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-CEL-9759194": ["r", "Nuclear events mediated by NFE2L2"], "R-HSA-9818026": ["r", "NFE2L2 regulating inflammation associated genes"], "R-HSA-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-HSA-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-MMU-933541": ["r", "TRAF6 mediated IRF7 activation"], "R-RNO-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-HSA-9818035": ["r", "NFE2L2 regulating ER-stress associated genes"], "R-CEL-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-HSA-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-RNO-3371568": ["r", "Attenuation phase"], "R-HSA-918233": ["r", "TRAF3-dependent IRF activation pathway"], "R-HSA-9759194": ["r", "Nuclear events mediated by NFE2L2"], "R-HSA-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-HSA-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-HSA-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-HSA-9818032": ["r", "NFE2L2 regulating MDR associated enzymes"], "R-MMU-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-HSA-9842640": ["r", "Signaling by LTK in cancer"], "R-MMU-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-CFA-9013409": ["r", "RHOJ GTPase cycle"], "R-BTA-198203": ["r", "PI3K/AKT activation"], "R-MMU-5654720": ["r", "PI-3K cascade:FGFR4"], "R-HSA-912631": ["r", "Regulation of signaling by CBL"], "R-BTA-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-RNO-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-BTA-5654710": ["r", "PI-3K cascade:FGFR3"], "R-RNO-912631": ["r", "Regulation of signaling by CBL"], "R-HSA-5654695": ["r", "PI-3K cascade:FGFR2"], "R-MMU-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-CFA-9013148": ["r", "CDC42 GTPase cycle"], "R-DDI-5673001": ["r", "RAF/MAP kinase cascade"], "R-RNO-5663220": ["r", "RHO GTPases Activate Formins"], "R-XTR-9013148": ["r", "CDC42 GTPase cycle"], "R-DRE-9035034": ["r", "RHOF GTPase cycle"], "R-HSA-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-RNO-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-BTA-5654689": ["r", "PI-3K cascade:FGFR1"], "R-BTA-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-BTA-430116": ["r", "GP1b-IX-V activation signalling"], "R-XTR-9013026": ["r", "RHOB GTPase cycle"], "R-CFA-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-CFA-9696264": ["r", "RND3 GTPase cycle"], "R-BTA-9927354": ["r", "Co-stimulation by ICOS"], "R-GGA-9013149": ["r", "RAC1 GTPase cycle"], "R-CFA-9696270": ["r", "RND2 GTPase cycle"], "R-HSA-112399": ["r", "IRS-mediated signalling"], "R-BTA-180292": ["r", "GAB1 signalosome"], "R-HSA-9842663": ["r", "Signaling by LTK"], "R-RNO-5654689": ["r", "PI-3K cascade:FGFR1"], "R-CFA-9696273": ["r", "RND1 GTPase cycle"], "R-XTR-8980692": ["r", "RHOA GTPase cycle"], "R-DRE-9013420": ["r", "RHOU GTPase cycle"], "R-BTA-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-BTA-9696264": ["r", "RND3 GTPase cycle"], "R-GGA-8980692": ["r", "RHOA GTPase cycle"], "R-BTA-9027276": ["r", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "R-CEL-8980692": ["r", "RHOA GTPase cycle"], "R-BTA-202424": ["r", "Downstream TCR signaling"], "R-HSA-9670439": ["r", "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants"], "R-RNO-9027276": ["r", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "R-DRE-9013406": ["r", "RHOQ GTPase cycle"], "R-MMU-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-RNO-198203": ["r", "PI3K/AKT activation"], "R-MMU-5654695": ["r", "PI-3K cascade:FGFR2"], "R-BTA-9013409": ["r", "RHOJ GTPase cycle"], "R-DDI-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-9673767": ["r", "Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants"], "R-BTA-112399": ["r", "IRS-mediated signalling"], "R-GGA-9013406": ["r", "RHOQ GTPase cycle"], "R-RNO-9927354": ["r", "Co-stimulation by ICOS"], "R-RNO-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-HSA-9927354": ["r", "Co-stimulation by ICOS"], "R-XTR-9013409": ["r", "RHOJ GTPase cycle"], "R-GGA-9013148": ["r", "CDC42 GTPase cycle"], "R-GGA-9013423": ["r", "RAC3 GTPase cycle"], "R-SCE-9035034": ["r", "RHOF GTPase cycle"], "R-MMU-9027276": ["r", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "R-MMU-5654710": ["r", "PI-3K cascade:FGFR3"], "R-HSA-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-BTA-5654720": ["r", "PI-3K cascade:FGFR4"], "R-RNO-109704": ["r", "PI3K Cascade"], "R-CFA-9013149": ["r", "RAC1 GTPase cycle"], "R-MMU-9842663": ["r", "Signaling by LTK"], "R-MMU-198203": ["r", "PI3K/AKT activation"], "R-HSA-9673770": ["r", "Signaling by PDGFRA extracellular domain mutants"], "R-BTA-201556": ["r", "Signaling by ALK"], "R-BTA-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-SPO-9035034": ["r", "RHOF GTPase cycle"], "R-MMU-9927354": ["r", "Co-stimulation by ICOS"], "R-HSA-983189": ["r", "Kinesins"], "R-HSA-5654710": ["r", "PI-3K cascade:FGFR3"], "R-DDI-1169092": ["r", "Activation of RAS in B cells"], "R-GGA-9013026": ["r", "RHOB GTPase cycle"], "R-BTA-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-HSA-9603381": ["r", "Activated NTRK3 signals through PI3K"], "R-GGA-9013404": ["r", "RAC2 GTPase cycle"], "R-DRE-5663220": ["r", "RHO GTPases Activate Formins"], "R-CFA-9013406": ["r", "RHOQ GTPase cycle"], "R-CFA-8980692": ["r", "RHOA GTPase cycle"], "R-HSA-5654689": ["r", "PI-3K cascade:FGFR1"], "R-XTR-9013408": ["r", "RHOG GTPase cycle"], "R-SPO-9013148": ["r", "CDC42 GTPase cycle"], "R-MMU-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-BTA-2424491": ["r", "DAP12 signaling"], "R-MMU-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-RNO-9842663": ["r", "Signaling by LTK"], "R-MMU-430116": ["r", "GP1b-IX-V activation signalling"], "R-MMU-983189": ["r", "Kinesins"], "R-BTA-5654695": ["r", "PI-3K cascade:FGFR2"], "R-HSA-9028335": ["r", "Activated NTRK2 signals through PI3K"], "R-HSA-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-HSA-9027276": ["r", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "R-SCE-9013409": ["r", "RHOJ GTPase cycle"], "R-MMU-912631": ["r", "Regulation of signaling by CBL"], "R-BTA-9696270": ["r", "RND2 GTPase cycle"], "R-RNO-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-DDI-392517": ["r", "Rap1 signalling"], "R-BTA-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-BTA-109704": ["r", "PI3K Cascade"], "R-RNO-5654695": ["r", "PI-3K cascade:FGFR2"], "R-XTR-9013406": ["r", "RHOQ GTPase cycle"], "R-BTA-9607240": ["r", "FLT3 Signaling"], "R-MMU-5654689": ["r", "PI-3K cascade:FGFR1"], "R-BTA-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-XTR-9013106": ["r", "RHOC GTPase cycle"], "R-DDI-354192": ["r", "Integrin signaling"], "R-RNO-5654710": ["r", "PI-3K cascade:FGFR3"], "R-HSA-430116": ["r", "GP1b-IX-V activation signalling"], "R-GGA-9013106": ["r", "RHOC GTPase cycle"], "R-BTA-9035034": ["r", "RHOF GTPase cycle"], "R-RNO-112399": ["r", "IRS-mediated signalling"], "R-SCE-9013149": ["r", "RAC1 GTPase cycle"], "R-CFA-9013408": ["r", "RHOG GTPase cycle"], "R-GGA-9013409": ["r", "RHOJ GTPase cycle"], "R-RNO-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-DDI-193648": ["r", "NRAGE signals death through JNK"], "R-BTA-912631": ["r", "Regulation of signaling by CBL"], "R-SCE-9013148": ["r", "CDC42 GTPase cycle"], "R-HSA-9703648": ["r", "Signaling by FLT3 ITD and TKD mutants"], "R-CFA-9013106": ["r", "RHOC GTPase cycle"], "R-HSA-5654720": ["r", "PI-3K cascade:FGFR4"], "R-BTA-114604": ["r", "GPVI-mediated activation cascade"], "R-DME-140875": ["r", "Common Pathway of Fibrin Clot Formation"], "R-SSC-3000178": ["r", "ECM proteoglycans"], "R-DME-5694530": ["r", "Cargo concentration in the ER"], "R-MMU-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-GGA-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-BTA-194002": ["r", "Glucocorticoid biosynthesis"], "R-HSA-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-HSA-9948001": ["r", "CASP4 inflammasome assembly"], "R-DME-9948001": ["r", "CASP4 inflammasome assembly"], "R-BTA-5694530": ["r", "Cargo concentration in the ER"], "R-DME-9757110": ["r", "Prednisone ADME"], "R-MMU-9757110": ["r", "Prednisone ADME"], "R-DME-204005": ["r", "COPII-mediated vesicle transport"], "R-DME-194002": ["r", "Glucocorticoid biosynthesis"], "R-DME-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-DME-8957275": ["r", "Post-translational protein phosphorylation"], "R-HSA-9757110": ["r", "Prednisone ADME"], "R-SSC-114608": ["r", "Platelet degranulation"], "R-DME-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-RNO-9757110": ["r", "Prednisone ADME"], "R-HSA-5357905": ["r", "Regulation of TNFR1 signaling"], "R-DME-140837": ["r", "Intrinsic Pathway of Fibrin Clot Formation"], "R-MMU-194002": ["r", "Glucocorticoid biosynthesis"], "R-BTA-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-RNO-1650814": ["r", "Collagen biosynthesis and modifying enzymes"], "R-BTA-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-RNO-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-RNO-194002": ["r", "Glucocorticoid biosynthesis"], "R-MMU-9948001": ["r", "CASP4 inflammasome assembly"], "R-HSA-194002": ["r", "Glucocorticoid biosynthesis"], "R-RNO-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-HSA-9646399": ["r", "Aggrephagy"], "R-SSC-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-HSA-9833482": ["r", "PKR-mediated signaling"], "R-XTR-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-RNO-5610787": ["r", "Hedgehog 'off' state"], "R-MMU-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-SSC-5620924": ["r", "Intraflagellar transport"], "R-SSC-9833482": ["r", "PKR-mediated signaling"], "R-BTA-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-RNO-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-BTA-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-SSC-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-SSC-8854518": ["r", "AURKA Activation by TPX2"], "R-HSA-5620924": ["r", "Intraflagellar transport"], "R-MMU-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-HSA-437239": ["r", "Recycling pathway of L1"], "R-MMU-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-SSC-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-CEL-5620924": ["r", "Intraflagellar transport"], "R-XTR-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-MMU-9646399": ["r", "Aggrephagy"], "R-HSA-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-SSC-6807878": ["r", "COPI-mediated anterograde transport"], "R-HSA-389960": ["r", "Formation of tubulin folding intermediates by CCT/TriC"], "R-RNO-5620924": ["r", "Intraflagellar transport"], "R-HSA-389957": ["r", "Prefoldin mediated transfer of substrate to CCT/TriC"], "R-BTA-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-HSA-9609736": ["r", "Assembly and cell surface presentation of NMDA receptors"], "R-RNO-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-GGA-6807878": ["r", "COPI-mediated anterograde transport"], "R-GGA-9646399": ["r", "Aggrephagy"], "R-DDI-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-MMU-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-MMU-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-SSC-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-MMU-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-SSC-5610787": ["r", "Hedgehog 'off' state"], "R-RNO-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-MMU-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-BTA-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-XTR-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-SSC-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-SSC-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-MMU-437239": ["r", "Recycling pathway of L1"], "R-DDI-5610787": ["r", "Hedgehog 'off' state"], "R-DME-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-RNO-437239": ["r", "Recycling pathway of L1"], "R-RNO-68877": ["r", "Mitotic Prometaphase"], "R-XTR-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-RNO-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-HSA-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-XTR-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-RNO-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-XTR-9646399": ["r", "Aggrephagy"], "R-RNO-9646399": ["r", "Aggrephagy"], "R-RNO-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-XTR-8854518": ["r", "AURKA Activation by TPX2"], "R-RNO-9833482": ["r", "PKR-mediated signaling"], "R-XTR-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-SSC-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-SSC-5663220": ["r", "RHO GTPases Activate Formins"], "R-HSA-190861": ["r", "Gap junction assembly"], "R-RNO-983189": ["r", "Kinesins"], "R-DME-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-HSA-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-DDI-9646399": ["r", "Aggrephagy"], "R-SSC-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-HSA-8854518": ["r", "AURKA Activation by TPX2"], "R-DDI-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-MMU-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-RNO-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-BTA-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-HSA-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-MMU-9833482": ["r", "PKR-mediated signaling"], "R-SSC-9013407": ["r", "RHOH GTPase cycle"], "R-XTR-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-GGA-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-BTA-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-HSA-389977": ["r", "Post-chaperonin tubulin folding pathway"], "R-MMU-5620924": ["r", "Intraflagellar transport"], "R-SSC-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-PFA-9646399": ["r", "Aggrephagy"], "R-XTR-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-DDI-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-XTR-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-GGA-5620924": ["r", "Intraflagellar transport"], "R-SSC-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-HSA-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-MMU-8854518": ["r", "AURKA Activation by TPX2"], "R-BTA-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-RNO-2467813": ["r", "Separation of Sister Chromatids"], "R-BTA-9646399": ["r", "Aggrephagy"], "R-GGA-983189": ["r", "Kinesins"], "R-BTA-5620924": ["r", "Intraflagellar transport"], "R-XTR-114608": ["r", "Platelet degranulation"], "R-SSC-983189": ["r", "Kinesins"], "R-SSC-9646399": ["r", "Aggrephagy"], "R-SSC-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-SSC-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-HSA-9619483": ["r", "Activation of AMPK downstream of NMDARs"], "R-HSA-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-RNO-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-DDI-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-XTR-2467813": ["r", "Separation of Sister Chromatids"], "R-SSC-68877": ["r", "Mitotic Prometaphase"], "R-XTR-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-RNO-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-GGA-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-HSA-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-BTA-2467813": ["r", "Separation of Sister Chromatids"], "R-SSC-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-RNO-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-GGA-2467813": ["r", "Separation of Sister Chromatids"], "R-BTA-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-PFA-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-MMU-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-RNO-8854518": ["r", "AURKA Activation by TPX2"], "R-HSA-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-CEL-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-XTR-5663220": ["r", "RHO GTPases Activate Formins"], "R-RNO-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-XTR-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-XTR-68877": ["r", "Mitotic Prometaphase"], "R-SSC-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-SSC-2467813": ["r", "Separation of Sister Chromatids"], "R-XTR-983189": ["r", "Kinesins"], "R-BTA-8854518": ["r", "AURKA Activation by TPX2"], "R-BTA-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-XTR-5620924": ["r", "Intraflagellar transport"], "R-XTR-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-SSC-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-PFA-5620920": ["r", "Cargo trafficking to the periciliary membrane"], "R-RNO-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-SSC-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-HSA-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-XTR-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-PFA-8955332": ["r", "Carboxyterminal post-translational modifications of tubulin"], "R-GGA-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-DRE-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-DRE-5419276": ["r", "Mitochondrial translation termination"], "R-MMU-209952": ["r", "Peptide hormone biosynthesis"], "R-DDI-9754706": ["r", "Atorvastatin ADME"], "R-MMU-9953170": ["r", "GBP-mediated host defense"], "R-RNO-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "R-SPO-8964038": ["r", "LDL clearance"], "R-HSA-1181150": ["r", "Signaling by NODAL"], "R-DME-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-PFA-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-MMU-167060": ["r", "NGF processing"], "R-SCE-8964038": ["r", "LDL clearance"], "R-HSA-400511": ["r", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "R-HSA-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "R-RNO-9953170": ["r", "GBP-mediated host defense"], "R-HSA-9733458": ["r", "Induction of Cell-Cell Fusion"], "R-MMU-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-RNO-209952": ["r", "Peptide hormone biosynthesis"], "R-DDI-159418": ["r", "Recycling of bile acids and salts"], "R-MMU-8874177": ["r", "ATF6B (ATF6-beta) activates chaperones"], "R-HSA-8874177": ["r", "ATF6B (ATF6-beta) activates chaperones"], "R-RNO-167060": ["r", "NGF processing"], "R-DME-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-CEL-186797": ["r", "Signaling by PDGF"], "R-HSA-9953170": ["r", "GBP-mediated host defense"], "R-DME-186797": ["r", "Signaling by PDGF"], "R-DRE-4641258": ["r", "Degradation of DVL"], "R-HSA-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-HSA-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-RNO-5576894": ["r", "Phase 1 - inactivation of fast Na+ channels"], "R-CEL-5632684": ["r", "Hedgehog 'on' state"], "R-DRE-5632684": ["r", "Hedgehog 'on' state"], "R-DRE-8951664": ["r", "Neddylation"], "R-HSA-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-MMU-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-MMU-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-BTA-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-MMU-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-RNO-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-MMU-3232118": ["r", "SUMOylation of transcription factors"], "R-MMU-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-MMU-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-DRE-9696270": ["r", "RND2 GTPase cycle"], "R-HSA-9708530": ["r", "Regulation of BACH1 activity"], "R-GGA-9696264": ["r", "RND3 GTPase cycle"], "R-RNO-4641258": ["r", "Degradation of DVL"], "R-HSA-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-BTA-5576894": ["r", "Phase 1 - inactivation of fast Na+ channels"], "R-XTR-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-DME-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-CEL-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-HSA-6783310": ["r", "Fanconi Anemia Pathway"], "R-MMU-9708530": ["r", "Regulation of BACH1 activity"], "R-DRE-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-GGA-1296072": ["r", "Voltage gated Potassium channels"], "R-HSA-3232118": ["r", "SUMOylation of transcription factors"], "R-GGA-3232118": ["r", "SUMOylation of transcription factors"], "R-MMU-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-BTA-8951664": ["r", "Neddylation"], "R-DME-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-XTR-5632684": ["r", "Hedgehog 'on' state"], "R-SSC-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-DME-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-GGA-8951664": ["r", "Neddylation"], "R-DME-5576894": ["r", "Phase 1 - inactivation of fast Na+ channels"], "R-HSA-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-SSC-8951664": ["r", "Neddylation"], "R-DME-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-MMU-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-DRE-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-DRE-9696264": ["r", "RND3 GTPase cycle"], "R-SSC-5689880": ["r", "Ub-specific processing proteases"], "R-DME-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-GGA-9696270": ["r", "RND2 GTPase cycle"], "R-DME-216167": ["r", "Nuclear CI is degraded"], "R-DME-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-DME-210671": ["r", "Transcriptional repression by nuclear factors"], "R-HSA-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-MMU-5576894": ["r", "Phase 1 - inactivation of fast Na+ channels"], "R-BTA-5632684": ["r", "Hedgehog 'on' state"], "R-HSA-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-RNO-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-RNO-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-GGA-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-CEL-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-MMU-6783310": ["r", "Fanconi Anemia Pathway"], "R-HSA-9707587": ["r", "Regulation of HMOX1 expression and activity"], "R-MMU-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-HSA-5576894": ["r", "Phase 1 - inactivation of fast Na+ channels"], "R-MMU-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-BTA-5649702": ["r", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "R-HSA-9629232": ["r", "Defective Base Excision Repair Associated with NEIL3"], "R-MMU-5649702": ["r", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "R-MMU-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-MMU-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-HSA-9636003": ["r", "NEIL3-mediated resolution of ICLs"], "R-HSA-5649702": ["r", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "R-BTA-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-GGA-8939242": ["r", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "R-BTA-9757110": ["r", "Prednisone ADME"], "R-HSA-9686347": ["r", "Microbial modulation of RIPK1-mediated regulated necrosis"], "R-BTA-9948001": ["r", "CASP4 inflammasome assembly"], "R-HSA-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-SSC-9762292": ["r", "Regulation of CDH11 function"], "R-BTA-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-RNO-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-HSA-9861718": ["r", "Regulation of pyruvate metabolism"], "R-SSC-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-BTA-437239": ["r", "Recycling pathway of L1"], "R-HSA-111932": ["r", "CaMK IV-mediated phosphorylation of CREB"], "R-MMU-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-DRE-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-DRE-9861718": ["r", "Regulation of pyruvate metabolism"], "R-DRE-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-HSA-442729": ["r", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "R-HSA-9754189": ["r", "Germ layer formation at gastrulation"], "R-RNO-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-MMU-525793": ["r", "Myogenesis"], "R-BTA-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-RNO-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-MMU-6805567": ["r", "Keratinization"], "R-HSA-182218": ["r", "Nef Mediated CD8 Down-regulation"], "R-BTA-9762292": ["r", "Regulation of CDH11 function"], "R-DRE-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-BTA-8951430": ["r", "RUNX3 regulates WNT signaling"], "R-SSC-9013026": ["r", "RHOB GTPase cycle"], "R-HSA-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-HSA-9823730": ["r", "Formation of definitive endoderm"], "R-HSA-9796292": ["r", "Formation of axial mesoderm"], "R-HSA-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-DRE-8853884": ["r", "Transcriptional Regulation by VENTX"], "R-HSA-5358749": ["r", "CTNNB1 S37 mutants aren't phosphorylated"], "R-BTA-418990": ["r", "Adherens junctions interactions"], "R-SSC-418990": ["r", "Adherens junctions interactions"], "R-CEL-9764561": ["r", "Regulation of CDH1 Function"], "R-DRE-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-HSA-5467340": ["r", "AXIN missense mutants destabilize the destruction complex"], "R-DME-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-DME-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-RNO-8951430": ["r", "RUNX3 regulates WNT signaling"], "R-MMU-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-CEL-6809371": ["r", "Formation of the cornified envelope"], "R-HSA-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-RNO-5689896": ["r", "Ovarian tumor domain proteases"], "R-HSA-5467333": ["r", "APC truncation mutants are not K63 polyubiquitinated"], "R-MMU-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-BTA-9766229": ["r", "Degradation of CDH1"], "R-CEL-201681": ["r", "TCF dependent signaling in response to WNT"], "R-HSA-8853884": ["r", "Transcriptional Regulation by VENTX"], "R-HSA-5358751": ["r", "CTNNB1 S45 mutants aren't phosphorylated"], "R-SPO-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-DME-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-BTA-6805567": ["r", "Keratinization"], "R-HSA-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-DME-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-BTA-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-HSA-5339716": ["r", "Signaling by GSK3beta mutants"], "R-DDI-2871796": ["r", "FCERI mediated MAPK activation"], "R-MMU-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-SSC-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-MMU-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-RNO-6809371": ["r", "Formation of the cornified envelope"], "R-RNO-9764561": ["r", "Regulation of CDH1 Function"], "R-BTA-9764561": ["r", "Regulation of CDH1 Function"], "R-BTA-909733": ["r", "Interferon alpha/beta signaling"], "R-RNO-909733": ["r", "Interferon alpha/beta signaling"], "R-MMU-177504": ["r", "Retrograde neurotrophin signalling"], "R-DME-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-DRE-525793": ["r", "Myogenesis"], "R-SCE-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-DDI-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-DME-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-CEL-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-SPO-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-DRE-5389840": ["r", "Mitochondrial translation elongation"], "R-SPO-416482": ["r", "G alpha (12/13) signalling events"], "R-GGA-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-MMU-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-RNO-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-HSA-9027284": ["r", "Erythropoietin activates RAS"], "R-GGA-416482": ["r", "G alpha (12/13) signalling events"], "R-CEL-9607240": ["r", "FLT3 Signaling"], "R-DME-9607240": ["r", "FLT3 Signaling"], "R-MMU-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-CEL-74751": ["r", "Insulin receptor signalling cascade"], "R-SCE-193648": ["r", "NRAGE signals death through JNK"], "R-HSA-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-CEL-1433557": ["r", "Signaling by SCF-KIT"], "R-CEL-8851805": ["r", "MET activates RAS signaling"], "R-DME-193648": ["r", "NRAGE signals death through JNK"], "R-MMU-977443": ["r", "GABA receptor activation"], "R-MMU-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-CEL-9748787": ["r", "Azathioprine ADME"], "R-CEL-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-MMU-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-DME-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-HSA-9034864": ["r", "Activated NTRK3 signals through RAS"], "R-DME-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-DME-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-DME-74749": ["r", "Signal attenuation"], "R-HSA-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-DME-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-CEL-179812": ["r", "GRB2 events in EGFR signaling"], "R-HSA-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-DME-186763": ["r", "Downstream signal transduction"], "R-DRE-193648": ["r", "NRAGE signals death through JNK"], "R-MMU-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-CEL-210993": ["r", "Tie2 Signaling"], "R-SCE-416482": ["r", "G alpha (12/13) signalling events"], "R-RNO-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-DME-912631": ["r", "Regulation of signaling by CBL"], "R-HSA-9026519": ["r", "Activated NTRK2 signals through RAS"], "R-HSA-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-MMU-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-DME-210993": ["r", "Tie2 Signaling"], "R-CEL-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-HSA-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-DME-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-RNO-9748787": ["r", "Azathioprine ADME"], "R-MMU-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-DME-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-RNO-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-DME-8853659": ["r", "RET signaling"], "R-CEL-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-HSA-167044": ["r", "Signalling to RAS"], "R-DME-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-DME-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-HSA-375165": ["r", "NCAM signaling for neurite out-growth"], "R-HSA-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-DME-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-CEL-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-CEL-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-DME-9748787": ["r", "Azathioprine ADME"], "R-DME-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-HSA-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-DME-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-HSA-112412": ["r", "SOS-mediated signalling"], "R-CFA-416482": ["r", "G alpha (12/13) signalling events"], "R-MMU-418885": ["r", "DCC mediated attractive signaling"], "R-HSA-442982": ["r", "Ras activation upon Ca2+ influx through NMDA receptor"], "R-MMU-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-DME-74751": ["r", "Insulin receptor signalling cascade"], "R-GGA-9013420": ["r", "RHOU GTPase cycle"], "R-MMU-167044": ["r", "Signalling to RAS"], "R-HSA-8983432": ["r", "Interleukin-15 signaling"], "R-HSA-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-DME-416482": ["r", "G alpha (12/13) signalling events"], "R-CEL-8849932": ["r", "Synaptic adhesion-like molecules"], "R-MMU-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-HSA-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-RNO-9027284": ["r", "Erythropoietin activates RAS"], "R-DME-1433557": ["r", "Signaling by SCF-KIT"], "R-MMU-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-CFA-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-GGA-193648": ["r", "NRAGE signals death through JNK"], "R-HSA-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-MMU-112412": ["r", "SOS-mediated signalling"], "R-HSA-9032845": ["r", "Activated NTRK2 signals through CDK5"], "R-DME-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-MMU-9027284": ["r", "Erythropoietin activates RAS"], "R-CEL-193648": ["r", "NRAGE signals death through JNK"], "R-DRE-9013409": ["r", "RHOJ GTPase cycle"], "R-HSA-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-MMU-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-DME-112412": ["r", "SOS-mediated signalling"], "R-DME-167044": ["r", "Signalling to RAS"], "R-MMU-8983432": ["r", "Interleukin-15 signaling"], "R-CEL-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-HSA-9634285": ["r", "Constitutive Signaling by Overexpressed ERBB2"], "R-MMU-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-HSA-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-BTA-9027284": ["r", "Erythropoietin activates RAS"], "R-DME-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-HSA-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-DME-375165": ["r", "NCAM signaling for neurite out-growth"], "R-DME-114604": ["r", "GPVI-mediated activation cascade"], "R-CEL-912631": ["r", "Regulation of signaling by CBL"], "R-CEL-416482": ["r", "G alpha (12/13) signalling events"], "R-MMU-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-DME-2424491": ["r", "DAP12 signaling"], "R-BTA-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-CEL-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-DME-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-MMU-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-RNO-418885": ["r", "DCC mediated attractive signaling"], "R-DME-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-MMU-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-DRE-416482": ["r", "G alpha (12/13) signalling events"], "R-HSA-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-MMU-375165": ["r", "NCAM signaling for neurite out-growth"], "R-RNO-977443": ["r", "GABA receptor activation"], "R-CEL-375165": ["r", "NCAM signaling for neurite out-growth"], "R-HSA-977443": ["r", "GABA receptor activation"], "R-DME-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-HSA-9619229": ["r", "Activation of RAC1 downstream of NMDARs"], "R-MMU-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-HSA-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-DRE-9013408": ["r", "RHOG GTPase cycle"], "R-MMU-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-CEL-180336": ["r", "SHC1 events in EGFR signaling"], "R-GGA-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-DME-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-CFA-193648": ["r", "NRAGE signals death through JNK"], "R-CEL-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-CEL-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-MMU-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-CEL-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-HSA-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-BTA-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-RNO-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-RNO-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-BTA-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-BTA-1169408": ["r", "ISG15 antiviral mechanism"], "R-HSA-9617324": ["r", "Negative regulation of NMDA receptor-mediated neuronal transmission"], "R-HSA-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-RNO-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-SSC-9766229": ["r", "Degradation of CDH1"], "R-DRE-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-SPO-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-BTA-201681": ["r", "TCF dependent signaling in response to WNT"], "R-HSA-5467337": ["r", "APC truncation mutants have impaired AXIN binding"], "R-RNO-177504": ["r", "Retrograde neurotrophin signalling"], "R-RNO-6805567": ["r", "Keratinization"], "R-CEL-4086398": ["r", "Ca2+ pathway"], "R-MMU-909733": ["r", "Interferon alpha/beta signaling"], "R-HSA-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-BTA-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-DRE-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-HSA-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-BTA-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-MMU-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-MMU-201681": ["r", "TCF dependent signaling in response to WNT"], "R-SPO-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-DRE-201681": ["r", "TCF dependent signaling in response to WNT"], "R-DRE-9766229": ["r", "Degradation of CDH1"], "R-HSA-909733": ["r", "Interferon alpha/beta signaling"], "R-BTA-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-BTA-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-HSA-9762292": ["r", "Regulation of CDH11 function"], "R-DRE-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-RNO-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-SSC-8980692": ["r", "RHOA GTPase cycle"], "R-HSA-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-RNO-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-BTA-8866427": ["r", "VLDLR internalisation and degradation"], "R-HSA-6805567": ["r", "Keratinization"], "R-HSA-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-DRE-6809371": ["r", "Formation of the cornified envelope"], "R-HSA-167590": ["r", "Nef Mediated CD4 Down-regulation"], "R-DME-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-DME-209407": ["r", "Transport of ARM to the nucleus"], "R-CEL-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-SSC-6805567": ["r", "Keratinization"], "R-HSA-9833576": ["r", "CDH11 homotypic and heterotypic interactions"], "R-SSC-9013106": ["r", "RHOC GTPase cycle"], "R-RNO-201681": ["r", "TCF dependent signaling in response to WNT"], "R-HSA-5689896": ["r", "Ovarian tumor domain proteases"], "R-CEL-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-HSA-9013425": ["r", "RHOT1 GTPase cycle"], "R-DRE-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-HSA-9764561": ["r", "Regulation of CDH1 Function"], "R-HSA-5358747": ["r", "CTNNB1 S33 mutants aren't phosphorylated"], "R-RNO-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-DRE-9013407": ["r", "RHOH GTPase cycle"], "R-DME-201681": ["r", "TCF dependent signaling in response to WNT"], "R-DME-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-DME-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-CEL-525793": ["r", "Myogenesis"], "R-DRE-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-DRE-6805567": ["r", "Keratinization"], "R-SSC-9013406": ["r", "RHOQ GTPase cycle"], "R-BTA-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-DRE-4086398": ["r", "Ca2+ pathway"], "R-MMU-9762292": ["r", "Regulation of CDH11 function"], "R-HSA-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-DRE-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-DME-9764561": ["r", "Regulation of CDH1 Function"], "R-DME-209421": ["r", "Transcription activation by ARM"], "R-SSC-9013148": ["r", "CDC42 GTPase cycle"], "R-CEL-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-BTA-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-DDI-909733": ["r", "Interferon alpha/beta signaling"], "R-HSA-5467348": ["r", "Truncations of AMER1 destabilize the destruction complex"], "R-RNO-9762292": ["r", "Regulation of CDH11 function"], "R-DME-525793": ["r", "Myogenesis"], "R-CEL-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-MMU-9764561": ["r", "Regulation of CDH1 Function"], "R-HSA-525793": ["r", "Myogenesis"], "R-DME-4086398": ["r", "Ca2+ pathway"], "R-BTA-6809371": ["r", "Formation of the cornified envelope"], "R-BTA-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-MMU-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-BTA-9861718": ["r", "Regulation of pyruvate metabolism"], "R-DME-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-HSA-9764302": ["r", "Regulation of CDH19 Expression and Function"], "R-DME-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-HSA-8876493": ["r", "InlA-mediated entry of Listeria monocytogenes into host cells"], "R-HSA-177504": ["r", "Retrograde neurotrophin signalling"], "R-MMU-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-RNO-4086398": ["r", "Ca2+ pathway"], "R-HSA-9013419": ["r", "RHOT2 GTPase cycle"], "R-MMU-9861718": ["r", "Regulation of pyruvate metabolism"], "R-CEL-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-MMU-5689896": ["r", "Ovarian tumor domain proteases"], "R-SCE-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-RNO-525793": ["r", "Myogenesis"], "R-BTA-525793": ["r", "Myogenesis"], "R-SSC-9764561": ["r", "Regulation of CDH1 Function"], "R-RNO-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-BTA-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-HSA-5358752": ["r", "CTNNB1 T41 mutants aren't phosphorylated"], "R-MMU-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-DRE-9764561": ["r", "Regulation of CDH1 Function"], "R-DME-6809371": ["r", "Formation of the cornified envelope"], "R-BTA-177504": ["r", "Retrograde neurotrophin signalling"], "R-HSA-164940": ["r", "Nef mediated downregulation of MHC class I complex cell surface expression"], "R-HSA-9851151": ["r", "MDK and PTN in ALK signaling"], "R-DME-8849932": ["r", "Synaptic adhesion-like molecules"], "R-GGA-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-MMU-1059683": ["r", "Interleukin-6 signaling"], "R-RNO-8873719": ["r", "RAB geranylgeranylation"], "R-MMU-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-MMU-8849472": ["r", "PTK6 Down-Regulation"], "R-RNO-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-GGA-512988": ["r", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "R-HSA-389948": ["r", "Co-inhibition by PD-1"], "R-MMU-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-HSA-5675221": ["r", "Negative regulation of MAPK pathway"], "R-HSA-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-SSC-5689603": ["r", "UCH proteinases"], "R-RNO-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-BTA-5689880": ["r", "Ub-specific processing proteases"], "R-SSC-8948751": ["r", "Regulation of PTEN stability and activity"], "R-BTA-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-HSA-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-SSC-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-SPO-5689880": ["r", "Ub-specific processing proteases"], "R-CFA-9907900": ["r", "Proteasome assembly"], "R-DDI-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-BTA-69481": ["r", "G2/M Checkpoints"], "R-RNO-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-HSA-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-SCE-5689880": ["r", "Ub-specific processing proteases"], "R-RNO-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-SSC-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-HSA-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-DDI-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-SPO-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-DDI-4641258": ["r", "Degradation of DVL"], "R-BTA-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-HSA-180534": ["r", "Vpu mediated degradation of CD4"], "R-SSC-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-BTA-4641257": ["r", "Degradation of AXIN"], "R-SSC-9932298": ["r", "Degradation of CRY and PER proteins"], "R-RNO-69481": ["r", "G2/M Checkpoints"], "R-HSA-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-BTA-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-DDI-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-RNO-5632684": ["r", "Hedgehog 'on' state"], "R-MMU-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-BTA-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-SSC-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-RNO-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-MMU-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-BTA-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-BTA-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-MMU-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-BTA-2871837": ["r", "FCERI mediated NF-kB activation"], "R-HSA-9907900": ["r", "Proteasome assembly"], "R-CEL-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-BTA-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-SCE-1236974": ["r", "ER-Phagosome pathway"], "R-HSA-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-SSC-5358346": ["r", "Hedgehog ligand biogenesis"], "R-DDI-5689880": ["r", "Ub-specific processing proteases"], "R-SSC-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-BTA-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-CEL-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-SSC-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-RNO-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-SSC-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-BTA-9929356": ["r", "GSK3B-mediated proteasomal degradation of PD-L1(CD274)"], "R-MMU-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-MMU-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-RNO-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-RNO-68867": ["r", "Assembly of the pre-replicative complex"], "R-RNO-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-RNO-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-CEL-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-HSA-5358346": ["r", "Hedgehog ligand biogenesis"], "R-SPO-9907900": ["r", "Proteasome assembly"], "R-BTA-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-RNO-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-DDI-1236974": ["r", "ER-Phagosome pathway"], "R-DDI-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-SSC-4641257": ["r", "Degradation of AXIN"], "R-SSC-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-DDI-8951664": ["r", "Neddylation"], "R-RNO-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-CEL-5689603": ["r", "UCH proteinases"], "R-CEL-382556": ["r", "ABC-family proteins mediated transport"], "R-MMU-9929356": ["r", "GSK3B-mediated proteasomal degradation of PD-L1(CD274)"], "R-HSA-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-SCE-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-RNO-9929356": ["r", "GSK3B-mediated proteasomal degradation of PD-L1(CD274)"], "R-BTA-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-HSA-69481": ["r", "G2/M Checkpoints"], "R-BTA-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-SSC-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-HSA-5678895": ["r", "Defective CFTR causes cystic fibrosis"], "R-BTA-5358346": ["r", "Hedgehog ligand biogenesis"], "R-SSC-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-SPO-5689603": ["r", "UCH proteinases"], "R-SSC-68949": ["r", "Orc1 removal from chromatin"], "R-HSA-180585": ["r", "Vif-mediated degradation of APOBEC3G"], "R-SPO-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-RNO-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-BTA-4641258": ["r", "Degradation of DVL"], "R-CEL-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-SSC-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-BTA-1236974": ["r", "ER-Phagosome pathway"], "R-BTA-382556": ["r", "ABC-family proteins mediated transport"], "R-SCE-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-RNO-1236974": ["r", "ER-Phagosome pathway"], "R-DDI-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-RNO-5689603": ["r", "UCH proteinases"], "R-RNO-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-HSA-5362768": ["r", "Hh mutants are degraded by ERAD"], "R-SSC-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-SSC-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-HSA-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-BTA-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-BTA-9907900": ["r", "Proteasome assembly"], "R-DDI-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-BTA-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-RNO-9907900": ["r", "Proteasome assembly"], "R-BTA-8948751": ["r", "Regulation of PTEN stability and activity"], "R-RNO-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-SSC-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-HSA-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-SSC-4641258": ["r", "Degradation of DVL"], "R-HSA-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-BTA-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-SSC-2871837": ["r", "FCERI mediated NF-kB activation"], "R-BTA-5689603": ["r", "UCH proteinases"], "R-DDI-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-RNO-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-HSA-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-SSC-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-BTA-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-DDI-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-SSC-5632684": ["r", "Hedgehog 'on' state"], "R-MMU-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-SCE-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-HSA-3371511": ["r", "HSF1 activation"], "R-SPO-3371568": ["r", "Attenuation phase"], "R-BTA-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-BTA-3371568": ["r", "Attenuation phase"], "R-CEL-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-SPO-3371571": ["r", "HSF1-dependent transactivation"], "R-BTA-3371511": ["r", "HSF1 activation"], "R-HSA-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-CEL-3371571": ["r", "HSF1-dependent transactivation"], "R-CEL-3371511": ["r", "HSF1 activation"], "R-MMU-3371571": ["r", "HSF1-dependent transactivation"], "R-BTA-3371571": ["r", "HSF1-dependent transactivation"], "R-SCE-3371568": ["r", "Attenuation phase"], "R-DME-3371511": ["r", "HSF1 activation"], "R-CEL-3371568": ["r", "Attenuation phase"], "R-SPO-3371511": ["r", "HSF1 activation"], "R-DME-3371568": ["r", "Attenuation phase"], "R-DME-3371571": ["r", "HSF1-dependent transactivation"], "R-MMU-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-DME-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-MMU-3371511": ["r", "HSF1 activation"], "R-HSA-3371571": ["r", "HSF1-dependent transactivation"], "R-BTA-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-SCE-3371511": ["r", "HSF1 activation"], "R-SCE-3371571": ["r", "HSF1-dependent transactivation"], "R-CEL-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-HSA-9764562": ["r", "Regulation of CDH1 mRNA translation by microRNAs"], "R-CFA-418990": ["r", "Adherens junctions interactions"], "R-HSA-9759811": ["r", "Regulation of CDH11 mRNA translation by microRNAs"], "R-DRE-418990": ["r", "Adherens junctions interactions"], "R-CFA-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-SSC-351906": ["r", "Apoptotic cleavage of cell adhesion proteins"], "R-CFA-6805567": ["r", "Keratinization"], "R-GGA-525793": ["r", "Myogenesis"], "R-SSC-9696270": ["r", "RND2 GTPase cycle"], "R-SSC-9696264": ["r", "RND3 GTPase cycle"], "R-DRE-1474228": ["r", "Degradation of the extracellular matrix"], "R-CFA-216083": ["r", "Integrin cell surface interactions"], "R-CFA-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-CFA-6809371": ["r", "Formation of the cornified envelope"], "R-CFA-9766229": ["r", "Degradation of CDH1"], "R-GGA-418990": ["r", "Adherens junctions interactions"], "R-CFA-9764561": ["r", "Regulation of CDH1 Function"], "R-GGA-5389840": ["r", "Mitochondrial translation elongation"], "R-DME-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-RNO-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-HSA-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-BTA-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-SCE-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-DDI-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-BTA-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-HSA-9735869": ["r", "SARS-CoV-1 modulates host translation machinery"], "R-HSA-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-RNO-72649": ["r", "Translation initiation complex formation"], "R-CEL-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-CEL-72649": ["r", "Translation initiation complex formation"], "R-DME-5389840": ["r", "Mitochondrial translation elongation"], "R-DME-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-BTA-72649": ["r", "Translation initiation complex formation"], "R-DDI-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-SPO-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-CEL-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-DME-72649": ["r", "Translation initiation complex formation"], "R-CEL-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-MMU-72649": ["r", "Translation initiation complex formation"], "R-GGA-5419276": ["r", "Mitochondrial translation termination"], "R-SCE-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-MMU-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-GGA-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-MMU-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-DME-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-SPO-72649": ["r", "Translation initiation complex formation"], "R-CEL-5389840": ["r", "Mitochondrial translation elongation"], "R-SPO-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-RNO-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-HSA-9754678": ["r", "SARS-CoV-2 modulates host translation machinery"], "R-HSA-72649": ["r", "Translation initiation complex formation"], "R-SCE-72649": ["r", "Translation initiation complex formation"], "R-DME-5419276": ["r", "Mitochondrial translation termination"], "R-CEL-5419276": ["r", "Mitochondrial translation termination"], "R-RNO-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-SPO-6811438": ["r", "Intra-Golgi traffic"], "R-HSA-6811438": ["r", "Intra-Golgi traffic"], "R-SCE-6811438": ["r", "Intra-Golgi traffic"], "R-HSA-9673768": ["r", "Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"], "R-RNO-418555": ["r", "G alpha (s) signalling events"], "R-BTA-5635838": ["r", "Activation of SMO"], "R-MMU-5635838": ["r", "Activation of SMO"], "R-RNO-5635838": ["r", "Activation of SMO"], "R-RNO-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-BTA-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-BTA-111933": ["r", "Calmodulin induced events"], "R-DME-5635838": ["r", "Activation of SMO"], "R-SSC-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-DRE-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-HSA-6782315": ["r", "tRNA modification in the nucleus and cytosol"], "R-MMU-9674555": ["r", "Signaling by CSF3 (G-CSF)"], "R-GGA-8865999": ["r", "MET activates PTPN11"], "R-GGA-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-RNO-8854691": ["r", "Interleukin-20 family signaling"], "R-GGA-5654695": ["r", "PI-3K cascade:FGFR2"], "R-DRE-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-RNO-877312": ["r", "Regulation of IFNG signaling"], "R-MMU-202430": ["r", "Translocation of ZAP-70 to Immunological synapse"], "R-GGA-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-HSA-202427": ["r", "Phosphorylation of CD3 and TCR zeta chains"], "R-CEL-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-DME-210693": ["r", "STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol"], "R-RNO-375165": ["r", "NCAM signaling for neurite out-growth"], "R-CEL-182971": ["r", "EGFR downregulation"], "R-MMU-449836": ["r", "Other interleukin signaling"], "R-GGA-5654689": ["r", "PI-3K cascade:FGFR1"], "R-RNO-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-HSA-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-HSA-1170546": ["r", "Prolactin receptor signaling"], "R-GGA-1059683": ["r", "Interleukin-6 signaling"], "R-GGA-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-HSA-9927353": ["r", "Co-inhibition by BTLA"], "R-RNO-5675221": ["r", "Negative regulation of MAPK pathway"], "R-MMU-5690714": ["r", "CD22 mediated BCR regulation"], "R-DRE-8849932": ["r", "Synaptic adhesion-like molecules"], "R-HSA-1295596": ["r", "Spry regulation of FGF signaling"], "R-GGA-389948": ["r", "Co-inhibition by PD-1"], "R-GGA-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-DME-416700": ["r", "Other semaphorin interactions"], "R-MMU-9851151": ["r", "MDK and PTN in ALK signaling"], "R-RNO-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-MMU-5675221": ["r", "Negative regulation of MAPK pathway"], "R-HSA-1059683": ["r", "Interleukin-6 signaling"], "R-RNO-9851151": ["r", "MDK and PTN in ALK signaling"], "R-HSA-8849932": ["r", "Synaptic adhesion-like molecules"], "R-RNO-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-RNO-5690714": ["r", "CD22 mediated BCR regulation"], "R-RNO-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-HSA-877312": ["r", "Regulation of IFNG signaling"], "R-GGA-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-GGA-1433557": ["r", "Signaling by SCF-KIT"], "R-MMU-877312": ["r", "Regulation of IFNG signaling"], "R-HSA-389513": ["r", "Co-inhibition by CTLA4"], "R-HSA-9706369": ["r", "Negative regulation of FLT3"], "R-GGA-210993": ["r", "Tie2 Signaling"], "R-RNO-416700": ["r", "Other semaphorin interactions"], "R-BTA-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-HSA-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-MMU-9927353": ["r", "Co-inhibition by BTLA"], "R-MMU-9706369": ["r", "Negative regulation of FLT3"], "R-GGA-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-HSA-5690714": ["r", "CD22 mediated BCR regulation"], "R-BTA-8849932": ["r", "Synaptic adhesion-like molecules"], "R-HSA-110056": ["r", "MAPK3 (ERK1) activation"], "R-MMU-8873719": ["r", "RAB geranylgeranylation"], "R-MMU-389513": ["r", "Co-inhibition by CTLA4"], "R-MMU-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-GGA-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-DME-9833482": ["r", "PKR-mediated signaling"], "R-MMU-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-RNO-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-RNO-389948": ["r", "Co-inhibition by PD-1"], "R-HSA-9702518": ["r", "STAT5 activation downstream of FLT3 ITD mutants"], "R-DME-210688": ["r", "Dephosphorylation by PTP61F phosphatases"], "R-DRE-1433557": ["r", "Signaling by SCF-KIT"], "R-HSA-391160": ["r", "Signal regulatory protein family interactions"], "R-RNO-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-HSA-112411": ["r", "MAPK1 (ERK2) activation"], "R-GGA-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-RNO-9927353": ["r", "Co-inhibition by BTLA"], "R-MMU-1295596": ["r", "Spry regulation of FGF signaling"], "R-RNO-8849472": ["r", "PTK6 Down-Regulation"], "R-RNO-202427": ["r", "Phosphorylation of CD3 and TCR zeta chains"], "R-GGA-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-MMU-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-HSA-202430": ["r", "Translocation of ZAP-70 to Immunological synapse"], "R-GGA-109704": ["r", "PI3K Cascade"], "R-GGA-8854691": ["r", "Interleukin-20 family signaling"], "R-GGA-5654720": ["r", "PI-3K cascade:FGFR4"], "R-GGA-180292": ["r", "GAB1 signalosome"], "R-RNO-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-HSA-8849472": ["r", "PTK6 Down-Regulation"], "R-MMU-8849932": ["r", "Synaptic adhesion-like molecules"], "R-GGA-8853659": ["r", "RET signaling"], "R-MMU-982772": ["r", "Growth hormone receptor signaling"], "R-HSA-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-HSA-8854691": ["r", "Interleukin-20 family signaling"], "R-GGA-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-HSA-982772": ["r", "Growth hormone receptor signaling"], "R-RNO-389513": ["r", "Co-inhibition by CTLA4"], "R-MMU-202427": ["r", "Phosphorylation of CD3 and TCR zeta chains"], "R-HSA-9674555": ["r", "Signaling by CSF3 (G-CSF)"], "R-HSA-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-RNO-8849932": ["r", "Synaptic adhesion-like molecules"], "R-MMU-416700": ["r", "Other semaphorin interactions"], "R-GGA-5654710": ["r", "PI-3K cascade:FGFR3"], "R-HSA-449836": ["r", "Other interleukin signaling"], "R-RNO-9674555": ["r", "Signaling by CSF3 (G-CSF)"], "R-HSA-8873719": ["r", "RAB geranylgeranylation"], "R-HSA-9034015": ["r", "Signaling by NTRK3 (TRKC)"], "R-MMU-112411": ["r", "MAPK1 (ERK2) activation"], "R-RNO-1295596": ["r", "Spry regulation of FGF signaling"], "R-HSA-418886": ["r", "Netrin mediated repulsion signals"], "R-RNO-1059683": ["r", "Interleukin-6 signaling"], "R-RNO-449836": ["r", "Other interleukin signaling"], "R-CEL-416700": ["r", "Other semaphorin interactions"], "R-GGA-186763": ["r", "Downstream signal transduction"], "R-HSA-416700": ["r", "Other semaphorin interactions"], "R-RNO-110056": ["r", "MAPK3 (ERK1) activation"], "R-HSA-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-GGA-389513": ["r", "Co-inhibition by CTLA4"], "R-MMU-110056": ["r", "MAPK3 (ERK1) activation"], "R-RNO-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-MMU-389948": ["r", "Co-inhibition by PD-1"], "R-MMU-8854691": ["r", "Interleukin-20 family signaling"], "R-RNO-112411": ["r", "MAPK1 (ERK2) activation"], "R-HSA-9645135": ["r", "STAT5 Activation"], "R-CEL-5675221": ["r", "Negative regulation of MAPK pathway"], "R-GGA-210990": ["r", "PECAM1 interactions"], "R-RNO-982772": ["r", "Growth hormone receptor signaling"], "R-DME-877312": ["r", "Regulation of IFNG signaling"], "R-CEL-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-SPO-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-HSA-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-MMU-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-CEL-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-DME-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-HSA-73980": ["r", "RNA Polymerase III Transcription Termination"], "R-CEL-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-DDI-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-DME-72163": ["r", "mRNA Splicing - Major Pathway"], "R-BTA-76071": ["r", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "R-SPO-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DDI-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-DDI-72163": ["r", "mRNA Splicing - Major Pathway"], "R-DME-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-HSA-167158": ["r", "Formation of the HIV-1 Early Elongation Complex"], "R-MMU-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-MMU-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-BTA-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-SCE-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-SPO-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-HSA-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-BTA-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-DME-72086": ["r", "mRNA Capping"], "R-DDI-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-DME-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-CEL-9770562": ["r", "mRNA Polyadenylation"], "R-HSA-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-MMU-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-CEL-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-SPO-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-HSA-749476": ["r", "RNA Polymerase III Abortive And Retractive Initiation"], "R-DME-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-CEL-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-DME-6782135": ["r", "Dual incision in TC-NER"], "R-BTA-73863": ["r", "RNA Polymerase I Transcription Termination"], "R-SCE-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-BTA-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-DME-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-BTA-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-SPO-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-BTA-6782135": ["r", "Dual incision in TC-NER"], "R-HSA-6803529": ["r", "FGFR2 alternative splicing"], "R-HSA-167242": ["r", "Abortive elongation of HIV-1 transcript in the absence of Tat"], "R-CEL-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-HSA-8851708": ["r", "Signaling by FGFR2 IIIa TM"], "R-HSA-167161": ["r", "HIV Transcription Initiation"], "R-CEL-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-DME-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-CEL-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-HSA-167160": ["r", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"], "R-DDI-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-CEL-6782135": ["r", "Dual incision in TC-NER"], "R-SPO-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-MMU-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-MMU-72086": ["r", "mRNA Capping"], "R-BTA-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-DDI-113418": ["r", "Formation of the Early Elongation Complex"], "R-SPO-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-BTA-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-SCE-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-DDI-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-HSA-6781827": ["r", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)"], "R-SPO-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-DME-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-DME-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-CEL-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-DME-9770562": ["r", "mRNA Polyadenylation"], "R-DME-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-MMU-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-BTA-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-HSA-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-DDI-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-CEL-4641257": ["r", "Degradation of AXIN"], "R-MMU-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-RNO-68949": ["r", "Orc1 removal from chromatin"], "R-CFA-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-MMU-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-BTA-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-MMU-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-RNO-382556": ["r", "ABC-family proteins mediated transport"], "R-MMU-69481": ["r", "G2/M Checkpoints"], "R-SSC-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-MMU-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-BTA-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-MMU-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-BTA-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-HSA-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-BTA-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-HSA-5610783": ["r", "Degradation of GLI2 by the proteasome"], "R-MMU-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-BTA-68867": ["r", "Assembly of the pre-replicative complex"], "R-MMU-68867": ["r", "Assembly of the pre-replicative complex"], "R-HSA-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-CFA-1236974": ["r", "ER-Phagosome pathway"], "R-SSC-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-SSC-382556": ["r", "ABC-family proteins mediated transport"], "R-DDI-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-CEL-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-RNO-5358346": ["r", "Hedgehog ligand biogenesis"], "R-SSC-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-HSA-68949": ["r", "Orc1 removal from chromatin"], "R-HSA-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-RNO-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-SSC-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-BTA-68949": ["r", "Orc1 removal from chromatin"], "R-CFA-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-MMU-68949": ["r", "Orc1 removal from chromatin"], "R-RNO-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-CEL-9907900": ["r", "Proteasome assembly"], "R-SSC-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-RNO-4641257": ["r", "Degradation of AXIN"], "R-DDI-5689603": ["r", "UCH proteinases"], "R-SSC-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-CEL-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-DDI-2467813": ["r", "Separation of Sister Chromatids"], "R-RNO-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-MMU-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-BTA-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-SSC-9020702": ["r", "Interleukin-1 signaling"], "R-MMU-382556": ["r", "ABC-family proteins mediated transport"], "R-BTA-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-BTA-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-DDI-9907900": ["r", "Proteasome assembly"], "R-SCE-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-RNO-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-SSC-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-MMU-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-SSC-202424": ["r", "Downstream TCR signaling"], "R-DDI-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-BTA-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-CEL-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-HSA-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-DDI-5632684": ["r", "Hedgehog 'on' state"], "R-CEL-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-SSC-68867": ["r", "Assembly of the pre-replicative complex"], "R-HSA-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-BTA-9932298": ["r", "Degradation of CRY and PER proteins"], "R-SSC-69481": ["r", "G2/M Checkpoints"], "R-BTA-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-RNO-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-HSA-68867": ["r", "Assembly of the pre-replicative complex"], "R-MMU-9907900": ["r", "Proteasome assembly"], "R-CEL-4641258": ["r", "Degradation of DVL"], "R-BTA-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-RNO-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-SSC-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-BTA-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-MMU-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-DDI-68949": ["r", "Orc1 removal from chromatin"], "R-RNO-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-HSA-5689603": ["r", "UCH proteinases"], "R-BTA-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-HSA-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-DDI-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-HSA-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-BTA-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-SSC-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-HSA-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-SPO-1236974": ["r", "ER-Phagosome pathway"], "R-MMU-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-SSC-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-CEL-1236974": ["r", "ER-Phagosome pathway"], "R-MMU-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-MMU-5358346": ["r", "Hedgehog ligand biogenesis"], "R-SSC-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-MMU-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-MMU-5689603": ["r", "UCH proteinases"], "R-SSC-5658442": ["r", "Regulation of RAS by GAPs"], "R-MMU-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-RNO-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-SSC-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-CEL-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-RNO-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-HSA-382556": ["r", "ABC-family proteins mediated transport"], "R-SCE-9907900": ["r", "Proteasome assembly"], "R-HSA-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-HSA-9929356": ["r", "GSK3B-mediated proteasomal degradation of PD-L1(CD274)"], "R-CEL-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-CEL-68949": ["r", "Orc1 removal from chromatin"], "R-MMU-1236974": ["r", "ER-Phagosome pathway"], "R-RNO-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-SSC-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-DDI-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-RNO-8964208": ["r", "Phenylalanine metabolism"], "R-HSA-8964208": ["r", "Phenylalanine metabolism"], "R-BTA-8964208": ["r", "Phenylalanine metabolism"], "R-DRE-8964208": ["r", "Phenylalanine metabolism"], "R-DME-8964208": ["r", "Phenylalanine metabolism"], "R-MMU-8964208": ["r", "Phenylalanine metabolism"], "R-HSA-444821": ["r", "Relaxin receptors"], "R-MMU-444821": ["r", "Relaxin receptors"], "R-RNO-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-DDI-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-GGA-351433": ["r", "ATM mediated phosphorylation of repair proteins"], "R-RNO-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-RNO-72163": ["r", "mRNA Splicing - Major Pathway"], "R-MMU-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-CEL-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-MMU-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-MMU-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-MMU-69473": ["r", "G2/M DNA damage checkpoint"], "R-DRE-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-MMU-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DRE-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-GGA-217106": ["r", "Chk1-controlled and DNA-damage induced centrosome duplication"], "R-MMU-5625900": ["r", "RHO GTPases activate CIT"], "R-SCE-69473": ["r", "G2/M DNA damage checkpoint"], "R-RNO-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-DME-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-DRE-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-HSA-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-RNO-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-HSA-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DME-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-DRE-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-DRE-5693607": ["r", "Processing of DNA double-strand break ends"], "R-HSA-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-SCE-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-MMU-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-DME-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-SPO-69473": ["r", "G2/M DNA damage checkpoint"], "R-DRE-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-RNO-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-MMU-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-HSA-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-RNO-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-RNO-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-BTA-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-MMU-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-GGA-351442": ["r", "ATM mediated response to DNA double-strand break"], "R-MMU-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-SCE-3232118": ["r", "SUMOylation of transcription factors"], "R-MMU-5693607": ["r", "Processing of DNA double-strand break ends"], "R-HSA-9701192": ["r", "Defective homologous recombination repair (HRR) due to BRCA1 loss of function"], "R-CEL-69473": ["r", "G2/M DNA damage checkpoint"], "R-MMU-6804757": ["r", "Regulation of TP53 Degradation"], "R-HSA-9709603": ["r", "Impaired BRCA2 binding to PALB2"], "R-XTR-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-SPO-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-HSA-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-CEL-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-RNO-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-BTA-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-DME-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-HSA-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-SCE-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-HSA-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-MMU-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-HSA-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-MMU-69541": ["r", "Stabilization of p53"], "R-DDI-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-DRE-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-HSA-9709570": ["r", "Impaired BRCA2 binding to RAD51"], "R-MMU-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-HSA-6804757": ["r", "Regulation of TP53 Degradation"], "R-SPO-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-DRE-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-RNO-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-MMU-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-DME-69473": ["r", "G2/M DNA damage checkpoint"], "R-RNO-5693607": ["r", "Processing of DNA double-strand break ends"], "R-DRE-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-RNO-69473": ["r", "G2/M DNA damage checkpoint"], "R-HSA-9704331": ["r", "Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function"], "R-DRE-69473": ["r", "G2/M DNA damage checkpoint"], "R-RNO-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-SPO-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-DRE-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-HSA-5693554": ["r", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"], "R-RNO-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-MMU-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-HSA-9704646": ["r", "Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function"], "R-DDI-69473": ["r", "G2/M DNA damage checkpoint"], "R-CEL-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-SCE-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-DDI-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-DRE-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-GGA-351444": ["r", "Recruitment of repair and signaling proteins to double-strand breaks"], "R-RNO-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-HSA-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-RNO-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-HSA-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-MMU-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-HSA-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-SPO-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-HSA-69541": ["r", "Stabilization of p53"], "R-SPO-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-SPO-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-DME-69541": ["r", "Stabilization of p53"], "R-DRE-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-HSA-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-HSA-168888": ["r", "Inhibition of IFN-beta"], "R-HSA-168315": ["r", "Inhibition of Host mRNA Processing and RNA Silencing"], "R-HSA-169131": ["r", "Inhibition of PKR"], "PWY-7159": ["t", "3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"], "PWY-5531": ["t", "3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)"], "PWY-7766": ["t", "heme b biosynthesis IV (Gram-positive bacteria)"], "R-DDI-189451": ["r", "Heme biosynthesis"], "R-RNO-189451": ["r", "Heme biosynthesis"], "R-DRE-189451": ["r", "Heme biosynthesis"], "R-DME-189451": ["r", "Heme biosynthesis"], "R-MMU-189451": ["r", "Heme biosynthesis"], "R-SCE-189451": ["r", "Heme biosynthesis"], "R-SPO-189451": ["r", "Heme biosynthesis"], "R-HSA-189451": ["r", "Heme biosynthesis"], "PWY-4302": ["t", "aerobic respiration III (alternative oxidase pathway)"], "PWY-6692": ["t", "Fe(II) oxidation"], "PWY-3781": ["t", "aerobic respiration I (cytochrome c)"], "PWY-5083": ["t", "NAD(P)/NADPH interconversion"], "R-SSC-5419276": ["r", "Mitochondrial translation termination"], "R-HSA-6799198": ["r", "Complex I biogenesis"], "R-MMU-6799198": ["r", "Complex I biogenesis"], "R-DME-6799198": ["r", "Complex I biogenesis"], "R-RNO-6799198": ["r", "Complex I biogenesis"], "R-DRE-611105": ["r", "Respiratory electron transport"], "R-SSC-6799198": ["r", "Complex I biogenesis"], "R-GGA-6799198": ["r", "Complex I biogenesis"], "R-GGA-611105": ["r", "Respiratory electron transport"], "R-DRE-6799198": ["r", "Complex I biogenesis"], "R-BTA-6799198": ["r", "Complex I biogenesis"], "R-BTA-611105": ["r", "Respiratory electron transport"], "R-DDI-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-HSA-8875360": ["r", "InlB-mediated entry of Listeria monocytogenes into host cell"], "R-BTA-390918": ["r", "Peroxisomal lipid metabolism"], "R-SPO-390918": ["r", "Peroxisomal lipid metabolism"], "R-HSA-189483": ["r", "Heme degradation"], "R-RNO-9793528": ["r", "Ciprofloxacin ADME"], "R-MMU-189483": ["r", "Heme degradation"], "R-MMU-9749641": ["r", "Aspirin ADME"], "R-RNO-189483": ["r", "Heme degradation"], "R-SSC-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-SSC-8957275": ["r", "Post-translational protein phosphorylation"], "R-MMU-9793528": ["r", "Ciprofloxacin ADME"], "R-HSA-9749641": ["r", "Aspirin ADME"], "R-HSA-9793528": ["r", "Ciprofloxacin ADME"], "R-RNO-9749641": ["r", "Aspirin ADME"], "R-BTA-391908": ["r", "Prostanoid ligand receptors"], "R-HSA-198765": ["r", "Signalling to ERK5"], "R-MMU-205043": ["r", "NRIF signals cell death from the nucleus"], "R-RNO-9664873": ["r", "Pexophagy"], "R-DRE-420029": ["r", "Tight junction interactions"], "R-MMU-209560": ["r", "NF-kB is activated and signals survival"], "R-CEL-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-RNO-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-HSA-9673324": ["r", "WNT5:FZD7-mediated leishmania damping"], "R-MMU-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-DME-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-DRE-5578775": ["r", "Ion homeostasis"], "R-DRE-936837": ["r", "Ion transport by P-type ATPases"], "R-BTA-5578775": ["r", "Ion homeostasis"], "R-HSA-936837": ["r", "Ion transport by P-type ATPases"], "R-MMU-936837": ["r", "Ion transport by P-type ATPases"], "R-SSC-5578775": ["r", "Ion homeostasis"], "R-BTA-936837": ["r", "Ion transport by P-type ATPases"], "R-RNO-936837": ["r", "Ion transport by P-type ATPases"], "R-SSC-936837": ["r", "Ion transport by P-type ATPases"], "R-HSA-390666": ["r", "Serotonin receptors"], "R-DRE-418597": ["r", "G alpha (z) signalling events"], "R-DRE-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-HSA-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-SSC-380108": ["r", "Chemokine receptors bind chemokines"], "R-HSA-2485179": ["r", "Activation of the phototransduction cascade"], "R-DRE-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-RNO-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-MMU-391906": ["r", "Leukotriene receptors"], "R-RNO-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-CEL-418555": ["r", "G alpha (s) signalling events"], "R-RNO-3296197": ["r", "Hydroxycarboxylic acid-binding receptors"], "R-SSC-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-XTR-5610787": ["r", "Hedgehog 'off' state"], "R-CEL-391908": ["r", "Prostanoid ligand receptors"], "R-SSC-417957": ["r", "P2Y receptors"], "R-HSA-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-HSA-391906": ["r", "Leukotriene receptors"], "R-BTA-418597": ["r", "G alpha (z) signalling events"], "R-XTR-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-BTA-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-CFA-418594": ["r", "G alpha (i) signalling events"], "R-MMU-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-MMU-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-MMU-390666": ["r", "Serotonin receptors"], "R-MMU-444473": ["r", "Formyl peptide receptors bind formyl peptides and many other ligands"], "R-DRE-2485179": ["r", "Activation of the phototransduction cascade"], "R-BTA-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-CEL-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-RNO-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-CFA-419771": ["r", "Opsins"], "R-MMU-392851": ["r", "Prostacyclin signalling through prostacyclin receptor"], "R-RNO-400511": ["r", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "R-MMU-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-HSA-9918443": ["r", "Defective visual phototransduction due to OPN1SW loss of function"], "R-HSA-5619099": ["r", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "R-CEL-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-GGA-417973": ["r", "Adenosine P1 receptors"], "R-HSA-417973": ["r", "Adenosine P1 receptors"], "R-HSA-3296197": ["r", "Hydroxycarboxylic acid-binding receptors"], "R-HSA-5579031": ["r", "Defective ACTH causes obesity and POMCD"], "R-HSA-390650": ["r", "Histamine receptors"], "R-MMU-2485179": ["r", "Activation of the phototransduction cascade"], "R-DRE-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-GGA-5683826": ["r", "Surfactant metabolism"], "R-RNO-444821": ["r", "Relaxin receptors"], "R-MMU-390651": ["r", "Dopamine receptors"], "R-MMU-444209": ["r", "Free fatty acid receptors"], "R-RNO-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-CFA-391908": ["r", "Prostanoid ligand receptors"], "R-HSA-381753": ["r", "Olfactory Signaling Pathway"], "R-HSA-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-DME-390648": ["r", "Muscarinic acetylcholine receptors"], "R-SSC-419771": ["r", "Opsins"], "R-CEL-390648": ["r", "Muscarinic acetylcholine receptors"], "R-RNO-390651": ["r", "Dopamine receptors"], "R-RNO-375280": ["r", "Amine ligand-binding receptors"], "R-HSA-391903": ["r", "Eicosanoid ligand-binding receptors"], "R-SSC-2485179": ["r", "Activation of the phototransduction cascade"], "R-DRE-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-HSA-9918436": ["r", "Defective visual phototransduction due to OPN1MW loss of function"], "R-RNO-390650": ["r", "Histamine receptors"], "R-RNO-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-SSC-375281": ["r", "Hormone ligand-binding receptors"], "R-HSA-375281": ["r", "Hormone ligand-binding receptors"], "R-CEL-417973": ["r", "Adenosine P1 receptors"], "R-BTA-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-HSA-428930": ["r", "Thromboxane signalling through TP receptor"], "R-DRE-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-DME-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-SSC-416482": ["r", "G alpha (12/13) signalling events"], "R-CFA-5683826": ["r", "Surfactant metabolism"], "R-CEL-202040": ["r", "G-protein activation"], "R-BTA-390648": ["r", "Muscarinic acetylcholine receptors"], "R-HSA-9660821": ["r", "ADORA2B mediated anti-inflammatory cytokines production"], "R-MMU-419771": ["r", "Opsins"], "R-CEL-375276": ["r", "Peptide ligand-binding receptors"], "R-CEL-390666": ["r", "Serotonin receptors"], "R-MMU-375281": ["r", "Hormone ligand-binding receptors"], "R-CEL-390650": ["r", "Histamine receptors"], "R-RNO-428930": ["r", "Thromboxane signalling through TP receptor"], "R-DME-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-DRE-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-BTA-380108": ["r", "Chemokine receptors bind chemokines"], "R-BTA-419771": ["r", "Opsins"], "R-BTA-428930": ["r", "Thromboxane signalling through TP receptor"], "R-CEL-390651": ["r", "Dopamine receptors"], "R-CFA-390696": ["r", "Adrenoceptors"], "R-DME-390666": ["r", "Serotonin receptors"], "R-MMU-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-CFA-375281": ["r", "Hormone ligand-binding receptors"], "R-BTA-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-MMU-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-HSA-9918450": ["r", "Defective visual phototransduction due to OPN1LW loss of function"], "R-DME-390696": ["r", "Adrenoceptors"], "R-SSC-390648": ["r", "Muscarinic acetylcholine receptors"], "R-DME-390650": ["r", "Histamine receptors"], "R-HSA-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-MMU-390650": ["r", "Histamine receptors"], "R-RNO-444209": ["r", "Free fatty acid receptors"], "R-RNO-390648": ["r", "Muscarinic acetylcholine receptors"], "R-DME-390651": ["r", "Dopamine receptors"], "R-MMU-417973": ["r", "Adenosine P1 receptors"], "R-SSC-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-HSA-392851": ["r", "Prostacyclin signalling through prostacyclin receptor"], "R-HSA-390651": ["r", "Dopamine receptors"], "R-RNO-419771": ["r", "Opsins"], "R-HSA-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-BTA-417973": ["r", "Adenosine P1 receptors"], "R-CFA-375276": ["r", "Peptide ligand-binding receptors"], "R-GGA-418555": ["r", "G alpha (s) signalling events"], "R-MMU-400511": ["r", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "R-RNO-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-HSA-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-HSA-375280": ["r", "Amine ligand-binding receptors"], "R-RNO-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-BTA-390696": ["r", "Adrenoceptors"], "R-DME-419771": ["r", "Opsins"], "R-RNO-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-GGA-390648": ["r", "Muscarinic acetylcholine receptors"], "R-SSC-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-BTA-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-BTA-380095": ["r", "Tachykinin receptors bind tachykinins"], "R-DRE-375280": ["r", "Amine ligand-binding receptors"], "R-RNO-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-CEL-391906": ["r", "Leukotriene receptors"], "R-CFA-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-HSA-187024": ["r", "NGF-independant TRKA activation"], "R-CFA-390650": ["r", "Histamine receptors"], "R-CFA-444821": ["r", "Relaxin receptors"], "R-SSC-390696": ["r", "Adrenoceptors"], "R-CFA-381753": ["r", "Olfactory Signaling Pathway"], "R-SSC-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-MMU-3296197": ["r", "Hydroxycarboxylic acid-binding receptors"], "R-MMU-428930": ["r", "Thromboxane signalling through TP receptor"], "R-MMU-381753": ["r", "Olfactory Signaling Pathway"], "R-BTA-2485179": ["r", "Activation of the phototransduction cascade"], "R-RNO-375281": ["r", "Hormone ligand-binding receptors"], "R-BTA-373076": ["r", "Class A/1 (Rhodopsin-like receptors)"], "R-CEL-390696": ["r", "Adrenoceptors"], "R-RNO-391906": ["r", "Leukotriene receptors"], "R-BTA-391906": ["r", "Leukotriene receptors"], "R-MMU-375280": ["r", "Amine ligand-binding receptors"], "R-DRE-388479": ["r", "Vasopressin-like receptors"], "R-SSC-392023": ["r", "Adrenaline signalling through Alpha-2 adrenergic receptor"], "R-SSC-418597": ["r", "G alpha (z) signalling events"], "R-SSC-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-MMU-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-HSA-390648": ["r", "Muscarinic acetylcholine receptors"], "R-RNO-390666": ["r", "Serotonin receptors"], "R-SSC-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-CEL-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-HSA-9752946": ["r", "Expression and translocation of olfactory receptors"], "R-CEL-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-DRE-390696": ["r", "Adrenoceptors"], "R-BTA-390651": ["r", "Dopamine receptors"], "R-BTA-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-RNO-417973": ["r", "Adenosine P1 receptors"], "R-BTA-375281": ["r", "Hormone ligand-binding receptors"], "R-HSA-9827857": ["r", "Specification of primordial germ cells"], "R-CFA-417973": ["r", "Adenosine P1 receptors"], "R-RNO-392851": ["r", "Prostacyclin signalling through prostacyclin receptor"], "R-HSA-444209": ["r", "Free fatty acid receptors"], "R-DRE-419771": ["r", "Opsins"], "R-DME-418597": ["r", "G alpha (z) signalling events"], "R-HSA-419771": ["r", "Opsins"], "R-CFA-390666": ["r", "Serotonin receptors"], "R-RNO-2485179": ["r", "Activation of the phototransduction cascade"], "R-RNO-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-SSC-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-MMU-390648": ["r", "Muscarinic acetylcholine receptors"], "R-BTA-5610787": ["r", "Hedgehog 'off' state"], "R-SCE-1614603": ["r", "Cysteine formation from homocysteine"], "R-DDI-1614603": ["r", "Cysteine formation from homocysteine"], "R-MMU-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-MMU-1614603": ["r", "Cysteine formation from homocysteine"], "R-CEL-1614603": ["r", "Cysteine formation from homocysteine"], "R-DDI-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-RNO-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-SCE-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-HSA-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-SPO-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-SPO-1614603": ["r", "Cysteine formation from homocysteine"], "R-MTU-937250": ["r", "Sulfur amino acid metabolism"], "R-HSA-1614603": ["r", "Cysteine formation from homocysteine"], "R-RNO-1614603": ["r", "Cysteine formation from homocysteine"], "R-DDI-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-DDI-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-DDI-9018519": ["r", "Estrogen-dependent gene expression"], "R-HSA-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-HSA-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-HSA-73780": ["r", "RNA Polymerase III Chain Elongation"], "R-MMU-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-DDI-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-CEL-72163": ["r", "mRNA Splicing - Major Pathway"], "R-HSA-167172": ["r", "Transcription of the HIV genome"], "R-BTA-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-SCE-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-HSA-76071": ["r", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "R-DME-113418": ["r", "Formation of the Early Elongation Complex"], "R-HSA-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-MMU-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-CEL-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-BTA-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-HSA-167243": ["r", "Tat-mediated HIV elongation arrest and recovery"], "R-SCE-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-MMU-76071": ["r", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "R-BTA-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-BTA-6803529": ["r", "FGFR2 alternative splicing"], "R-HSA-73863": ["r", "RNA Polymerase I Transcription Termination"], "R-HSA-167290": ["r", "Pausing and recovery of HIV elongation"], "R-SPO-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-DME-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-MMU-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-HSA-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-MMU-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-SPO-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-DME-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-HSA-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-HSA-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-BTA-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-BTA-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-SCE-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-SPO-72163": ["r", "mRNA Splicing - Major Pathway"], "R-HSA-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-HSA-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-MMU-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-HSA-167238": ["r", "Pausing and recovery of Tat-mediated HIV elongation"], "R-SCE-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-MMU-113418": ["r", "Formation of the Early Elongation Complex"], "R-DME-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DME-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-BTA-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-SPO-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-MMU-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-HSA-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-HSA-167287": ["r", "HIV elongation arrest and recovery"], "R-BTA-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-HSA-167246": ["r", "Tat-mediated elongation of the HIV-1 transcript"], "R-HSA-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-HSA-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-SPO-72086": ["r", "mRNA Capping"], "R-MMU-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-DDI-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-MMU-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-SPO-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-SPO-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-HSA-5601884": ["r", "PIWI-interacting RNA (piRNA) biogenesis"], "R-SPO-113418": ["r", "Formation of the Early Elongation Complex"], "R-CEL-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-DDI-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-DME-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-BTA-72086": ["r", "mRNA Capping"], "R-DDI-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DDI-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-DDI-72086": ["r", "mRNA Capping"], "R-CEL-113418": ["r", "Formation of the Early Elongation Complex"], "R-MMU-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-MMU-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-SCE-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-DDI-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-CEL-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DME-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-HSA-167200": ["r", "Formation of HIV-1 elongation complex containing HIV-1 Tat"], "R-SCE-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-DME-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-SCE-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-MMU-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-CEL-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-SCE-6782135": ["r", "Dual incision in TC-NER"], "R-MMU-6803529": ["r", "FGFR2 alternative splicing"], "R-DDI-6782135": ["r", "Dual incision in TC-NER"], "R-SCE-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-MMU-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-MMU-6782135": ["r", "Dual incision in TC-NER"], "R-HSA-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-BTA-113418": ["r", "Formation of the Early Elongation Complex"], "R-DME-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-CEL-72086": ["r", "mRNA Capping"], "R-HSA-72086": ["r", "mRNA Capping"], "R-HSA-167162": ["r", "RNA Polymerase II HIV Promoter Escape"], "R-DDI-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-HSA-167152": ["r", "Formation of HIV elongation complex in the absence of HIV Tat"], "R-HSA-113418": ["r", "Formation of the Early Elongation Complex"], "R-HSA-1834949": ["r", "Cytosolic sensors of pathogen-associated DNA"], "R-BTA-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-SCE-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-BTA-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-SPO-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-SCE-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-SCE-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-BTA-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-SPO-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-SCE-113418": ["r", "Formation of the Early Elongation Complex"], "R-SCE-72086": ["r", "mRNA Capping"], "R-MMU-73863": ["r", "RNA Polymerase I Transcription Termination"], "R-HSA-6782135": ["r", "Dual incision in TC-NER"], "R-CEL-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-SCE-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-DDI-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-SPO-6782135": ["r", "Dual incision in TC-NER"], "R-CEL-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-CEL-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-CEL-6803529": ["r", "FGFR2 alternative splicing"], "R-BTA-211945": ["r", "Phase I - Functionalization of compounds"], "R-RNO-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-HSA-420029": ["r", "Tight junction interactions"], "R-DME-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-MMU-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-RNO-205043": ["r", "NRIF signals cell death from the nucleus"], "R-DME-9664873": ["r", "Pexophagy"], "R-CEL-204005": ["r", "COPII-mediated vesicle transport"], "R-HSA-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-MMU-420029": ["r", "Tight junction interactions"], "R-RNO-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-HSA-209560": ["r", "NF-kB is activated and signals survival"], "R-CEL-1912408": ["r", "Pre-NOTCH Transcription and Translation"], "R-HSA-205043": ["r", "NRIF signals cell death from the nucleus"], "R-RNO-209560": ["r", "NF-kB is activated and signals survival"], "R-HSA-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-RNO-420029": ["r", "Tight junction interactions"], "R-DME-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-RNO-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-MMU-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-MMU-1912408": ["r", "Pre-NOTCH Transcription and Translation"], "R-HSA-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-SPO-8941237": ["r", "Invadopodia formation"], "R-RNO-1912408": ["r", "Pre-NOTCH Transcription and Translation"], "R-DRE-1912408": ["r", "Pre-NOTCH Transcription and Translation"], "R-MMU-9664873": ["r", "Pexophagy"], "R-DRE-112411": ["r", "MAPK1 (ERK2) activation"], "R-RNO-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-DRE-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-MMU-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-DRE-877312": ["r", "Regulation of IFNG signaling"], "R-SSC-8854691": ["r", "Interleukin-20 family signaling"], "R-MMU-9020591": ["r", "Interleukin-12 signaling"], "R-HSA-399719": ["r", "Trafficking of AMPA receptors"], "R-RNO-399719": ["r", "Trafficking of AMPA receptors"], "R-DME-6794361": ["r", "Neurexins and neuroligins"], "R-SSC-9020591": ["r", "Interleukin-12 signaling"], "R-DRE-1266695": ["r", "Interleukin-7 signaling"], "R-SSC-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-RNO-8983432": ["r", "Interleukin-15 signaling"], "R-DRE-877300": ["r", "Interferon gamma signaling"], "R-DME-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-DME-437239": ["r", "Recycling pathway of L1"], "R-RNO-8984722": ["r", "Interleukin-35 Signalling"], "R-CEL-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-HSA-9020933": ["r", "Interleukin-23 signaling"], "R-DRE-8854691": ["r", "Interleukin-20 family signaling"], "R-DRE-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-RNO-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-MMU-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-SSC-877312": ["r", "Regulation of IFNG signaling"], "R-DRE-1059683": ["r", "Interleukin-6 signaling"], "R-HSA-9020591": ["r", "Interleukin-12 signaling"], "R-MMU-1170546": ["r", "Prolactin receptor signaling"], "R-RNO-8985947": ["r", "Interleukin-9 signaling"], "R-CEL-8874081": ["r", "MET activates PTK2 signaling"], "R-MMU-399719": ["r", "Trafficking of AMPA receptors"], "R-SSC-5673000": ["r", "RAF activation"], "R-RNO-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-HSA-9006335": ["r", "Signaling by Erythropoietin"], "R-SSC-69231": ["r", "Cyclin D associated events in G1"], "R-MMU-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-SSC-112411": ["r", "MAPK1 (ERK2) activation"], "R-SSC-982772": ["r", "Growth hormone receptor signaling"], "R-DME-209209": ["r", "Formation of the activated receptor complex"], "R-SSC-9674555": ["r", "Signaling by CSF3 (G-CSF)"], "R-HSA-9027283": ["r", "Erythropoietin activates STAT5"], "R-RNO-9732724": ["r", "IFNG signaling activates MAPKs"], "R-DME-8985947": ["r", "Interleukin-9 signaling"], "R-DRE-909733": ["r", "Interferon alpha/beta signaling"], "R-DRE-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-SSC-9027284": ["r", "Erythropoietin activates RAS"], "R-RNO-9020958": ["r", "Interleukin-21 signaling"], "R-RNO-9006335": ["r", "Signaling by Erythropoietin"], "R-DRE-8983432": ["r", "Interleukin-15 signaling"], "R-HSA-8985947": ["r", "Interleukin-9 signaling"], "R-DME-373752": ["r", "Netrin-1 signaling"], "R-MMU-9020956": ["r", "Interleukin-27 signaling"], "R-BTA-6794361": ["r", "Neurexins and neuroligins"], "R-HSA-9020558": ["r", "Interleukin-2 signaling"], "R-RNO-1170546": ["r", "Prolactin receptor signaling"], "R-SSC-1059683": ["r", "Interleukin-6 signaling"], "R-MMU-391160": ["r", "Signal regulatory protein family interactions"], "R-SSC-9006335": ["r", "Signaling by Erythropoietin"], "R-RNO-391160": ["r", "Signal regulatory protein family interactions"], "R-CEL-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-HSA-9020956": ["r", "Interleukin-27 signaling"], "R-MMU-8985947": ["r", "Interleukin-9 signaling"], "R-DRE-9732724": ["r", "IFNG signaling activates MAPKs"], "R-DRE-6783783": ["r", "Interleukin-10 signaling"], "R-DME-451806": ["r", "Phosphorylation-independent inhibition of YKI"], "R-MMU-9020933": ["r", "Interleukin-23 signaling"], "R-SSC-9732724": ["r", "IFNG signaling activates MAPKs"], "R-RNO-9020956": ["r", "Interleukin-27 signaling"], "R-MMU-9020558": ["r", "Interleukin-2 signaling"], "R-CEL-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-DDI-6799198": ["r", "Complex I biogenesis"], "R-BTA-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-MMU-3214815": ["r", "HDACs deacetylate histones"], "R-DRE-2467813": ["r", "Separation of Sister Chromatids"], "R-MMU-1538133": ["r", "G0 and Early G1"], "R-SPO-3214815": ["r", "HDACs deacetylate histones"], "R-GGA-8943724": ["r", "Regulation of PTEN gene transcription"], "R-GGA-1538133": ["r", "G0 and Early G1"], "R-HSA-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-MMU-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-HSA-9022537": ["r", "Loss of MECP2 binding ability to the NCoR/SMRT complex"], "R-BTA-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-DDI-3371511": ["r", "HSF1 activation"], "R-DME-1538133": ["r", "G0 and Early G1"], "R-RNO-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-DDI-3214815": ["r", "HDACs deacetylate histones"], "R-BTA-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-DME-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-BTA-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-DME-350054": ["r", "Notch-HLH transcription pathway"], "R-DME-3214815": ["r", "HDACs deacetylate histones"], "R-CEL-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-DME-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-HSA-1538133": ["r", "G0 and Early G1"], "R-HSA-9615710": ["r", "Late endosomal microautophagy"], "R-BTA-1538133": ["r", "G0 and Early G1"], "R-RNO-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-DDI-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-GGA-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-MMU-8943724": ["r", "Regulation of PTEN gene transcription"], "R-GGA-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-XTR-3214815": ["r", "HDACs deacetylate histones"], "R-DDI-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-DDI-1538133": ["r", "G0 and Early G1"], "R-GGA-350054": ["r", "Notch-HLH transcription pathway"], "R-DDI-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-DRE-3214815": ["r", "HDACs deacetylate histones"], "R-HSA-8943724": ["r", "Regulation of PTEN gene transcription"], "R-CEL-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-BTA-9022692": ["r", "Regulation of MECP2 expression and activity"], "R-GGA-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-DME-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-GGA-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-RNO-1538133": ["r", "G0 and Early G1"], "R-GGA-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-HSA-193670": ["r", "p75NTR negatively regulates cell cycle via SC1"], "R-RNO-9022692": ["r", "Regulation of MECP2 expression and activity"], "R-XTR-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-SCE-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-RNO-73762": ["r", "RNA Polymerase I Transcription Initiation"], "R-RNO-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-HSA-1362277": ["r", "Transcription of E2F targets under negative control by DREAM complex"], "R-HSA-9613829": ["r", "Chaperone Mediated Autophagy"], "R-DME-8943724": ["r", "Regulation of PTEN gene transcription"], "R-RNO-8943724": ["r", "Regulation of PTEN gene transcription"], "R-HSA-69205": ["r", "G1/S-Specific Transcription"], "R-HSA-9022538": ["r", "Loss of MECP2 binding ability to 5mC-DNA"], "R-GGA-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-HSA-9615017": ["r", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "R-CEL-8943724": ["r", "Regulation of PTEN gene transcription"], "R-MMU-9022692": ["r", "Regulation of MECP2 expression and activity"], "R-GGA-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-DME-209394": ["r", "Transcriptional activtion and repression of REL-68 target genes"], "R-XTR-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-BTA-8943724": ["r", "Regulation of PTEN gene transcription"], "R-GGA-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-GGA-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-HSA-4641265": ["r", "Repression of WNT target genes"], "R-HSA-1362300": ["r", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"], "R-DRE-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-SCE-3214815": ["r", "HDACs deacetylate histones"], "R-BTA-350054": ["r", "Notch-HLH transcription pathway"], "R-SCE-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-CEL-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-GGA-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-RNO-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-DRE-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-SSC-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-SSC-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-SSC-72649": ["r", "Translation initiation complex formation"], "R-DRE-72649": ["r", "Translation initiation complex formation"], "R-DRE-72702": ["r", "Ribosomal scanning and start codon recognition"], "PWY-7953": ["t", "UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing)"], "PWY-6387": ["t", "UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing)"], "PWY-6386": ["t", "UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing)"], "R-XTR-159763": ["r", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"], "R-XTR-159740": ["r", "Gamma-carboxylation of protein precursors"], "R-XTR-159782": ["r", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "R-RNO-9840310": ["r", "Glycosphingolipid catabolism"], "R-RNO-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-BTA-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-BTA-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-BTA-9840310": ["r", "Glycosphingolipid catabolism"], "R-SPO-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-DME-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-BTA-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-SCE-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-BTA-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "R-BTA-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-MMU-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "PWY-7429": ["t", "arsenite to oxygen electron transfer (via azurin)"], "PWY-8271": ["t", "NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane)"], "PWY-4521": ["t", "arsenite to oxygen electron transfer"], "PWY-7279": ["t", "aerobic respiration II (cytochrome c) (yeast)"], "R-GGA-9707564": ["r", "Cytoprotection by HMOX1"], "R-SSC-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-DRE-9864848": ["r", "Complex IV assembly"], "R-RNO-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-SSC-9864848": ["r", "Complex IV assembly"], "R-HSA-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-HSA-9864848": ["r", "Complex IV assembly"], "R-DME-9864848": ["r", "Complex IV assembly"], "R-SSC-9707564": ["r", "Cytoprotection by HMOX1"], "R-GGA-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-MMU-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-MMU-9864848": ["r", "Complex IV assembly"], "R-DRE-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-DME-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-HSA-9020958": ["r", "Interleukin-21 signaling"], "R-RNO-9020558": ["r", "Interleukin-2 signaling"], "R-RNO-9020591": ["r", "Interleukin-12 signaling"], "R-DME-9020558": ["r", "Interleukin-2 signaling"], "R-HSA-9732724": ["r", "IFNG signaling activates MAPKs"], "R-SSC-9020933": ["r", "Interleukin-23 signaling"], "R-MMU-9020958": ["r", "Interleukin-21 signaling"], "R-MMU-9732724": ["r", "IFNG signaling activates MAPKs"], "R-SSC-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-SSC-1170546": ["r", "Prolactin receptor signaling"], "R-CFA-6794361": ["r", "Neurexins and neuroligins"], "R-HSA-8984722": ["r", "Interleukin-35 Signalling"], "R-HSA-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-RNO-212436": ["r", "Generic Transcription Pathway"], "R-BTA-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-DRE-9843940": ["r", "Regulation of endogenous retroelements by KRAB-ZFP proteins"], "R-HSA-8948747": ["r", "Regulation of PTEN localization"], "R-MMU-844456": ["r", "The NLRP3 inflammasome"], "R-DRE-3899300": ["r", "SUMOylation of transcription cofactors"], "R-HSA-933543": ["r", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "PWY-6562": ["t", "norspermidine biosynthesis"], "PWY-2942": ["t", "L-lysine biosynthesis III"], "PWY-8088": ["t", "dipicolinate biosynthesis"], "PWY-8296": ["t", "cremeomycin biosynthesis"], "PWY-6559": ["t", "spermidine biosynthesis II"], "PWY-6160": ["t", "3-dehydroquinate biosynthesis II (archaea)"], "PWY-5097": ["t", "L-lysine biosynthesis VI"], "PWY-7153": ["t", "grixazone biosynthesis"], "PWY-8179": ["t", "platensimycin biosynthesis"], "PWY-2941": ["t", "L-lysine biosynthesis II"], "R-DRE-5358346": ["r", "Hedgehog ligand biogenesis"], "R-DME-5362798": ["r", "Release of Hh-Np from the secreting cell"], "R-GGA-5632681": ["r", "Ligand-receptor interactions"], "R-GGA-5358346": ["r", "Hedgehog ligand biogenesis"], "R-RNO-5632681": ["r", "Ligand-receptor interactions"], "R-DME-5632681": ["r", "Ligand-receptor interactions"], "R-DME-209338": ["r", "Assembly of the 'signalling complexes'"], "R-DME-209471": ["r", "Formation and transport of the N-HH ligand"], "R-MMU-5632681": ["r", "Ligand-receptor interactions"], "R-HSA-5632681": ["r", "Ligand-receptor interactions"], "R-DRE-5632681": ["r", "Ligand-receptor interactions"], "R-HSA-9758920": ["r", "Formation of lateral plate mesoderm"], "R-HSA-5658034": ["r", "HHAT G278V doesn't palmitoylate Hh-Np"], "R-RNO-5362798": ["r", "Release of Hh-Np from the secreting cell"], "R-GGA-5362798": ["r", "Release of Hh-Np from the secreting cell"], "R-HSA-9690406": ["r", "Transcriptional regulation of testis differentiation"], "R-DME-5358346": ["r", "Hedgehog ligand biogenesis"], "R-MMU-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-HSA-189085": ["r", "Digestion of dietary carbohydrate"], "R-HSA-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-HSA-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-HSA-9683686": ["r", "Maturation of spike protein"], "R-HSA-9694548": ["r", "Maturation of spike protein"], "R-HSA-5357609": ["r", "Glycogen storage disease type II (GAA)"], "R-MMU-189085": ["r", "Digestion of dietary carbohydrate"], "R-RNO-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-SPO-189085": ["r", "Digestion of dietary carbohydrate"], "R-SPO-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-HSA-5659898": ["r", "Intestinal saccharidase deficiencies"], "R-RNO-189085": ["r", "Digestion of dietary carbohydrate"], "R-HSA-901042": ["r", "Calnexin/calreticulin cycle"], "R-SSC-189085": ["r", "Digestion of dietary carbohydrate"], "R-BTA-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-CFA-209905": ["r", "Catecholamine biosynthesis"], "R-DME-209905": ["r", "Catecholamine biosynthesis"], "R-HSA-209905": ["r", "Catecholamine biosynthesis"], "R-RNO-209905": ["r", "Catecholamine biosynthesis"], "R-MMU-209905": ["r", "Catecholamine biosynthesis"], "R-DRE-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-SSC-4090294": ["r", "SUMOylation of intracellular receptors"], "R-SSC-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-DDI-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-SCE-9845614": ["r", "Sphingolipid catabolism"], "R-BTA-9845614": ["r", "Sphingolipid catabolism"], "R-DME-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-RNO-9845614": ["r", "Sphingolipid catabolism"], "R-SPO-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-DDI-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-XTR-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-DRE-9969896": ["r", "Lanosterol biosynthesis"], "R-SPO-9845614": ["r", "Sphingolipid catabolism"], "R-SCE-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-HSA-3274531": ["r", "Glycogen storage disease type Ia (G6PC)"], "R-DRE-70263": ["r", "Gluconeogenesis"], "R-DME-9845614": ["r", "Sphingolipid catabolism"], "R-CEL-9845614": ["r", "Sphingolipid catabolism"], "R-CEL-419408": ["r", "Lysosphingolipid and LPA receptors"], "R-MMU-9845614": ["r", "Sphingolipid catabolism"], "R-HSA-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-DDI-9845614": ["r", "Sphingolipid catabolism"], "R-SSC-9845614": ["r", "Sphingolipid catabolism"], "R-SPO-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-HSA-9845614": ["r", "Sphingolipid catabolism"], "R-MMU-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-HSA-3282872": ["r", "Severe congenital neutropenia type 4 (G6PC3)"], "R-HSA-2892245": ["r", "POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation"], "R-RNO-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-RNO-76071": ["r", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "R-DME-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-RNO-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-HSA-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-HSA-9823739": ["r", "Formation of the anterior neural plate"], "R-HSA-9832991": ["r", "Formation of the posterior neural plate"], "R-MMU-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-HSA-2892247": ["r", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "R-XTR-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-HSA-1462054": ["r", "Alpha-defensins"], "PWY-7250": ["t", "[2Fe-2S] iron-sulfur cluster biosynthesis"], "R-MMU-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-SSC-877300": ["r", "Interferon gamma signaling"], "R-RNO-9020933": ["r", "Interleukin-23 signaling"], "R-SSC-8984722": ["r", "Interleukin-35 Signalling"], "R-MMU-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-DRE-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-DRE-110056": ["r", "MAPK3 (ERK1) activation"], "R-CEL-418885": ["r", "DCC mediated attractive signaling"], "R-BTA-373752": ["r", "Netrin-1 signaling"], "R-SSC-9027276": ["r", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "R-SSC-9020956": ["r", "Interleukin-27 signaling"], "R-MMU-8984722": ["r", "Interleukin-35 Signalling"], "R-DRE-9020958": ["r", "Interleukin-21 signaling"], "R-MMU-9006335": ["r", "Signaling by Erythropoietin"], "R-HSA-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-DME-209228": ["r", "Formation of the activated STAT92E dimer and transport to the nucleus"], "PWY-6368": ["t", "3-phosphoinositide degradation"], "R-CFA-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-SPO-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-SPO-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-RNO-5624958": ["r", "ARL13B-mediated ciliary trafficking of INPP5E"], "R-CFA-1855204": ["r", "Synthesis of IP3 and IP4 in the cytosol"], "R-HSA-5624958": ["r", "ARL13B-mediated ciliary trafficking of INPP5E"], "R-MMU-5624958": ["r", "ARL13B-mediated ciliary trafficking of INPP5E"], "R-SPO-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-SCE-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-CEL-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-SCE-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-DRE-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-MMU-1300645": ["r", "Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "R-RNO-446107": ["r", "Type I hemidesmosome assembly"], "R-RNO-1300645": ["r", "Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "R-HSA-1300645": ["r", "Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "R-BTA-1300645": ["r", "Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "R-HSA-5336415": ["r", "Uptake and function of diphtheria toxin"], "R-MMU-446107": ["r", "Type I hemidesmosome assembly"], "PWY-3341": ["t", "L-proline biosynthesis III (from L-ornithine)"], "PWY-8187": ["t", "L-arginine degradation XIII (reductive Stickland reaction)"], "R-BTA-8964539": ["r", "Glutamate and glutamine metabolism"], "R-HSA-8964539": ["r", "Glutamate and glutamine metabolism"], "R-DDI-8964539": ["r", "Glutamate and glutamine metabolism"], "R-RNO-8964539": ["r", "Glutamate and glutamine metabolism"], "R-SPO-8964539": ["r", "Glutamate and glutamine metabolism"], "R-MMU-8964539": ["r", "Glutamate and glutamine metabolism"], "R-CEL-8964539": ["r", "Glutamate and glutamine metabolism"], "R-SCE-8964539": ["r", "Glutamate and glutamine metabolism"], "R-DRE-8964539": ["r", "Glutamate and glutamine metabolism"], "R-BTA-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-BTA-6783310": ["r", "Fanconi Anemia Pathway"], "R-RNO-6783310": ["r", "Fanconi Anemia Pathway"], "R-RNO-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-BTA-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-MMU-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-RNO-1632852": ["r", "Macroautophagy"], "R-HSA-9635644": ["r", "Inhibition of membrane repair"], "R-BTA-182971": ["r", "EGFR downregulation"], "R-SCE-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-DME-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-BTA-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-HSA-3656532": ["r", "TGFBR1 KD Mutants in Cancer"], "R-BTA-6807004": ["r", "Negative regulation of MET activity"], "R-DME-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-HSA-3304356": ["r", "SMAD2/3 Phosphorylation Motif Mutants in Cancer"], "R-HSA-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-RNO-2028269": ["r", "Signaling by Hippo"], "R-GGA-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-BTA-205025": ["r", "NADE modulates death signalling"], "R-RNO-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-BTA-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-BTA-9968551": ["r", "Regulation of GBP-mediated host defense"], "R-GGA-5675221": ["r", "Negative regulation of MAPK pathway"], "R-DRE-166208": ["r", "mTORC1-mediated signalling"], "R-RNO-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-CEL-165159": ["r", "MTOR signalling"], "R-XTR-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-HSA-170984": ["r", "ARMS-mediated activation"], "R-RNO-165159": ["r", "MTOR signalling"], "R-GGA-3371511": ["r", "HSF1 activation"], "R-MMU-170968": ["r", "Frs2-mediated activation"], "R-MMU-392517": ["r", "Rap1 signalling"], "R-CEL-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-HSA-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-RNO-205025": ["r", "NADE modulates death signalling"], "R-RNO-3371511": ["r", "HSF1 activation"], "R-DRE-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-PFA-5673000": ["r", "RAF activation"], "R-DRE-5673000": ["r", "RAF activation"], "R-GGA-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-BTA-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-DME-5675221": ["r", "Negative regulation of MAPK pathway"], "R-DME-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-MMU-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-DME-390098": ["r", "Phosphorylation-dependent inhibition of YKI"], "R-PFA-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-DRE-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-HSA-9726840": ["r", "SHOC2 M1731 mutant abolishes MRAS complex function"], "R-DME-165159": ["r", "MTOR signalling"], "R-CEL-170968": ["r", "Frs2-mediated activation"], "R-XTR-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-HSA-392517": ["r", "Rap1 signalling"], "R-MMU-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-HSA-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-RNO-166208": ["r", "mTORC1-mediated signalling"], "R-RNO-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-XTR-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-HSA-166208": ["r", "mTORC1-mediated signalling"], "R-DME-392517": ["r", "Rap1 signalling"], "R-RNO-9013700": ["r", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "R-BTA-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-PFA-430116": ["r", "GP1b-IX-V activation signalling"], "R-DRE-2028269": ["r", "Signaling by Hippo"], "R-DDI-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-BTA-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-XTR-430116": ["r", "GP1b-IX-V activation signalling"], "R-GGA-392517": ["r", "Rap1 signalling"], "R-DRE-170968": ["r", "Frs2-mediated activation"], "R-RNO-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-PFA-5675221": ["r", "Negative regulation of MAPK pathway"], "R-CEL-430116": ["r", "GP1b-IX-V activation signalling"], "R-GGA-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-HSA-9726842": ["r", "Gain-of-function MRAS complexes activate RAF signaling"], "R-GGA-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-HSA-9755779": ["r", "SARS-CoV-2 targets host intracellular signalling and regulatory pathways"], "R-XTR-5673000": ["r", "RAF activation"], "R-DME-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-HSA-170968": ["r", "Frs2-mediated activation"], "R-HSA-205025": ["r", "NADE modulates death signalling"], "R-CEL-166208": ["r", "mTORC1-mediated signalling"], "R-MMU-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-GGA-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-GGA-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-DRE-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-XTR-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-BTA-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-RNO-392517": ["r", "Rap1 signalling"], "R-GGA-170968": ["r", "Frs2-mediated activation"], "R-RNO-170968": ["r", "Frs2-mediated activation"], "R-BTA-392517": ["r", "Rap1 signalling"], "R-XTR-392517": ["r", "Rap1 signalling"], "R-GGA-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-DME-5674135": ["r", "MAP2K and MAPK activation"], "R-BTA-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-MMU-165159": ["r", "MTOR signalling"], "R-GGA-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-XTR-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-GGA-430116": ["r", "GP1b-IX-V activation signalling"], "R-XTR-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-DRE-165159": ["r", "MTOR signalling"], "R-HSA-9968551": ["r", "Regulation of GBP-mediated host defense"], "R-GGA-8854518": ["r", "AURKA Activation by TPX2"], "R-XTR-2028269": ["r", "Signaling by Hippo"], "R-BTA-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-BTA-2028269": ["r", "Signaling by Hippo"], "R-DME-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-DRE-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-XTR-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-MMU-205025": ["r", "NADE modulates death signalling"], "R-DME-430116": ["r", "GP1b-IX-V activation signalling"], "R-CEL-5625740": ["r", "RHO GTPases activate PKNs"], "R-DME-166208": ["r", "mTORC1-mediated signalling"], "R-DRE-5675221": ["r", "Negative regulation of MAPK pathway"], "R-XTR-166208": ["r", "mTORC1-mediated signalling"], "R-PFA-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-GGA-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-DME-170968": ["r", "Frs2-mediated activation"], "R-CEL-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-DRE-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-BTA-9013700": ["r", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "R-CEL-392517": ["r", "Rap1 signalling"], "R-CEL-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-GGA-2028269": ["r", "Signaling by Hippo"], "R-RNO-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-DME-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-GGA-166208": ["r", "mTORC1-mediated signalling"], "R-GGA-165159": ["r", "MTOR signalling"], "R-GGA-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-DME-9614399": ["r", "Regulation of localization of FOXO transcription factors"], "R-XTR-165159": ["r", "MTOR signalling"], "R-DRE-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-CEL-2028269": ["r", "Signaling by Hippo"], "R-DRE-392517": ["r", "Rap1 signalling"], "R-HSA-165159": ["r", "MTOR signalling"], "R-RNO-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-MMU-166208": ["r", "mTORC1-mediated signalling"], "R-XTR-5675221": ["r", "Negative regulation of MAPK pathway"], "R-HSA-4655427": ["r", "SUMOylation of DNA methylation proteins"], "R-HSA-5632928": ["r", "Defective Mismatch Repair Associated With MSH2"], "R-BTA-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-MMU-4655427": ["r", "SUMOylation of DNA methylation proteins"], "R-RNO-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-MMU-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-HSA-5632968": ["r", "Defective Mismatch Repair Associated With MSH6"], "R-HSA-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-HSA-1834941": ["r", "STING mediated induction of host immune responses"], "R-HSA-9635465": ["r", "Suppression of apoptosis"], "R-HSA-212436": ["r", "Generic Transcription Pathway"], "R-RNO-3899300": ["r", "SUMOylation of transcription cofactors"], "R-MMU-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-RNO-844456": ["r", "The NLRP3 inflammasome"], "R-HSA-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-HSA-844456": ["r", "The NLRP3 inflammasome"], "R-HSA-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-MMU-212436": ["r", "Generic Transcription Pathway"], "R-SSC-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-HSA-192905": ["r", "vRNP Assembly"], "R-DME-1295596": ["r", "Spry regulation of FGF signaling"], "R-SSC-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-DDI-198753": ["r", "ERK/MAPK targets"], "R-SSC-1295596": ["r", "Spry regulation of FGF signaling"], "R-HSA-198753": ["r", "ERK/MAPK targets"], "R-HSA-163767": ["r", "PP2A-mediated dephosphorylation of key metabolic factors"], "R-HSA-202670": ["r", "ERKs are inactivated"], "R-SSC-389356": ["r", "Co-stimulation by CD28"], "R-DDI-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-SSC-432142": ["r", "Platelet sensitization by LDL"], "R-RNO-180024": ["r", "DARPP-32 events"], "R-RNO-202670": ["r", "ERKs are inactivated"], "R-HSA-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-RNO-6804757": ["r", "Regulation of TP53 Degradation"], "R-HSA-389356": ["r", "Co-stimulation by CD28"], "R-CEL-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-RNO-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-SSC-202670": ["r", "ERKs are inactivated"], "R-SSC-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-SSC-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-SSC-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-MMU-202670": ["r", "ERKs are inactivated"], "R-DME-389513": ["r", "Co-inhibition by CTLA4"], "R-SSC-389513": ["r", "Co-inhibition by CTLA4"], "R-HSA-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-DDI-1632852": ["r", "Macroautophagy"], "R-DDI-166208": ["r", "mTORC1-mediated signalling"], "R-MMU-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-MMU-198753": ["r", "ERK/MAPK targets"], "R-SSC-180024": ["r", "DARPP-32 events"], "R-SSC-198753": ["r", "ERK/MAPK targets"], "R-SSC-5675221": ["r", "Negative regulation of MAPK pathway"], "R-CEL-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-DME-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-SSC-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-MMU-389356": ["r", "Co-stimulation by CD28"], "R-CEL-389513": ["r", "Co-inhibition by CTLA4"], "R-CEL-9833482": ["r", "PKR-mediated signaling"], "R-DDI-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-RNO-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-SSC-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-SPO-202670": ["r", "ERKs are inactivated"], "R-SPO-198753": ["r", "ERK/MAPK targets"], "R-BTA-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-DME-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DME-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-MMU-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-MMU-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-CEL-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-HSA-9670615": ["r", "Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations"], "R-RNO-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-RNO-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-MMU-9031628": ["r", "NGF-stimulated transcription"], "R-HSA-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-MMU-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-HSA-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-HSA-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-BTA-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-HSA-9670613": ["r", "Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations"], "R-CEL-9031628": ["r", "NGF-stimulated transcription"], "R-DRE-5696400": ["r", "Dual Incision in GG-NER"], "R-CEL-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-HSA-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-DME-3214858": ["r", "RMTs methylate histone arginines"], "R-DME-9031628": ["r", "NGF-stimulated transcription"], "R-BTA-5696400": ["r", "Dual Incision in GG-NER"], "R-MMU-5696400": ["r", "Dual Incision in GG-NER"], "R-RNO-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-BTA-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-HSA-5696400": ["r", "Dual Incision in GG-NER"], "R-DME-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-DRE-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-MMU-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-HSA-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-RNO-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-CEL-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-MMU-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-BTA-5663220": ["r", "RHO GTPases Activate Formins"], "R-BTA-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-DRE-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-DME-5689603": ["r", "UCH proteinases"], "R-DME-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-BTA-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-CEL-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-BTA-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-RNO-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-BTA-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-HSA-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-MMU-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-HSA-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-CEL-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-BTA-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-HSA-5674400": ["r", "Constitutive Signaling by AKT1 E17K in Cancer"], "R-MMU-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-RNO-165181": ["r", "Inhibition of TSC complex formation by PKB"], "R-SPO-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-HSA-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-MMU-165181": ["r", "Inhibition of TSC complex formation by PKB"], "R-RNO-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-HSA-165181": ["r", "Inhibition of TSC complex formation by PKB"], "R-MMU-9839406": ["r", "TGFBR3 regulates activin signaling"], "R-HSA-9839406": ["r", "TGFBR3 regulates activin signaling"], "R-GGA-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-DME-1502540": ["r", "Signaling by Activin"], "R-HSA-3656535": ["r", "TGFBR1 LBD Mutants in Cancer"], "R-BTA-201451": ["r", "Signaling by BMP"], "R-GGA-1502540": ["r", "Signaling by Activin"], "R-RNO-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-HSA-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-BTA-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-RNO-201451": ["r", "Signaling by BMP"], "R-RNO-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-MMU-1502540": ["r", "Signaling by Activin"], "R-HSA-3645790": ["r", "TGFBR2 Kinase Domain Mutants in Cancer"], "R-CEL-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-GGA-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-MMU-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-BTA-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-GGA-201451": ["r", "Signaling by BMP"], "R-BTA-1502540": ["r", "Signaling by Activin"], "R-HSA-1502540": ["r", "Signaling by Activin"], "R-BTA-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-BTA-9839406": ["r", "TGFBR3 regulates activin signaling"], "R-GGA-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-GGA-9839406": ["r", "TGFBR3 regulates activin signaling"], "R-DME-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-GGA-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-RNO-1502540": ["r", "Signaling by Activin"], "R-HSA-3642279": ["r", "TGFBR2 MSI Frameshift Mutants in Cancer"], "R-HSA-1433617": ["r", "Regulation of signaling by NODAL"], "R-RNO-9839406": ["r", "TGFBR3 regulates activin signaling"], "PWY-6788": ["t", "cellulose degradation II (fungi)"], "R-MMU-977444": ["r", "GABA B receptor activation"], "R-HSA-977444": ["r", "GABA B receptor activation"], "R-DDI-418594": ["r", "G alpha (i) signalling events"], "R-HSA-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-DDI-977444": ["r", "GABA B receptor activation"], "R-HSA-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-CEL-977444": ["r", "GABA B receptor activation"], "R-RNO-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-RNO-977444": ["r", "GABA B receptor activation"], "R-DDI-420499": ["r", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "R-MMU-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-RNO-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-MMU-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-CEL-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-CEL-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-DDI-8873719": ["r", "RAB geranylgeranylation"], "R-BTA-202670": ["r", "ERKs are inactivated"], "R-SCE-8948747": ["r", "Regulation of PTEN localization"], "R-HSA-3785653": ["r", "Myoclonic epilepsy of Lafora"], "R-CEL-202670": ["r", "ERKs are inactivated"], "R-HSA-1483148": ["r", "Synthesis of PG"], "R-DRE-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-DRE-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-MMU-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-HSA-3322077": ["r", "Glycogen synthesis"], "R-CEL-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-DDI-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-SPO-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-SCE-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-DME-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-DRE-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-GGA-437980": ["r", "Activated TAK1 mediates p38 MAP kinase phosphorylation"], "R-DRE-72086": ["r", "mRNA Capping"], "R-SCE-202670": ["r", "ERKs are inactivated"], "R-BTA-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-DME-202670": ["r", "ERKs are inactivated"], "R-RNO-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-DDI-202670": ["r", "ERKs are inactivated"], "R-BTA-5675221": ["r", "Negative regulation of MAPK pathway"], "R-HSA-9652817": ["r", "Signaling by MAPK mutants"], "R-HSA-112409": ["r", "RAF-independent MAPK1/3 activation"], "R-SCE-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-GGA-437986": ["r", "Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation"], "PWY-6352": ["t", "3-phosphoinositide biosynthesis"], "R-CEL-5654695": ["r", "PI-3K cascade:FGFR2"], "R-CEL-1257604": ["r", "PIP3 activates AKT signaling"], "R-DDI-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-CEL-5654720": ["r", "PI-3K cascade:FGFR4"], "R-CEL-5654689": ["r", "PI-3K cascade:FGFR1"], "R-CEL-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-MMU-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-DDI-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-CEL-201556": ["r", "Signaling by ALK"], "R-CEL-180292": ["r", "GAB1 signalosome"], "R-CEL-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-DDI-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-CEL-5654710": ["r", "PI-3K cascade:FGFR3"], "R-DDI-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-CEL-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-HSA-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "PWY-5188": ["t", "tetrapyrrole biosynthesis I (from glutamate)"], "R-RNO-202430": ["r", "Translocation of ZAP-70 to Immunological synapse"], "R-RNO-1251985": ["r", "Nuclear signaling by ERBB4"], "R-DME-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-HSA-9665249": ["r", "Resistance of ERBB2 KD mutants to afatinib"], "R-HSA-9665250": ["r", "Resistance of ERBB2 KD mutants to AEE788"], "R-HSA-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-MMU-1251985": ["r", "Nuclear signaling by ERBB4"], "R-HSA-74752": ["r", "Signaling by Insulin receptor"], "R-HSA-2428928": ["r", "IRS-related events triggered by IGF1R"], "R-CEL-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-MMU-74752": ["r", "Signaling by Insulin receptor"], "R-HSA-9665247": ["r", "Resistance of ERBB2 KD mutants to osimertinib"], "R-HSA-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-CEL-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-RNO-2404192": ["r", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "R-HSA-9665244": ["r", "Resistance of ERBB2 KD mutants to sapitinib"], "R-HSA-2404192": ["r", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "R-CEL-177929": ["r", "Signaling by EGFR"], "R-CEL-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-DME-110478": ["r", "Insulin signaling pathway"], "R-RNO-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-RNO-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-CEL-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-HSA-9665245": ["r", "Resistance of ERBB2 KD mutants to tesevatinib"], "R-CEL-1251985": ["r", "Nuclear signaling by ERBB4"], "R-CEL-8847993": ["r", "ERBB2 Activates PTK6 Signaling"], "R-MMU-2428928": ["r", "IRS-related events triggered by IGF1R"], "R-DME-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-MMU-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-HSA-9665246": ["r", "Resistance of ERBB2 KD mutants to neratinib"], "R-RNO-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-HSA-9665233": ["r", "Resistance of ERBB2 KD mutants to trastuzumab"], "R-CEL-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-MMU-2404192": ["r", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "R-RNO-2428928": ["r", "IRS-related events triggered by IGF1R"], "R-DRE-196025": ["r", "Formation of annular gap junctions"], "R-MMU-190872": ["r", "Transport of connexons to the plasma membrane"], "R-BTA-196025": ["r", "Formation of annular gap junctions"], "R-GGA-190861": ["r", "Gap junction assembly"], "R-HSA-190873": ["r", "Gap junction degradation"], "R-HSA-191650": ["r", "Regulation of gap junction activity"], "R-RNO-191650": ["r", "Regulation of gap junction activity"], "R-MMU-191650": ["r", "Regulation of gap junction activity"], "R-DRE-191650": ["r", "Regulation of gap junction activity"], "R-BTA-190704": ["r", "Oligomerization of connexins into connexons"], "R-BTA-190873": ["r", "Gap junction degradation"], "R-BTA-190861": ["r", "Gap junction assembly"], "R-BTA-191650": ["r", "Regulation of gap junction activity"], "R-MMU-190873": ["r", "Gap junction degradation"], "R-RNO-196025": ["r", "Formation of annular gap junctions"], "R-RNO-190873": ["r", "Gap junction degradation"], "R-XTR-190861": ["r", "Gap junction assembly"], "R-BTA-190872": ["r", "Transport of connexons to the plasma membrane"], "R-HSA-112303": ["r", "Electric Transmission Across Gap Junctions"], "R-HSA-9705677": ["r", "SARS-CoV-2 targets PDZ proteins in cell-cell junction"], "R-BTA-112303": ["r", "Electric Transmission Across Gap Junctions"], "R-HSA-190704": ["r", "Oligomerization of connexins into connexons"], "R-RNO-190704": ["r", "Oligomerization of connexins into connexons"], "R-HSA-190827": ["r", "Transport of connexins along the secretory pathway"], "R-RNO-112303": ["r", "Electric Transmission Across Gap Junctions"], "R-SSC-190861": ["r", "Gap junction assembly"], "R-HSA-196025": ["r", "Formation of annular gap junctions"], "R-BTA-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-RNO-190861": ["r", "Gap junction assembly"], "R-MMU-196025": ["r", "Formation of annular gap junctions"], "R-GGA-112303": ["r", "Electric Transmission Across Gap Junctions"], "R-DRE-190861": ["r", "Gap junction assembly"], "R-GGA-190872": ["r", "Transport of connexons to the plasma membrane"], "R-HSA-190872": ["r", "Transport of connexons to the plasma membrane"], "R-CFA-190861": ["r", "Gap junction assembly"], "R-SSC-112303": ["r", "Electric Transmission Across Gap Junctions"], "R-RNO-190872": ["r", "Transport of connexons to the plasma membrane"], "R-MMU-190704": ["r", "Oligomerization of connexins into connexons"], "R-DRE-190840": ["r", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"], "R-MMU-112303": ["r", "Electric Transmission Across Gap Junctions"], "R-MMU-190861": ["r", "Gap junction assembly"], "R-MMU-8849468": ["r", "PTK6 Regulates Proteins Involved in RNA Processing"], "R-PFA-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-PFA-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-PFA-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-PFA-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-HSA-9638334": ["r", "Iron assimilation using enterobactin"], "R-HSA-9638482": ["r", "Metal ion assimilation from the host"], "R-GGA-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-SSC-163359": ["r", "Glucagon signaling in metabolic regulation"], "R-BTA-420092": ["r", "Glucagon-type ligand receptors"], "R-SSC-420092": ["r", "Glucagon-type ligand receptors"], "R-SSC-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-BTA-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-RNO-420092": ["r", "Glucagon-type ligand receptors"], "R-HSA-420092": ["r", "Glucagon-type ligand receptors"], "R-BTA-163359": ["r", "Glucagon signaling in metabolic regulation"], "R-MMU-163359": ["r", "Glucagon signaling in metabolic regulation"], "R-HSA-163359": ["r", "Glucagon signaling in metabolic regulation"], "R-BTA-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-SSC-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-GGA-420092": ["r", "Glucagon-type ligand receptors"], "R-GGA-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-RNO-163359": ["r", "Glucagon signaling in metabolic regulation"], "R-MMU-420092": ["r", "Glucagon-type ligand receptors"], "R-BTA-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-GGA-163359": ["r", "Glucagon signaling in metabolic regulation"], "R-GGA-445355": ["r", "Smooth Muscle Contraction"], "R-SSC-9013424": ["r", "RHOV GTPase cycle"], "R-BTA-390522": ["r", "Striated Muscle Contraction"], "R-SSC-390522": ["r", "Striated Muscle Contraction"], "R-GGA-390522": ["r", "Striated Muscle Contraction"], "R-SSC-445355": ["r", "Smooth Muscle Contraction"], "R-CEL-445355": ["r", "Smooth Muscle Contraction"], "R-HSA-390522": ["r", "Striated Muscle Contraction"], "PWY-5154": ["t", "L-arginine biosynthesis III (via N-acetyl-L-citrulline)"], "R-DDI-70635": ["r", "Urea cycle"], "R-SCE-70635": ["r", "Urea cycle"], "R-SPO-70635": ["r", "Urea cycle"], "R-SSC-9013404": ["r", "RAC2 GTPase cycle"], "R-SSC-9013408": ["r", "RHOG GTPase cycle"], "R-RNO-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-BTA-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-BTA-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-SPO-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-SCE-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-MMU-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-SSC-1251985": ["r", "Nuclear signaling by ERBB4"], "R-SSC-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-DME-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-SSC-8939211": ["r", "ESR-mediated signaling"], "R-DRE-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-CEL-159418": ["r", "Recycling of bile acids and salts"], "R-CFA-9707564": ["r", "Cytoprotection by HMOX1"], "R-GGA-5362517": ["r", "Signaling by Retinoic Acid"], "R-GGA-68867": ["r", "Assembly of the pre-replicative complex"], "R-RNO-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-BTA-8948747": ["r", "Regulation of PTEN localization"], "R-DME-209447": ["r", "Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY"], "R-CFA-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-DME-2871837": ["r", "FCERI mediated NF-kB activation"], "R-DME-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-CFA-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-DDI-8948747": ["r", "Regulation of PTEN localization"], "R-BTA-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-GGA-5655862": ["r", "Translesion synthesis by POLK"], "R-MMU-937039": ["r", "IRAK1 recruits IKK complex"], "R-CEL-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-GGA-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-GGA-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-MMU-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-DME-5675482": ["r", "Regulation of necroptotic cell death"], "R-GGA-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-CEL-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-GGA-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-SSC-182971": ["r", "EGFR downregulation"], "R-MMU-4755510": ["r", "SUMOylation of immune response proteins"], "R-SSC-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-SSC-209543": ["r", "p75NTR recruits signalling complexes"], "R-SSC-5357905": ["r", "Regulation of TNFR1 signaling"], "R-RNO-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-SSC-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-CEL-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-MMU-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-CEL-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-CFA-1295596": ["r", "Spry regulation of FGF signaling"], "R-RNO-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-BTA-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-HSA-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-BTA-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-SCE-917937": ["r", "Iron uptake and transport"], "R-SCE-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-RNO-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-GGA-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-BTA-5656169": ["r", "Termination of translesion DNA synthesis"], "R-MMU-8983711": ["r", "OAS antiviral response"], "R-DME-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-SSC-6783310": ["r", "Fanconi Anemia Pathway"], "R-SSC-6782135": ["r", "Dual incision in TC-NER"], "R-DME-9646399": ["r", "Aggrephagy"], "R-DME-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-RNO-5696400": ["r", "Dual Incision in GG-NER"], "R-SCE-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-SSC-9770562": ["r", "mRNA Polyadenylation"], "R-MMU-2559585": ["r", "Oncogene Induced Senescence"], "R-DME-209560": ["r", "NF-kB is activated and signals survival"], "R-BTA-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-CFA-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-CFA-69541": ["r", "Stabilization of p53"], "R-XTR-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-DDI-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-GGA-1227888": ["r", "Negative Regulation of MDA5 signaling"], "R-HSA-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-GGA-5675482": ["r", "Regulation of necroptotic cell death"], "R-BTA-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-GGA-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-HSA-9694631": ["r", "Maturation of nucleoprotein"], "R-RNO-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-BTA-3065679": ["r", "SUMO is proteolytically processed"], "R-MMU-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-CFA-912631": ["r", "Regulation of signaling by CBL"], "R-GGA-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-DME-6804757": ["r", "Regulation of TP53 Degradation"], "R-SSC-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-BTA-110312": ["r", "Translesion synthesis by REV1"], "R-CEL-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-MMU-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-CFA-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-DME-68949": ["r", "Orc1 removal from chromatin"], "R-BTA-5689877": ["r", "Josephin domain DUBs"], "R-RNO-4655427": ["r", "SUMOylation of DNA methylation proteins"], "R-BTA-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-GGA-201681": ["r", "TCF dependent signaling in response to WNT"], "R-RNO-5675482": ["r", "Regulation of necroptotic cell death"], "R-SSC-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "R-GGA-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-CFA-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-RNO-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-RNO-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-CEL-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-CFA-2559585": ["r", "Oncogene Induced Senescence"], "R-CFA-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-GGA-433871": ["r", "TRAF6 mediated induction of proinflammatory cytokines"], "R-RNO-5656121": ["r", "Translesion synthesis by POLI"], "R-RNO-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-RNO-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "R-SPO-8951664": ["r", "Neddylation"], "R-BTA-205043": ["r", "NRIF signals cell death from the nucleus"], "R-GGA-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-CFA-5689901": ["r", "Metalloprotease DUBs"], "R-CFA-209560": ["r", "NF-kB is activated and signals survival"], "R-DME-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-GGA-9020702": ["r", "Interleukin-1 signaling"], "R-CFA-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-DDI-9664873": ["r", "Pexophagy"], "R-CEL-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-CFA-202424": ["r", "Downstream TCR signaling"], "R-CFA-5689896": ["r", "Ovarian tumor domain proteases"], "R-MMU-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-HSA-5678420": ["r", "Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome"], "R-RNO-422356": ["r", "Regulation of insulin secretion"], "R-RNO-1296025": ["r", "ATP sensitive Potassium channels"], "R-MMU-1296025": ["r", "ATP sensitive Potassium channels"], "R-HSA-1296025": ["r", "ATP sensitive Potassium channels"], "R-HSA-5683177": ["r", "Defective ABCC8 can cause hypo- and hyper-glycemias"], "R-HSA-9913143": ["r", "Antimicrobial resistance"], "R-HSA-5250968": ["r", "Toxicity of botulinum toxin type A (botA)"], "R-HSA-5250971": ["r", "Toxicity of botulinum toxin type C (botC)"], "R-HSA-5250982": ["r", "Toxicity of tetanus toxin (tetX)"], "R-HSA-5250992": ["r", "Toxicity of botulinum toxin type E (botE)"], "R-HSA-5250955": ["r", "Toxicity of botulinum toxin type D (botD)"], "R-HSA-5250981": ["r", "Toxicity of botulinum toxin type F (botF)"], "PWY-7199": ["t", "pyrimidine deoxyribonucleosides salvage"], "PWY-7187": ["t", "pyrimidine deoxyribonucleotides de novo biosynthesis II"], "PWY-3841": ["t", "folate transformations II (plants)"], "R-SCE-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-DME-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-SPO-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-RNO-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-DDI-389599": ["r", "Alpha-oxidation of phytanate"], "R-SCE-389599": ["r", "Alpha-oxidation of phytanate"], "R-CEL-210991": ["r", "Basigin interactions"], "R-RNO-210991": ["r", "Basigin interactions"], "R-DME-210991": ["r", "Basigin interactions"], "R-MMU-210991": ["r", "Basigin interactions"], "R-SSC-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-CEL-936837": ["r", "Ion transport by P-type ATPases"], "R-CFA-936837": ["r", "Ion transport by P-type ATPases"], "R-HSA-210991": ["r", "Basigin interactions"], "R-SCE-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-HSA-3270619": ["r", "IRF3-mediated induction of type I IFN"], "R-SCE-1632852": ["r", "Macroautophagy"], "R-MMU-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-DME-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-DDI-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-MMU-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-RNO-168138": ["r", "Toll Like Receptor 9 (TLR9) Cascade"], "R-XTR-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-DME-176187": ["r", "Activation of ATR in response to replication stress"], "R-HSA-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-CEL-6804757": ["r", "Regulation of TP53 Degradation"], "R-HSA-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-XTR-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-SPO-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-RNO-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-GGA-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-CEL-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-SPO-9930044": ["r", "Nuclear RNA decay"], "R-XTR-113418": ["r", "Formation of the Early Elongation Complex"], "R-DRE-9930044": ["r", "Nuclear RNA decay"], "R-HSA-72200": ["r", "mRNA Editing: C to U Conversion"], "R-CEL-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-SCE-166208": ["r", "mTORC1-mediated signalling"], "R-MMU-9930044": ["r", "Nuclear RNA decay"], "R-HSA-9694686": ["r", "Replication of the SARS-CoV-2 genome"], "R-DME-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-XTR-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-MMU-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-HSA-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-SCE-429947": ["r", "Deadenylation of mRNA"], "R-RNO-9634638": ["r", "Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "R-HSA-428359": ["r", "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"], "R-CEL-9629569": ["r", "Protein hydroxylation"], "R-SPO-166208": ["r", "mTORC1-mediated signalling"], "R-RNO-9930044": ["r", "Nuclear RNA decay"], "R-XTR-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-DDI-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-HSA-8849468": ["r", "PTK6 Regulates Proteins Involved in RNA Processing"], "R-CEL-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-DRE-72163": ["r", "mRNA Splicing - Major Pathway"], "R-HSA-9836573": ["r", "Mitochondrial RNA degradation"], "R-MMU-72200": ["r", "mRNA Editing: C to U Conversion"], "R-MMU-429947": ["r", "Deadenylation of mRNA"], "R-MMU-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-MMU-2980766": ["r", "Nuclear Envelope Breakdown"], "R-SPO-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-SSC-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-RNO-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-BTA-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-HSA-9022707": ["r", "MECP2 regulates transcription factors"], "R-SPO-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-XTR-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-XTR-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-SSC-72163": ["r", "mRNA Splicing - Major Pathway"], "R-XTR-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-SSC-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-BTA-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-MMU-9629569": ["r", "Protein hydroxylation"], "R-DDI-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-HSA-9909620": ["r", "Regulation of PD-L1(CD274) translation"], "R-CEL-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-RNO-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-MMU-426496": ["r", "Post-transcriptional silencing by small RNAs"], "R-DRE-113418": ["r", "Formation of the Early Elongation Complex"], "R-RNO-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-SSC-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-RNO-72200": ["r", "mRNA Editing: C to U Conversion"], "R-SCE-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-XTR-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-HSA-75094": ["r", "Formation of the Editosome"], "R-RNO-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-CEL-9930044": ["r", "Nuclear RNA decay"], "R-CFA-200425": ["r", "Carnitine shuttle"], "R-MMU-8866910": ["r", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "R-CEL-4090294": ["r", "SUMOylation of intracellular receptors"], "R-RNO-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-SSC-5689896": ["r", "Ovarian tumor domain proteases"], "R-XTR-383280": ["r", "Nuclear Receptor transcription pathway"], "R-BTA-4090294": ["r", "SUMOylation of intracellular receptors"], "R-DME-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-CFA-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-CFA-5362517": ["r", "Signaling by Retinoic Acid"], "R-RNO-8866910": ["r", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "R-HSA-9768777": ["r", "Regulation of NPAS4 gene transcription"], "R-DRE-1257604": ["r", "PIP3 activates AKT signaling"], "R-DRE-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-BTA-8939211": ["r", "ESR-mediated signaling"], "R-GGA-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-BTA-8866910": ["r", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "R-BTA-9623433": ["r", "NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis"], "R-HSA-8939211": ["r", "ESR-mediated signaling"], "R-BTA-1251985": ["r", "Nuclear signaling by ERBB4"], "R-DRE-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-MMU-8939211": ["r", "ESR-mediated signaling"], "R-CEL-9841922": ["r", "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis"], "R-BTA-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-SSC-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-CFA-383280": ["r", "Nuclear Receptor transcription pathway"], "R-DRE-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-SSC-1257604": ["r", "PIP3 activates AKT signaling"], "R-HSA-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-DME-8866427": ["r", "VLDLR internalisation and degradation"], "R-RNO-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-CEL-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-SSC-8866910": ["r", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "R-BTA-9029569": ["r", "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"], "R-MMU-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-DRE-5689896": ["r", "Ovarian tumor domain proteases"], "R-SSC-8940973": ["r", "RUNX2 regulates osteoblast differentiation"], "R-DME-4090294": ["r", "SUMOylation of intracellular receptors"], "R-DRE-8939211": ["r", "ESR-mediated signaling"], "R-BTA-5689896": ["r", "Ovarian tumor domain proteases"], "R-CEL-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-SSC-8931987": ["r", "RUNX1 regulates estrogen receptor mediated transcription"], "R-BTA-381340": ["r", "Transcriptional regulation of white adipocyte differentiation"], "R-BTA-110320": ["r", "Translesion Synthesis by POLH"], "R-SSC-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-GGA-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-CFA-8951664": ["r", "Neddylation"], "R-MMU-110320": ["r", "Translesion Synthesis by POLH"], "R-SSC-909733": ["r", "Interferon alpha/beta signaling"], "R-SSC-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-CFA-5656121": ["r", "Translesion synthesis by POLI"], "R-RNO-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-CFA-9648002": ["r", "RAS processing"], "R-CFA-9932298": ["r", "Degradation of CRY and PER proteins"], "R-CFA-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-RNO-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-BTA-937039": ["r", "IRAK1 recruits IKK complex"], "R-SSC-209560": ["r", "NF-kB is activated and signals survival"], "R-SSC-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-RNO-110320": ["r", "Translesion Synthesis by POLH"], "R-DRE-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-SCE-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-HSA-9683683": ["r", "Maturation of protein E"], "R-GGA-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-SPO-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-GGA-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-DRE-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-GGA-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-CFA-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-BTA-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-CFA-9861718": ["r", "Regulation of pyruvate metabolism"], "R-CFA-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-GGA-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-GGA-5632684": ["r", "Hedgehog 'on' state"], "R-DME-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-SSC-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-GGA-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-HSA-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-CFA-205043": ["r", "NRIF signals cell death from the nucleus"], "R-MMU-917937": ["r", "Iron uptake and transport"], "R-SSC-917937": ["r", "Iron uptake and transport"], "R-GGA-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-BTA-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-GGA-6783310": ["r", "Fanconi Anemia Pathway"], "R-DME-5357905": ["r", "Regulation of TNFR1 signaling"], "R-DME-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-SSC-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-SSC-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-BTA-69231": ["r", "Cyclin D associated events in G1"], "R-DME-5656121": ["r", "Translesion synthesis by POLI"], "R-GGA-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-GGA-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-GGA-4641257": ["r", "Degradation of AXIN"], "R-CFA-6783310": ["r", "Fanconi Anemia Pathway"], "R-BTA-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-CFA-9020702": ["r", "Interleukin-1 signaling"], "R-HSA-110312": ["r", "Translesion synthesis by REV1"], "R-CFA-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-CEL-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-CFA-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-CEL-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-DRE-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-CFA-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-DME-382556": ["r", "ABC-family proteins mediated transport"], "R-DME-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-CFA-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-RNO-2672351": ["r", "Stimuli-sensing channels"], "R-DDI-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-BTA-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-DME-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-SSC-6807004": ["r", "Negative regulation of MET activity"], "R-RNO-6782135": ["r", "Dual incision in TC-NER"], "R-DRE-4755510": ["r", "SUMOylation of immune response proteins"], "R-GGA-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-XTR-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-RNO-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-XTR-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-GGA-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-DME-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-SPO-3899300": ["r", "SUMOylation of transcription cofactors"], "R-SCE-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-DDI-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-DDI-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-SPO-9664873": ["r", "Pexophagy"], "R-SPO-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-SCE-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-DRE-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-HSA-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-CEL-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-DRE-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-MMU-176187": ["r", "Activation of ATR in response to replication stress"], "R-DRE-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-SPO-1632852": ["r", "Macroautophagy"], "R-CEL-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-XTR-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-SCE-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-GGA-353423": ["r", "Non-homologous end joining (NHEJ)"], "R-DDI-3371571": ["r", "HSF1-dependent transactivation"], "R-DDI-8943724": ["r", "Regulation of PTEN gene transcription"], "R-DDI-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-SPO-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-DDI-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-RNO-3371571": ["r", "HSF1-dependent transactivation"], "R-XTR-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-DME-1632852": ["r", "Macroautophagy"], "R-SPO-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-DME-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-SCE-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-DME-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-CEL-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-MMU-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-DDI-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-HSA-176187": ["r", "Activation of ATR in response to replication stress"], "R-DRE-1251985": ["r", "Nuclear signaling by ERBB4"], "R-RNO-8939211": ["r", "ESR-mediated signaling"], "R-DME-6806664": ["r", "Metabolism of vitamin K"], "R-DDI-6806664": ["r", "Metabolism of vitamin K"], "R-DME-2142789": ["r", "Ubiquinol biosynthesis"], "R-XTR-6806664": ["r", "Metabolism of vitamin K"], "R-HSA-6806664": ["r", "Metabolism of vitamin K"], "R-MMU-6806664": ["r", "Metabolism of vitamin K"], "R-RNO-6806664": ["r", "Metabolism of vitamin K"], "R-DRE-6806664": ["r", "Metabolism of vitamin K"], "R-CEL-2142789": ["r", "Ubiquinol biosynthesis"], "R-RNO-2142845": ["r", "Hyaluronan metabolism"], "R-BTA-2142845": ["r", "Hyaluronan metabolism"], "R-HSA-2142845": ["r", "Hyaluronan metabolism"], "R-SSC-2022854": ["r", "Keratan sulfate biosynthesis"], "R-SSC-2022857": ["r", "Keratan sulfate degradation"], "R-HSA-2022857": ["r", "Keratan sulfate degradation"], "R-MMU-2160916": ["r", "Hyaluronan degradation"], "R-MMU-2142845": ["r", "Hyaluronan metabolism"], "R-MMU-2022854": ["r", "Keratan sulfate biosynthesis"], "R-RNO-2022857": ["r", "Keratan sulfate degradation"], "R-HSA-3656244": ["r", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "R-HSA-2022854": ["r", "Keratan sulfate biosynthesis"], "R-HSA-3656243": ["r", "Defective ST3GAL3 causes MCT12 and EIEE15"], "R-HSA-3656225": ["r", "Defective CHST6 causes MCDC1"], "R-HSA-3000497": ["r", "Scavenging by Class H Receptors"], "R-MMU-3000497": ["r", "Scavenging by Class H Receptors"], "R-BTA-2160916": ["r", "Hyaluronan degradation"], "R-HSA-2160916": ["r", "Hyaluronan degradation"], "R-MMU-2022857": ["r", "Keratan sulfate degradation"], "R-RNO-2022854": ["r", "Keratan sulfate biosynthesis"], "R-RNO-2160916": ["r", "Hyaluronan degradation"], "R-DRE-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-GGA-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-DME-216217": ["r", "Activation of SMO"], "R-DRE-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-DME-4086400": ["r", "PCP/CE pathway"], "R-DRE-5610787": ["r", "Hedgehog 'off' state"], "R-DRE-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-DME-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-DME-209472": ["r", "Assembly of receptor complex"], "R-DME-5610787": ["r", "Hedgehog 'off' state"], "R-RNO-4086400": ["r", "PCP/CE pathway"], "R-DRE-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-MMU-4086400": ["r", "PCP/CE pathway"], "R-DME-209387": ["r", "Phosphorylation of ARR"], "R-DME-216119": ["r", "Activation of CI"], "R-GGA-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-DRE-5635838": ["r", "Activation of SMO"], "R-DME-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-GGA-4086398": ["r", "Ca2+ pathway"], "PWY-6626": ["t", "cytidine-5'-diphosphate-glycerol biosynthesis"], "PWY-7529": ["t", "CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"], "PWY-7888": ["t", "tRNA-uridine 2-thiolation (cytoplasmic)"], "PWY-6322": ["t", "phosphinothricin tripeptide biosynthesis"], "PWY-7769": ["t", "phosalacine biosynthesis"], "PWY-7904": ["t", "tRNA-uridine 2-thiolation (thermophilic bacteria)"], "PWY-6749": ["t", "CMP-legionaminate biosynthesis I"], "PWY-6998": ["t", "CDP-D-arabitol biosynthesis"], "PWY-7127": ["t", "CDP-D-mannitol biosynthesis"], "PWY-8117": ["t", "colibactin biosynthesis"], "PWY-7706": ["t", "dapdiamides biosynthesis"], "R-SSC-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-DRE-1483191": ["r", "Synthesis of PC"], "R-RNO-1483191": ["r", "Synthesis of PC"], "R-HSA-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-XTR-200425": ["r", "Carnitine shuttle"], "R-MMU-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-SCE-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-DRE-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-RNO-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "PWY-7524": ["t", "mevalonate pathway III (Thermoplasma)"], "PWY-7391": ["t", "isoprene biosynthesis II (engineered)"], "PWY-922": ["t", "mevalonate pathway I (eukaryotes and bacteria)"], "PWY-8125": ["t", "mevalonate pathway IV (archaea)"], "PWY-6174": ["t", "mevalonate pathway II (haloarchaea)"], "PWY-7571": ["t", "ferrichrome A biosynthesis"], "R-CEL-9969896": ["r", "Lanosterol biosynthesis"], "R-SPO-77111": ["r", "Synthesis of Ketone Bodies"], "R-SCE-77111": ["r", "Synthesis of Ketone Bodies"], "R-SSC-77111": ["r", "Synthesis of Ketone Bodies"], "R-CEL-77111": ["r", "Synthesis of Ketone Bodies"], "R-XTR-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-XTR-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-DME-350369": ["r", "Negative feedback loop regulates asymmetric localisation"], "R-XTR-4086400": ["r", "PCP/CE pathway"], "R-SCE-418594": ["r", "G alpha (i) signalling events"], "R-BTA-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-XTR-201688": ["r", "WNT mediated activation of DVL"], "R-CEL-201688": ["r", "WNT mediated activation of DVL"], "R-RNO-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-HSA-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-DME-5099900": ["r", "WNT5A-dependent internalization of FZD4"], "R-DME-5663220": ["r", "RHO GTPases Activate Formins"], "R-CEL-4086400": ["r", "PCP/CE pathway"], "R-XTR-4641258": ["r", "Degradation of DVL"], "R-RNO-201688": ["r", "WNT mediated activation of DVL"], "R-CEL-5663220": ["r", "RHO GTPases Activate Formins"], "R-MMU-422356": ["r", "Regulation of insulin secretion"], "R-HSA-5368598": ["r", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins"], "R-DME-4641258": ["r", "Degradation of DVL"], "R-MMU-201688": ["r", "WNT mediated activation of DVL"], "R-CEL-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-MMU-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-XTR-8856828": ["r", "Clathrin-mediated endocytosis"], "R-HSA-201688": ["r", "WNT mediated activation of DVL"], "R-HSA-429947": ["r", "Deadenylation of mRNA"], "R-CEL-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-HSA-9820841": ["r", "M-decay: degradation of maternal mRNAs by maternally stored factors"], "R-DDI-3899300": ["r", "SUMOylation of transcription cofactors"], "R-RNO-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-DME-429947": ["r", "Deadenylation of mRNA"], "R-HSA-9682706": ["r", "Replication of the SARS-CoV-1 genome"], "R-DRE-191859": ["r", "snRNP Assembly"], "R-HSA-9820865": ["r", "Z-decay: degradation of maternal mRNAs by zygotically expressed factors"], "R-GGA-72163": ["r", "mRNA Splicing - Major Pathway"], "R-BTA-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DME-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-BTA-429947": ["r", "Deadenylation of mRNA"], "R-SCE-3899300": ["r", "SUMOylation of transcription cofactors"], "R-DME-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-RNO-429947": ["r", "Deadenylation of mRNA"], "R-SPO-429947": ["r", "Deadenylation of mRNA"], "R-XTR-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-XTR-72163": ["r", "mRNA Splicing - Major Pathway"], "R-XTR-429947": ["r", "Deadenylation of mRNA"], "R-XTR-975957": ["r", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "R-DRE-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-DDI-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-GGA-429947": ["r", "Deadenylation of mRNA"], "R-BTA-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-DME-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-CEL-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-SCE-9664873": ["r", "Pexophagy"], "R-DME-5693607": ["r", "Processing of DNA double-strand break ends"], "R-RNO-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-DME-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-CEL-1632852": ["r", "Macroautophagy"], "R-SCE-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-DDI-5693607": ["r", "Processing of DNA double-strand break ends"], "R-RNO-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-MMU-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-RNO-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-MMU-209563": ["r", "Axonal growth stimulation"], "R-RNO-209563": ["r", "Axonal growth stimulation"], "R-HSA-209563": ["r", "Axonal growth stimulation"], "R-CEL-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-SCE-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-SPO-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-HSA-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-RNO-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-XTR-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-MMU-8850843": ["r", "Phosphate bond hydrolysis by NTPDase proteins"], "R-SCE-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-MMU-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-HSA-6793080": ["r", "rRNA modification in the mitochondrion"], "R-CEL-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-HSA-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-SCE-264642": ["r", "Acetylcholine Neurotransmitter Release Cycle"], "R-BTA-200425": ["r", "Carnitine shuttle"], "R-DME-1483191": ["r", "Synthesis of PC"], "R-BTA-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-SSC-1483191": ["r", "Synthesis of PC"], "PWY-7382": ["t", "lipoate biosynthesis and incorporation IV (yeast)"], "PWY-6987": ["t", "lipoate biosynthesis and incorporation III (Bacillus)"], "R-XTR-9857492": ["r", "Protein lipoylation"], "R-DRE-9857492": ["r", "Protein lipoylation"], "R-HSA-5653890": ["r", "Lactose synthesis"], "R-SSC-5653890": ["r", "Lactose synthesis"], "R-MMU-5653890": ["r", "Lactose synthesis"], "R-SPO-437239": ["r", "Recycling pathway of L1"], "R-SCE-8856828": ["r", "Clathrin-mediated endocytosis"], "R-DME-190873": ["r", "Gap junction degradation"], "R-DME-8964038": ["r", "LDL clearance"], "R-DDI-8964038": ["r", "LDL clearance"], "R-DME-177504": ["r", "Retrograde neurotrophin signalling"], "R-DME-196025": ["r", "Formation of annular gap junctions"], "R-CEL-8866427": ["r", "VLDLR internalisation and degradation"], "R-CEL-8964038": ["r", "LDL clearance"], "R-SCE-196025": ["r", "Formation of annular gap junctions"], "R-SPO-196025": ["r", "Formation of annular gap junctions"], "R-CEL-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-CEL-190873": ["r", "Gap junction degradation"], "R-DDI-437239": ["r", "Recycling pathway of L1"], "R-CEL-437239": ["r", "Recycling pathway of L1"], "R-SCE-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-DDI-8866427": ["r", "VLDLR internalisation and degradation"], "R-SPO-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-CEL-196025": ["r", "Formation of annular gap junctions"], "R-DDI-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-DME-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-SPO-8856828": ["r", "Clathrin-mediated endocytosis"], "R-SCE-437239": ["r", "Recycling pathway of L1"], "R-BTA-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "PWY-7853": ["t", "6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus)"], "PWY-7852": ["t", "6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)"], "R-PFA-72689": ["r", "Formation of a pool of free 40S subunits"], "R-PFA-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-PFA-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-PFA-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-DME-201688": ["r", "WNT mediated activation of DVL"], "R-SPO-418594": ["r", "G alpha (i) signalling events"], "R-DME-196807": ["r", "Nicotinate metabolism"], "R-DRE-196807": ["r", "Nicotinate metabolism"], "R-DDI-196807": ["r", "Nicotinate metabolism"], "R-RNO-196807": ["r", "Nicotinate metabolism"], "R-SSC-5674135": ["r", "MAP2K and MAPK activation"], "R-XTR-525793": ["r", "Myogenesis"], "R-CEL-114608": ["r", "Platelet degranulation"], "R-GGA-9764561": ["r", "Regulation of CDH1 Function"], "R-HSA-8849175": ["r", "Threonine catabolism"], "R-SCE-8849175": ["r", "Threonine catabolism"], "R-RNO-977347": ["r", "Serine metabolism"], "R-DDI-8849175": ["r", "Threonine catabolism"], "R-MMU-8849175": ["r", "Threonine catabolism"], "R-RNO-8849175": ["r", "Threonine catabolism"], "R-BTA-977347": ["r", "Serine metabolism"], "R-MMU-9818564": ["r", "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "R-HSA-9818564": ["r", "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "R-DME-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-MMU-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-SPO-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-CEL-936440": ["r", "Negative regulators of DDX58/IFIH1 signaling"], "R-HSA-9937008": ["r", "Mitochondrial mRNA modification"], "R-CEL-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-HSA-5626978": ["r", "TNFR1-mediated ceramide production"], "R-MMU-5626978": ["r", "TNFR1-mediated ceramide production"], "R-HSA-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-HSA-163615": ["r", "PKA activation"], "R-DME-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-CEL-3000178": ["r", "ECM proteoglycans"], "R-CEL-202733": ["r", "Cell surface interactions at the vascular wall"], "R-CEL-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-BTA-9634597": ["r", "GPER1 signaling"], "R-CEL-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-DME-354192": ["r", "Integrin signaling"], "R-HSA-447041": ["r", "CHL1 interactions"], "R-DME-216083": ["r", "Integrin cell surface interactions"], "R-HSA-75892": ["r", "Platelet Adhesion to exposed collagen"], "R-DDI-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-BTA-1566977": ["r", "Fibronectin matrix formation"], "R-CEL-1566977": ["r", "Fibronectin matrix formation"], "R-DME-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-DME-2129379": ["r", "Molecules associated with elastic fibres"], "R-BTA-8874081": ["r", "MET activates PTK2 signaling"], "R-DME-202733": ["r", "Cell surface interactions at the vascular wall"], "R-DME-209968": ["r", "Thyroxine biosynthesis"], "R-DRE-209968": ["r", "Thyroxine biosynthesis"], "R-CEL-209968": ["r", "Thyroxine biosynthesis"], "PWY-6897": ["t", "thiamine diphosphate salvage II"], "PWY-7356": ["t", "thiamine diphosphate salvage IV (yeast)"], "PWY-7357": ["t", "thiamine diphosphate formation from pyrithiamine and oxythiamine (yeast)"], "PWY-8457": ["t", "thiamine diphosphate salvage V"], "R-BTA-2559585": ["r", "Oncogene Induced Senescence"], "R-HSA-2559585": ["r", "Oncogene Induced Senescence"], "R-CEL-2559585": ["r", "Oncogene Induced Senescence"], "R-PFA-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-GGA-1632852": ["r", "Macroautophagy"], "R-SCE-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-SSC-947581": ["r", "Molybdenum cofactor biosynthesis"], "R-CEL-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-MTU-936654": ["r", "Cysteine synthesis from O-phosphoserine"], "R-SCE-164378": ["r", "PKA activation in glucagon signalling"], "R-DDI-180024": ["r", "DARPP-32 events"], "R-PFA-8963896": ["r", "HDL assembly"], "R-PFA-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-MMU-1296061": ["r", "HCN channels"], "R-PFA-180024": ["r", "DARPP-32 events"], "R-HSA-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-DME-164378": ["r", "PKA activation in glucagon signalling"], "R-RNO-164378": ["r", "PKA activation in glucagon signalling"], "R-DME-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-SPO-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-CEL-6814848": ["r", "Glycerophospholipid catabolism"], "R-PFA-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-PFA-5610787": ["r", "Hedgehog 'off' state"], "R-SPO-5610787": ["r", "Hedgehog 'off' state"], "R-CEL-9648002": ["r", "RAS processing"], "R-DME-9648002": ["r", "RAS processing"], "R-DRE-163615": ["r", "PKA activation"], "R-DME-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-CEL-180024": ["r", "DARPP-32 events"], "R-HSA-164378": ["r", "PKA activation in glucagon signalling"], "R-BTA-164378": ["r", "PKA activation in glucagon signalling"], "R-GGA-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-GGA-164378": ["r", "PKA activation in glucagon signalling"], "R-HSA-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-HSA-6814848": ["r", "Glycerophospholipid catabolism"], "R-PFA-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-BTA-163615": ["r", "PKA activation"], "R-DME-6814848": ["r", "Glycerophospholipid catabolism"], "R-DDI-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-MMU-418457": ["r", "cGMP effects"], "R-DDI-163615": ["r", "PKA activation"], "R-GGA-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-CEL-164378": ["r", "PKA activation in glucagon signalling"], "R-MMU-163615": ["r", "PKA activation"], "R-SPO-164378": ["r", "PKA activation in glucagon signalling"], "R-DDI-9634597": ["r", "GPER1 signaling"], "R-CEL-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-CEL-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-RNO-418457": ["r", "cGMP effects"], "R-CEL-2485179": ["r", "Activation of the phototransduction cascade"], "R-PFA-9837999": ["r", "Mitochondrial protein degradation"], "R-DRE-164378": ["r", "PKA activation in glucagon signalling"], "R-RNO-1296061": ["r", "HCN channels"], "R-SPO-180024": ["r", "DARPP-32 events"], "R-MMU-164378": ["r", "PKA activation in glucagon signalling"], "R-BTA-418457": ["r", "cGMP effects"], "R-MMU-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-DRE-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-CEL-9634597": ["r", "GPER1 signaling"], "R-GGA-2485179": ["r", "Activation of the phototransduction cascade"], "R-SPO-6814848": ["r", "Glycerophospholipid catabolism"], "R-PFA-9634597": ["r", "GPER1 signaling"], "R-BTA-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-SCE-163615": ["r", "PKA activation"], "R-SCE-180024": ["r", "DARPP-32 events"], "R-DME-9634597": ["r", "GPER1 signaling"], "R-SSC-211945": ["r", "Phase I - Functionalization of compounds"], "R-DME-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-SCE-8876725": ["r", "Protein methylation"], "R-RNO-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-CEL-156902": ["r", "Peptide chain elongation"], "R-BTA-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-DRE-156902": ["r", "Peptide chain elongation"], "R-DME-156902": ["r", "Peptide chain elongation"], "R-SPO-156902": ["r", "Peptide chain elongation"], "R-SPO-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-DDI-156902": ["r", "Peptide chain elongation"], "R-BTA-8876725": ["r", "Protein methylation"], "R-DRE-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-RNO-156902": ["r", "Peptide chain elongation"], "R-SCE-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-CEL-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-CEL-8876725": ["r", "Protein methylation"], "R-SPO-8876725": ["r", "Protein methylation"], "R-DDI-8876725": ["r", "Protein methylation"], "R-MMU-156902": ["r", "Peptide chain elongation"], "R-DME-8876725": ["r", "Protein methylation"], "R-DRE-8876725": ["r", "Protein methylation"], "R-MMU-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-SCE-156902": ["r", "Peptide chain elongation"], "R-BTA-156902": ["r", "Peptide chain elongation"], "R-HSA-5358493": ["r", "Synthesis of diphthamide-EEF2"], "R-DDI-5358493": ["r", "Synthesis of diphthamide-EEF2"], "PWY-8119": ["t", "microcin B17 biosynthesis"], "R-SPO-9840373": ["r", "Cellular response to mitochondrial stress"], "R-SCE-9840373": ["r", "Cellular response to mitochondrial stress"], "PWY-6261": ["t", "thyroid hormone metabolism II (via conjugation and/or degradation)"], "PWY-6260": ["t", "thyroid hormone metabolism I (via deiodination)"], "R-RNO-350864": ["r", "Regulation of thyroid hormone activity"], "R-CFA-350864": ["r", "Regulation of thyroid hormone activity"], "R-BTA-350864": ["r", "Regulation of thyroid hormone activity"], "R-SSC-350864": ["r", "Regulation of thyroid hormone activity"], "R-MMU-350864": ["r", "Regulation of thyroid hormone activity"], "R-HSA-350864": ["r", "Regulation of thyroid hormone activity"], "R-CFA-2672351": ["r", "Stimuli-sensing channels"], "R-SCE-2672351": ["r", "Stimuli-sensing channels"], "R-SPO-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-HSA-9613354": ["r", "Lipophagy"], "R-DDI-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-MMU-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-SSC-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-HSA-2151209": ["r", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation"], "R-BTA-1632852": ["r", "Macroautophagy"], "R-SSC-1632852": ["r", "Macroautophagy"], "R-BTA-9748787": ["r", "Azathioprine ADME"], "R-SPO-2672351": ["r", "Stimuli-sensing channels"], "R-DDI-9748787": ["r", "Azathioprine ADME"], "R-BTA-2672351": ["r", "Stimuli-sensing channels"], "R-DDI-2672351": ["r", "Stimuli-sensing channels"], "R-SSC-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-SCE-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-SSC-2672351": ["r", "Stimuli-sensing channels"], "R-DRE-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-SCE-9748787": ["r", "Azathioprine ADME"], "R-DRE-9748787": ["r", "Azathioprine ADME"], "R-SCE-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-SPO-9748787": ["r", "Azathioprine ADME"], "R-HSA-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-DDI-192105": ["r", "Synthesis of bile acids and bile salts"], "R-SCE-1482801": ["r", "Acyl chain remodelling of PS"], "R-SPO-192105": ["r", "Synthesis of bile acids and bile salts"], "R-XTR-192105": ["r", "Synthesis of bile acids and bile salts"], "R-DDI-1482801": ["r", "Acyl chain remodelling of PS"], "R-SPO-1482801": ["r", "Acyl chain remodelling of PS"], "R-SCE-192105": ["r", "Synthesis of bile acids and bile salts"], "PWY-7174": ["t", "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"], "R-DME-2559585": ["r", "Oncogene Induced Senescence"], "R-MMU-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-BTA-8939247": ["r", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "R-DME-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-GGA-2559585": ["r", "Oncogene Induced Senescence"], "R-RNO-2559585": ["r", "Oncogene Induced Senescence"], "R-HSA-399956": ["r", "CRMPs in Sema3A signaling"], "R-DRE-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-HSA-9674519": ["r", "Defective F8 sulfation at Y1699"], "R-HSA-9672397": ["r", "Defective F8 secretion"], "R-DRE-194306": ["r", "Neurophilin interactions with VEGF and VEGFR"], "R-MMU-399956": ["r", "CRMPs in Sema3A signaling"], "R-MMU-3000171": ["r", "Non-integrin membrane-ECM interactions"], "R-HSA-9672387": ["r", "Defective F8 accelerates dissociation of the A2 domain"], "R-HSA-447038": ["r", "NrCAM interactions"], "R-HSA-9672395": ["r", "Defective F8 binding to the cell membrane"], "R-HSA-9672393": ["r", "Defective F8 binding to von Willebrand factor"], "R-RNO-3000171": ["r", "Non-integrin membrane-ECM interactions"], "R-HSA-447043": ["r", "Neurofascin interactions"], "R-RNO-399956": ["r", "CRMPs in Sema3A signaling"], "R-HSA-5083635": ["r", "Defective B3GALTL causes PpS"], "R-MMU-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-HSA-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-HSA-194306": ["r", "Neurophilin interactions with VEGF and VEGFR"], "R-RNO-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-HSA-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-RNO-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-DRE-399956": ["r", "CRMPs in Sema3A signaling"], "R-MMU-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-MMU-194306": ["r", "Neurophilin interactions with VEGF and VEGFR"], "R-RNO-194306": ["r", "Neurophilin interactions with VEGF and VEGFR"], "R-CEL-3000171": ["r", "Non-integrin membrane-ECM interactions"], "PWY-6168": ["t", "flavin biosynthesis III (fungi)"], "PWY-6167": ["t", "flavin biosynthesis II (archaea)"], "R-DRE-9837999": ["r", "Mitochondrial protein degradation"], "R-CEL-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-MMU-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-DME-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-RNO-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-DRE-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-HSA-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-CFA-432047": ["r", "Passive transport by Aquaporins"], "R-HSA-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-RNO-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-RNO-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-DME-432047": ["r", "Passive transport by Aquaporins"], "R-DME-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-HSA-432030": ["r", "Transport of glycerol from adipocytes to the liver by Aquaporins"], "R-HSA-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-BTA-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-DDI-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-RNO-432047": ["r", "Passive transport by Aquaporins"], "R-CFA-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-SPO-432047": ["r", "Passive transport by Aquaporins"], "R-SPO-432030": ["r", "Transport of glycerol from adipocytes to the liver by Aquaporins"], "R-DDI-432047": ["r", "Passive transport by Aquaporins"], "R-CFA-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-MMU-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-DDI-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-DME-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-MMU-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-SSC-432047": ["r", "Passive transport by Aquaporins"], "R-DDI-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-SCE-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-BTA-432047": ["r", "Passive transport by Aquaporins"], "R-GGA-432047": ["r", "Passive transport by Aquaporins"], "R-MMU-432047": ["r", "Passive transport by Aquaporins"], "R-SCE-432030": ["r", "Transport of glycerol from adipocytes to the liver by Aquaporins"], "R-RNO-432030": ["r", "Transport of glycerol from adipocytes to the liver by Aquaporins"], "R-PFA-432047": ["r", "Passive transport by Aquaporins"], "R-PFA-432030": ["r", "Transport of glycerol from adipocytes to the liver by Aquaporins"], "R-HSA-432047": ["r", "Passive transport by Aquaporins"], "R-BTA-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-MMU-432030": ["r", "Transport of glycerol from adipocytes to the liver by Aquaporins"], "R-CFA-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-SCE-432047": ["r", "Passive transport by Aquaporins"], "R-DME-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-DME-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-DDI-5689901": ["r", "Metalloprotease DUBs"], "R-CEL-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DDI-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DME-202424": ["r", "Downstream TCR signaling"], "R-DME-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-DME-5689901": ["r", "Metalloprotease DUBs"], "R-DME-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-SSC-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DME-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-DME-9020702": ["r", "Interleukin-1 signaling"], "R-DME-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-DRE-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DME-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-DME-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-DME-209406": ["r", "Degradation of NF-kappa-B inhibitor, CACT"], "R-GGA-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-CEL-5689901": ["r", "Metalloprotease DUBs"], "R-HSA-418457": ["r", "cGMP effects"], "R-DRE-9634597": ["r", "GPER1 signaling"], "R-RNO-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-SCE-5610787": ["r", "Hedgehog 'off' state"], "R-CEL-163615": ["r", "PKA activation"], "R-DRE-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-PFA-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-MMU-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-SCE-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-SPO-9634597": ["r", "GPER1 signaling"], "R-SPO-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-DME-2485179": ["r", "Activation of the phototransduction cascade"], "R-PFA-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-CFA-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-GGA-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-RNO-163615": ["r", "PKA activation"], "R-PFA-163615": ["r", "PKA activation"], "R-DME-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-SCE-6814848": ["r", "Glycerophospholipid catabolism"], "R-DRE-180024": ["r", "DARPP-32 events"], "R-CEL-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-SPO-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-SPO-163615": ["r", "PKA activation"], "R-DME-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-GGA-163615": ["r", "PKA activation"], "R-CEL-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-HSA-1296061": ["r", "HCN channels"], "R-DME-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-MMU-180024": ["r", "DARPP-32 events"], "R-DME-163615": ["r", "PKA activation"], "R-GGA-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-DDI-164378": ["r", "PKA activation in glucagon signalling"], "R-SCE-9634597": ["r", "GPER1 signaling"], "R-CFA-2485179": ["r", "Activation of the phototransduction cascade"], "R-HSA-180024": ["r", "DARPP-32 events"], "R-GGA-180024": ["r", "DARPP-32 events"], "R-RNO-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-MMU-6814848": ["r", "Glycerophospholipid catabolism"], "R-GGA-5610787": ["r", "Hedgehog 'off' state"], "R-DME-180024": ["r", "DARPP-32 events"], "R-BTA-180024": ["r", "DARPP-32 events"], "R-DRE-442720": ["r", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "R-CEL-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-PFA-164378": ["r", "PKA activation in glucagon signalling"], "PWY-6531": ["t", "mannitol cycle"], "PWY-5030": ["t", "L-histidine degradation III"], "PWY-6613": ["t", "tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate"], "PWY-1722": ["t", "formate assimilation into 5,10-methylenetetrahydrofolate"], "PWY-2201": ["t", "folate transformations I"], "PWY-5497": ["t", "purine nucleobases degradation II (anaerobic)"], "PWY-8303": ["t", "reductive glycine pathway of autotrophic CO2 fixation"], "PWY-7909": ["t", "formaldehyde oxidation VII (THF pathway)"], "R-DME-196757": ["r", "Metabolism of folate and pterines"], "R-MMU-196757": ["r", "Metabolism of folate and pterines"], "R-BTA-196757": ["r", "Metabolism of folate and pterines"], "R-RNO-196757": ["r", "Metabolism of folate and pterines"], "R-SCE-196757": ["r", "Metabolism of folate and pterines"], "R-SPO-196757": ["r", "Metabolism of folate and pterines"], "R-HSA-196757": ["r", "Metabolism of folate and pterines"], "R-RNO-8851680": ["r", "Butyrophilin (BTN) family interactions"], "R-HSA-8851680": ["r", "Butyrophilin (BTN) family interactions"], "R-HSA-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-RNO-74259": ["r", "Purine catabolism"], "R-GGA-421178": ["r", "Urate synthesis"], "R-DME-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-MMU-8851680": ["r", "Butyrophilin (BTN) family interactions"], "R-HSA-74259": ["r", "Purine catabolism"], "R-RNO-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-DME-74259": ["r", "Purine catabolism"], "R-MMU-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-CEL-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-MMU-74259": ["r", "Purine catabolism"], "R-DDI-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-DDI-74259": ["r", "Purine catabolism"], "R-DRE-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-RNO-3232118": ["r", "SUMOylation of transcription factors"], "R-GGA-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-DME-5683826": ["r", "Surfactant metabolism"], "R-CFA-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-SPO-5676934": ["r", "Protein repair"], "R-HSA-5676934": ["r", "Protein repair"], "R-DDI-5676934": ["r", "Protein repair"], "R-DRE-5676934": ["r", "Protein repair"], "R-CEL-5676934": ["r", "Protein repair"], "R-SSC-5676934": ["r", "Protein repair"], "R-RNO-5676934": ["r", "Protein repair"], "R-MMU-5676934": ["r", "Protein repair"], "R-DME-5676934": ["r", "Protein repair"], "R-DME-1236974": ["r", "ER-Phagosome pathway"], "R-DME-2467813": ["r", "Separation of Sister Chromatids"], "R-DME-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-DME-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-RNO-5689901": ["r", "Metalloprotease DUBs"], "R-BTA-5689901": ["r", "Metalloprotease DUBs"], "R-GGA-72649": ["r", "Translation initiation complex formation"], "R-DME-9907900": ["r", "Proteasome assembly"], "R-DRE-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DME-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-SPO-5689901": ["r", "Metalloprotease DUBs"], "R-DME-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-DME-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-GGA-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-DME-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-HSA-4085001": ["r", "Sialic acid metabolism"], "R-HSA-4085011": ["r", "Defective GNE causes sialuria, NK and IBM2"], "R-MMU-4085001": ["r", "Sialic acid metabolism"], "R-RNO-4085001": ["r", "Sialic acid metabolism"], "R-MMU-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "R-RNO-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "R-BTA-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "R-DME-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-HSA-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-HSA-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "R-SPO-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "R-RNO-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-MMU-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-DDI-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "R-SCE-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "PWY-7511": ["t", "protein ubiquitination"], "R-GGA-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-DME-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-DRE-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-RNO-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-CEL-5357905": ["r", "Regulation of TNFR1 signaling"], "R-MMU-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-DDI-3232118": ["r", "SUMOylation of transcription factors"], "R-HSA-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-BTA-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-DRE-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-HSA-9956593": ["r", "Enterobacterial factors antagonize host defense"], "R-MMU-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-RNO-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-DRE-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-XTR-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-RNO-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-MMU-5357905": ["r", "Regulation of TNFR1 signaling"], "R-DME-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-HSA-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-DRE-3232118": ["r", "SUMOylation of transcription factors"], "R-XTR-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-GGA-5693607": ["r", "Processing of DNA double-strand break ends"], "R-DDI-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-MMU-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-RNO-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-DRE-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-XTR-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-DDI-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-BTA-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-DRE-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-CEL-201451": ["r", "Signaling by BMP"], "R-MMU-176412": ["r", "Phosphorylation of the APC/C"], "R-GGA-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-GGA-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-BTA-5357905": ["r", "Regulation of TNFR1 signaling"], "R-HSA-937039": ["r", "IRAK1 recruits IKK complex"], "R-MMU-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-HSA-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-CEL-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-DDI-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-DDI-5578775": ["r", "Ion homeostasis"], "R-CEL-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-RNO-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-DME-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-DDI-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-CEL-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-DME-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-CEL-5578775": ["r", "Ion homeostasis"], "R-SPO-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-SSC-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-BTA-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-MMU-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-SCE-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-BTA-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-DDI-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-SSC-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-HSA-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-DME-538864": ["r", "Degradation of CRY"], "R-DME-68867": ["r", "Assembly of the pre-replicative complex"], "R-BTA-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-RNO-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-SPO-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-HSA-5632927": ["r", "Defective Mismatch Repair Associated With MSH3"], "R-HSA-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-DDI-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-SCE-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-DME-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-BTA-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-SCE-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-SPO-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-MMU-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-SPO-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-CEL-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-XTR-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-DRE-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-XTR-156827": ["r", "L13a-mediated translational silencing of Ceruloplasmin expression"], "R-XTR-5689901": ["r", "Metalloprotease DUBs"], "R-BTA-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-DRE-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-DRE-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-DDI-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-GGA-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-DRE-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-DRE-427413": ["r", "NoRC negatively regulates rRNA expression"], "R-DRE-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-DRE-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-DRE-427359": ["r", "SIRT1 negatively regulates rRNA expression"], "R-DRE-110331": ["r", "Cleavage of the damaged purine"], "R-DRE-212300": ["r", "PRC2 methylates histones and DNA"], "R-DRE-73772": ["r", "RNA Polymerase I Promoter Escape"], "R-DDI-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-GGA-5689880": ["r", "Ub-specific processing proteases"], "R-DDI-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-XTR-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-DRE-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-DRE-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-DRE-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-RNO-5357905": ["r", "Regulation of TNFR1 signaling"], "R-BTA-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-HSA-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-SPO-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-GGA-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-BTA-5675482": ["r", "Regulation of necroptotic cell death"], "R-RNO-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-CEL-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-SPO-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-HSA-9687136": ["r", "Aberrant regulation of mitotic exit in cancer due to RB1 defects"], "R-HSA-9683610": ["r", "Maturation of nucleoprotein"], "R-DRE-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-SPO-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-DDI-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-DDI-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-BTA-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-RNO-168638": ["r", "NOD1/2 Signaling Pathway"], "R-DRE-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-CEL-5689896": ["r", "Ovarian tumor domain proteases"], "R-DDI-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-CEL-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-SPO-3232118": ["r", "SUMOylation of transcription factors"], "R-DDI-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-DRE-4655427": ["r", "SUMOylation of DNA methylation proteins"], "R-SCE-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-DDI-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-DDI-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-RNO-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-CEL-9646399": ["r", "Aggrephagy"], "R-DRE-6783310": ["r", "Fanconi Anemia Pathway"], "R-HSA-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-RNO-937039": ["r", "IRAK1 recruits IKK complex"], "R-CEL-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-DME-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-BTA-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-GGA-69473": ["r", "G2/M DNA damage checkpoint"], "R-XTR-3899300": ["r", "SUMOylation of transcription cofactors"], "R-DRE-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-HSA-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-DDI-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-DRE-68867": ["r", "Assembly of the pre-replicative complex"], "R-RNO-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-HSA-4755510": ["r", "SUMOylation of immune response proteins"], "R-DME-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-BTA-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-DME-5689896": ["r", "Ovarian tumor domain proteases"], "R-SCE-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-DDI-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-SCE-9646399": ["r", "Aggrephagy"], "R-RNO-5656169": ["r", "Termination of translesion DNA synthesis"], "R-DDI-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-DRE-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-GGA-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-CEL-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-MMU-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-RNO-176412": ["r", "Phosphorylation of the APC/C"], "PWY-8130": ["t", "5'-deoxyadenosine degradation I"], "PWY-8132": ["t", "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III"], "PWY-8131": ["t", "5'-deoxyadenosine degradation II"], "PWY-4361": ["t", "S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"], "R-DRE-1237112": ["r", "Methionine salvage pathway"], "R-SCE-72731": ["r", "Recycling of eIF2:GDP"], "R-HSA-72731": ["r", "Recycling of eIF2:GDP"], "R-MMU-72731": ["r", "Recycling of eIF2:GDP"], "R-CEL-72731": ["r", "Recycling of eIF2:GDP"], "R-SPO-1237112": ["r", "Methionine salvage pathway"], "R-RNO-1237112": ["r", "Methionine salvage pathway"], "R-DDI-72731": ["r", "Recycling of eIF2:GDP"], "R-SPO-72731": ["r", "Recycling of eIF2:GDP"], "R-MMU-1237112": ["r", "Methionine salvage pathway"], "R-BTA-72731": ["r", "Recycling of eIF2:GDP"], "R-XTR-1237112": ["r", "Methionine salvage pathway"], "R-RNO-72731": ["r", "Recycling of eIF2:GDP"], "R-CEL-1237112": ["r", "Methionine salvage pathway"], "R-DME-1237112": ["r", "Methionine salvage pathway"], "R-HSA-1237112": ["r", "Methionine salvage pathway"], "R-SCE-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-XTR-5673001": ["r", "RAF/MAP kinase cascade"], "R-XTR-354192": ["r", "Integrin signaling"], "R-XTR-1169092": ["r", "Activation of RAS in B cells"], "R-SCE-354192": ["r", "Integrin signaling"], "R-BTA-354192": ["r", "Integrin signaling"], "R-SCE-392517": ["r", "Rap1 signalling"], "R-MMU-1169092": ["r", "Activation of RAS in B cells"], "R-HSA-1169092": ["r", "Activation of RAS in B cells"], "R-SPO-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-RNO-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-HSA-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-DME-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-SPO-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-MMU-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-CEL-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-DME-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-SSC-2168880": ["r", "Scavenging of heme from plasma"], "R-SSC-202733": ["r", "Cell surface interactions at the vascular wall"], "R-MMU-166662": ["r", "Lectin pathway of complement activation"], "R-DRE-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-GGA-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-RNO-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-RNO-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-DRE-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-DRE-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-DDI-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-RNO-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-DRE-9843970": ["r", "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"], "R-GGA-2299718": ["r", "Condensation of Prophase Chromosomes"], "PWY-2161": ["t", "folate polyglutamylation"], "R-DME-1855231": ["r", "Synthesis of IPs in the ER lumen"], "R-RNO-1855231": ["r", "Synthesis of IPs in the ER lumen"], "R-SPO-1483166": ["r", "Synthesis of PA"], "R-DDI-1483166": ["r", "Synthesis of PA"], "R-DME-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-CEL-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-MMU-1855231": ["r", "Synthesis of IPs in the ER lumen"], "R-HSA-1855231": ["r", "Synthesis of IPs in the ER lumen"], "R-DDI-1855231": ["r", "Synthesis of IPs in the ER lumen"], "R-DRE-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-GGA-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-GGA-1442490": ["r", "Collagen degradation"], "R-GGA-1592389": ["r", "Activation of Matrix Metalloproteinases"], "R-DME-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-RNO-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-DDI-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-MMU-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-MMU-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-DDI-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-SPO-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-GGA-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-DDI-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-SCE-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-SCE-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-SPO-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-MMU-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-BTA-176412": ["r", "Phosphorylation of the APC/C"], "R-DME-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-DME-937039": ["r", "IRAK1 recruits IKK complex"], "R-DRE-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-GGA-4755510": ["r", "SUMOylation of immune response proteins"], "R-DRE-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-RNO-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-DDI-176412": ["r", "Phosphorylation of the APC/C"], "R-GGA-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-DRE-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-XTR-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-HSA-176412": ["r", "Phosphorylation of the APC/C"], "R-MMU-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-XTR-4090294": ["r", "SUMOylation of intracellular receptors"], "R-DRE-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-XTR-3232118": ["r", "SUMOylation of transcription factors"], "R-DME-176412": ["r", "Phosphorylation of the APC/C"], "R-GGA-4655427": ["r", "SUMOylation of DNA methylation proteins"], "R-DDI-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-DDI-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-DRE-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-CEL-9020702": ["r", "Interleukin-1 signaling"], "R-BTA-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-XTR-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-DDI-9020702": ["r", "Interleukin-1 signaling"], "R-HSA-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-HSA-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-HSA-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-CEL-3232118": ["r", "SUMOylation of transcription factors"], "R-DME-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-MMU-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-DRE-176412": ["r", "Phosphorylation of the APC/C"], "R-HSA-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-GGA-3899300": ["r", "SUMOylation of transcription cofactors"], "R-SPO-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-GGA-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-RNO-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-GGA-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-DRE-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-BTA-168638": ["r", "NOD1/2 Signaling Pathway"], "R-SPO-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-BTA-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-DRE-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-RNO-4755510": ["r", "SUMOylation of immune response proteins"], "PWY-5532": ["t", "nucleoside and nucleotide degradation (archaea)"], "R-DRE-2142789": ["r", "Ubiquinol biosynthesis"], "R-BTA-2142789": ["r", "Ubiquinol biosynthesis"], "R-CFA-9770562": ["r", "mRNA Polyadenylation"], "R-RNO-173623": ["r", "Classical antibody-mediated complement activation"], "R-SSC-174577": ["r", "Activation of C3 and C5"], "R-GGA-2132285": ["r", "Complement Cascade"], "R-RNO-2855086": ["r", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "R-DME-977068": ["r", "Termination of O-glycan biosynthesis"], "R-MMU-173623": ["r", "Classical antibody-mediated complement activation"], "R-BTA-166663": ["r", "Initial triggering of complement"], "R-CEL-913709": ["r", "O-linked glycosylation of mucins"], "R-GGA-2132281": ["r", "Regulation of complement cascades"], "R-SSC-173736": ["r", "Alternative complement activation"], "R-DME-913709": ["r", "O-linked glycosylation of mucins"], "R-GGA-2132263": ["r", "Creation of classical C3 convertase"], "R-RNO-166662": ["r", "Lectin pathway of complement activation"], "R-MMU-2855086": ["r", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "R-SSC-977606": ["r", "Regulation of Complement cascade"], "R-GGA-2132273": ["r", "Formation of membrane-bound convertase C3"], "R-GGA-2132293": ["r", "Formation of fluid-phase convertase C3"], "PWY-5743": ["t", "3-hydroxypropanoate cycle"], "PWY-5789": ["t", "3-hydroxypropanoate/4-hydroxybutanate cycle"], "PWY-6722": ["t", "candicidin biosynthesis"], "PWY-4381": ["t", "fatty acid biosynthesis initiation (type II)"], "PWY-5744": ["t", "glyoxylate assimilation"], "R-GGA-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-BTA-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-RNO-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-HSA-9638771": ["r", "Action of antimicrobials"], "R-HSA-804914": ["r", "Transport of fatty acids"], "R-CEL-5365859": ["r", "RA biosynthesis pathway"], "R-BTA-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-HSA-6799990": ["r", "Metal sequestration by antimicrobial proteins"], "R-MMU-163560": ["r", "Triglyceride catabolism"], "R-HSA-9918442": ["r", "Defective visual phototransduction due to LRAT loss of function"], "R-RNO-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-RNO-5365859": ["r", "RA biosynthesis pathway"], "R-RNO-917937": ["r", "Iron uptake and transport"], "R-HSA-6809583": ["r", "Retinoid metabolism disease events"], "R-CEL-5362517": ["r", "Signaling by Retinoic Acid"], "R-HSA-5365859": ["r", "RA biosynthesis pathway"], "R-GGA-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-CFA-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-RNO-163560": ["r", "Triglyceride catabolism"], "R-MMU-5365859": ["r", "RA biosynthesis pathway"], "R-BTA-5365859": ["r", "RA biosynthesis pathway"], "R-MMU-6799990": ["r", "Metal sequestration by antimicrobial proteins"], "R-HSA-9918449": ["r", "Defective visual phototransduction due to STRA6 loss of function"], "R-RNO-6799990": ["r", "Metal sequestration by antimicrobial proteins"], "R-RNO-804914": ["r", "Transport of fatty acids"], "R-HSA-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-CEL-163560": ["r", "Triglyceride catabolism"], "R-MMU-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-CEL-189483": ["r", "Heme degradation"], "R-SSC-804914": ["r", "Transport of fatty acids"], "R-CEL-975634": ["r", "Retinoid metabolism and transport"], "R-BTA-163560": ["r", "Triglyceride catabolism"], "R-SSC-163560": ["r", "Triglyceride catabolism"], "R-MMU-804914": ["r", "Transport of fatty acids"], "R-HSA-917937": ["r", "Iron uptake and transport"], "R-CEL-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-DRE-8949613": ["r", "Cristae formation"], "R-GGA-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-GGA-8949613": ["r", "Cristae formation"], "R-GGA-9837999": ["r", "Mitochondrial protein degradation"], "R-DRE-163210": ["r", "Formation of ATP by chemiosmotic coupling"], "R-BTA-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "PWY-6163": ["t", "chorismate biosynthesis from 3-dehydroquinate"], "R-MTU-964903": ["r", "Chorismate via Shikimate Pathway"], "R-DME-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-CEL-5689877": ["r", "Josephin domain DUBs"], "R-GGA-68949": ["r", "Orc1 removal from chromatin"], "R-BTA-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-SSC-110320": ["r", "Translesion Synthesis by POLH"], "R-GGA-209560": ["r", "NF-kB is activated and signals survival"], "R-GGA-8948751": ["r", "Regulation of PTEN stability and activity"], "R-RNO-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-SSC-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-GGA-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-GGA-5689877": ["r", "Josephin domain DUBs"], "R-BTA-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-GGA-6807004": ["r", "Negative regulation of MET activity"], "R-DDI-917937": ["r", "Iron uptake and transport"], "R-RNO-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-BTA-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-GGA-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-SSC-8948747": ["r", "Regulation of PTEN localization"], "R-CEL-5358346": ["r", "Hedgehog ligand biogenesis"], "R-GGA-9932298": ["r", "Degradation of CRY and PER proteins"], "R-GGA-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-SPO-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-BTA-9648002": ["r", "RAS processing"], "R-SSC-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-SSC-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-CFA-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-GGA-353303": ["r", "Nucleotide Excision Repair"], "R-CFA-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-CFA-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-SSC-5689877": ["r", "Josephin domain DUBs"], "R-GGA-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-CFA-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-CFA-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-SCE-3065679": ["r", "SUMO is proteolytically processed"], "R-RNO-8934903": ["r", "Receptor Mediated Mitophagy"], "R-SCE-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-SSC-8934903": ["r", "Receptor Mediated Mitophagy"], "R-SSC-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-SPO-8934903": ["r", "Receptor Mediated Mitophagy"], "R-CEL-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-BTA-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-DRE-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-DRE-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-DRE-201688": ["r", "WNT mediated activation of DVL"], "R-HSA-8934903": ["r", "Receptor Mediated Mitophagy"], "R-DRE-8948751": ["r", "Regulation of PTEN stability and activity"], "R-SPO-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-DRE-8934903": ["r", "Receptor Mediated Mitophagy"], "R-RNO-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-DDI-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-MMU-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-SSC-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-BTA-8934903": ["r", "Receptor Mediated Mitophagy"], "R-MMU-8934903": ["r", "Receptor Mediated Mitophagy"], "R-HSA-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-DRE-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-SSC-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-SCE-8934903": ["r", "Receptor Mediated Mitophagy"], "R-DME-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-SCE-2514853": ["r", "Condensation of Prometaphase Chromosomes"], "R-CEL-8934903": ["r", "Receptor Mediated Mitophagy"], "R-SSC-201688": ["r", "WNT mediated activation of DVL"], "R-DME-8934903": ["r", "Receptor Mediated Mitophagy"], "R-SSC-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-BTA-201688": ["r", "WNT mediated activation of DVL"], "R-DME-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "PWY-3821": ["t", "D-galactose detoxification"], "PWY-6317": ["t", "D-galactose degradation I (Leloir pathway)"], "R-HSA-70370": ["r", "Galactose catabolism"], "R-HSA-5609976": ["r", "Defective GALK1 causes GALCT2"], "R-MMU-70370": ["r", "Galactose catabolism"], "R-CFA-70370": ["r", "Galactose catabolism"], "R-BTA-70370": ["r", "Galactose catabolism"], "R-HSA-9927020": ["r", "Heme assimilation"], "PWY-6470": ["t", "peptidoglycan biosynthesis V (beta-lactam resistance)"], "PWY-6471": ["t", "peptidoglycan biosynthesis IV (Enterococcus faecium)"], "PWY-5265": ["t", "peptidoglycan biosynthesis II (staphylococci)"], "PWY-6385": ["t", "peptidoglycan biosynthesis III (mycobacteria)"], "R-SCE-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-MMU-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-SPO-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-HSA-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-DDI-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-HSA-4549356": ["r", "Defective DPAGT1 causes CDG-1j, CMSTA2"], "R-XTR-381426": ["r", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "R-HSA-6803211": ["r", "TP53 Regulates Transcription of Death Receptors and Ligands"], "R-RNO-6803211": ["r", "TP53 Regulates Transcription of Death Receptors and Ligands"], "R-MMU-6803211": ["r", "TP53 Regulates Transcription of Death Receptors and Ligands"], "R-MMU-419812": ["r", "Calcitonin-like ligand receptors"], "R-RNO-419812": ["r", "Calcitonin-like ligand receptors"], "R-CFA-419812": ["r", "Calcitonin-like ligand receptors"], "R-HSA-419812": ["r", "Calcitonin-like ligand receptors"], "R-HSA-9630222": ["r", "Defective NTHL1 substrate binding"], "R-CEL-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-BTA-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-SPO-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-CEL-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-SPO-110331": ["r", "Cleavage of the damaged purine"], "R-HSA-9630221": ["r", "Defective NTHL1 substrate processing"], "PWY-6118": ["t", "glycerol-3-phosphate shuttle"], "PWY-4261": ["t", "glycerol degradation I"], "PWY-6952": ["t", "glycerophosphodiester degradation"], "R-DDI-163560": ["r", "Triglyceride catabolism"], "R-SCE-163560": ["r", "Triglyceride catabolism"], "R-SPO-163560": ["r", "Triglyceride catabolism"], "R-CEL-1483166": ["r", "Synthesis of PA"], "R-SCE-1483166": ["r", "Synthesis of PA"], "R-MMU-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-RNO-193692": ["r", "Regulated proteolysis of p75NTR"], "R-DME-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-DME-4755510": ["r", "SUMOylation of immune response proteins"], "R-RNO-448706": ["r", "Interleukin-1 processing"], "R-HSA-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-GGA-1227892": ["r", "TRAF6 mediated NF-kB activation"], "R-DME-209400": ["r", "Transcriptional activtion by phosphorylated DL/DIF dimer"], "R-MMU-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-HSA-5603029": ["r", "IkBA variant leads to EDA-ID"], "R-GGA-434131": ["r", "NFkB activation mediated by RIP1 complexed with activated TLR3"], "R-MMU-448706": ["r", "Interleukin-1 processing"], "R-HSA-193692": ["r", "Regulated proteolysis of p75NTR"], "R-DME-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-RNO-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-DME-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-MMU-193692": ["r", "Regulated proteolysis of p75NTR"], "R-HSA-9834752": ["r", "Respiratory syncytial virus genome replication"], "R-DRE-9629569": ["r", "Protein hydroxylation"], "R-SCE-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-DRE-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-HSA-9828721": ["r", "Translation of respiratory syncytial virus mRNAs"], "R-DRE-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-XTR-9629569": ["r", "Protein hydroxylation"], "R-BTA-9629569": ["r", "Protein hydroxylation"], "R-XTR-9770562": ["r", "mRNA Polyadenylation"], "R-XTR-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-XTR-191859": ["r", "snRNP Assembly"], "R-HSA-9828642": ["r", "Respiratory syncytial virus genome transcription"], "R-DDI-9629569": ["r", "Protein hydroxylation"], "R-XTR-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-PFA-72163": ["r", "mRNA Splicing - Major Pathway"], "R-CEL-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-GGA-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-DDI-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-SSC-3065678": ["r", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "R-SSC-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-GGA-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-CEL-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-CFA-6804757": ["r", "Regulation of TP53 Degradation"], "R-CFA-5632684": ["r", "Hedgehog 'on' state"], "R-SSC-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-GGA-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-GGA-5656121": ["r", "Translesion synthesis by POLI"], "R-HSA-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-SPO-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-GGA-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-GGA-110320": ["r", "Translesion Synthesis by POLH"], "R-GGA-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-GGA-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-CFA-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-SSC-9861718": ["r", "Regulation of pyruvate metabolism"], "R-SSC-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-CFA-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-CEL-6807004": ["r", "Negative regulation of MET activity"], "R-SSC-8866427": ["r", "VLDLR internalisation and degradation"], "R-CEL-3065679": ["r", "SUMO is proteolytically processed"], "R-DME-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-GGA-9766229": ["r", "Degradation of CDH1"], "R-HSA-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-CFA-5358346": ["r", "Hedgehog ligand biogenesis"], "R-CFA-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-DME-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-MMU-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-BTA-209543": ["r", "p75NTR recruits signalling complexes"], "R-DDI-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-CFA-68867": ["r", "Assembly of the pre-replicative complex"], "R-CFA-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-GGA-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-SSC-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-RNO-5689877": ["r", "Josephin domain DUBs"], "R-DDI-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-SSC-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-MMU-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-CFA-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-BTA-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-CFA-8948751": ["r", "Regulation of PTEN stability and activity"], "R-CFA-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-BTA-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-GGA-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-GGA-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-CFA-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-CFA-209543": ["r", "p75NTR recruits signalling complexes"], "R-HSA-5603027": ["r", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)"], "R-RNO-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-GGA-5689603": ["r", "UCH proteinases"], "R-CEL-110320": ["r", "Translesion Synthesis by POLH"], "R-CFA-8866427": ["r", "VLDLR internalisation and degradation"], "R-CEL-917937": ["r", "Iron uptake and transport"], "R-DME-9861718": ["r", "Regulation of pyruvate metabolism"], "R-SSC-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-CFA-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-GGA-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-RNO-1169092": ["r", "Activation of RAS in B cells"], "PWY-8404": ["t", "glycolysis VI (from fructose)"], "PWY-6142": ["t", "gluconeogenesis II (Methanobacterium thermoautotrophicum)"], "PWY-7003": ["t", "glycerol degradation to butanol"], "R-PFA-70263": ["r", "Gluconeogenesis"], "R-GGA-352875": ["r", "Gluconeogenesis"], "R-DDI-70171": ["r", "Glycolysis"], "R-DME-70263": ["r", "Gluconeogenesis"], "R-GGA-70171": ["r", "Glycolysis"], "R-PFA-70171": ["r", "Glycolysis"], "R-GGA-70263": ["r", "Gluconeogenesis"], "R-XTR-70171": ["r", "Glycolysis"], "R-GGA-352882": ["r", "Glycolysis"], "R-DRE-70171": ["r", "Glycolysis"], "R-XTR-70263": ["r", "Gluconeogenesis"], "R-DME-428930": ["r", "Thromboxane signalling through TP receptor"], "R-BTA-202040": ["r", "G-protein activation"], "R-CFA-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-CFA-202040": ["r", "G-protein activation"], "R-DME-202040": ["r", "G-protein activation"], "R-SSC-428930": ["r", "Thromboxane signalling through TP receptor"], "R-SSC-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-SSC-202040": ["r", "G-protein activation"], "R-DME-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-SSC-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-CFA-9856530": ["r", "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"], "R-CFA-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-SSC-112043": ["r", "PLC beta mediated events"], "R-CFA-399997": ["r", "Acetylcholine regulates insulin secretion"], "R-CFA-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-SSC-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-BTA-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-CFA-428930": ["r", "Thromboxane signalling through TP receptor"], "R-SSC-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-CFA-434316": ["r", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"], "R-CFA-112043": ["r", "PLC beta mediated events"], "PWY-7204": ["t", "pyridoxal 5'-phosphate salvage II (plants)"], "PWY-7282": ["t", "4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II"], "R-BTA-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-SCE-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-SPO-964975": ["r", "Vitamin B6 activation to pyridoxal phosphate"], "R-MMU-5578768": ["r", "Physiological factors"], "R-CFA-5578768": ["r", "Physiological factors"], "R-RNO-5578768": ["r", "Physiological factors"], "R-SSC-5578768": ["r", "Physiological factors"], "R-BTA-5578768": ["r", "Physiological factors"], "R-CEL-5694530": ["r", "Cargo concentration in the ER"], "R-HSA-448706": ["r", "Interleukin-1 processing"], "R-HSA-5660668": ["r", "CLEC7A/inflammasome pathway"], "R-DME-214416": ["r", "Phosphorylated REL is cleaved by and dissociates from DREDD"], "R-DME-214411": ["r", "REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'"], "R-RNO-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-GGA-434001": ["r", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex"], "R-DME-214399": ["r", "Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'"], "R-BTA-1268020": ["r", "Mitochondrial protein import"], "R-SPO-1482925": ["r", "Acyl chain remodelling of PG"], "R-SCE-1483226": ["r", "Synthesis of PI"], "R-DME-1483076": ["r", "Synthesis of CL"], "R-RNO-1483076": ["r", "Synthesis of CL"], "R-SCE-1482925": ["r", "Acyl chain remodelling of PG"], "R-GGA-1483191": ["r", "Synthesis of PC"], "R-DME-1483226": ["r", "Synthesis of PI"], "R-DDI-1483213": ["r", "Synthesis of PE"], "R-HSA-1483213": ["r", "Synthesis of PE"], "R-DME-1482925": ["r", "Acyl chain remodelling of PG"], "R-HSA-1483226": ["r", "Synthesis of PI"], "R-MMU-1483076": ["r", "Synthesis of CL"], "R-CEL-1482925": ["r", "Acyl chain remodelling of PG"], "R-RNO-1483213": ["r", "Synthesis of PE"], "R-MMU-1483226": ["r", "Synthesis of PI"], "R-HSA-1483076": ["r", "Synthesis of CL"], "R-MMU-1483213": ["r", "Synthesis of PE"], "R-SCE-1483076": ["r", "Synthesis of CL"], "R-SCE-1483213": ["r", "Synthesis of PE"], "R-BTA-1483213": ["r", "Synthesis of PE"], "R-SPO-1483076": ["r", "Synthesis of CL"], "R-SPO-1483213": ["r", "Synthesis of PE"], "R-CEL-1483076": ["r", "Synthesis of CL"], "R-RNO-1483226": ["r", "Synthesis of PI"], "R-SPO-1483226": ["r", "Synthesis of PI"], "R-SPO-1483191": ["r", "Synthesis of PC"], "R-BTA-400206": ["r", "Regulation of lipid metabolism by PPARalpha"], "R-BTA-189483": ["r", "Heme degradation"], "R-DRE-189483": ["r", "Heme degradation"], "R-BTA-9707564": ["r", "Cytoprotection by HMOX1"], "R-DRE-163560": ["r", "Triglyceride catabolism"], "R-SPO-5696400": ["r", "Dual Incision in GG-NER"], "R-DME-5696400": ["r", "Dual Incision in GG-NER"], "R-DME-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-RNO-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-CEL-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-DRE-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-RNO-9629569": ["r", "Protein hydroxylation"], "R-HSA-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-DME-9930044": ["r", "Nuclear RNA decay"], "R-DRE-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-XTR-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-DME-9629569": ["r", "Protein hydroxylation"], "R-SPO-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-MMU-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-HSA-9930044": ["r", "Nuclear RNA decay"], "R-DME-77595": ["r", "Processing of Intronless Pre-mRNAs"], "R-DRE-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-HSA-9820962": ["r", "Assembly and release of respiratory syncytial virus (RSV) virions"], "R-XTR-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-DRE-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-BTA-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-MMU-1614517": ["r", "Sulfide oxidation to sulfate"], "R-HSA-1614517": ["r", "Sulfide oxidation to sulfate"], "R-DME-1614517": ["r", "Sulfide oxidation to sulfate"], "R-RNO-1614517": ["r", "Sulfide oxidation to sulfate"], "R-CEL-389542": ["r", "NADPH regeneration"], "R-SPO-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-MMU-389542": ["r", "NADPH regeneration"], "R-RNO-389542": ["r", "NADPH regeneration"], "R-CEL-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-CEL-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-HSA-389542": ["r", "NADPH regeneration"], "R-DDI-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-RNO-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-DDI-389542": ["r", "NADPH regeneration"], "R-SCE-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-HSA-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-RNO-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-BTA-75109": ["r", "Triglyceride biosynthesis"], "R-DDI-75109": ["r", "Triglyceride biosynthesis"], "R-BTA-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-MMU-75109": ["r", "Triglyceride biosynthesis"], "R-CEL-75109": ["r", "Triglyceride biosynthesis"], "R-MMU-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-HSA-75109": ["r", "Triglyceride biosynthesis"], "R-RNO-75109": ["r", "Triglyceride biosynthesis"], "R-CEL-5661270": ["r", "Formation of xylulose-5-phosphate"], "PWY-7111": ["t", "pyruvate fermentation to isobutanol (engineered)"], "PWY-5101": ["t", "L-isoleucine biosynthesis II"], "PWY-5103": ["t", "L-isoleucine biosynthesis III"], "PWY-5104": ["t", "L-isoleucine biosynthesis IV"], "R-RNO-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-CEL-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-CFA-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-DRE-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-DRE-390918": ["r", "Peroxisomal lipid metabolism"], "R-RNO-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-MMU-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-HSA-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-HSA-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-DME-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-BTA-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-DDI-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-SCE-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-DRE-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-XTR-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-HSA-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-MMU-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-MMU-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-SPO-77289": ["r", "Mitochondrial Fatty Acid Beta-Oxidation"], "R-XTR-390918": ["r", "Peroxisomal lipid metabolism"], "R-RNO-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-BTA-5576893": ["r", "Phase 2 - plateau phase"], "R-RNO-5576893": ["r", "Phase 2 - plateau phase"], "R-RNO-112308": ["r", "Presynaptic depolarization and calcium channel opening"], "R-MMU-5576892": ["r", "Phase 0 - rapid depolarisation"], "R-BTA-112308": ["r", "Presynaptic depolarization and calcium channel opening"], "R-BTA-5576892": ["r", "Phase 0 - rapid depolarisation"], "R-HSA-5576893": ["r", "Phase 2 - plateau phase"], "R-MMU-5576893": ["r", "Phase 2 - plateau phase"], "R-BTA-422356": ["r", "Regulation of insulin secretion"], "R-HSA-112308": ["r", "Presynaptic depolarization and calcium channel opening"], "R-MMU-112308": ["r", "Presynaptic depolarization and calcium channel opening"], "R-RNO-5576892": ["r", "Phase 0 - rapid depolarisation"], "R-SSC-3000170": ["r", "Syndecan interactions"], "R-CFA-1442490": ["r", "Collagen degradation"], "R-MMU-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-HSA-5689877": ["r", "Josephin domain DUBs"], "R-CFA-9033241": ["r", "Peroxisomal protein import"], "R-SSC-9708530": ["r", "Regulation of BACH1 activity"], "R-CFA-5696400": ["r", "Dual Incision in GG-NER"], "R-CEL-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-CFA-5689877": ["r", "Josephin domain DUBs"], "R-SSC-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-GGA-3065679": ["r", "SUMO is proteolytically processed"], "R-BTA-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-SSC-3065679": ["r", "SUMO is proteolytically processed"], "R-GGA-9664873": ["r", "Pexophagy"], "R-SSC-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-SSC-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-CFA-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-HSA-5656121": ["r", "Translesion synthesis by POLI"], "R-GGA-5696400": ["r", "Dual Incision in GG-NER"], "R-HSA-9694493": ["r", "Maturation of protein E"], "R-DME-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-DDI-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-MMU-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-BTA-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-GGA-69541": ["r", "Stabilization of p53"], "R-SSC-9793242": ["r", "SUMOylation of nuclear envelope proteins"], "R-GGA-5357905": ["r", "Regulation of TNFR1 signaling"], "R-CEL-5655862": ["r", "Translesion synthesis by POLK"], "R-DME-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-CFA-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-CFA-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-SSC-4655427": ["r", "SUMOylation of DNA methylation proteins"], "R-SSC-912631": ["r", "Regulation of signaling by CBL"], "R-CFA-5656169": ["r", "Termination of translesion DNA synthesis"], "R-SSC-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-GGA-1295596": ["r", "Spry regulation of FGF signaling"], "R-GGA-9929491": ["r", "SPOP-mediated proteasomal degradation of PD-L1(CD274)"], "R-BTA-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-SSC-9648002": ["r", "RAS processing"], "R-BTA-5656121": ["r", "Translesion synthesis by POLI"], "R-CFA-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-GGA-9645460": ["r", "Alpha-protein kinase 1 signaling pathway"], "R-SSC-5655862": ["r", "Translesion synthesis by POLK"], "R-BTA-3232118": ["r", "SUMOylation of transcription factors"], "R-CEL-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-CFA-9664873": ["r", "Pexophagy"], "R-DME-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-GGA-382556": ["r", "ABC-family proteins mediated transport"], "R-BTA-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-CFA-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-BTA-9708530": ["r", "Regulation of BACH1 activity"], "R-CFA-6782135": ["r", "Dual incision in TC-NER"], "R-CFA-4641257": ["r", "Degradation of AXIN"], "R-DDI-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-CFA-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-CFA-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-MMU-110312": ["r", "Translesion synthesis by REV1"], "R-CFA-5675482": ["r", "Regulation of necroptotic cell death"], "R-BTA-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-CFA-5689880": ["r", "Ub-specific processing proteases"], "R-BTA-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-SSC-9706369": ["r", "Negative regulation of FLT3"], "R-SSC-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-CFA-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-GGA-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-SSC-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-HSA-9706377": ["r", "FLT3 signaling by CBL mutants"], "R-DDI-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-MMU-5689877": ["r", "Josephin domain DUBs"], "R-SSC-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-CFA-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-MMU-446353": ["r", "Cell-extracellular matrix interactions"], "R-DDI-446353": ["r", "Cell-extracellular matrix interactions"], "R-MMU-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-DME-446353": ["r", "Cell-extracellular matrix interactions"], "R-HSA-6802953": ["r", "RAS signaling downstream of NF1 loss-of-function variants"], "R-HSA-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-DRE-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-RNO-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-DRE-5658442": ["r", "Regulation of RAS by GAPs"], "R-HSA-446353": ["r", "Cell-extracellular matrix interactions"], "R-BTA-5674135": ["r", "MAP2K and MAPK activation"], "R-CEL-428930": ["r", "Thromboxane signalling through TP receptor"], "R-GGA-909733": ["r", "Interferon alpha/beta signaling"], "R-CFA-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-CFA-909733": ["r", "Interferon alpha/beta signaling"], "R-SSC-193993": ["r", "Mineralocorticoid biosynthesis"], "R-SSC-209968": ["r", "Thyroxine biosynthesis"], "R-RNO-193993": ["r", "Mineralocorticoid biosynthesis"], "R-RNO-193048": ["r", "Androgen biosynthesis"], "R-HSA-193993": ["r", "Mineralocorticoid biosynthesis"], "R-HSA-193048": ["r", "Androgen biosynthesis"], "R-SSC-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-MMU-193048": ["r", "Androgen biosynthesis"], "R-BTA-193993": ["r", "Mineralocorticoid biosynthesis"], "R-BTA-209968": ["r", "Thyroxine biosynthesis"], "R-BTA-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-SSC-193048": ["r", "Androgen biosynthesis"], "R-MMU-193993": ["r", "Mineralocorticoid biosynthesis"], "R-BTA-193048": ["r", "Androgen biosynthesis"], "R-HSA-209822": ["r", "Glycoprotein hormones"], "R-SSC-209822": ["r", "Glycoprotein hormones"], "R-MMU-209822": ["r", "Glycoprotein hormones"], "R-RNO-209822": ["r", "Glycoprotein hormones"], "R-BTA-209822": ["r", "Glycoprotein hormones"], "R-HSA-9825895": ["r", "Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence"], "R-RNO-171319": ["r", "Telomere Extension By Telomerase"], "R-HSA-171319": ["r", "Telomere Extension By Telomerase"], "R-MMU-171319": ["r", "Telomere Extension By Telomerase"], "R-HSA-9026357": ["r", "NTF4 activates NTRK2 (TRKB) signaling"], "R-HSA-198745": ["r", "Signalling to STAT3"], "R-HSA-9846298": ["r", "Defective binding of VWF variant to GPIb:IX:V"], "R-RNO-5682910": ["r", "LGI-ADAM interactions"], "R-HSA-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-MMU-5682910": ["r", "LGI-ADAM interactions"], "R-RNO-9839383": ["r", "TGFBR3 PTM regulation"], "R-SSC-216083": ["r", "Integrin cell surface interactions"], "R-MMU-9839383": ["r", "TGFBR3 PTM regulation"], "R-SSC-2129379": ["r", "Molecules associated with elastic fibres"], "R-CFA-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-CFA-9009391": ["r", "Extra-nuclear estrogen signaling"], "R-HSA-9839383": ["r", "TGFBR3 PTM regulation"], "R-CEL-1442490": ["r", "Collagen degradation"], "R-MMU-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-SCE-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-RNO-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-SSC-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-BTA-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-RNO-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-BTA-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-GGA-205043": ["r", "NRIF signals cell death from the nucleus"], "R-GGA-9770562": ["r", "mRNA Polyadenylation"], "R-DME-917937": ["r", "Iron uptake and transport"], "R-DDI-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-CFA-182971": ["r", "EGFR downregulation"], "R-SSC-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-SSC-5696400": ["r", "Dual Incision in GG-NER"], "R-SPO-3065679": ["r", "SUMO is proteolytically processed"], "R-GGA-9929356": ["r", "GSK3B-mediated proteasomal degradation of PD-L1(CD274)"], "R-DME-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-GGA-5689896": ["r", "Ovarian tumor domain proteases"], "R-DDI-5358346": ["r", "Hedgehog ligand biogenesis"], "R-CFA-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-CFA-5675221": ["r", "Negative regulation of MAPK pathway"], "R-GGA-69231": ["r", "Cyclin D associated events in G1"], "R-SSC-5656169": ["r", "Termination of translesion DNA synthesis"], "R-DME-110320": ["r", "Translesion Synthesis by POLH"], "R-CFA-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-CEL-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-CFA-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-GGA-9861718": ["r", "Regulation of pyruvate metabolism"], "R-SSC-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-DME-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-CFA-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-CFA-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-SSC-3065676": ["r", "SUMO is conjugated to E1 (UBA2:SAE1)"], "R-CFA-2173788": ["r", "Downregulation of TGF-beta receptor signaling"], "R-CFA-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-CFA-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-MMU-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-CEL-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-SSC-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-SSC-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-DME-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-CFA-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-GGA-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-SSC-5656121": ["r", "Translesion synthesis by POLI"], "R-GGA-5685942": ["r", "HDR through Homologous Recombination (HRR)"], "R-CFA-2467813": ["r", "Separation of Sister Chromatids"], "R-CFA-68949": ["r", "Orc1 removal from chromatin"], "R-GGA-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-BTA-9010553": ["r", "Regulation of expression of SLITs and ROBOs"], "R-SSC-5689901": ["r", "Metalloprotease DUBs"], "R-RNO-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-CFA-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-CFA-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-RNO-110312": ["r", "Translesion synthesis by REV1"], "R-CEL-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-GGA-6782135": ["r", "Dual incision in TC-NER"], "R-SSC-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-CFA-382556": ["r", "ABC-family proteins mediated transport"], "R-CFA-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-GGA-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-CFA-8948747": ["r", "Regulation of PTEN localization"], "R-CFA-937039": ["r", "IRAK1 recruits IKK complex"], "R-CFA-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-SSC-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-SSC-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-RNO-389356": ["r", "Co-stimulation by CD28"], "R-RNO-198753": ["r", "ERK/MAPK targets"], "PWY-7226": ["t", "guanosine deoxyribonucleotides de novo biosynthesis I"], "PWY-7222": ["t", "guanosine deoxyribonucleotides de novo biosynthesis II"], "PWY-7220": ["t", "adenosine deoxyribonucleotides de novo biosynthesis II"], "PWY-7227": ["t", "adenosine deoxyribonucleotides de novo biosynthesis I"], "R-DRE-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-CEL-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-HSA-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-BTA-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "PWY-7400": ["t", "L-arginine biosynthesis IV (archaea)"], "PWY-4984": ["t", "urea cycle"], "PWY-5": ["t", "canavanine biosynthesis"], "PWY-4983": ["t", "nitric oxide biosynthesis II (mammals)"], "R-GGA-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-RNO-70635": ["r", "Urea cycle"], "R-DRE-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-GGA-187630": ["r", "Arginine metabolism"], "R-GGA-421203": ["r", "De novo synthesis of AMP"], "R-HSA-9956529": ["r", "ASL variants cause argininosuccinate aciduria"], "R-BTA-70635": ["r", "Urea cycle"], "R-DME-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-DME-170660": ["r", "Adenylate cyclase activating pathway"], "R-HSA-170660": ["r", "Adenylate cyclase activating pathway"], "R-HSA-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-MMU-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-MMU-170660": ["r", "Adenylate cyclase activating pathway"], "R-RNO-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-RNO-170660": ["r", "Adenylate cyclase activating pathway"], "PWY-3801": ["t", "sucrose degradation II (sucrose synthase)"], "R-DRE-2022854": ["r", "Keratan sulfate biosynthesis"], "R-GGA-2022857": ["r", "Keratan sulfate degradation"], "R-HSA-9845620": ["r", "Enhanced binding of GP1BA variant to VWF multimer:collagen"], "R-CEL-2243919": ["r", "Crosslinking of collagen fibrils"], "R-HSA-9603505": ["r", "NTRK3 as a dependence receptor"], "R-RNO-9603381": ["r", "Activated NTRK3 signals through PI3K"], "R-XTR-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-HSA-9034013": ["r", "NTF3 activates NTRK3 signaling"], "R-RNO-9032759": ["r", "NTRK2 activates RAC1"], "R-HSA-187706": ["r", "Signalling to p38 via RIT and RIN"], "R-CEL-8941413": ["r", "Events associated with phagocytolytic activity of PMN cells"], "R-MMU-9032759": ["r", "NTRK2 activates RAC1"], "R-MMU-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-HSA-5682910": ["r", "LGI-ADAM interactions"], "R-GGA-388844": ["r", "Receptor-type tyrosine-protein phosphatases"], "R-HSA-187042": ["r", "TRKA activation by NGF"], "R-BTA-5682910": ["r", "LGI-ADAM interactions"], "R-RNO-9034013": ["r", "NTF3 activates NTRK3 signaling"], "R-HSA-9024909": ["r", "BDNF activates NTRK2 (TRKB) signaling"], "R-GGA-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-RNO-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-MMU-9034013": ["r", "NTF3 activates NTRK3 signaling"], "R-HSA-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-HSA-9032759": ["r", "NTRK2 activates RAC1"], "R-RNO-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-HSA-9025046": ["r", "NTF3 activates NTRK2 (TRKB) signaling"], "R-MMU-9603381": ["r", "Activated NTRK3 signals through PI3K"], "R-HSA-9032500": ["r", "Activated NTRK2 signals through FYN"], "PWY-101": ["t", "photosynthesis light reactions"], "R-HSA-5218900": ["r", "CASP8 activity is inhibited"], "R-BTA-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-DME-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-DDI-9930044": ["r", "Nuclear RNA decay"], "R-CEL-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-SSC-159236": ["r", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "R-DDI-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-XTR-6803529": ["r", "FGFR2 alternative splicing"], "R-RNO-6803529": ["r", "FGFR2 alternative splicing"], "R-RNO-72086": ["r", "mRNA Capping"], "R-BTA-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-DDI-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-MMU-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-BTA-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-XTR-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-DRE-6803529": ["r", "FGFR2 alternative splicing"], "R-HSA-8986944": ["r", "Transcriptional Regulation by MECP2"], "R-HSA-426496": ["r", "Post-transcriptional silencing by small RNAs"], "R-SSC-72187": ["r", "mRNA 3'-end processing"], "R-GGA-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-SSC-6803529": ["r", "FGFR2 alternative splicing"], "R-RNO-113418": ["r", "Formation of the Early Elongation Complex"], "R-HSA-8943723": ["r", "Regulation of PTEN mRNA translation"], "R-DME-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-RNO-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-HSA-9692914": ["r", "SARS-CoV-1-host interactions"], "R-XTR-72086": ["r", "mRNA Capping"], "R-DRE-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-CEL-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-HSA-8948700": ["r", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation"], "R-DRE-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-CEL-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-SPO-9696273": ["r", "RND1 GTPase cycle"], "R-BTA-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-SSC-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-SSC-9664873": ["r", "Pexophagy"], "R-SSC-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-GGA-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-CFA-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-CFA-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-SSC-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-DME-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-CFA-5689603": ["r", "UCH proteinases"], "R-GGA-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-GGA-9013507": ["r", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "R-CFA-5655862": ["r", "Translesion synthesis by POLK"], "R-CFA-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-SSC-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-BTA-917937": ["r", "Iron uptake and transport"], "R-CFA-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-SSC-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-CFA-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-CFA-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-CFA-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-GGA-1169091": ["r", "Activation of NF-kappaB in B cells"], "R-CFA-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-CFA-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-CFA-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-SSC-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-GGA-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-DME-5689877": ["r", "Josephin domain DUBs"], "R-GGA-8948747": ["r", "Regulation of PTEN localization"], "R-RNO-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-DDI-5689877": ["r", "Josephin domain DUBs"], "R-RNO-2122948": ["r", "Activated NOTCH1 Transmits Signal to the Nucleus"], "R-SSC-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-GGA-4641258": ["r", "Degradation of DVL"], "R-CFA-110312": ["r", "Translesion synthesis by REV1"], "R-DME-110312": ["r", "Translesion synthesis by REV1"], "R-CFA-5696395": ["r", "Formation of Incision Complex in GG-NER"], "R-HSA-110320": ["r", "Translesion Synthesis by POLH"], "R-HSA-3065679": ["r", "SUMO is proteolytically processed"], "R-CFA-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-SSC-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-XTR-3065679": ["r", "SUMO is proteolytically processed"], "R-GGA-110312": ["r", "Translesion synthesis by REV1"], "R-SSC-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-DRE-3065679": ["r", "SUMO is proteolytically processed"], "R-BTA-209560": ["r", "NF-kB is activated and signals survival"], "R-BTA-5655862": ["r", "Translesion synthesis by POLK"], "R-CFA-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-CEL-877312": ["r", "Regulation of IFNG signaling"], "R-CFA-917937": ["r", "Iron uptake and transport"], "R-SSC-3108214": ["r", "SUMOylation of DNA damage response and repair proteins"], "R-CFA-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-GGA-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "R-HSA-5602636": ["r", "IKBKB deficiency causes SCID"], "R-SSC-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-GGA-351465": ["r", "Fanconi Anemia Pathway in DNA repair"], "R-GGA-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-SSC-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-DDI-9861718": ["r", "Regulation of pyruvate metabolism"], "R-GGA-6804757": ["r", "Regulation of TP53 Degradation"], "R-CFA-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-CFA-2022870": ["r", "CS-GAG biosynthesis"], "R-DRE-2022857": ["r", "Keratan sulfate degradation"], "R-DME-8941413": ["r", "Events associated with phagocytolytic activity of PMN cells"], "R-CFA-2024101": ["r", "CS/DS degradation"], "R-BTA-2022854": ["r", "Keratan sulfate biosynthesis"], "R-CFA-2022923": ["r", "DS-GAG biosynthesis"], "R-GGA-2022854": ["r", "Keratan sulfate biosynthesis"], "R-CFA-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-BTA-2022857": ["r", "Keratan sulfate degradation"], "PWY-5981": ["t", "CDP-diacylglycerol biosynthesis III"], "PWY-7817": ["t", "type I lipoteichoic acid biosynthesis (S. aureus)"], "PWY-5667": ["t", "CDP-diacylglycerol biosynthesis I"], "R-CEL-1483148": ["r", "Synthesis of PG"], "R-SPO-1483148": ["r", "Synthesis of PG"], "R-DME-1483148": ["r", "Synthesis of PG"], "R-SCE-1483148": ["r", "Synthesis of PG"], "R-CEL-1483226": ["r", "Synthesis of PI"], "R-RNO-1483148": ["r", "Synthesis of PG"], "R-MMU-1483148": ["r", "Synthesis of PG"], "R-BTA-1483148": ["r", "Synthesis of PG"], "R-DDI-169911": ["r", "Regulation of Apoptosis"], "R-BTA-75153": ["r", "Apoptotic execution phase"], "R-SSC-1169408": ["r", "ISG15 antiviral mechanism"], "R-SPO-169911": ["r", "Regulation of Apoptosis"], "R-CFA-1169408": ["r", "ISG15 antiviral mechanism"], "R-SCE-169911": ["r", "Regulation of Apoptosis"], "R-MMU-203641": ["r", "NOSTRIN mediated eNOS trafficking"], "R-RNO-75153": ["r", "Apoptotic execution phase"], "R-RNO-203641": ["r", "NOSTRIN mediated eNOS trafficking"], "R-HSA-75153": ["r", "Apoptotic execution phase"], "R-DRE-75153": ["r", "Apoptotic execution phase"], "R-SCE-75153": ["r", "Apoptotic execution phase"], "R-DDI-75153": ["r", "Apoptotic execution phase"], "R-MMU-75153": ["r", "Apoptotic execution phase"], "R-CEL-75153": ["r", "Apoptotic execution phase"], "R-SPO-75153": ["r", "Apoptotic execution phase"], "R-PFA-75153": ["r", "Apoptotic execution phase"], "R-HSA-9693928": ["r", "Defective RIPK1-mediated regulated necrosis"], "R-MMU-3371378": ["r", "Regulation by c-FLIP"], "R-RNO-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-HSA-9692913": ["r", "SARS-CoV-1-mediated effects on programmed cell death"], "R-DRE-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-HSA-69416": ["r", "Dimerization of procaspase-8"], "R-MMU-69416": ["r", "Dimerization of procaspase-8"], "R-DRE-5357905": ["r", "Regulation of TNFR1 signaling"], "R-BTA-3371378": ["r", "Regulation by c-FLIP"], "R-MMU-5669034": ["r", "TNFs bind their physiological receptors"], "R-DRE-5675482": ["r", "Regulation of necroptotic cell death"], "R-DRE-75893": ["r", "TNF signaling"], "R-DME-69416": ["r", "Dimerization of procaspase-8"], "R-CEL-373752": ["r", "Netrin-1 signaling"], "R-MMU-5218900": ["r", "CASP8 activity is inhibited"], "R-RNO-205017": ["r", "NFG and proNGF binds to p75NTR"], "R-RNO-3371378": ["r", "Regulation by c-FLIP"], "R-DRE-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-DME-5218900": ["r", "CASP8 activity is inhibited"], "R-SSC-3371378": ["r", "Regulation by c-FLIP"], "R-MMU-447043": ["r", "Neurofascin interactions"], "R-RNO-69416": ["r", "Dimerization of procaspase-8"], "R-HSA-193681": ["r", "Ceramide signalling"], "R-BTA-75893": ["r", "TNF signaling"], "R-HSA-5357956": ["r", "TNFR1-induced NF-kappa-B signaling pathway"], "R-SSC-75157": ["r", "FasL/ CD95L signaling"], "R-BTA-69416": ["r", "Dimerization of procaspase-8"], "R-DME-214397": ["r", "Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'"], "R-HSA-5669034": ["r", "TNFs bind their physiological receptors"], "R-HSA-75893": ["r", "TNF signaling"], "R-SSC-69416": ["r", "Dimerization of procaspase-8"], "R-RNO-5626978": ["r", "TNFR1-mediated ceramide production"], "R-MMU-75893": ["r", "TNF signaling"], "R-HSA-75158": ["r", "TRAIL signaling"], "R-DME-3371378": ["r", "Regulation by c-FLIP"], "R-MMU-445095": ["r", "Interaction between L1 and Ankyrins"], "R-HSA-3371378": ["r", "Regulation by c-FLIP"], "R-MMU-75158": ["r", "TRAIL signaling"], "R-MMU-205017": ["r", "NFG and proNGF binds to p75NTR"], "R-HSA-205017": ["r", "NFG and proNGF binds to p75NTR"], "R-HSA-418889": ["r", "Caspase activation via Dependence Receptors in the absence of ligand"], "R-BTA-9930044": ["r", "Nuclear RNA decay"], "R-XTR-9930044": ["r", "Nuclear RNA decay"], "R-HSA-9854907": ["r", "Regulation of MITF-M dependent genes involved in metabolism"], "R-DME-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-CEL-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-BTA-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-CEL-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-XTR-975956": ["r", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"], "R-XTR-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-HSA-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-HSA-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-GGA-72165": ["r", "mRNA Splicing - Minor Pathway"], "R-DRE-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-RNO-75094": ["r", "Formation of the Editosome"], "R-MMU-75094": ["r", "Formation of the Editosome"], "R-DRE-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-DRE-3214841": ["r", "PKMTs methylate histone lysines"], "R-DRE-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-MMU-9634638": ["r", "Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "R-RNO-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-XTR-6791226": ["r", "Major pathway of rRNA processing in the nucleolus and cytosol"], "R-XTR-9954716": ["r", "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA"], "R-XTR-1799339": ["r", "SRP-dependent cotranslational protein targeting to membrane"], "R-XTR-9954714": ["r", "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA"], "R-XTR-72706": ["r", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "R-XTR-9954709": ["r", "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide"], "R-CFA-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-DME-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-DME-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-GGA-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-RNO-8983711": ["r", "OAS antiviral response"], "R-SSC-5675482": ["r", "Regulation of necroptotic cell death"], "R-GGA-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-BTA-9833482": ["r", "PKR-mediated signaling"], "R-RNO-69541": ["r", "Stabilization of p53"], "R-SSC-4085377": ["r", "SUMOylation of SUMOylation proteins"], "R-GGA-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-SSC-3899300": ["r", "SUMOylation of transcription cofactors"], "R-CFA-168638": ["r", "NOD1/2 Signaling Pathway"], "R-SSC-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-GGA-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-DME-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-CFA-3769402": ["r", "Deactivation of the beta-catenin transactivating complex"], "R-GGA-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-HSA-5655862": ["r", "Translesion synthesis by POLK"], "R-CFA-2871837": ["r", "FCERI mediated NF-kB activation"], "R-CFA-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-CFA-9929356": ["r", "GSK3B-mediated proteasomal degradation of PD-L1(CD274)"], "R-SSC-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-GGA-182971": ["r", "EGFR downregulation"], "R-RNO-9861718": ["r", "Regulation of pyruvate metabolism"], "R-GGA-5689901": ["r", "Metalloprotease DUBs"], "R-DME-5655862": ["r", "Translesion synthesis by POLK"], "R-CFA-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-CFA-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-GGA-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-RNO-3065679": ["r", "SUMO is proteolytically processed"], "R-DDI-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-CFA-5693565": ["r", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "R-GGA-1227882": ["r", "TRAF mediated activation of IRF"], "R-GGA-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-CFA-69231": ["r", "Cyclin D associated events in G1"], "R-GGA-901032": ["r", "ER Quality Control Compartment (ERQC)"], "R-MMU-5656121": ["r", "Translesion synthesis by POLI"], "R-CEL-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-BTA-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-CEL-8948747": ["r", "Regulation of PTEN localization"], "R-SCE-5689603": ["r", "UCH proteinases"], "R-DDI-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-CFA-4641258": ["r", "Degradation of DVL"], "R-BTA-9706369": ["r", "Negative regulation of FLT3"], "R-BTA-8863795": ["r", "Downregulation of ERBB2 signaling"], "R-GGA-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-BTA-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-GGA-5656169": ["r", "Termination of translesion DNA synthesis"], "R-SCE-8856825": ["r", "Cargo recognition for clathrin-mediated endocytosis"], "R-CFA-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-MMU-3065679": ["r", "SUMO is proteolytically processed"], "R-GGA-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-CFA-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-SSC-4755510": ["r", "SUMOylation of immune response proteins"], "R-RNO-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-CFA-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-MMU-5655862": ["r", "Translesion synthesis by POLK"], "R-SSC-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-GGA-2672351": ["r", "Stimuli-sensing channels"], "R-RNO-2473224": ["r", "Antagonism of Activin by Follistatin"], "R-MMU-2473224": ["r", "Antagonism of Activin by Follistatin"], "R-HSA-2473224": ["r", "Antagonism of Activin by Follistatin"], "PWY-6823": ["t", "molybdopterin biosynthesis"], "R-HSA-5674404": ["r", "PTEN Loss of Function in Cancer"], "R-CEL-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-RNO-75157": ["r", "FasL/ CD95L signaling"], "R-MMU-75157": ["r", "FasL/ CD95L signaling"], "R-DRE-5218900": ["r", "CASP8 activity is inhibited"], "R-MMU-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-RNO-75893": ["r", "TNF signaling"], "R-BTA-5669034": ["r", "TNFs bind their physiological receptors"], "R-BTA-5218900": ["r", "CASP8 activity is inhibited"], "R-BTA-75157": ["r", "FasL/ CD95L signaling"], "R-DRE-3371378": ["r", "Regulation by c-FLIP"], "R-RNO-5218900": ["r", "CASP8 activity is inhibited"], "R-HSA-75157": ["r", "FasL/ CD95L signaling"], "R-RNO-5669034": ["r", "TNFs bind their physiological receptors"], "R-DRE-69416": ["r", "Dimerization of procaspase-8"], "R-SSC-5218900": ["r", "CASP8 activity is inhibited"], "PWY-6614": ["t", "tetrahydrofolate biosynthesis I"], "R-CEL-9759218": ["r", "Cobalamin (Cbl) metabolism"], "R-RNO-9759218": ["r", "Cobalamin (Cbl) metabolism"], "R-DDI-9759218": ["r", "Cobalamin (Cbl) metabolism"], "R-HSA-3359469": ["r", "Defective MTR causes HMAG"], "R-MMU-9759218": ["r", "Cobalamin (Cbl) metabolism"], "R-HSA-9759218": ["r", "Cobalamin (Cbl) metabolism"], "R-HSA-3359467": ["r", "Defective MTRR causes HMAE"], "R-SSC-9839406": ["r", "TGFBR3 regulates activin signaling"], "R-SSC-2473224": ["r", "Antagonism of Activin by Follistatin"], "R-BTA-2473224": ["r", "Antagonism of Activin by Follistatin"], "R-SSC-1502540": ["r", "Signaling by Activin"], "R-SSC-201451": ["r", "Signaling by BMP"], "R-RNO-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-HSA-9665251": ["r", "Resistance of ERBB2 KD mutants to lapatinib"], "R-RNO-74752": ["r", "Signaling by Insulin receptor"], "R-RNO-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-DME-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-MMU-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-DME-1251985": ["r", "Nuclear signaling by ERBB4"], "R-DME-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-DME-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-CEL-1227986": ["r", "Signaling by ERBB2"], "R-HSA-9665737": ["r", "Drug resistance in ERBB2 TMD/JMD mutants"], "PWY-8146": ["t", "cytochrome c biogenesis (system II type)"], "PWY-8145": ["t", "cytochrome c biogenesis (system III type)"], "R-CEL-611105": ["r", "Respiratory electron transport"], "R-HSA-2206302": ["r", "MPS I - Hurler syndrome (HS-GAG degradation)"], "R-CFA-2024096": ["r", "HS-GAG degradation"], "R-HSA-9953038": ["r", "MPS I - Hurler syndrome (CS/DS degradation)"], "R-DME-2024101": ["r", "CS/DS degradation"], "R-HSA-1222538": ["r", "Tolerance by Mtb to nitric oxide produced by macrophages"], "R-MMU-2534343": ["r", "Interaction With Cumulus Cells And The Zona Pellucida"], "R-SSC-2534343": ["r", "Interaction With Cumulus Cells And The Zona Pellucida"], "R-BTA-2534343": ["r", "Interaction With Cumulus Cells And The Zona Pellucida"], "R-HSA-2534343": ["r", "Interaction With Cumulus Cells And The Zona Pellucida"], "R-PFA-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-PFA-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-GGA-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-SSC-937039": ["r", "IRAK1 recruits IKK complex"], "R-CFA-69481": ["r", "G2/M Checkpoints"], "R-RNO-5655862": ["r", "Translesion synthesis by POLK"], "R-CFA-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-SSC-110312": ["r", "Translesion synthesis by REV1"], "R-BTA-4755510": ["r", "SUMOylation of immune response proteins"], "R-SPO-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-BTA-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-SCE-8951664": ["r", "Neddylation"], "R-GGA-209543": ["r", "p75NTR recruits signalling complexes"], "R-GGA-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-CFA-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-BTA-1295596": ["r", "Spry regulation of FGF signaling"], "R-SSC-937041": ["r", "IKK complex recruitment mediated by RIP1"], "R-CFA-9706369": ["r", "Negative regulation of FLT3"], "R-CFA-5357905": ["r", "Regulation of TNFR1 signaling"], "R-GGA-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-CFA-9646399": ["r", "Aggrephagy"], "R-GGA-9931295": ["r", "PD-L1(CD274) glycosylation and translocation to plasma membrane"], "R-CFA-110320": ["r", "Translesion Synthesis by POLH"], "R-CFA-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-SSC-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-CFA-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-GGA-353299": ["r", "RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases"], "R-SSC-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-SSC-6804757": ["r", "Regulation of TP53 Degradation"], "R-GGA-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-BTA-9664873": ["r", "Pexophagy"], "R-SSC-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-BTA-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-MMU-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-CEL-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-BTA-6804757": ["r", "Regulation of TP53 Degradation"], "R-SSC-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-DME-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-BTA-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-GGA-877312": ["r", "Regulation of IFNG signaling"], "R-CFA-983168": ["r", "Antigen processing: Ubiquitination & Proteasome degradation"], "R-GGA-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-BTA-3899300": ["r", "SUMOylation of transcription cofactors"], "R-GGA-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-CFA-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-GGA-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-CFA-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-BTA-8849469": ["r", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "R-GGA-912631": ["r", "Regulation of signaling by CBL"], "R-HSA-8983711": ["r", "OAS antiviral response"], "R-CFA-201681": ["r", "TCF dependent signaling in response to WNT"], "R-BTA-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-SSC-4551638": ["r", "SUMOylation of chromatin organization proteins"], "R-CFA-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-GGA-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-SSC-4641263": ["r", "Regulation of FZD by ubiquitination"], "R-GGA-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-BTA-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-CEL-110312": ["r", "Translesion synthesis by REV1"], "R-SSC-3232118": ["r", "SUMOylation of transcription factors"], "R-BTA-1660516": ["r", "Synthesis of PIPs at the early endosome membrane"], "R-BTA-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-DDI-5689896": ["r", "Ovarian tumor domain proteases"], "R-CFA-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-HSA-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-BTA-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-CEL-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-DRE-1660517": ["r", "Synthesis of PIPs at the late endosome membrane"], "R-DME-8873719": ["r", "RAB geranylgeranylation"], "R-RNO-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-CEL-202424": ["r", "Downstream TCR signaling"], "R-MMU-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-XTR-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-SCE-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-CFA-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-XTR-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-HSA-165160": ["r", "PDE3B signalling"], "R-SCE-2871796": ["r", "FCERI mediated MAPK activation"], "R-SSC-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-DDI-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-DRE-912631": ["r", "Regulation of signaling by CBL"], "R-HSA-5676594": ["r", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "R-BTA-8854521": ["r", "Interaction between PHLDA1 and AURKA"], "R-HSA-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-RNO-442729": ["r", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "R-DDI-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-GGA-9705462": ["r", "Inactivation of CSF3 (G-CSF) signaling"], "R-BTA-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-PFA-5675482": ["r", "Regulation of necroptotic cell death"], "R-DRE-190375": ["r", "FGFR2c ligand binding and activation"], "R-HSA-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-CEL-156711": ["r", "Polo-like kinase mediated events"], "R-BTA-5621480": ["r", "Dectin-2 family"], "R-DRE-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-HSA-9702600": ["r", "midostaurin-resistant FLT3 mutants"], "R-DRE-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-PFA-5357905": ["r", "Regulation of TNFR1 signaling"], "R-DDI-156711": ["r", "Polo-like kinase mediated events"], "R-DME-422356": ["r", "Regulation of insulin secretion"], "R-XTR-202424": ["r", "Downstream TCR signaling"], "R-HSA-9674401": ["r", "Sunitinib-resistant PDGFR mutants"], "R-SCE-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-MMU-73728": ["r", "RNA Polymerase I Promoter Opening"], "R-CEL-190373": ["r", "FGFR1c ligand binding and activation"], "R-DME-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-GGA-9031628": ["r", "NGF-stimulated transcription"], "R-RNO-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-HSA-9661069": ["r", "Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)"], "R-CEL-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-HSA-9674396": ["r", "Imatinib-resistant PDGFR mutants"], "R-DME-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-DRE-937039": ["r", "IRAK1 recruits IKK complex"], "R-SSC-8875513": ["r", "MET interacts with TNS proteins"], "R-BTA-375165": ["r", "NCAM signaling for neurite out-growth"], "R-HSA-9717316": ["r", "alectinib-resistant ALK mutants"], "R-MMU-190370": ["r", "FGFR1b ligand binding and activation"], "R-MMU-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "R-DME-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-SSC-2029481": ["r", "FCGR activation"], "R-MMU-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-SPO-68949": ["r", "Orc1 removal from chromatin"], "R-RNO-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-BTA-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-XTR-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-MMU-8935690": ["r", "Digestion"], "R-CEL-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-HSA-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-HSA-2408522": ["r", "Selenoamino acid metabolism"], "R-DME-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-HSA-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-PFA-70350": ["r", "Fructose catabolism"], "R-RNO-70350": ["r", "Fructose catabolism"], "R-GGA-70350": ["r", "Fructose catabolism"], "R-DRE-70350": ["r", "Fructose catabolism"], "R-HSA-70350": ["r", "Fructose catabolism"], "R-DME-70350": ["r", "Fructose catabolism"], "R-CEL-70350": ["r", "Fructose catabolism"], "R-HSA-5657560": ["r", "Hereditary fructose intolerance"], "R-MMU-70350": ["r", "Fructose catabolism"], "R-DDI-70350": ["r", "Fructose catabolism"], "R-SSC-1236394": ["r", "Signaling by ERBB4"], "R-HSA-9018677": ["r", "Biosynthesis of DHA-derived SPMs"], "R-GGA-9018679": ["r", "Biosynthesis of EPA-derived SPMs"], "R-GGA-5673001": ["r", "RAF/MAP kinase cascade"], "R-SSC-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-GGA-8857538": ["r", "PTK6 promotes HIF1A stabilization"], "R-DDI-2129379": ["r", "Molecules associated with elastic fibres"], "R-RNO-9018677": ["r", "Biosynthesis of DHA-derived SPMs"], "R-GGA-9027604": ["r", "Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives"], "R-GGA-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-GGA-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-SSC-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-DDI-3000178": ["r", "ECM proteoglycans"], "R-MMU-9027604": ["r", "Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives"], "R-BTA-166665": ["r", "Terminal pathway of complement"], "R-MMU-9025094": ["r", "Biosynthesis of DPAn-3 SPMs"], "R-MMU-9018677": ["r", "Biosynthesis of DHA-derived SPMs"], "R-SSC-179812": ["r", "GRB2 events in EGFR signaling"], "R-DDI-1566977": ["r", "Fibronectin matrix formation"], "R-SSC-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-GGA-375165": ["r", "NCAM signaling for neurite out-growth"], "R-RNO-203615": ["r", "eNOS activation"], "R-MMU-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-RNO-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-DME-165181": ["r", "Inhibition of TSC complex formation by PKB"], "R-DDI-444257": ["r", "RSK activation"], "R-MMU-442742": ["r", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"], "R-CEL-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-RNO-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-HSA-165158": ["r", "Activation of AKT2"], "R-RNO-444257": ["r", "RSK activation"], "R-CEL-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-HSA-442742": ["r", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"], "R-RNO-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-DRE-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-DDI-8963896": ["r", "HDL assembly"], "R-HSA-444257": ["r", "RSK activation"], "R-HSA-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-SCE-444257": ["r", "RSK activation"], "R-CEL-9634638": ["r", "Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "R-GGA-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-DME-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-SCE-4086398": ["r", "Ca2+ pathway"], "R-SSC-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-DDI-525793": ["r", "Myogenesis"], "R-DME-877300": ["r", "Interferon gamma signaling"], "R-HSA-113507": ["r", "E2F-enabled inhibition of pre-replication complex formation"], "R-RNO-442742": ["r", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"], "R-BTA-399719": ["r", "Trafficking of AMPA receptors"], "R-RNO-198765": ["r", "Signalling to ERK5"], "R-SSC-6806942": ["r", "MET Receptor Activation"], "R-BTA-69478": ["r", "G2/M DNA replication checkpoint"], "R-BTA-202427": ["r", "Phosphorylation of CD3 and TCR zeta chains"], "R-DRE-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-RNO-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-DDI-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-DDI-198765": ["r", "Signalling to ERK5"], "R-CEL-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-CEL-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-HSA-9758919": ["r", "Epithelial-Mesenchymal Transition (EMT) during gastrulation"], "R-DRE-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-CEL-198753": ["r", "ERK/MAPK targets"], "R-DRE-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-BTA-877300": ["r", "Interferon gamma signaling"], "R-GGA-5621480": ["r", "Dectin-2 family"], "R-DRE-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-DRE-1433559": ["r", "Regulation of KIT signaling"], "R-DRE-210993": ["r", "Tie2 Signaling"], "R-DRE-444257": ["r", "RSK activation"], "R-DME-381042": ["r", "PERK regulates gene expression"], "R-RNO-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-CFA-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-PFA-9833482": ["r", "PKR-mediated signaling"], "R-RNO-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-DRE-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-SPO-525793": ["r", "Myogenesis"], "R-DRE-2682334": ["r", "EPH-Ephrin signaling"], "R-BTA-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-DME-111465": ["r", "Apoptotic cleavage of cellular proteins"], "R-BTA-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-BTA-381042": ["r", "PERK regulates gene expression"], "R-CEL-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-MMU-68911": ["r", "G2 Phase"], "R-DME-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-CEL-203615": ["r", "eNOS activation"], "R-HSA-8853334": ["r", "Signaling by FGFR3 fusions in cancer"], "R-DME-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-MMU-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-RNO-381042": ["r", "PERK regulates gene expression"], "R-DRE-190373": ["r", "FGFR1c ligand binding and activation"], "R-CEL-432142": ["r", "Platelet sensitization by LDL"], "R-DRE-210990": ["r", "PECAM1 interactions"], "R-GGA-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-SPO-156711": ["r", "Polo-like kinase mediated events"], "R-HSA-1307965": ["r", "betaKlotho-mediated ligand binding"], "R-DRE-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-DME-209159": ["r", "Assembly of the CI containing complexes"], "R-PFA-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-HSA-163358": ["r", "PKA-mediated phosphorylation of key metabolic factors"], "R-GGA-2871796": ["r", "FCERI mediated MAPK activation"], "R-MMU-156711": ["r", "Polo-like kinase mediated events"], "R-MMU-2682334": ["r", "EPH-Ephrin signaling"], "R-BTA-1433559": ["r", "Regulation of KIT signaling"], "R-DRE-1295596": ["r", "Spry regulation of FGF signaling"], "R-CEL-190371": ["r", "FGFR3b ligand binding and activation"], "R-HSA-176417": ["r", "Phosphorylation of Emi1"], "R-MMU-5173105": ["r", "O-linked glycosylation"], "R-DME-390150": ["r", "DS ligand bound to FT receptor"], "R-DDI-1474228": ["r", "Degradation of the extracellular matrix"], "R-DDI-8964058": ["r", "HDL remodeling"], "R-SSC-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-HSA-140180": ["r", "COX reactions"], "R-SSC-8847993": ["r", "ERBB2 Activates PTK6 Signaling"], "R-SSC-1227986": ["r", "Signaling by ERBB2"], "R-RNO-140180": ["r", "COX reactions"], "R-GGA-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-DRE-6794361": ["r", "Neurexins and neuroligins"], "R-GGA-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-HSA-9025094": ["r", "Biosynthesis of DPAn-3 SPMs"], "R-MMU-140180": ["r", "COX reactions"], "R-SSC-180336": ["r", "SHC1 events in EGFR signaling"], "R-SSC-8857538": ["r", "PTK6 promotes HIF1A stabilization"], "R-RNO-9027604": ["r", "Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives"], "R-DDI-9793528": ["r", "Ciprofloxacin ADME"], "R-GGA-9018677": ["r", "Biosynthesis of DHA-derived SPMs"], "R-HSA-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-MMU-8941237": ["r", "Invadopodia formation"], "R-CEL-2534343": ["r", "Interaction With Cumulus Cells And The Zona Pellucida"], "R-GGA-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-GGA-9025094": ["r", "Biosynthesis of DPAn-3 SPMs"], "R-GGA-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-DDI-189483": ["r", "Heme degradation"], "R-GGA-199920": ["r", "CREB phosphorylation"], "R-DRE-6804757": ["r", "Regulation of TP53 Degradation"], "R-CEL-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-DRE-9031628": ["r", "NGF-stimulated transcription"], "R-RNO-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-MMU-444257": ["r", "RSK activation"], "R-DME-199920": ["r", "CREB phosphorylation"], "R-SCE-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-CEL-199920": ["r", "CREB phosphorylation"], "R-GGA-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-SPO-444257": ["r", "RSK activation"], "R-DME-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-MMU-203615": ["r", "eNOS activation"], "R-CEL-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-HSA-111931": ["r", "PKA-mediated phosphorylation of CREB"], "R-RNO-5625900": ["r", "RHO GTPases activate CIT"], "R-SSC-1433559": ["r", "Regulation of KIT signaling"], "R-SPO-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-DDI-168638": ["r", "NOD1/2 Signaling Pathway"], "R-CEL-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-HSA-203615": ["r", "eNOS activation"], "R-DME-68962": ["r", "Activation of the pre-replicative complex"], "R-BTA-68875": ["r", "Mitotic Prophase"], "R-SSC-210990": ["r", "PECAM1 interactions"], "R-SPO-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-RNO-446343": ["r", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "R-HSA-69478": ["r", "G2/M DNA replication checkpoint"], "R-DME-109704": ["r", "PI3K Cascade"], "R-SSC-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-DME-190377": ["r", "FGFR2b ligand binding and activation"], "R-SCE-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-XTR-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-DRE-3928662": ["r", "EPHB-mediated forward signaling"], "R-CEL-2024096": ["r", "HS-GAG degradation"], "R-MMU-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-SPO-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-CEL-171007": ["r", "p38MAPK events"], "R-HSA-190371": ["r", "FGFR3b ligand binding and activation"], "R-DRE-190374": ["r", "FGFR1c and Klotho ligand binding and activation"], "R-DRE-375165": ["r", "NCAM signaling for neurite out-growth"], "R-HSA-9680187": ["r", "Signaling by extracellular domain mutants of KIT"], "R-CFA-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-MMU-975871": ["r", "MyD88 cascade initiated on plasma membrane"], "R-CEL-2022928": ["r", "HS-GAG biosynthesis"], "R-BTA-9627069": ["r", "Regulation of the apoptosome activity"], "R-DDI-170968": ["r", "Frs2-mediated activation"], "R-BTA-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-MMU-9706374": ["r", "FLT3 signaling through SRC family kinases"], "R-XTR-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-HSA-2023837": ["r", "Signaling by FGFR2 amplification mutants"], "R-DDI-3214858": ["r", "RMTs methylate histone arginines"], "R-RNO-111932": ["r", "CaMK IV-mediated phosphorylation of CREB"], "R-SPO-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-MMU-8854521": ["r", "Interaction between PHLDA1 and AURKA"], "R-RNO-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-RNO-8941237": ["r", "Invadopodia formation"], "R-GGA-177929": ["r", "Signaling by EGFR"], "R-SSC-180292": ["r", "GAB1 signalosome"], "R-SSC-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-HSA-3000484": ["r", "Scavenging by Class F Receptors"], "R-SSC-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-GGA-1227986": ["r", "Signaling by ERBB2"], "R-GGA-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-RNO-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-MMU-9018679": ["r", "Biosynthesis of EPA-derived SPMs"], "R-HSA-8941237": ["r", "Invadopodia formation"], "R-GGA-179812": ["r", "GRB2 events in EGFR signaling"], "R-GGA-1306955": ["r", "GRB7 events in ERBB2 signaling"], "R-CFA-140180": ["r", "COX reactions"], "R-DDI-9753281": ["r", "Paracetamol ADME"], "R-DRE-186797": ["r", "Signaling by PDGF"], "R-DDI-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-RNO-9025094": ["r", "Biosynthesis of DPAn-3 SPMs"], "R-DME-390023": ["r", "Subcellular localisation of D"], "R-DDI-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-HSA-9018679": ["r", "Biosynthesis of EPA-derived SPMs"], "R-SSC-212718": ["r", "EGFR interacts with phospholipase C-gamma"], "R-GGA-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-CEL-2160916": ["r", "Hyaluronan degradation"], "R-GGA-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-GGA-1236394": ["r", "Signaling by ERBB4"], "R-GGA-1250342": ["r", "PI3K events in ERBB4 signaling"], "R-SSC-2179392": ["r", "EGFR Transactivation by Gastrin"], "PWY-5189": ["t", "tetrapyrrole biosynthesis II (from glycine)"], "R-BTA-189451": ["r", "Heme biosynthesis"], "R-CFA-9753281": ["r", "Paracetamol ADME"], "R-DRE-9753281": ["r", "Paracetamol ADME"], "R-DRE-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-CEL-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-DME-2022928": ["r", "HS-GAG biosynthesis"], "R-CFA-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-CEL-9753281": ["r", "Paracetamol ADME"], "R-SCE-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-SCE-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-MMU-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-CEL-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-GGA-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-BTA-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-SPO-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-DME-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-RNO-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-DDI-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-GGA-9818027": ["r", "NFE2L2 regulating anti-oxidant/detoxification enzymes"], "R-DME-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-BTA-6803211": ["r", "TP53 Regulates Transcription of Death Receptors and Ligands"], "PWY-702": ["t", "L-methionine biosynthesis II"], "PWY-7530": ["t", "Escherichia coli serotype O:104 O antigen biosynthesis"], "PWY-7940": ["t", "lauryl-hydroxychlorobactene glucoside biosynthesis"], "PWY-6922": ["t", "L-Ndelta-acetylornithine biosynthesis"], "R-HSA-168330": ["r", "Viral RNP Complexes in the Host Cell Nucleus"], "R-BTA-2168880": ["r", "Scavenging of heme from plasma"], "R-GGA-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-XTR-2168880": ["r", "Scavenging of heme from plasma"], "R-GGA-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-HSA-8981607": ["r", "Intracellular oxygen transport"], "R-XTR-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-DRE-8981607": ["r", "Intracellular oxygen transport"], "R-DRE-203615": ["r", "eNOS activation"], "R-XTR-9707616": ["r", "Heme signaling"], "R-MMU-8981607": ["r", "Intracellular oxygen transport"], "R-RNO-8981607": ["r", "Intracellular oxygen transport"], "R-BTA-8981607": ["r", "Intracellular oxygen transport"], "R-XTR-9707564": ["r", "Cytoprotection by HMOX1"], "R-XTR-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-SSC-8981607": ["r", "Intracellular oxygen transport"], "R-GGA-8981607": ["r", "Intracellular oxygen transport"], "R-RNO-1462054": ["r", "Alpha-defensins"], "R-MMU-1462054": ["r", "Alpha-defensins"], "R-GGA-6803157": ["r", "Antimicrobial peptides"], "R-RNO-6803157": ["r", "Antimicrobial peptides"], "R-CFA-6803157": ["r", "Antimicrobial peptides"], "R-BTA-6803157": ["r", "Antimicrobial peptides"], "R-SSC-6803157": ["r", "Antimicrobial peptides"], "R-DME-6803157": ["r", "Antimicrobial peptides"], "R-HSA-6803157": ["r", "Antimicrobial peptides"], "R-MMU-6803157": ["r", "Antimicrobial peptides"], "R-CFA-6798695": ["r", "Neutrophil degranulation"], "R-GGA-5653890": ["r", "Lactose synthesis"], "R-SSC-9012546": ["r", "Interleukin-18 signaling"], "R-MMU-9960525": ["r", "CASP5-mediated substrate cleavage"], "R-BTA-448706": ["r", "Interleukin-1 processing"], "R-HSA-9960525": ["r", "CASP5-mediated substrate cleavage"], "R-HSA-5620971": ["r", "Pyroptosis"], "R-BTA-9960525": ["r", "CASP5-mediated substrate cleavage"], "R-HSA-9960519": ["r", "CASP4-mediated substrate cleavage"], "R-SSC-5620971": ["r", "Pyroptosis"], "R-BTA-9960519": ["r", "CASP4-mediated substrate cleavage"], "R-RNO-5620971": ["r", "Pyroptosis"], "R-BTA-5620971": ["r", "Pyroptosis"], "R-MMU-9960519": ["r", "CASP4-mediated substrate cleavage"], "R-BTA-9012546": ["r", "Interleukin-18 signaling"], "R-SSC-448706": ["r", "Interleukin-1 processing"], "R-MMU-5660668": ["r", "CLEC7A/inflammasome pathway"], "R-SSC-9960525": ["r", "CASP5-mediated substrate cleavage"], "R-RNO-5660668": ["r", "CLEC7A/inflammasome pathway"], "R-RNO-9012546": ["r", "Interleukin-18 signaling"], "R-SSC-9960519": ["r", "CASP4-mediated substrate cleavage"], "R-MMU-5620971": ["r", "Pyroptosis"], "R-BTA-68962": ["r", "Activation of the pre-replicative complex"], "R-RNO-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-DRE-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-CEL-68911": ["r", "G2 Phase"], "R-GGA-389356": ["r", "Co-stimulation by CD28"], "R-SCE-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-DME-5654689": ["r", "PI-3K cascade:FGFR1"], "R-DME-209397": ["r", "Formation of the cytosolic BSK 'scaffolding complex'"], "R-DME-190373": ["r", "FGFR1c ligand binding and activation"], "R-DME-176417": ["r", "Phosphorylation of Emi1"], "R-XTR-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-BTA-176187": ["r", "Activation of ATR in response to replication stress"], "R-BTA-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-RNO-8854521": ["r", "Interaction between PHLDA1 and AURKA"], "R-XTR-176417": ["r", "Phosphorylation of Emi1"], "R-DME-190370": ["r", "FGFR1b ligand binding and activation"], "R-DME-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-BTA-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-PFA-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-DRE-430116": ["r", "GP1b-IX-V activation signalling"], "R-HSA-9703009": ["r", "tamatinib-resistant FLT3 mutants"], "R-HSA-2980766": ["r", "Nuclear Envelope Breakdown"], "R-BTA-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-CFA-9851151": ["r", "MDK and PTN in ALK signaling"], "R-GGA-114604": ["r", "GPVI-mediated activation cascade"], "R-CEL-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-SCE-176187": ["r", "Activation of ATR in response to replication stress"], "R-XTR-1295596": ["r", "Spry regulation of FGF signaling"], "R-MMU-8849474": ["r", "PTK6 Activates STAT3"], "R-MMU-176417": ["r", "Phosphorylation of Emi1"], "R-SSC-8875555": ["r", "MET activates RAP1 and RAC1"], "R-BTA-198753": ["r", "ERK/MAPK targets"], "R-HSA-9669914": ["r", "Dasatinib-resistant KIT mutants"], "R-RNO-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-HSA-9674428": ["r", "PDGFR mutants bind TKIs"], "R-HSA-9702569": ["r", "KW2449-resistant FLT3 mutants"], "R-MMU-381042": ["r", "PERK regulates gene expression"], "R-RNO-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-SSC-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-PFA-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-MMU-69478": ["r", "G2/M DNA replication checkpoint"], "R-DRE-5654710": ["r", "PI-3K cascade:FGFR3"], "R-GGA-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-CEL-2024101": ["r", "CS/DS degradation"], "R-MMU-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-RNO-9018679": ["r", "Biosynthesis of EPA-derived SPMs"], "R-HSA-9027604": ["r", "Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives"], "R-GGA-180336": ["r", "SHC1 events in EGFR signaling"], "R-SSC-177929": ["r", "Signaling by EGFR"], "R-MMU-6811438": ["r", "Intra-Golgi traffic"], "R-DME-6811438": ["r", "Intra-Golgi traffic"], "R-DDI-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-DME-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-DDI-204005": ["r", "COPII-mediated vesicle transport"], "R-RNO-6811438": ["r", "Intra-Golgi traffic"], "R-DDI-6811438": ["r", "Intra-Golgi traffic"], "R-BTA-6811438": ["r", "Intra-Golgi traffic"], "R-SSC-71288": ["r", "Creatine metabolism"], "R-GGA-71288": ["r", "Creatine metabolism"], "R-CEL-176187": ["r", "Activation of ATR in response to replication stress"], "R-SSC-75035": ["r", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "R-SSC-176187": ["r", "Activation of ATR in response to replication stress"], "R-RNO-176187": ["r", "Activation of ATR in response to replication stress"], "R-DDI-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-HSA-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-SSC-156711": ["r", "Polo-like kinase mediated events"], "R-SPO-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-BTA-156711": ["r", "Polo-like kinase mediated events"], "R-SSC-5625740": ["r", "RHO GTPases activate PKNs"], "R-SPO-176187": ["r", "Activation of ATR in response to replication stress"], "R-SSC-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-DME-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-SCE-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-DDI-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-DME-156711": ["r", "Polo-like kinase mediated events"], "R-MMU-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-DDI-69202": ["r", "Cyclin E associated events during G1/S transition"], "PWY-6373": ["t", "acrylate degradation I"], "PWY-7989": ["t", "acinetoferrin biosynthesis"], "PWY-8157": ["t", "avenanthramide biosynthesis"], "PWY-8051": ["t", "anandamide biosynthesis I"], "PWY-7029": ["t", "terminal olefins biosynthesis II"], "PWY-6320": ["t", "phaselate biosynthesis"], "PWY-7265": ["t", "lampranthin biosynthesis"], "PWY-7670": ["t", "fusaridione A biosynthesis"], "PWY-6627": ["t", "salinosporamide A biosynthesis"], "PWY-6946": ["t", "cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"], "PWY-7261": ["t", "anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"], "PWY-7280": ["t", "ternatin C3 biosynthesis"], "PWY-7711": ["t", "calonectrin biosynthesis"], "PWY-6945": ["t", "cholesterol degradation to androstenedione I (cholesterol oxidase)"], "PWY-7688": ["t", "dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"], "PWY-7563": ["t", "bassianin and desmethylbassianin biosynthesis"], "PWY-6027": ["t", "capsiconiate biosynthesis"], "PWY-7677": ["t", "rosamicin biosynthesis"], "PWY-7632": ["t", "hinokiresinol biosynthesis"], "PWY-7412": ["t", "mycinamicin biosynthesis"], "PWY-7907": ["t", "(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"], "PWY-7577": ["t", "ferrichrome biosynthesis"], "PWY-6378": ["t", "putrebactin biosynthesis"], "PWY-8075": ["t", "(Kdo)2-lipid A biosynthesis (P. putida)"], "PWY-7726": ["t", "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"], "PWY-6379": ["t", "alcaligin biosynthesis"], "PWY-7543": ["t", "5-N-acetylardeemin biosynthesis"], "PWY-7583": ["t", "arachidonate biosynthesis II (bacteria)"], "PWY-6679": ["t", "jadomycin biosynthesis"], "PWY-7656": ["t", "Spodoptera littoralis pheromone biosynthesis"], "PWY-7452": ["t", "cyanidin dimalonylglucoside biosynthesis"], "PWY-8049": ["t", "pederin biosynthesis"], "PWY-7679": ["t", "anthocyanidin acylglucoside and acylsambubioside biosynthesis"], "PWY-7448": ["t", "galloylated catechin biosynthesis"], "PWY-7694": ["t", "zwittermicin A biosynthesis"], "PWY-7693": ["t", "guadinomine B biosynthesis"], "PWY-7624": ["t", "nystatin biosynthesis"], "PWY-7532": ["t", "acetylaszonalenin biosynthesis"], "PWY-6672": ["t", "cis-geranyl-CoA degradation"], "PWY-7458": ["t", "violdelphin biosynthesis"], "PWY-7716": ["t", "penicillin G and penicillin V biosynthesis"], "PWY-7987": ["t", "vanchrobactin biosynthesis"], "PWY-4801": ["t", "aloesone and aloesin biosynthesis"], "PWY-5318": ["t", "calystegine biosynthesis"], "PWY-7172": ["t", "flavonol acylglucoside biosynthesis III - quercetin derivatives"], "PWY-7983": ["t", "pseudomonine biosynthesis"], "PWY-7053": ["t", "docosahexaenoate biosynthesis I (lower eukaryotes)"], "PWY-6056": ["t", "dimethylsulfoniopropanoate degradation II (cleavage)"], "PWY-8133": ["t", "succinoglycan biosynthesis"], "PWY-5292": ["t", "vindoline, vindorosine and vinblastine biosynthesis"], "PWY-8374": ["t", "antimycin biosynthesis"], "PWY-8337": ["t", "gamma-butyrobetaine degradation I"], "PWY-5139": ["t", "pelargonidin conjugates biosynthesis"], "PWY-5307": ["t", "gentiodelphin biosynthesis"], "PWY-8084": ["t", "daurichromenate biosynthesis"], "PWY-7354": ["t", "aclacinomycin biosynthesis"], "PWY-6032": ["t", "digitoxigenin biosynthesis"], "PWY-7815": ["t", "poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"], "PWY-7696": ["t", "citreoisocoumarin and bikisocoumarin biosynthesis"], "PWY-8447": ["t", "carminate biosynthesis"], "PWY-7415": ["t", "tylosin biosynthesis"], "PWY-7475": ["t", "des-methyl avenacin A-1 biosynthesis"], "PWY-7555": ["t", "alpha-cyclopiazonate biosynthesis"], "PWY-7171": ["t", "flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"], "PWY-7950": ["t", "diadinoxanthin and fucoxanthin biosynthesis (diatoms)"], "PWY-7318": ["t", "dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"], "PWY-8012": ["t", "mupirocin biosynthesis"], "PWY-7984": ["t", "acinetobactin biosynthesis"], "PWY-8038": ["t", "naphthomycin biosynthesis"], "PWY-7730": ["t", "T-2 toxin biosynthesis"], "PWY-5710": ["t", "capsaicin biosynthesis"], "PWY-7602": ["t", "icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"], "PWY-6036": ["t", "cardenolide glucosides biosynthesis"], "PWY-8032": ["t", "chloramphenicol biosynthesis"], "PWY-7690": ["t", "holomycin biosynthesis"], "PWY-7474": ["t", "avenacin A-2 biosynthesis"], "PWY-7930": ["t", "pyoluteorin biosynthesis"], "PWY-7465": ["t", "3,3'-thiodipropanoate degradation"], "PWY-84": ["t", "resveratrol biosynthesis"], "PWY-6316": ["t", "aromatic polyketides biosynthesis"], "PWY-8343": ["t", "leinamycin biosynthesis"], "PWY-7471": ["t", "D-carnitine degradation I"], "PWY-8151": ["t", "cholesterol degradation to androstenedione III (anaerobic)"], "PWY-5048": ["t", "rosmarinic acid biosynthesis I"], "PWY-7470": ["t", "phosphatidylcholine biosynthesis VII"], "PWY-6920": ["t", "6-gingerol analog biosynthesis (engineered)"], "PWY-6763": ["t", "salicortin biosynthesis"], "PWY-5313": ["t", "superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"], "PWY-8243": ["t", "colanic acid (Escherichia coli K12) biosynthesis"], "PWY-6397": ["t", "mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"], "PWY-5679": ["t", "clavulanate biosynthesis"], "PWY-7727": ["t", "docosahexaenoate biosynthesis IV (4-desaturase, mammals)"], "PWY-5284": ["t", "shisonin biosynthesis"], "PWY-8152": ["t", "androstenedione degradation II (anaerobic)"], "PWY-7746": ["t", "mycobacterial sulfolipid biosynthesis"], "PWY-8231": ["t", "Escherichia coli serotype O:127 O antigen biosynthesis"], "PWY-8464": ["t", "sphingofungin B-D biosynthesis"], "PWY-7702": ["t", "sch210971 and sch210972 biosynthesis"], "PWY-5984": ["t", "rifamycin B biosynthesis"], "PWY-7816": ["t", "poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"], "PWY-7687": ["t", "stipitatate biosynthesis"], "PWY-8407": ["t", "fumagillin biosynthesis"], "PWY-7818": ["t", "type IV lipoteichoic acid biosynthesis (S. pneumoniae)"], "PWY-7660": ["t", "tryptoquialanine biosynthesis"], "PWY-6944": ["t", "androstenedione degradation I (aerobic)"], "PWY-7407": ["t", "aurachin A, B, C and D biosynthesis"], "PWY-7713": ["t", "nivalenol biosynthesis"], "PWY-7599": ["t", "anditomin biosynthesis"], "PWY-7049": ["t", "icosapentaenoate biosynthesis II (6-desaturase, mammals)"], "PWY-8082": ["t", "glycine lipid biosynthesis"], "PWY-7601": ["t", "arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"], "PWY-8116": ["t", "ochratoxin A biosynthesis"], "PWY-7988": ["t", "baumannoferrin biosynthesis"], "PWY-5477": ["t", "gallotannin biosynthesis"], "PWY-7954": ["t", "tabtoxinine-beta-lactam biosynthesis"], "PWY-7450": ["t", "anthocyanidin modification (Arabidopsis)"], "PWY-6312": ["t", "aloin biosynthesis"], "PWY-7728": ["t", "(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"], "PWY-5473": ["t", "hydroxycinnamic acid serotonin amides biosynthesis"], "PWY-8045": ["t", "cylindrospermopsin biosynthesis"], "PWY-7585": ["t", "docosahexaenoate biosynthesis II (bacteria)"], "PWY-4922": ["t", "6-methoxymellein biosynthesis"], "PWY-7460": ["t", "2-O-acetyl-3-O-trans-coutarate biosynthesis"], "PWY-8053": ["t", "anandamide biosynthesis II"], "PWY-6930": ["t", "phenolic malonylglucosides biosynthesis"], "PWY-8166": ["t", "emodin biosynthesis"], "PWY-5875": ["t", "staphyloxanthin biosynthesis"], "PWY-5660": ["t", "taxol biosynthesis"], "PWY-7621": ["t", "autoinducer CAI-1 biosynthesis"], "PWY-5794": ["t", "malonate degradation I (biotin-independent)"], "PWY-6799": ["t", "fatty acid biosynthesis initiation (plant mitochondria)"], "PWY-6314": ["t", "plumbagin biosynthesis"], "PWY-7612": ["t", "chaetoglobosin A biosynthesis"], "PWY-7714": ["t", "harzianum A and trichodermin biosynthesis"], "PWY-7401": ["t", "crotonate fermentation (to acetate and cyclohexane carboxylate)"], "PWY-6039": ["t", "chlorogenic acid biosynthesis I"], "PWY-5475": ["t", "pentagalloylglucose biosynthesis"], "PWY-7050": ["t", "icosapentaenoate biosynthesis IV (bacteria)"], "PWY-7672": ["t", "fusaric acid biosynthesis"], "PWY-7464": ["t", "cyanidin 3,7-diglucoside polyacylation biosynthesis"], "PWY-7473": ["t", "avenacin A-1 biosynthesis"], "PWY-8272": ["t", "Escherichia coli serotype O:49 O antigen biosynthesis"], "PWY-6958": ["t", "icosapentaenoate biosynthesis I (lower eukaryotes)"], "PWY-5317": ["t", "tropane alkaloids biosynthesis"], "PWY-6948": ["t", "sitosterol degradation to androstenedione"], "PWY-7986": ["t", "anguibactin biosynthesis"], "PWY-8058": ["t", "2-deoxy-D-ribose degradation II"], "PWY-5903": ["t", "bacillibactin biosynthesis"], "PWY-8366": ["t", "septacidin biosynthesis"], "PWY-8434": ["t", "cucurbitacin biosynthesis"], "PWY-5353": ["t", "arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"], "PWY-7352": ["t", "daunorubicin biosynthesis"], "PWY-7405": ["t", "aurachin RE biosynthesis"], "PWY-6407": ["t", "yersiniabactin biosynthesis"], "PWY-7168": ["t", "flavonol acylglucoside biosynthesis I - kaempferol derivatives"], "PWY-6453": ["t", "stigma estolide biosynthesis"], "PWY-361": ["t", "monolignol biosynthesis"], "PWY-3602": ["t", "L-carnitine degradation III"], "PWY-7738": ["t", "polyacyltrehalose biosynthesis"], "PWY-6673": ["t", "caffeoylglucarate biosynthesis"], "PWY-7561": ["t", "tenellin biosynthesis"], "PWY-8408": ["t", "erinacine biosynthesis"], "PWY-761": ["t", "rhizobactin 1021 biosynthesis"], "PWY-8371": ["t", "mannosylerythritol lipids biosynthesis"], "PWY-7461": ["t", "hydroxycinnamate sugar acid ester biosynthesis"], "PWY-5268": ["t", "salvianin biosynthesis"], "PWY-7708": ["t", "lyngbyatoxin biosynthesis"], "PWY-5994": ["t", "palmitate biosynthesis I (type I fatty acid synthase)"], "PWY-8055": ["t", "palmitoyl ethanolamide biosynthesis"], "PWY-7606": ["t", "docosahexaenoate biosynthesis III (6-desaturase, mammals)"], "PWY-5400": ["t", "amaranthin biosynthesis"], "PWY-6971": ["t", "oleandomycin biosynthesis"], "PWY-7592": ["t", "arachidonate biosynthesis III (6-desaturase, mammals)"], "PWY-7565": ["t", "aspyridone A biosynthesis"], "R-DDI-1482798": ["r", "Acyl chain remodeling of CL"], "R-SCE-1482798": ["r", "Acyl chain remodeling of CL"], "R-DRE-1268020": ["r", "Mitochondrial protein import"], "R-SCE-1268020": ["r", "Mitochondrial protein import"], "R-DME-1482798": ["r", "Acyl chain remodeling of CL"], "R-DDI-71384": ["r", "Ethanol oxidation"], "R-DRE-77111": ["r", "Synthesis of Ketone Bodies"], "R-HSA-389599": ["r", "Alpha-oxidation of phytanate"], "R-HSA-177128": ["r", "Conjugation of salicylate with glycine"], "R-RNO-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-MMU-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-MTU-9635470": ["r", "Dimycocersyl phthiocerol biosynthesis"], "R-HSA-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-HSA-174414": ["r", "Processive synthesis on the C-strand of the telomere"], "R-SCE-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-MMU-110381": ["r", "Resolution of AP sites via the single-nucleotide replacement pathway"], "R-RNO-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-DDI-110381": ["r", "Resolution of AP sites via the single-nucleotide replacement pathway"], "R-RNO-69183": ["r", "Processive synthesis on the lagging strand"], "R-MMU-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-MMU-174414": ["r", "Processive synthesis on the C-strand of the telomere"], "R-CEL-69183": ["r", "Processive synthesis on the lagging strand"], "R-DME-69183": ["r", "Processive synthesis on the lagging strand"], "R-CEL-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-DDI-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-DDI-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-RNO-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-DME-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-SCE-69183": ["r", "Processive synthesis on the lagging strand"], "R-MMU-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-DDI-69183": ["r", "Processive synthesis on the lagging strand"], "R-SPO-69183": ["r", "Processive synthesis on the lagging strand"], "R-HSA-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-DME-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-HSA-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-CEL-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-MMU-69183": ["r", "Processive synthesis on the lagging strand"], "R-DDI-5649702": ["r", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "R-HSA-110381": ["r", "Resolution of AP sites via the single-nucleotide replacement pathway"], "R-HSA-69183": ["r", "Processive synthesis on the lagging strand"], "R-RNO-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-CEL-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-RNO-174414": ["r", "Processive synthesis on the C-strand of the telomere"], "R-SPO-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-BTA-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-SPO-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-MMU-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-DDI-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-DRE-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-HSA-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-SCE-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-RNO-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-XTR-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-BTA-1227986": ["r", "Signaling by ERBB2"], "R-CEL-6783783": ["r", "Interleukin-10 signaling"], "R-XTR-1433557": ["r", "Signaling by SCF-KIT"], "R-DME-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-XTR-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-DRE-186763": ["r", "Downstream signal transduction"], "R-DME-6783783": ["r", "Interleukin-10 signaling"], "R-XTR-74749": ["r", "Signal attenuation"], "R-DDI-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-GGA-877300": ["r", "Interferon gamma signaling"], "R-MMU-75892": ["r", "Platelet Adhesion to exposed collagen"], "R-RNO-8849474": ["r", "PTK6 Activates STAT3"], "R-CEL-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-XTR-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-XTR-5654689": ["r", "PI-3K cascade:FGFR1"], "R-BTA-8866376": ["r", "Reelin signalling pathway"], "R-HSA-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-XTR-182971": ["r", "EGFR downregulation"], "R-HSA-9706374": ["r", "FLT3 signaling through SRC family kinases"], "R-DRE-1253288": ["r", "Downregulation of ERBB4 signaling"], "R-SSC-389359": ["r", "CD28 dependent Vav1 pathway"], "R-BTA-8854691": ["r", "Interleukin-20 family signaling"], "R-CEL-8854691": ["r", "Interleukin-20 family signaling"], "R-CEL-909733": ["r", "Interferon alpha/beta signaling"], "R-XTR-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-MMU-5676594": ["r", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "R-SPO-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-MMU-9619229": ["r", "Activation of RAC1 downstream of NMDARs"], "R-SSC-2559585": ["r", "Oncogene Induced Senescence"], "R-CEL-1538133": ["r", "G0 and Early G1"], "R-CFA-1433559": ["r", "Regulation of KIT signaling"], "R-SCE-381070": ["r", "IRE1alpha activates chaperones"], "R-CEL-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-HSA-9652169": ["r", "Signaling by MAP2K mutants"], "R-SSC-399956": ["r", "CRMPs in Sema3A signaling"], "R-RNO-8935690": ["r", "Digestion"], "R-DRE-190322": ["r", "FGFR4 ligand binding and activation"], "R-RNO-975871": ["r", "MyD88 cascade initiated on plasma membrane"], "R-SCE-198765": ["r", "Signalling to ERK5"], "R-SCE-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-HSA-176034": ["r", "Interactions of Tat with host cellular proteins"], "R-MMU-9008059": ["r", "Interleukin-37 signaling"], "R-DRE-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-RNO-190322": ["r", "FGFR4 ligand binding and activation"], "R-CEL-444257": ["r", "RSK activation"], "R-MMU-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-BTA-210990": ["r", "PECAM1 interactions"], "R-RNO-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-DME-168638": ["r", "NOD1/2 Signaling Pathway"], "R-RNO-190374": ["r", "FGFR1c and Klotho ligand binding and activation"], "R-DRE-1227986": ["r", "Signaling by ERBB2"], "R-CEL-2682334": ["r", "EPH-Ephrin signaling"], "R-HSA-68911": ["r", "G2 Phase"], "R-DME-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-GGA-176187": ["r", "Activation of ATR in response to replication stress"], "R-BTA-982772": ["r", "Growth hormone receptor signaling"], "R-BTA-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-DDI-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-SSC-373753": ["r", "Nephrin family interactions"], "R-MMU-190377": ["r", "FGFR2b ligand binding and activation"], "R-MMU-381070": ["r", "IRE1alpha activates chaperones"], "R-DME-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-CEL-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-DDI-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-SSC-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-HSA-190322": ["r", "FGFR4 ligand binding and activation"], "R-XTR-9833482": ["r", "PKR-mediated signaling"], "R-SSC-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-SCE-156711": ["r", "Polo-like kinase mediated events"], "R-HSA-9669929": ["r", "Regorafenib-resistant KIT mutants"], "R-CEL-2871837": ["r", "FCERI mediated NF-kB activation"], "R-DRE-69231": ["r", "Cyclin D associated events in G1"], "R-DRE-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-RNO-165158": ["r", "Activation of AKT2"], "R-BTA-2980766": ["r", "Nuclear Envelope Breakdown"], "R-SSC-9032759": ["r", "NTRK2 activates RAC1"], "R-BTA-171319": ["r", "Telomere Extension By Telomerase"], "R-SPO-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-SPO-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-BTA-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-RNO-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-BTA-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-DME-69656": ["r", "Cyclin A:Cdk2-associated events at S phase entry"], "R-SSC-166665": ["r", "Terminal pathway of complement"], "R-CFA-166665": ["r", "Terminal pathway of complement"], "R-CFA-977606": ["r", "Regulation of Complement cascade"], "R-SCE-71384": ["r", "Ethanol oxidation"], "R-MMU-389599": ["r", "Alpha-oxidation of phytanate"], "R-DME-71384": ["r", "Ethanol oxidation"], "R-RNO-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-HSA-5619108": ["r", "Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)"], "R-HSA-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-MMU-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-HSA-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-HSA-177162": ["r", "Conjugation of phenylacetate with glutamine"], "R-HSA-71384": ["r", "Ethanol oxidation"], "R-SCE-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-SPO-71384": ["r", "Ethanol oxidation"], "R-SCE-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-RNO-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-SCE-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-RNO-389599": ["r", "Alpha-oxidation of phytanate"], "R-RNO-177135": ["r", "Conjugation of benzoate with glycine"], "R-MMU-177128": ["r", "Conjugation of salicylate with glycine"], "R-DME-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-RNO-177128": ["r", "Conjugation of salicylate with glycine"], "R-HSA-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-RNO-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-MMU-177135": ["r", "Conjugation of benzoate with glycine"], "R-RNO-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-MMU-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-SCE-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-HSA-177135": ["r", "Conjugation of benzoate with glycine"], "R-DDI-77111": ["r", "Synthesis of Ketone Bodies"], "R-DDI-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-DDI-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-MMU-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-DDI-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-RNO-177162": ["r", "Conjugation of phenylacetate with glutamine"], "R-MMU-177162": ["r", "Conjugation of phenylacetate with glutamine"], "R-HSA-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-BTA-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-SPO-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-HSA-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-MMU-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-MMU-71384": ["r", "Ethanol oxidation"], "R-CFA-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-SSC-9008059": ["r", "Interleukin-37 signaling"], "R-SSC-2424491": ["r", "DAP12 signaling"], "R-BTA-74749": ["r", "Signal attenuation"], "R-CEL-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-DDI-8984722": ["r", "Interleukin-35 Signalling"], "R-BTA-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-XTR-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-CEL-9008059": ["r", "Interleukin-37 signaling"], "R-DME-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-GGA-8875555": ["r", "MET activates RAP1 and RAC1"], "R-BTA-8983432": ["r", "Interleukin-15 signaling"], "R-GGA-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-BTA-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-RNO-75892": ["r", "Platelet Adhesion to exposed collagen"], "R-BTA-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-BTA-167044": ["r", "Signalling to RAS"], "R-DDI-9008059": ["r", "Interleukin-37 signaling"], "R-MMU-8964315": ["r", "G beta:gamma signalling through BTK"], "R-GGA-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-XTR-389359": ["r", "CD28 dependent Vav1 pathway"], "R-GGA-8875656": ["r", "MET receptor recycling"], "R-XTR-8875555": ["r", "MET activates RAP1 and RAC1"], "R-DDI-877312": ["r", "Regulation of IFNG signaling"], "R-DME-5654720": ["r", "PI-3K cascade:FGFR4"], "R-SSC-3928664": ["r", "Ephrin signaling"], "R-XTR-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-XTR-186763": ["r", "Downstream signal transduction"], "R-BTA-9020958": ["r", "Interleukin-21 signaling"], "R-DDI-201556": ["r", "Signaling by ALK"], "R-DME-8854691": ["r", "Interleukin-20 family signaling"], "R-GGA-1433559": ["r", "Regulation of KIT signaling"], "R-GGA-170984": ["r", "ARMS-mediated activation"], "R-XTR-8853659": ["r", "RET signaling"], "R-XTR-375165": ["r", "NCAM signaling for neurite out-growth"], "R-XTR-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-DME-1059683": ["r", "Interleukin-6 signaling"], "R-BTA-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-HSA-9632700": ["r", "Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6"], "R-BTA-198765": ["r", "Signalling to ERK5"], "R-DRE-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-SCE-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-PFA-5689880": ["r", "Ub-specific processing proteases"], "R-DME-9634638": ["r", "Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "R-HSA-9674403": ["r", "Regorafenib-resistant PDGFR mutants"], "R-SPO-168638": ["r", "NOD1/2 Signaling Pathway"], "R-SSC-200425": ["r", "Carnitine shuttle"], "R-DRE-442742": ["r", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"], "R-GGA-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-RNO-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-DRE-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-DRE-5621575": ["r", "CD209 (DC-SIGN) signaling"], "R-MMU-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-HSA-2682334": ["r", "EPH-Ephrin signaling"], "R-CFA-112411": ["r", "MAPK1 (ERK2) activation"], "R-HSA-9702590": ["r", "gilteritinib-resistant FLT3 mutants"], "R-DDI-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-MMU-975138": ["r", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"], "R-DRE-190371": ["r", "FGFR3b ligand binding and activation"], "R-RNO-975138": ["r", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"], "R-SPO-2871796": ["r", "FCERI mediated MAPK activation"], "R-SSC-9734091": ["r", "Drug-mediated inhibition of MET activation"], "R-SCE-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-RNO-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-CEL-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-SSC-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-HSA-9702636": ["r", "tandutinib-resistant FLT3 mutants"], "R-XTR-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-DDI-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-DME-428542": ["r", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "R-RNO-2682334": ["r", "EPH-Ephrin signaling"], "R-HSA-9717319": ["r", "brigatinib-resistant ALK mutants"], "R-CEL-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-DME-203615": ["r", "eNOS activation"], "R-DDI-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-GGA-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-HSA-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-MMU-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-CEL-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-DME-190371": ["r", "FGFR3b ligand binding and activation"], "R-RNO-73863": ["r", "RNA Polymerase I Transcription Termination"], "PWY-6454": ["t", "vancomycin resistance I"], "PWY-6455": ["t", "vancomycin resistance II"], "PWY-7039": ["t", "phosphatidate metabolism, as a signaling molecule"], "R-SSC-114508": ["r", "Effects of PIP2 hydrolysis"], "R-BTA-114508": ["r", "Effects of PIP2 hydrolysis"], "R-MTU-936635": ["r", "Sulfate assimilation"], "R-DDI-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-DME-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-DDI-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-BTA-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-SSC-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-XTR-156584": ["r", "Cytosolic sulfonation of small molecules"], "R-SSC-9851151": ["r", "MDK and PTN in ALK signaling"], "R-GGA-9851151": ["r", "MDK and PTN in ALK signaling"], "R-XTR-201556": ["r", "Signaling by ALK"], "R-GGA-201556": ["r", "Signaling by ALK"], "R-SSC-201556": ["r", "Signaling by ALK"], "R-BTA-9851151": ["r", "MDK and PTN in ALK signaling"], "R-XTR-9851151": ["r", "MDK and PTN in ALK signaling"], "PWY-5506": ["t", "methanol oxidation to formaldehyde IV"], "PWY-7193": ["t", "pyrimidine ribonucleosides salvage I"], "R-XTR-73614": ["r", "Pyrimidine salvage"], "R-CEL-73614": ["r", "Pyrimidine salvage"], "R-DRE-73614": ["r", "Pyrimidine salvage"], "R-SPO-73614": ["r", "Pyrimidine salvage"], "R-SCE-73614": ["r", "Pyrimidine salvage"], "R-DME-73614": ["r", "Pyrimidine salvage"], "R-DDI-73614": ["r", "Pyrimidine salvage"], "R-HSA-9694719": ["r", "Maturation of protein 3a"], "R-DME-190372": ["r", "FGFR3c ligand binding and activation"], "R-HSA-190372": ["r", "FGFR3c ligand binding and activation"], "R-BTA-913709": ["r", "O-linked glycosylation of mucins"], "R-MMU-190372": ["r", "FGFR3c ligand binding and activation"], "R-XTR-913709": ["r", "O-linked glycosylation of mucins"], "R-HSA-9683673": ["r", "Maturation of protein 3a"], "R-DDI-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-BTA-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-SSC-1222556": ["r", "ROS and RNS production in phagocytes"], "R-SSC-9013423": ["r", "RAC3 GTPase cycle"], "R-HSA-8935690": ["r", "Digestion"], "R-SSC-8935690": ["r", "Digestion"], "R-CEL-9864848": ["r", "Complex IV assembly"], "R-BTA-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-HSA-9845621": ["r", "Defective VWF cleavage by ADAMTS13 variant"], "R-DRE-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-HSA-9845619": ["r", "Enhanced cleavage of VWF variant by ADAMTS13"], "R-DME-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-CEL-5173214": ["r", "O-glycosylation of TSR domain-containing proteins"], "R-HSA-8948216": ["r", "Collagen chain trimerization"], "R-RNO-8948216": ["r", "Collagen chain trimerization"], "R-MMU-419037": ["r", "NCAM1 interactions"], "R-MMU-8948216": ["r", "Collagen chain trimerization"], "R-HSA-9845622": ["r", "Defective VWF binding to collagen type I"], "R-BTA-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-XTR-8865999": ["r", "MET activates PTPN11"], "R-SSC-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-DME-209405": ["r", "JAK/STAT pathway"], "R-SSC-8983432": ["r", "Interleukin-15 signaling"], "R-DDI-8854691": ["r", "Interleukin-20 family signaling"], "R-BTA-9020558": ["r", "Interleukin-2 signaling"], "R-DRE-5621480": ["r", "Dectin-2 family"], "R-RNO-2029481": ["r", "FCGR activation"], "R-SSC-3928662": ["r", "EPHB-mediated forward signaling"], "R-XTR-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-HSA-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-HSA-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-CEL-8983432": ["r", "Interleukin-15 signaling"], "R-BTA-1250196": ["r", "SHC1 events in ERBB2 signaling"], "R-RNO-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-XTR-179812": ["r", "GRB2 events in EGFR signaling"], "R-XTR-2424491": ["r", "DAP12 signaling"], "R-BTA-74751": ["r", "Insulin receptor signalling cascade"], "R-XTR-9842663": ["r", "Signaling by LTK"], "R-DRE-177929": ["r", "Signaling by EGFR"], "R-GGA-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-CEL-9020933": ["r", "Interleukin-23 signaling"], "R-XTR-8851907": ["r", "MET activates PI3K/AKT signaling"], "R-XTR-167044": ["r", "Signalling to RAS"], "R-XTR-2871796": ["r", "FCERI mediated MAPK activation"], "R-BTA-389356": ["r", "Co-stimulation by CD28"], "R-DME-8984722": ["r", "Interleukin-35 Signalling"], "R-CEL-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-RNO-170984": ["r", "ARMS-mediated activation"], "R-DME-909733": ["r", "Interferon alpha/beta signaling"], "R-MMU-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-BTA-389513": ["r", "Co-inhibition by CTLA4"], "R-SSC-8875791": ["r", "MET activates STAT3"], "R-DRE-373753": ["r", "Nephrin family interactions"], "R-XTR-112412": ["r", "SOS-mediated signalling"], "R-DRE-3928664": ["r", "Ephrin signaling"], "R-DRE-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-SSC-8866376": ["r", "Reelin signalling pathway"], "R-BTA-9674555": ["r", "Signaling by CSF3 (G-CSF)"], "R-DDI-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-BTA-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-SPO-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-CEL-110056": ["r", "MAPK3 (ERK1) activation"], "R-CEL-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-CEL-190375": ["r", "FGFR2c ligand binding and activation"], "R-CEL-168638": ["r", "NOD1/2 Signaling Pathway"], "R-DRE-5684264": ["r", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "R-HSA-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-HSA-9702998": ["r", "linifanib-resistant FLT3 mutants"], "R-CEL-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-DRE-190370": ["r", "FGFR1b ligand binding and activation"], "R-CFA-5674135": ["r", "MAP2K and MAPK activation"], "R-DRE-168638": ["r", "NOD1/2 Signaling Pathway"], "R-RNO-8932505": ["r", "DAG1 core M3 glycosylations"], "R-HSA-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-DDI-112411": ["r", "MAPK1 (ERK2) activation"], "R-XTR-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-XTR-174178": ["r", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"], "R-DDI-432142": ["r", "Platelet sensitization by LDL"], "R-HSA-9669921": ["r", "KIT mutants bind TKIs"], "R-CEL-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-RNO-9627069": ["r", "Regulation of the apoptosome activity"], "R-MMU-170984": ["r", "ARMS-mediated activation"], "R-DDI-68911": ["r", "G2 Phase"], "R-HSA-9702620": ["r", "quizartinib-resistant FLT3 mutants"], "R-CEL-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-DRE-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-GGA-5627123": ["r", "RHO GTPases activate PAKs"], "R-HSA-9717329": ["r", "lorlatinib-resistant ALK mutants"], "R-CEL-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-CEL-2871796": ["r", "FCERI mediated MAPK activation"], "R-BTA-399956": ["r", "CRMPs in Sema3A signaling"], "R-DRE-9851151": ["r", "MDK and PTN in ALK signaling"], "R-HSA-8853336": ["r", "Signaling by plasma membrane FGFR1 fusions"], "R-MMU-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-SSC-1236973": ["r", "Cross-presentation of particulate exogenous antigens (phagosomes)"], "R-SSC-9013149": ["r", "RAC1 GTPase cycle"], "R-SSC-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-SSC-9020558": ["r", "Interleukin-2 signaling"], "R-CFA-9020558": ["r", "Interleukin-2 signaling"], "R-RNO-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-RNO-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-RNO-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-RNO-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "R-BTA-3000171": ["r", "Non-integrin membrane-ECM interactions"], "R-BTA-8948216": ["r", "Collagen chain trimerization"], "R-RNO-419037": ["r", "NCAM1 interactions"], "PWY-7242": ["t", "D-fructuronate degradation"], "PWY-7562": ["t", "3,6-anhydro-alpha-L-galactopyranose degradation"], "PWY-6507": ["t", "4-deoxy-L-threo-hex-4-enopyranuronate degradation"], "PWY-2221": ["t", "Entner-Doudoroff pathway III (semi-phosphorylative)"], "PWY-7310": ["t", "D-glucosaminate degradation"], "PWY-7814": ["t", "dTDP-L-daunosamine biosynthesis"], "PWY-4081": ["t", "glutathione-peroxide redox reactions"], "R-HSA-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-BTA-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-RNO-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-CEL-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-CEL-2142712": ["r", "Synthesis of 12-eicosatetraenoic acid derivatives"], "R-MMU-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-HSA-2142712": ["r", "Synthesis of 12-eicosatetraenoic acid derivatives"], "R-BTA-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-RNO-2142712": ["r", "Synthesis of 12-eicosatetraenoic acid derivatives"], "R-SSC-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-HSA-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-SSC-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-HSA-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-BTA-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-BTA-2142712": ["r", "Synthesis of 12-eicosatetraenoic acid derivatives"], "R-RNO-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-MMU-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-SSC-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-DRE-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-BTA-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-HSA-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-HSA-2142688": ["r", "Synthesis of 5-eicosatetraenoic acids"], "R-SSC-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-MMU-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-SSC-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-SSC-2142712": ["r", "Synthesis of 12-eicosatetraenoic acid derivatives"], "R-MMU-2142712": ["r", "Synthesis of 12-eicosatetraenoic acid derivatives"], "R-RNO-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-RNO-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-MMU-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "PWY-8086": ["t", "(S)-lactate fermentation to propanoate, acetate and hydrogen"], "PWY-8377": ["t", "lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales)"], "PWY-8015": ["t", "glycine degradation (reductive Stickland reaction)"], "PWY-5485": ["t", "pyruvate fermentation to acetate IV"], "PWY-5482": ["t", "pyruvate fermentation to acetate II"], "PWY-6871": ["t", "3-methylbutanol biosynthesis (engineered)"], "R-SPO-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-DDI-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-XTR-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-SCE-2514859": ["r", "Inactivation, recovery and regulation of the phototransduction cascade"], "R-DDI-4086398": ["r", "Ca2+ pathway"], "R-HSA-8853333": ["r", "Signaling by FGFR2 fusions"], "R-BTA-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-HSA-9717301": ["r", "NVP-TAE684-resistant ALK mutants"], "R-DME-68875": ["r", "Mitotic Prophase"], "R-CEL-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-CEL-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-HSA-9630791": ["r", "Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4"], "R-BTA-9634638": ["r", "Estrogen-dependent nuclear events downstream of ESR-membrane signaling"], "R-DRE-9020702": ["r", "Interleukin-1 signaling"], "R-GGA-3928662": ["r", "EPHB-mediated forward signaling"], "R-CEL-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-SCE-432142": ["r", "Platelet sensitization by LDL"], "R-BTA-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-SSC-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-MMU-442729": ["r", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "R-DME-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-CEL-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-XTR-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-DRE-9842663": ["r", "Signaling by LTK"], "R-CEL-1502540": ["r", "Signaling by Activin"], "R-BTA-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-DRE-5676590": ["r", "NIK-->noncanonical NF-kB signaling"], "R-DRE-449836": ["r", "Other interleukin signaling"], "R-RNO-1307965": ["r", "betaKlotho-mediated ligand binding"], "R-BTA-171007": ["r", "p38MAPK events"], "R-HSA-1839122": ["r", "Signaling by activated point mutants of FGFR1"], "R-MMU-168928": ["r", "DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "R-DME-9627069": ["r", "Regulation of the apoptosome activity"], "R-BTA-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-CEL-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-DRE-5654695": ["r", "PI-3K cascade:FGFR2"], "R-SSC-8875656": ["r", "MET receptor recycling"], "R-SPO-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-HSA-9702632": ["r", "sunitinib-resistant FLT3 mutants"], "R-SPO-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-BTA-881907": ["r", "Gastrin-CREB signalling pathway via PKC and MAPK"], "R-PFA-5689896": ["r", "Ovarian tumor domain proteases"], "R-DRE-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-CEL-442729": ["r", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "R-CFA-198753": ["r", "ERK/MAPK targets"], "PWY-6423": ["t", "hemoglobin degradation"], "R-HSA-381042": ["r", "PERK regulates gene expression"], "R-SCE-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-DME-156842": ["r", "Eukaryotic Translation Elongation"], "R-MMU-156842": ["r", "Eukaryotic Translation Elongation"], "R-DME-72731": ["r", "Recycling of eIF2:GDP"], "R-BTA-156842": ["r", "Eukaryotic Translation Elongation"], "R-DDI-72764": ["r", "Eukaryotic Translation Termination"], "R-SPO-156842": ["r", "Eukaryotic Translation Elongation"], "R-SPO-72764": ["r", "Eukaryotic Translation Termination"], "R-GGA-8876725": ["r", "Protein methylation"], "R-DRE-72731": ["r", "Recycling of eIF2:GDP"], "R-DRE-381042": ["r", "PERK regulates gene expression"], "R-SPO-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-SCE-72764": ["r", "Eukaryotic Translation Termination"], "R-MMU-72764": ["r", "Eukaryotic Translation Termination"], "R-RNO-156842": ["r", "Eukaryotic Translation Elongation"], "R-GGA-156842": ["r", "Eukaryotic Translation Elongation"], "R-RNO-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-SCE-382556": ["r", "ABC-family proteins mediated transport"], "R-HSA-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-SSC-975634": ["r", "Retinoid metabolism and transport"], "R-XTR-975634": ["r", "Retinoid metabolism and transport"], "R-XTR-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-HSA-71240": ["r", "Tryptophan catabolism"], "R-RNO-71240": ["r", "Tryptophan catabolism"], "R-SCE-71240": ["r", "Tryptophan catabolism"], "R-MMU-71240": ["r", "Tryptophan catabolism"], "R-HSA-75108": ["r", "Activation, myristolyation of BID and translocation to mitochondria"], "R-HSA-162599": ["r", "Late Phase of HIV Life Cycle"], "R-RNO-75108": ["r", "Activation, myristolyation of BID and translocation to mitochondria"], "R-MMU-75108": ["r", "Activation, myristolyation of BID and translocation to mitochondria"], "R-SPO-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-CEL-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-HSA-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-SPO-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-MMU-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-CEL-6811438": ["r", "Intra-Golgi traffic"], "R-SCE-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-SCE-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-HSA-6787450": ["r", "tRNA modification in the mitochondrion"], "R-DRE-9639288": ["r", "Amino acids regulate mTORC1"], "R-XTR-9639288": ["r", "Amino acids regulate mTORC1"], "R-HSA-2142700": ["r", "Biosynthesis of Lipoxins (LX)"], "R-RNO-2142688": ["r", "Synthesis of 5-eicosatetraenoic acids"], "R-MMU-9026286": ["r", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "R-RNO-9025106": ["r", "Biosynthesis of DPAn-6 SPMs"], "R-MMU-2142688": ["r", "Synthesis of 5-eicosatetraenoic acids"], "R-SSC-9025106": ["r", "Biosynthesis of DPAn-6 SPMs"], "R-SSC-9018681": ["r", "Biosynthesis of protectins"], "R-HSA-9026290": ["r", "Biosynthesis of DPAn-3-derived maresins"], "R-SSC-375165": ["r", "NCAM signaling for neurite out-growth"], "R-XTR-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-RNO-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-CEL-877300": ["r", "Interferon gamma signaling"], "R-CEL-399956": ["r", "CRMPs in Sema3A signaling"], "R-XTR-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-XTR-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-DDI-9020591": ["r", "Interleukin-12 signaling"], "R-XTR-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-DDI-9020933": ["r", "Interleukin-23 signaling"], "R-XTR-5654695": ["r", "PI-3K cascade:FGFR2"], "R-BTA-8875513": ["r", "MET interacts with TNS proteins"], "R-XTR-74751": ["r", "Insulin receptor signalling cascade"], "R-XTR-109704": ["r", "PI3K Cascade"], "R-CEL-9020591": ["r", "Interleukin-12 signaling"], "R-CEL-8849472": ["r", "PTK6 Down-Regulation"], "R-XTR-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-MMU-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-SSC-8985947": ["r", "Interleukin-9 signaling"], "R-DDI-877300": ["r", "Interferon gamma signaling"], "R-DDI-9020956": ["r", "Interleukin-27 signaling"], "R-CEL-8849468": ["r", "PTK6 Regulates Proteins Involved in RNA Processing"], "R-DDI-1059683": ["r", "Interleukin-6 signaling"], "R-CEL-8984722": ["r", "Interleukin-35 Signalling"], "R-DDI-8983432": ["r", "Interleukin-15 signaling"], "R-RNO-373753": ["r", "Nephrin family interactions"], "R-RNO-112412": ["r", "SOS-mediated signalling"], "R-XTR-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-RNO-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-DME-5654695": ["r", "PI-3K cascade:FGFR2"], "R-XTR-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-CEL-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-DME-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-DME-112411": ["r", "MAPK1 (ERK2) activation"], "R-SCE-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-HSA-190374": ["r", "FGFR1c and Klotho ligand binding and activation"], "R-CEL-190377": ["r", "FGFR2b ligand binding and activation"], "R-HSA-68962": ["r", "Activation of the pre-replicative complex"], "R-HSA-9669926": ["r", "Nilotinib-resistant KIT mutants"], "R-DME-936837": ["r", "Ion transport by P-type ATPases"], "R-RNO-139910": ["r", "Activation of BMF and translocation to mitochondria"], "R-SPO-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-DRE-8874081": ["r", "MET activates PTK2 signaling"], "R-MMU-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-HSA-1606341": ["r", "IRF3 mediated activation of type 1 IFN"], "R-SSC-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-DRE-5654720": ["r", "PI-3K cascade:FGFR4"], "R-HSA-2033515": ["r", "t(4;14) translocations of FGFR3"], "R-MMU-446343": ["r", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "R-BTA-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-DDI-381070": ["r", "IRE1alpha activates chaperones"], "R-MMU-8932505": ["r", "DAG1 core M3 glycosylations"], "R-DME-190322": ["r", "FGFR4 ligand binding and activation"], "R-SCE-525793": ["r", "Myogenesis"], "R-XTR-176412": ["r", "Phosphorylation of the APC/C"], "R-DRE-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-CFA-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-CEL-442742": ["r", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"], "R-RNO-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-DDI-68962": ["r", "Activation of the pre-replicative complex"], "R-BTA-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-DME-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-DME-9840373": ["r", "Cellular response to mitochondrial stress"], "R-DDI-9840373": ["r", "Cellular response to mitochondrial stress"], "R-SCE-156842": ["r", "Eukaryotic Translation Elongation"], "R-DRE-382556": ["r", "ABC-family proteins mediated transport"], "R-SPO-382556": ["r", "ABC-family proteins mediated transport"], "R-MMU-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-DRE-9840373": ["r", "Cellular response to mitochondrial stress"], "R-HSA-156842": ["r", "Eukaryotic Translation Elongation"], "R-DME-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-DDI-156842": ["r", "Eukaryotic Translation Elongation"], "PWY-7383": ["t", "anaerobic energy metabolism (invertebrates, cytosol)"], "PWY-6638": ["t", "sulfolactate degradation III"], "PWY-7115": ["t", "C4 photosynthetic carbon assimilation cycle, NAD-ME type"], "PWY-6643": ["t", "coenzyme M biosynthesis II"], "PWY-7117": ["t", "C4 photosynthetic carbon assimilation cycle, PEPCK type"], "PWY-6642": ["t", "(R)-cysteate degradation"], "R-HSA-9856872": ["r", "Malate-aspartate shuttle"], "R-GGA-8963693": ["r", "Aspartate and asparagine metabolism"], "R-DDI-9856872": ["r", "Malate-aspartate shuttle"], "R-SSC-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-BTA-8963693": ["r", "Aspartate and asparagine metabolism"], "R-SSC-8964539": ["r", "Glutamate and glutamine metabolism"], "R-CEL-8963693": ["r", "Aspartate and asparagine metabolism"], "R-SPO-9856872": ["r", "Malate-aspartate shuttle"], "R-BTA-9856872": ["r", "Malate-aspartate shuttle"], "R-SCE-8963693": ["r", "Aspartate and asparagine metabolism"], "R-SCE-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-SPO-8963693": ["r", "Aspartate and asparagine metabolism"], "R-CEL-9856872": ["r", "Malate-aspartate shuttle"], "R-SCE-9856872": ["r", "Malate-aspartate shuttle"], "R-GGA-9856872": ["r", "Malate-aspartate shuttle"], "R-BTA-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-SSC-8963693": ["r", "Aspartate and asparagine metabolism"], "R-SSC-9856872": ["r", "Malate-aspartate shuttle"], "R-SPO-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-MMU-9856872": ["r", "Malate-aspartate shuttle"], "R-RNO-9856872": ["r", "Malate-aspartate shuttle"], "R-DDI-8963693": ["r", "Aspartate and asparagine metabolism"], "R-GGA-372568": ["r", "Amino acid metabolism"], "R-MMU-196108": ["r", "Pregnenolone biosynthesis"], "R-HSA-196108": ["r", "Pregnenolone biosynthesis"], "R-DRE-196108": ["r", "Pregnenolone biosynthesis"], "R-BTA-196108": ["r", "Pregnenolone biosynthesis"], "R-RNO-196108": ["r", "Pregnenolone biosynthesis"], "R-MMU-9025106": ["r", "Biosynthesis of DPAn-6 SPMs"], "R-HSA-9026403": ["r", "Biosynthesis of DPAn-3-derived 13-series resolvins"], "R-RNO-9026286": ["r", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "R-BTA-2142770": ["r", "Synthesis of 15-eicosatetraenoic acid derivatives"], "R-SSC-9018677": ["r", "Biosynthesis of DHA-derived SPMs"], "R-BTA-9026286": ["r", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "R-HSA-9025106": ["r", "Biosynthesis of DPAn-6 SPMs"], "R-BTA-9018681": ["r", "Biosynthesis of protectins"], "R-MMU-2142696": ["r", "Synthesis of Hepoxilins (HX) and Trioxilins (TrX)"], "R-HSA-9018681": ["r", "Biosynthesis of protectins"], "R-BTA-9018677": ["r", "Biosynthesis of DHA-derived SPMs"], "R-RNO-2142700": ["r", "Biosynthesis of Lipoxins (LX)"], "R-MMU-9018681": ["r", "Biosynthesis of protectins"], "R-HSA-2142696": ["r", "Synthesis of Hepoxilins (HX) and Trioxilins (TrX)"], "R-RNO-2142696": ["r", "Synthesis of Hepoxilins (HX) and Trioxilins (TrX)"], "R-SSC-9026286": ["r", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "R-MMU-2142700": ["r", "Biosynthesis of Lipoxins (LX)"], "R-BTA-9025106": ["r", "Biosynthesis of DPAn-6 SPMs"], "R-RNO-9026290": ["r", "Biosynthesis of DPAn-3-derived maresins"], "R-RNO-9026403": ["r", "Biosynthesis of DPAn-3-derived 13-series resolvins"], "R-MMU-9026290": ["r", "Biosynthesis of DPAn-3-derived maresins"], "R-MMU-9026403": ["r", "Biosynthesis of DPAn-3-derived 13-series resolvins"], "R-RNO-9018681": ["r", "Biosynthesis of protectins"], "R-HSA-9026286": ["r", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "PWY-6367": ["t", "D-myo-inositol-5-phosphate metabolism"], "PWY-6351": ["t", "D-myo-inositol (1,4,5)-trisphosphate biosynthesis"], "PWY-8052": ["t", "2-arachidonoylglycerol biosynthesis"], "R-XTR-180292": ["r", "GAB1 signalosome"], "R-BTA-8985947": ["r", "Interleukin-9 signaling"], "R-XTR-210993": ["r", "Tie2 Signaling"], "R-RNO-167044": ["r", "Signalling to RAS"], "R-CEL-9020956": ["r", "Interleukin-27 signaling"], "R-BTA-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-MMU-2029481": ["r", "FCGR activation"], "R-HSA-2029481": ["r", "FCGR activation"], "R-BTA-75892": ["r", "Platelet Adhesion to exposed collagen"], "R-DDI-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-XTR-1963642": ["r", "PI3K events in ERBB2 signaling"], "R-CEL-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-CEL-8985947": ["r", "Interleukin-9 signaling"], "R-BTA-180336": ["r", "SHC1 events in EGFR signaling"], "R-BTA-8849474": ["r", "PTK6 Activates STAT3"], "R-XTR-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-BTA-8851805": ["r", "MET activates RAS signaling"], "R-DDI-8985947": ["r", "Interleukin-9 signaling"], "R-DME-8983432": ["r", "Interleukin-15 signaling"], "R-XTR-1257604": ["r", "PIP3 activates AKT signaling"], "R-RNO-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-DDI-111995": ["r", "phospho-PLA2 pathway"], "R-HSA-190377": ["r", "FGFR2b ligand binding and activation"], "R-DME-390089": ["r", "Formation of the Hippo kinase cassette"], "R-DME-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-DME-111932": ["r", "CaMK IV-mediated phosphorylation of CREB"], "R-DRE-109704": ["r", "PI3K Cascade"], "R-RNO-199920": ["r", "CREB phosphorylation"], "R-DDI-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-HSA-111446": ["r", "Activation of BIM and translocation to mitochondria"], "R-DME-1181150": ["r", "Signaling by NODAL"], "R-DDI-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-DME-9007892": ["r", "Interleukin-38 signaling"], "R-HSA-190375": ["r", "FGFR2c ligand binding and activation"], "R-HSA-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-CEL-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-BTA-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-MMU-187042": ["r", "TRKA activation by NGF"], "R-SSC-3371571": ["r", "HSF1-dependent transactivation"], "R-SSC-3214858": ["r", "RMTs methylate histone arginines"], "R-CFA-5673000": ["r", "RAF activation"], "R-CEL-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-SSC-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-SSC-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-CEL-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-PFA-381042": ["r", "PERK regulates gene expression"], "R-HSA-9702605": ["r", "pexidartinib-resistant FLT3 mutants"], "R-DRE-9833482": ["r", "PKR-mediated signaling"], "R-MMU-190373": ["r", "FGFR1c ligand binding and activation"], "R-RNO-9619229": ["r", "Activation of RAC1 downstream of NMDARs"], "R-DDI-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-XTR-2173796": ["r", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "R-GGA-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-MMU-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-MMU-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-HSA-8942233": ["r", "Intestinal infectious diseases"], "R-RNO-156590": ["r", "Glutathione conjugation"], "R-MMU-156590": ["r", "Glutathione conjugation"], "R-HSA-156590": ["r", "Glutathione conjugation"], "R-SSC-156590": ["r", "Glutathione conjugation"], "R-BTA-156590": ["r", "Glutathione conjugation"], "R-SCE-156590": ["r", "Glutathione conjugation"], "PWY-7456": ["t", "beta-(1,4)-mannan degradation"], "R-CEL-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-CEL-8873719": ["r", "RAB geranylgeranylation"], "R-SPO-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-SCE-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-HSA-2564830": ["r", "Cytosolic iron-sulfur cluster assembly"], "PWY-7238": ["t", "sucrose biosynthesis II"], "PWY-6731": ["t", "starch degradation III"], "PWY-6737": ["t", "starch degradation V"], "R-SCE-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-DME-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-DDI-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-DRE-76071": ["r", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "R-MTU-936721": ["r", "Cysteine synthesis from O-acetylserine"], "R-CEL-9749641": ["r", "Aspirin ADME"], "R-DME-9749641": ["r", "Aspirin ADME"], "R-DME-112311": ["r", "Neurotransmitter clearance"], "R-BTA-9749641": ["r", "Aspirin ADME"], "R-HSA-112311": ["r", "Neurotransmitter clearance"], "R-CEL-112311": ["r", "Neurotransmitter clearance"], "R-CFA-201556": ["r", "Signaling by ALK"], "R-HSA-9717323": ["r", "ceritinib-resistant ALK mutants"], "R-HSA-9717264": ["r", "ASP-3026-resistant ALK mutants"], "R-HSA-9717326": ["r", "crizotinib-resistant ALK mutants"], "R-DRE-201556": ["r", "Signaling by ALK"], "R-CEL-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-MMU-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-HSA-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-DME-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-MMU-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-XTR-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-CEL-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-HSA-9708296": ["r", "tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis"], "R-DME-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-XTR-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-SSC-202427": ["r", "Phosphorylation of CD3 and TCR zeta chains"], "R-SSC-202433": ["r", "Generation of second messenger molecules"], "R-SSC-202430": ["r", "Translocation of ZAP-70 to Immunological synapse"], "R-SSC-389948": ["r", "Co-inhibition by PD-1"], "R-XTR-9764725": ["r", "Negative Regulation of CDH1 Gene Transcription"], "R-HSA-174430": ["r", "Telomere C-strand synthesis initiation"], "R-MMU-174430": ["r", "Telomere C-strand synthesis initiation"], "R-DRE-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-XTR-9909649": ["r", "Regulation of PD-L1(CD274) transcription"], "R-DME-198753": ["r", "ERK/MAPK targets"], "R-HSA-1839120": ["r", "Signaling by FGFR1 amplification mutants"], "R-CFA-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-MMU-190375": ["r", "FGFR2c ligand binding and activation"], "R-DME-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-HSA-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-CEL-165158": ["r", "Activation of AKT2"], "R-DRE-2871796": ["r", "FCERI mediated MAPK activation"], "R-SCE-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-BTA-1181150": ["r", "Signaling by NODAL"], "R-SSC-8874081": ["r", "MET activates PTK2 signaling"], "R-MMU-198765": ["r", "Signalling to ERK5"], "R-MMU-165158": ["r", "Activation of AKT2"], "R-DRE-5654732": ["r", "Negative regulation of FGFR3 signaling"], "R-CEL-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-DME-190375": ["r", "FGFR2c ligand binding and activation"], "R-SSC-8854521": ["r", "Interaction between PHLDA1 and AURKA"], "R-DRE-5654727": ["r", "Negative regulation of FGFR2 signaling"], "R-SPO-2500257": ["r", "Resolution of Sister Chromatid Cohesion"], "R-DRE-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-HSA-8854521": ["r", "Interaction between PHLDA1 and AURKA"], "R-DME-165158": ["r", "Activation of AKT2"], "R-HSA-9669933": ["r", "Signaling by kinase domain mutants of KIT"], "R-DME-209425": ["r", "Transcriptional activtion by AP-1 transcription factor"], "R-MMU-199920": ["r", "CREB phosphorylation"], "R-HSA-68875": ["r", "Mitotic Prophase"], "R-BTA-165158": ["r", "Activation of AKT2"], "R-DRE-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-DRE-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-DME-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-HSA-9630794": ["r", "Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6"], "R-DME-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-HSA-190373": ["r", "FGFR1c ligand binding and activation"], "R-DDI-383280": ["r", "Nuclear Receptor transcription pathway"], "R-DDI-165158": ["r", "Activation of AKT2"], "R-CEL-190372": ["r", "FGFR3c ligand binding and activation"], "R-CFA-8854518": ["r", "AURKA Activation by TPX2"], "R-CEL-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-DRE-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-SCE-198753": ["r", "ERK/MAPK targets"], "R-RNO-9031628": ["r", "NGF-stimulated transcription"], "R-HSA-9702624": ["r", "sorafenib-resistant FLT3 mutants"], "R-RNO-156711": ["r", "Polo-like kinase mediated events"], "R-DME-390178": ["r", "DS ligand not bound to FT receptor"], "R-DME-209409": ["r", "Formation of the nuclear AP-1 transcription factor 'scaffolding complex'"], "R-DME-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "R-CFA-4086398": ["r", "Ca2+ pathway"], "R-DRE-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-CEL-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "R-MMU-3270619": ["r", "IRF3-mediated induction of type I IFN"], "R-DRE-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-DRE-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-DRE-76061": ["r", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "R-DRE-73863": ["r", "RNA Polymerase I Transcription Termination"], "R-DRE-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-DRE-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-DRE-76066": ["r", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "PWY-7942": ["t", "5-oxo-L-proline metabolism"], "R-GGA-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-GGA-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-CEL-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-DME-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-DME-390193": ["r", "Transcriptional activation by YKI"], "PWY-8443": ["t", "cyclosporin A biosynthesis"], "PWY-8072": ["t", "alanine racemization"], "PWY-5466": ["t", "matairesinol biosynthesis"], "PWY-6824": ["t", "justicidin B biosynthesis"], "PWY-5461": ["t", "betanidin degradation"], "PWY-7445": ["t", "luteolin triglucuronide degradation"], "PWY-8249": ["t", "xanthommatin biosynthesis"], "PWY-7214": ["t", "baicalein degradation (hydrogen peroxide detoxification)"], "PWY-5469": ["t", "sesamin biosynthesis"], "R-RNO-444473": ["r", "Formyl peptide receptors bind formyl peptides and many other ligands"], "R-CFA-380108": ["r", "Chemokine receptors bind chemokines"], "R-GGA-380108": ["r", "Chemokine receptors bind chemokines"], "R-DRE-419812": ["r", "Calcitonin-like ligand receptors"], "R-DRE-9840310": ["r", "Glycosphingolipid catabolism"], "R-CFA-2022857": ["r", "Keratan sulfate degradation"], "R-CFA-9840310": ["r", "Glycosphingolipid catabolism"], "R-HSA-1663150": ["r", "The activation of arylsulfatases"], "R-HSA-9953078": ["r", "MPS II - Hunter syndrome (CS/DS degradation)"], "R-MMU-1663150": ["r", "The activation of arylsulfatases"], "R-HSA-2206285": ["r", "MPS VI - Maroteaux-Lamy syndrome"], "R-RNO-196071": ["r", "Metabolism of steroid hormones"], "R-MMU-196071": ["r", "Metabolism of steroid hormones"], "R-HSA-2206296": ["r", "MPS II - Hunter syndrome (HS-GAG degradation)"], "R-HSA-196071": ["r", "Metabolism of steroid hormones"], "R-SCE-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-HSA-2206290": ["r", "MPS IV - Morquio syndrome A"], "R-SPO-2022857": ["r", "Keratan sulfate degradation"], "R-HSA-2206305": ["r", "MPS IIID - Sanfilippo syndrome D"], "R-HSA-2206307": ["r", "MPS IIIA - Sanfilippo syndrome A"], "R-BTA-1663150": ["r", "The activation of arylsulfatases"], "R-DRE-1663150": ["r", "The activation of arylsulfatases"], "R-SPO-9840310": ["r", "Glycosphingolipid catabolism"], "R-CFA-1663150": ["r", "The activation of arylsulfatases"], "R-RNO-1663150": ["r", "The activation of arylsulfatases"], "R-SPO-196071": ["r", "Metabolism of steroid hormones"], "R-DDI-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "PWY-7991": ["t", "toxoflavin biosynthesis"], "R-RNO-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-DME-449836": ["r", "Other interleukin signaling"], "R-DME-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-GGA-449836": ["r", "Other interleukin signaling"], "R-BTA-449836": ["r", "Other interleukin signaling"], "R-HSA-8964315": ["r", "G beta:gamma signalling through BTK"], "R-CEL-373753": ["r", "Nephrin family interactions"], "R-RNO-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-SSC-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-DME-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-XTR-180336": ["r", "SHC1 events in EGFR signaling"], "R-DME-9020933": ["r", "Interleukin-23 signaling"], "R-XTR-5654720": ["r", "PI-3K cascade:FGFR4"], "R-DME-5654710": ["r", "PI-3K cascade:FGFR3"], "R-BTA-389948": ["r", "Co-inhibition by PD-1"], "R-XTR-5654710": ["r", "PI-3K cascade:FGFR3"], "R-BTA-1059683": ["r", "Interleukin-6 signaling"], "R-SSC-9020958": ["r", "Interleukin-21 signaling"], "R-DME-9020956": ["r", "Interleukin-27 signaling"], "R-DME-9008059": ["r", "Interleukin-37 signaling"], "R-DDI-6783783": ["r", "Interleukin-10 signaling"], "R-DRE-8853659": ["r", "RET signaling"], "R-SSC-9701898": ["r", "STAT3 nuclear events downstream of ALK signaling"], "R-DME-201556": ["r", "Signaling by ALK"], "R-XTR-6807004": ["r", "Negative regulation of MET activity"], "R-XTR-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-XTR-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-RNO-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-SSC-1266695": ["r", "Interleukin-7 signaling"], "R-SSC-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-HSA-8849474": ["r", "PTK6 Activates STAT3"], "R-BTA-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-XTR-912631": ["r", "Regulation of signaling by CBL"], "R-GGA-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-BTA-877312": ["r", "Regulation of IFNG signaling"], "R-XTR-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-SSC-186763": ["r", "Downstream signal transduction"], "R-XTR-9027284": ["r", "Erythropoietin activates RAS"], "R-SSC-8849474": ["r", "PTK6 Activates STAT3"], "R-GGA-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-XTR-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-DRE-456926": ["r", "Thrombin signalling through proteinase activated receptors (PARs)"], "R-GGA-4420097": ["r", "VEGFA-VEGFR2 Pathway"], "R-XTR-9607240": ["r", "FLT3 Signaling"], "R-CEL-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-BTA-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-CEL-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-DRE-3371571": ["r", "HSF1-dependent transactivation"], "R-DME-110056": ["r", "MAPK3 (ERK1) activation"], "R-GGA-265976": ["r", "Homologous DNA pairing and strand exchange"], "R-BTA-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-HSA-9627069": ["r", "Regulation of the apoptosome activity"], "R-CFA-1433557": ["r", "Signaling by SCF-KIT"], "R-MMU-190371": ["r", "FGFR3b ligand binding and activation"], "R-CFA-8854521": ["r", "Interaction between PHLDA1 and AURKA"], "R-DME-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-DME-8939211": ["r", "ESR-mediated signaling"], "R-DRE-8932505": ["r", "DAG1 core M3 glycosylations"], "R-RNO-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-MMU-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-SPO-4086398": ["r", "Ca2+ pathway"], "R-HSA-139910": ["r", "Activation of BMF and translocation to mitochondria"], "R-DME-171007": ["r", "p38MAPK events"], "R-SSC-9759194": ["r", "Nuclear events mediated by NFE2L2"], "R-DRE-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-GGA-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-HSA-1839128": ["r", "FGFR4 mutant receptor activation"], "R-DRE-171007": ["r", "p38MAPK events"], "R-XTR-9018519": ["r", "Estrogen-dependent gene expression"], "R-GGA-5635838": ["r", "Activation of SMO"], "R-CEL-6794361": ["r", "Neurexins and neuroligins"], "R-SCE-68962": ["r", "Activation of the pre-replicative complex"], "R-SSC-399719": ["r", "Trafficking of AMPA receptors"], "R-SCE-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-CEL-1181150": ["r", "Signaling by NODAL"], "R-BTA-446353": ["r", "Cell-extracellular matrix interactions"], "R-HSA-9702596": ["r", "lestaurtinib-resistant FLT3 mutants"], "R-CFA-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-CEL-419812": ["r", "Calcitonin-like ligand receptors"], "R-MMU-500753": ["r", "Pyrimidine biosynthesis"], "R-BTA-74217": ["r", "Purine salvage"], "R-SCE-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-MMU-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-DDI-500753": ["r", "Pyrimidine biosynthesis"], "R-RNO-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-SCE-74217": ["r", "Purine salvage"], "R-DME-500753": ["r", "Pyrimidine biosynthesis"], "R-HSA-9734281": ["r", "Defective HPRT1 disrupts guanine and hypoxanthine salvage"], "R-MMU-74217": ["r", "Purine salvage"], "R-HSA-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-CEL-500753": ["r", "Pyrimidine biosynthesis"], "R-XTR-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-BTA-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-HSA-500753": ["r", "Pyrimidine biosynthesis"], "R-RNO-74217": ["r", "Purine salvage"], "R-DDI-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-HSA-9734195": ["r", "Defective APRT disrupts adenine salvage"], "R-SPO-73843": ["r", "5-Phosphoribose 1-diphosphate biosynthesis"], "R-CEL-74217": ["r", "Purine salvage"], "R-SSC-74217": ["r", "Purine salvage"], "R-DME-74217": ["r", "Purine salvage"], "R-DDI-74217": ["r", "Purine salvage"], "R-HSA-74217": ["r", "Purine salvage"], "R-SSC-9748787": ["r", "Azathioprine ADME"], "R-SPO-74217": ["r", "Purine salvage"], "R-DME-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-CEL-2559580": ["r", "Oxidative Stress Induced Senescence"], "R-PFA-73621": ["r", "Pyrimidine catabolism"], "R-SCE-9755088": ["r", "Ribavirin ADME"], "R-PFA-73614": ["r", "Pyrimidine salvage"], "R-MMU-9755088": ["r", "Ribavirin ADME"], "R-BTA-1237112": ["r", "Methionine salvage pathway"], "R-HSA-9755088": ["r", "Ribavirin ADME"], "R-HSA-9735763": ["r", "Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine"], "R-CEL-73621": ["r", "Pyrimidine catabolism"], "R-RNO-9755088": ["r", "Ribavirin ADME"], "R-SCE-1237112": ["r", "Methionine salvage pathway"], "R-SPO-9755088": ["r", "Ribavirin ADME"], "R-SCE-74259": ["r", "Purine catabolism"], "R-SPO-74259": ["r", "Purine catabolism"], "R-HSA-3229133": ["r", "Glycogen storage disease type Ib (SLC37A4)"], "PWY-7219": ["t", "adenosine ribonucleotides de novo biosynthesis"], "R-SSC-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-DDI-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "R-GGA-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-PFA-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-XTR-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "PWY-6807": ["t", "xyloglucan degradation II (exoglucanase)"], "R-DDI-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-CEL-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-SSC-209905": ["r", "Catecholamine biosynthesis"], "R-HSA-2408552": ["r", "Methylation of MeSeH for excretion"], "R-CEL-209905": ["r", "Catecholamine biosynthesis"], "PWY-1622": ["t", "formaldehyde assimilation I (serine pathway)"], "PWY-7124": ["t", "ethene biosynthesis V (engineered)"], "PWY-6886": ["t", "1-butanol autotrophic biosynthesis (engineered)"], "PWY-7218": ["t", "photosynthetic 3-hydroxybutanoate biosynthesis (engineered)"], "PWY-6901": ["t", "superpathway of glucose and xylose degradation"], "PWY-8004": ["t", "Entner-Doudoroff pathway I"], "R-HSA-9636667": ["r", "Manipulation of host energy metabolism"], "R-XTR-8875656": ["r", "MET receptor recycling"], "R-XTR-8851805": ["r", "MET activates RAS signaling"], "R-CEL-1059683": ["r", "Interleukin-6 signaling"], "R-DME-9020591": ["r", "Interleukin-12 signaling"], "R-RNO-9008059": ["r", "Interleukin-37 signaling"], "R-HSA-879518": ["r", "Organic anion transport by SLCO transporters"], "R-SSC-432040": ["r", "Vasopressin regulates renal water homeostasis via Aquaporins"], "R-SSC-388479": ["r", "Vasopressin-like receptors"], "R-SSC-879518": ["r", "Organic anion transport by SLCO transporters"], "R-RNO-879518": ["r", "Organic anion transport by SLCO transporters"], "R-MMU-879518": ["r", "Organic anion transport by SLCO transporters"], "R-DRE-879518": ["r", "Organic anion transport by SLCO transporters"], "R-RNO-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "R-HSA-9669917": ["r", "Imatinib-resistant KIT mutants"], "R-DME-442729": ["r", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "R-SSC-9616222": ["r", "Transcriptional regulation of granulopoiesis"], "R-DME-433692": ["r", "Proton-coupled monocarboxylate transport"], "R-DME-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-CFA-445144": ["r", "Signal transduction by L1"], "R-XTR-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-RNO-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-MMU-111446": ["r", "Activation of BIM and translocation to mitochondria"], "R-DRE-190377": ["r", "FGFR2b ligand binding and activation"], "R-HSA-9674404": ["r", "Sorafenib-resistant PDGFR mutants"], "R-CEL-111932": ["r", "CaMK IV-mediated phosphorylation of CREB"], "R-BTA-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-XTR-1538133": ["r", "G0 and Early G1"], "R-CEL-446353": ["r", "Cell-extracellular matrix interactions"], "R-DRE-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-SPO-69231": ["r", "Cyclin D associated events in G1"], "R-RNO-1181150": ["r", "Signaling by NODAL"], "R-CEL-69478": ["r", "G2/M DNA replication checkpoint"], "R-SPO-418592": ["r", "ADP signalling through P2Y purinoceptor 1"], "R-SSC-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-BTA-68911": ["r", "G2 Phase"], "R-RNO-190373": ["r", "FGFR1c ligand binding and activation"], "R-CEL-190370": ["r", "FGFR1b ligand binding and activation"], "R-DRE-5654733": ["r", "Negative regulation of FGFR4 signaling"], "R-SCE-168638": ["r", "NOD1/2 Signaling Pathway"], "R-RNO-68962": ["r", "Activation of the pre-replicative complex"], "R-SCE-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-XTR-156711": ["r", "Polo-like kinase mediated events"], "R-XTR-9758274": ["r", "Regulation of NF-kappa B signaling"], "R-XTR-2871837": ["r", "FCERI mediated NF-kB activation"], "R-GGA-351451": ["r", "Homologous recombination repair of replication-dependent double-strand breaks"], "R-DDI-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-MMU-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-BTA-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-DDI-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-SCE-3214858": ["r", "RMTs methylate histone arginines"], "R-SPO-3214858": ["r", "RMTs methylate histone arginines"], "R-RNO-2243919": ["r", "Crosslinking of collagen fibrils"], "PWY-5404": ["t", "betaxanthin biosynthesis (via dopaxanthin)"], "PWY-7297": ["t", "octopamine biosynthesis"], "R-DME-4570464": ["r", "SUMOylation of RNA binding proteins"], "R-DME-3899300": ["r", "SUMOylation of transcription cofactors"], "R-XTR-69481": ["r", "G2/M Checkpoints"], "R-XTR-5696394": ["r", "DNA Damage Recognition in GG-NER"], "R-XTR-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-XTR-174154": ["r", "APC/C:Cdc20 mediated degradation of Securin"], "R-XTR-4608870": ["r", "Asymmetric localization of PCP proteins"], "R-DRE-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-GGA-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-XTR-68867": ["r", "Assembly of the pre-replicative complex"], "R-XTR-8948751": ["r", "Regulation of PTEN stability and activity"], "R-XTR-5689880": ["r", "Ub-specific processing proteases"], "R-XTR-174184": ["r", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"], "R-GGA-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-XTR-5689603": ["r", "UCH proteinases"], "R-SSC-8851805": ["r", "MET activates RAS signaling"], "R-RNO-9968551": ["r", "Regulation of GBP-mediated host defense"], "R-HSA-9669936": ["r", "Sorafenib-resistant KIT mutants"], "R-SSC-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-CEL-446343": ["r", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "R-DRE-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-HSA-9702577": ["r", "semaxanib-resistant FLT3 mutants"], "R-BTA-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "R-DRE-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-MMU-1181150": ["r", "Signaling by NODAL"], "R-GGA-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-RNO-163680": ["r", "AMPK inhibits chREBP transcriptional activation activity"], "R-HSA-9669924": ["r", "Masitinib-resistant KIT mutants"], "R-MMU-9627069": ["r", "Regulation of the apoptosome activity"], "R-DME-199418": ["r", "Negative regulation of the PI3K/AKT network"], "R-XTR-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-HSA-2033519": ["r", "Activated point mutants of FGFR2"], "R-SSC-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "R-BTA-110056": ["r", "MAPK3 (ERK1) activation"], "R-MMU-190322": ["r", "FGFR4 ligand binding and activation"], "R-SCE-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-SPO-381070": ["r", "IRE1alpha activates chaperones"], "R-GGA-451478": ["r", "ERK activation"], "R-HSA-381070": ["r", "IRE1alpha activates chaperones"], "R-SPO-68962": ["r", "Activation of the pre-replicative complex"], "R-SPO-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-DRE-5654689": ["r", "PI-3K cascade:FGFR1"], "R-XTR-5357905": ["r", "Regulation of TNFR1 signaling"], "R-RNO-190370": ["r", "FGFR1b ligand binding and activation"], "R-HSA-446343": ["r", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "R-DDI-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-HSA-9639775": ["r", "Antimicrobial action and antimicrobial resistance in Mtb"], "PWY-7822": ["t", "chitin degradation III (Serratia)"], "PWY-6902": ["t", "chitin degradation II (Vibrio)"], "PWY-6855": ["t", "chitin degradation I (archaea)"], "R-SCE-114608": ["r", "Platelet degranulation"], "R-GGA-6811438": ["r", "Intra-Golgi traffic"], "R-GGA-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-BTA-176417": ["r", "Phosphorylation of Emi1"], "R-XTR-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-SPO-9648025": ["r", "EML4 and NUDC in mitotic spindle formation"], "R-RNO-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-CEL-68884": ["r", "Mitotic Telophase/Cytokinesis"], "R-RNO-176417": ["r", "Phosphorylation of Emi1"], "R-MMU-217271": ["r", "FMO oxidises nucleophiles"], "R-CFA-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-DRE-187577": ["r", "SCF(Skp2)-mediated degradation of p27/p21"], "R-XTR-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-DRE-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-GGA-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-GGA-2871837": ["r", "FCERI mediated NF-kB activation"], "R-XTR-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-GGA-9907900": ["r", "Proteasome assembly"], "R-DRE-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-SSC-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-DRE-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-XTR-9907900": ["r", "Proteasome assembly"], "R-DRE-69481": ["r", "G2/M Checkpoints"], "R-GGA-202424": ["r", "Downstream TCR signaling"], "R-DRE-5610780": ["r", "Degradation of GLI1 by the proteasome"], "R-XTR-68949": ["r", "Orc1 removal from chromatin"], "R-XTR-8941858": ["r", "Regulation of RUNX3 expression and activity"], "R-DDI-165181": ["r", "Inhibition of TSC complex formation by PKB"], "R-XTR-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-MMU-5674499": ["r", "Negative feedback regulation of MAPK pathway"], "R-GGA-1227739": ["r", "Caspase-8 and -10 mediated induction of NF-kB"], "R-RNO-166058": ["r", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "R-HSA-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-HSA-9669935": ["r", "Signaling by juxtamembrane domain KIT mutants"], "R-CFA-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-CFA-432142": ["r", "Platelet sensitization by LDL"], "R-CEL-112411": ["r", "MAPK1 (ERK2) activation"], "R-DME-110523": ["r", "TOR signaling pathway"], "R-PFA-171007": ["r", "p38MAPK events"], "R-MMU-190374": ["r", "FGFR1c and Klotho ligand binding and activation"], "R-SPO-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-DRE-1307965": ["r", "betaKlotho-mediated ligand binding"], "R-HSA-190370": ["r", "FGFR1b ligand binding and activation"], "R-CEL-381070": ["r", "IRE1alpha activates chaperones"], "R-DRE-975144": ["r", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "R-BTA-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-SSC-8865999": ["r", "MET activates PTPN11"], "R-SPO-198765": ["r", "Signalling to ERK5"], "R-HSA-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "R-DDI-8934903": ["r", "Receptor Mediated Mitophagy"], "R-GGA-196299": ["r", "Beta-catenin phosphorylation cascade"], "R-DME-1307965": ["r", "betaKlotho-mediated ligand binding"], "R-BTA-446343": ["r", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "R-DRE-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-CEL-190322": ["r", "FGFR4 ligand binding and activation"], "R-HSA-8932505": ["r", "DAG1 core M3 glycosylations"], "R-SCE-5694530": ["r", "Cargo concentration in the ER"], "R-SPO-5694530": ["r", "Cargo concentration in the ER"], "R-DRE-6811438": ["r", "Intra-Golgi traffic"], "R-SPO-114608": ["r", "Platelet degranulation"], "R-CEL-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-DME-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-CEL-449836": ["r", "Other interleukin signaling"], "R-BTA-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-RNO-174437": ["r", "Removal of the Flap Intermediate from the C-strand"], "R-SPO-5656121": ["r", "Translesion synthesis by POLI"], "R-SPO-5656169": ["r", "Termination of translesion DNA synthesis"], "R-CEL-69166": ["r", "Removal of the Flap Intermediate"], "R-DRE-69183": ["r", "Processive synthesis on the lagging strand"], "R-PFA-69166": ["r", "Removal of the Flap Intermediate"], "R-BTA-69183": ["r", "Processive synthesis on the lagging strand"], "R-SPO-69166": ["r", "Removal of the Flap Intermediate"], "R-DRE-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-PFA-110312": ["r", "Translesion synthesis by REV1"], "R-SCE-69166": ["r", "Removal of the Flap Intermediate"], "R-PFA-5655862": ["r", "Translesion synthesis by POLK"], "R-DRE-5656121": ["r", "Translesion synthesis by POLI"], "R-PFA-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-DRE-6804114": ["r", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "R-BTA-174437": ["r", "Removal of the Flap Intermediate from the C-strand"], "R-DRE-5656169": ["r", "Termination of translesion DNA synthesis"], "R-DRE-69166": ["r", "Removal of the Flap Intermediate"], "R-BTA-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-DRE-110312": ["r", "Translesion synthesis by REV1"], "R-PFA-5656121": ["r", "Translesion synthesis by POLI"], "R-DRE-5655862": ["r", "Translesion synthesis by POLK"], "R-BTA-69091": ["r", "Polymerase switching"], "R-DDI-69166": ["r", "Removal of the Flap Intermediate"], "R-DME-5656169": ["r", "Termination of translesion DNA synthesis"], "R-DRE-6782135": ["r", "Dual incision in TC-NER"], "R-SPO-110320": ["r", "Translesion Synthesis by POLH"], "R-MMU-69166": ["r", "Removal of the Flap Intermediate"], "R-DRE-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-DME-69166": ["r", "Removal of the Flap Intermediate"], "R-PFA-110320": ["r", "Translesion Synthesis by POLH"], "R-SSC-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-HSA-5579019": ["r", "Defective FMO3 causes TMAU"], "R-HSA-217271": ["r", "FMO oxidises nucleophiles"], "R-RNO-217271": ["r", "FMO oxidises nucleophiles"], "R-CFA-217271": ["r", "FMO oxidises nucleophiles"], "R-BTA-217271": ["r", "FMO oxidises nucleophiles"], "R-SSC-217271": ["r", "FMO oxidises nucleophiles"], "R-DME-198323": ["r", "AKT phosphorylates targets in the cytosol"], "R-HSA-9022535": ["r", "Loss of phosphorylation of MECP2 at T308"], "R-MMU-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-DDI-375165": ["r", "NCAM signaling for neurite out-growth"], "R-HSA-199920": ["r", "CREB phosphorylation"], "R-GGA-198753": ["r", "ERK/MAPK targets"], "R-XTR-5610785": ["r", "GLI3 is processed to GLI3R by the proteasome"], "R-XTR-9766229": ["r", "Degradation of CDH1"], "R-XTR-69601": ["r", "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A"], "R-XTR-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-DRE-9907900": ["r", "Proteasome assembly"], "R-XTR-450408": ["r", "AUF1 (hnRNP D0) binds and destabilizes mRNA"], "R-DRE-9762114": ["r", "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2"], "R-DRE-68949": ["r", "Orc1 removal from chromatin"], "R-XTR-5358346": ["r", "Hedgehog ligand biogenesis"], "R-XTR-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-XTR-1234176": ["r", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "R-XTR-349425": ["r", "Autodegradation of the E3 ubiquitin ligase COP1"], "R-XTR-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-GGA-5658442": ["r", "Regulation of RAS by GAPs"], "R-DRE-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-XTR-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-DRE-5689603": ["r", "UCH proteinases"], "R-DRE-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-DRE-8939902": ["r", "Regulation of RUNX2 expression and activity"], "R-XTR-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-DRE-75815": ["r", "Ubiquitin-dependent degradation of Cyclin D"], "R-XTR-8951664": ["r", "Neddylation"], "R-XTR-174084": ["r", "Autodegradation of Cdh1 by Cdh1:APC/C"], "R-DRE-9932298": ["r", "Degradation of CRY and PER proteins"], "R-XTR-9932298": ["r", "Degradation of CRY and PER proteins"], "R-XTR-382556": ["r", "ABC-family proteins mediated transport"], "R-DRE-8854050": ["r", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"], "R-XTR-5687128": ["r", "MAPK6/MAPK4 signaling"], "R-XTR-350562": ["r", "Regulation of ornithine decarboxylase (ODC)"], "R-XTR-1236978": ["r", "Cross-presentation of soluble exogenous antigens (endosomes)"], "R-XTR-5668541": ["r", "TNFR2 non-canonical NF-kB pathway"], "R-DRE-8852276": ["r", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "R-XTR-4641257": ["r", "Degradation of AXIN"], "R-MMU-68962": ["r", "Activation of the pre-replicative complex"], "R-BTA-170968": ["r", "Frs2-mediated activation"], "R-SPO-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-CFA-525793": ["r", "Myogenesis"], "R-RNO-9604323": ["r", "Negative regulation of NOTCH4 signaling"], "R-GGA-9732724": ["r", "IFNG signaling activates MAPKs"], "R-SCE-5607761": ["r", "Dectin-1 mediated noncanonical NF-kB signaling"], "R-SCE-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-RNO-187042": ["r", "TRKA activation by NGF"], "R-HSA-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-MMU-139910": ["r", "Activation of BMF and translocation to mitochondria"], "R-DME-209459": ["r", "Imd pathway"], "R-RNO-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-BTA-9732724": ["r", "IFNG signaling activates MAPKs"], "R-RNO-69478": ["r", "G2/M DNA replication checkpoint"], "R-DME-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-CEL-381042": ["r", "PERK regulates gene expression"], "R-DME-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-PFA-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-HSA-9669934": ["r", "Sunitinib-resistant KIT mutants"], "R-RNO-111446": ["r", "Activation of BIM and translocation to mitochondria"], "R-XTR-5607764": ["r", "CLEC7A (Dectin-1) signaling"], "R-DRE-198753": ["r", "ERK/MAPK targets"], "R-DME-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-CEL-69091": ["r", "Polymerase switching"], "R-SCE-69091": ["r", "Polymerase switching"], "R-MMU-174417": ["r", "Telomere C-strand (Lagging Strand) Synthesis"], "R-HSA-174417": ["r", "Telomere C-strand (Lagging Strand) Synthesis"], "R-SPO-69091": ["r", "Polymerase switching"], "R-MMU-174437": ["r", "Removal of the Flap Intermediate from the C-strand"], "R-PFA-4615885": ["r", "SUMOylation of DNA replication proteins"], "R-PFA-6782135": ["r", "Dual incision in TC-NER"], "R-DME-69091": ["r", "Polymerase switching"], "R-PFA-69091": ["r", "Polymerase switching"], "R-DRE-174437": ["r", "Removal of the Flap Intermediate from the C-strand"], "R-DRE-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-MMU-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-PFA-69183": ["r", "Processive synthesis on the lagging strand"], "R-SPO-5655862": ["r", "Translesion synthesis by POLK"], "R-SPO-110312": ["r", "Translesion synthesis by REV1"], "R-BTA-174417": ["r", "Telomere C-strand (Lagging Strand) Synthesis"], "R-RNO-69166": ["r", "Removal of the Flap Intermediate"], "R-BTA-69166": ["r", "Removal of the Flap Intermediate"], "R-CEL-5656169": ["r", "Termination of translesion DNA synthesis"], "R-RNO-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-SPO-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-DRE-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-DDI-69091": ["r", "Polymerase switching"], "R-DRE-69091": ["r", "Polymerase switching"], "R-HSA-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-HSA-69166": ["r", "Removal of the Flap Intermediate"], "R-RNO-69091": ["r", "Polymerase switching"], "R-DRE-110320": ["r", "Translesion Synthesis by POLH"], "R-RNO-174417": ["r", "Telomere C-strand (Lagging Strand) Synthesis"], "R-DRE-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-HSA-69091": ["r", "Polymerase switching"], "R-BTA-174414": ["r", "Processive synthesis on the C-strand of the telomere"], "R-HSA-174437": ["r", "Removal of the Flap Intermediate from the C-strand"], "R-MMU-69091": ["r", "Polymerase switching"], "R-DME-8963678": ["r", "Intestinal lipid absorption"], "R-MMU-8963678": ["r", "Intestinal lipid absorption"], "R-RNO-8963678": ["r", "Intestinal lipid absorption"], "R-HSA-8963678": ["r", "Intestinal lipid absorption"], "R-SCE-8963678": ["r", "Intestinal lipid absorption"], "R-DME-9969896": ["r", "Lanosterol biosynthesis"], "R-CEL-8963678": ["r", "Intestinal lipid absorption"], "R-DME-192456": ["r", "Digestion of dietary lipid"], "R-BTA-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-MMU-192456": ["r", "Digestion of dietary lipid"], "R-RNO-192456": ["r", "Digestion of dietary lipid"], "R-BTA-192456": ["r", "Digestion of dietary lipid"], "R-GGA-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-DME-8964058": ["r", "HDL remodeling"], "R-XTR-195253": ["r", "Degradation of beta-catenin by the destruction complex"], "R-DME-5578768": ["r", "Physiological factors"], "R-HSA-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-SPO-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-DRE-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-DRE-190372": ["r", "FGFR3c ligand binding and activation"], "R-HSA-9702509": ["r", "FLT3 mutants bind TKIs"], "R-CEL-5654726": ["r", "Negative regulation of FGFR1 signaling"], "R-BTA-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-SPO-432142": ["r", "Platelet sensitization by LDL"], "R-DME-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-HSA-9702581": ["r", "crenolanib-resistant FLT3 mutants"], "R-RNO-68875": ["r", "Mitotic Prophase"], "R-DDI-110056": ["r", "MAPK3 (ERK1) activation"], "R-HSA-1839130": ["r", "Signaling by activated point mutants of FGFR3"], "R-MMU-68875": ["r", "Mitotic Prophase"], "R-CEL-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-SPO-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-CEL-9007892": ["r", "Interleukin-38 signaling"], "R-MMU-1307965": ["r", "betaKlotho-mediated ligand binding"], "R-XTR-6804756": ["r", "Regulation of TP53 Activity through Phosphorylation"], "R-CEL-9619229": ["r", "Activation of RAC1 downstream of NMDARs"], "R-DME-69478": ["r", "G2/M DNA replication checkpoint"], "R-RNO-68911": ["r", "G2 Phase"], "R-HSA-9632697": ["r", "Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4"], "R-DDI-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-DME-68911": ["r", "G2 Phase"], "R-CEL-419037": ["r", "NCAM1 interactions"], "R-MMU-111932": ["r", "CaMK IV-mediated phosphorylation of CREB"], "R-HSA-9702614": ["r", "ponatinib-resistant FLT3 mutants"], "R-DRE-450341": ["r", "Activation of the AP-1 family of transcription factors"], "R-DME-190374": ["r", "FGFR1c and Klotho ligand binding and activation"], "R-BTA-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-SPO-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-GGA-111367": ["r", "SLBP independent Processing of Histone Pre-mRNAs"], "R-GGA-191859": ["r", "snRNP Assembly"], "R-GGA-77588": ["r", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "R-BTA-191859": ["r", "snRNP Assembly"], "R-CEL-191859": ["r", "snRNP Assembly"], "R-DRE-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-DRE-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-SPO-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-DRE-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-MMU-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-HSA-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-MMU-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-SPO-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-DME-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-MMU-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-XTR-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-SCE-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-HSA-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-HSA-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-RNO-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-BTA-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-SCE-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-BTA-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-RNO-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-XTR-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-DRE-913709": ["r", "O-linked glycosylation of mucins"], "R-HSA-4719377": ["r", "Defective DPM2 causes DPM2-CDG"], "R-DDI-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-SCE-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-HSA-4719360": ["r", "Defective DPM3 causes DPM3-CDG"], "R-HSA-9037629": ["r", "Lewis blood group biosynthesis"], "R-SPO-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-DDI-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-SSC-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-DME-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-HSA-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-RNO-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-XTR-8866654": ["r", "E3 ubiquitin ligases ubiquitinate target proteins"], "R-CFA-2032785": ["r", "YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "R-GGA-1251985": ["r", "Nuclear signaling by ERBB4"], "R-RNO-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-DRE-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-GGA-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-CFA-1251985": ["r", "Nuclear signaling by ERBB4"], "R-CFA-8939236": ["r", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "R-DRE-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-CFA-8951671": ["r", "RUNX3 regulates YAP1-mediated transcription"], "R-MMU-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-SCE-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-XTR-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-HSA-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-RNO-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-DRE-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-HSA-5619111": ["r", "Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)"], "R-HSA-9694786": ["r", "Transcription of SARS-CoV-2 sgRNAs"], "R-HSA-9684325": ["r", "Maturation of replicase proteins"], "R-CFA-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-MMU-451307": ["r", "Activation of Na-permeable kainate receptors"], "R-RNO-352238": ["r", "Breakdown of the nuclear lamina"], "R-DME-352238": ["r", "Breakdown of the nuclear lamina"], "R-SSC-4419969": ["r", "Depolymerization of the Nuclear Lamina"], "R-CEL-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-HSA-352238": ["r", "Breakdown of the nuclear lamina"], "R-SSC-2980766": ["r", "Nuclear Envelope Breakdown"], "R-RNO-2980766": ["r", "Nuclear Envelope Breakdown"], "R-SSC-352238": ["r", "Breakdown of the nuclear lamina"], "R-MMU-352238": ["r", "Breakdown of the nuclear lamina"], "R-DRE-9027276": ["r", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "R-CFA-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-BTA-6785807": ["r", "Interleukin-4 and Interleukin-13 signaling"], "R-SSC-156842": ["r", "Eukaryotic Translation Elongation"], "R-XTR-156842": ["r", "Eukaryotic Translation Elongation"], "PWY-6573": ["t", "chondroitin sulfate degradation (metazoa)"], "R-SPO-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-BTA-8873719": ["r", "RAB geranylgeranylation"], "R-MMU-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-SCE-8873719": ["r", "RAB geranylgeranylation"], "R-SCE-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-BTA-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-BTA-9953170": ["r", "GBP-mediated host defense"], "R-RNO-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-SPO-9648002": ["r", "RAS processing"], "R-SPO-8873719": ["r", "RAB geranylgeranylation"], "R-DDI-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-DDI-9953170": ["r", "GBP-mediated host defense"], "R-SCE-9648002": ["r", "RAS processing"], "R-SCE-68949": ["r", "Orc1 removal from chromatin"], "R-RNO-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-HSA-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-SCE-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-DME-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-SPO-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-SCE-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-MMU-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-GGA-451534": ["r", "TLR5 cascade"], "R-HSA-844623": ["r", "The IPAF inflammasome"], "R-MMU-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-RNO-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-HSA-2172127": ["r", "DAP12 interactions"], "R-MMU-1236977": ["r", "Endosomal/Vacuolar pathway"], "R-MMU-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-SPO-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-DME-480985": ["r", "Synthesis of dolichyl-phosphate-glucose"], "R-MMU-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-HSA-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-RNO-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-MMU-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-HSA-9931953": ["r", "Biofilm formation"], "R-HSA-4717374": ["r", "Defective DPM1 causes DPM1-CDG"], "R-MMU-9037629": ["r", "Lewis blood group biosynthesis"], "PWY-6478": ["t", "GDP-D-glycero-alpha-D-manno-heptose biosynthesis"], "R-DME-2025928": ["r", "Calcineurin activates NFAT"], "R-SCE-2025928": ["r", "Calcineurin activates NFAT"], "R-HSA-2025928": ["r", "Calcineurin activates NFAT"], "R-RNO-2025928": ["r", "Calcineurin activates NFAT"], "R-SPO-2025928": ["r", "Calcineurin activates NFAT"], "R-BTA-166208": ["r", "mTORC1-mediated signalling"], "R-MMU-2025928": ["r", "Calcineurin activates NFAT"], "R-BTA-2025928": ["r", "Calcineurin activates NFAT"], "R-DDI-2025928": ["r", "Calcineurin activates NFAT"], "PWY-6854": ["t", "ethene biosynthesis III (microbes)"], "R-SCE-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-SPO-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-RNO-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-BTA-2243919": ["r", "Crosslinking of collagen fibrils"], "R-RNO-8852405": ["r", "Signaling by MST1"], "R-HSA-9683439": ["r", "Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)"], "R-HSA-9694271": ["r", "Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)"], "R-HSA-9682708": ["r", "Transcription of SARS-CoV-1 sgRNAs"], "R-HSA-9694301": ["r", "Maturation of replicase proteins"], "R-SCE-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-SCE-9833482": ["r", "PKR-mediated signaling"], "R-CEL-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-SPO-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-RNO-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-SPO-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-SCE-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-CEL-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-DDI-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-MMU-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-DRE-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-SPO-9833482": ["r", "PKR-mediated signaling"], "R-SCE-1483206": ["r", "Glycerophospholipid biosynthesis"], "R-CEL-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-RNO-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-SPO-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-MMU-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-XTR-69052": ["r", "Switching of origins to a post-replicative state"], "R-GGA-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-SPO-68867": ["r", "Assembly of the pre-replicative complex"], "R-HSA-176974": ["r", "Unwinding of DNA"], "R-CEL-68962": ["r", "Activation of the pre-replicative complex"], "R-XTR-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-DME-69052": ["r", "Switching of origins to a post-replicative state"], "R-CEL-68867": ["r", "Assembly of the pre-replicative complex"], "R-SCE-69052": ["r", "Switching of origins to a post-replicative state"], "R-HSA-69052": ["r", "Switching of origins to a post-replicative state"], "R-CEL-69052": ["r", "Switching of origins to a post-replicative state"], "R-SCE-68867": ["r", "Assembly of the pre-replicative complex"], "R-BTA-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-GGA-68962": ["r", "Activation of the pre-replicative complex"], "R-DDI-68867": ["r", "Assembly of the pre-replicative complex"], "R-XTR-68962": ["r", "Activation of the pre-replicative complex"], "R-BTA-69052": ["r", "Switching of origins to a post-replicative state"], "R-SPO-69052": ["r", "Switching of origins to a post-replicative state"], "R-DDI-69052": ["r", "Switching of origins to a post-replicative state"], "R-MMU-69052": ["r", "Switching of origins to a post-replicative state"], "R-BTA-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-SPO-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-MMU-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-RNO-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-CEL-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-SCE-9634600": ["r", "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"], "R-SSC-3134973": ["r", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"], "R-GGA-933541": ["r", "TRAF6 mediated IRF7 activation"], "R-SSC-3270619": ["r", "IRF3-mediated induction of type I IFN"], "R-BTA-918233": ["r", "TRAF3-dependent IRF activation pathway"], "R-MMU-9013973": ["r", "TICAM1-dependent activation of IRF3/IRF7"], "R-BTA-3270619": ["r", "IRF3-mediated induction of type I IFN"], "R-MMU-918233": ["r", "TRAF3-dependent IRF activation pathway"], "R-SSC-918233": ["r", "TRAF3-dependent IRF activation pathway"], "R-GGA-434136": ["r", "Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1"], "R-MMU-975110": ["r", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"], "R-BTA-1606341": ["r", "IRF3 mediated activation of type 1 IFN"], "R-GGA-975110": ["r", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"], "R-SSC-933541": ["r", "TRAF6 mediated IRF7 activation"], "R-SSC-1606341": ["r", "IRF3 mediated activation of type 1 IFN"], "R-GGA-9013973": ["r", "TICAM1-dependent activation of IRF3/IRF7"], "R-GGA-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-BTA-933541": ["r", "TRAF6 mediated IRF7 activation"], "R-BTA-9013973": ["r", "TICAM1-dependent activation of IRF3/IRF7"], "R-SSC-168928": ["r", "DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "R-DDI-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-DRE-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "R-BTA-211976": ["r", "Endogenous sterols"], "R-GGA-372987": ["r", "The tricarboxylic acid cycle"], "R-SCE-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-SSC-196108": ["r", "Pregnenolone biosynthesis"], "R-DRE-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-HSA-5579026": ["r", "Defective CYP11A1 causes AICSR"], "R-MMU-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-SSC-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-RNO-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-XTR-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-DME-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-DRE-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-DRE-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-SSC-211976": ["r", "Endogenous sterols"], "R-BTA-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-HSA-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-SSC-9857492": ["r", "Protein lipoylation"], "R-XTR-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-DME-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-SSC-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-PFA-917937": ["r", "Iron uptake and transport"], "R-RNO-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-HSA-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-GGA-425410": ["r", "Metal ion SLC transporters"], "R-MMU-425410": ["r", "Metal ion SLC transporters"], "R-DME-425410": ["r", "Metal ion SLC transporters"], "R-DME-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-PFA-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-RNO-425410": ["r", "Metal ion SLC transporters"], "R-PFA-425410": ["r", "Metal ion SLC transporters"], "R-HSA-425410": ["r", "Metal ion SLC transporters"], "R-MMU-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-HSA-5619048": ["r", "Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)"], "R-GGA-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-SSC-9013973": ["r", "TICAM1-dependent activation of IRF3/IRF7"], "R-BTA-168928": ["r", "DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "R-GGA-433819": ["r", "Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK"], "R-MMU-1606341": ["r", "IRF3 mediated activation of type 1 IFN"], "R-RNO-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-HSA-4085023": ["r", "Defective GFPT1 causes CMSTA1"], "R-BTA-9864848": ["r", "Complex IV assembly"], "R-CFA-72695": ["r", "Formation of the ternary complex, and subsequently, the 43S complex"], "R-CFA-72702": ["r", "Ribosomal scanning and start codon recognition"], "R-CEL-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-CEL-425410": ["r", "Metal ion SLC transporters"], "R-DDI-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-GGA-1222556": ["r", "ROS and RNS production in phagocytes"], "R-DDI-425410": ["r", "Metal ion SLC transporters"], "R-SSC-2022928": ["r", "HS-GAG biosynthesis"], "R-BTA-3000170": ["r", "Syndecan interactions"], "R-DME-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-BTA-2024096": ["r", "HS-GAG degradation"], "PWY-8411": ["t", "representative whole plasma arachidonate-derived icosanoids II"], "PWY-7783": ["t", "plasmalogen degradation"], "PWY-7416": ["t", "phospholipid remodeling (phosphatidylcholine, yeast)"], "PWY-8398": ["t", "alpha-linolenate metabolites biosynthesis"], "PWY-7417": ["t", "phospholipid remodeling (phosphatidate, yeast)"], "PWY-8400": ["t", "docosahexaenoate metabolites biosynthesis"], "PWY-8399": ["t", "icosapentaenoate metabolites biosynthesis"], "PWY-7409": ["t", "phospholipid remodeling (phosphatidylethanolamine, yeast)"], "PWY-6803": ["t", "phosphatidylcholine acyl editing"], "PWY-8395": ["t", "linoleate metabolites biosynthesis"], "PWY-8356": ["t", "maresin biosynthesis"], "PWY-8357": ["t", "protectin biosynthesis"], "PWY-8396": ["t", "di-homo-gamma-linolenate metabolites biosynthesis"], "PWY-8413": ["t", "representative whole plasma EPA-derived icosanoids"], "PWY-8412": ["t", "representative whole plasma DHA-derived icosanoids"], "PWY-8410": ["t", "representative whole plasma arachidonate-derived icosanoids I"], "R-CFA-1482788": ["r", "Acyl chain remodelling of PC"], "R-CFA-1482839": ["r", "Acyl chain remodelling of PE"], "R-CFA-1482922": ["r", "Acyl chain remodelling of PI"], "R-CFA-1482925": ["r", "Acyl chain remodelling of PG"], "R-CFA-1483166": ["r", "Synthesis of PA"], "R-CFA-1482801": ["r", "Acyl chain remodelling of PS"], "R-RNO-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-MMU-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-HSA-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-SCE-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-XTR-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-SPO-3214841": ["r", "PKMTs methylate histone lysines"], "R-HSA-6804754": ["r", "Regulation of TP53 Expression"], "R-DME-3214841": ["r", "PKMTs methylate histone lysines"], "R-DME-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-DRE-6804760": ["r", "Regulation of TP53 Activity through Methylation"], "R-HSA-9944997": ["r", "Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome"], "R-DDI-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-XTR-3214841": ["r", "PKMTs methylate histone lysines"], "R-XTR-212300": ["r", "PRC2 methylates histones and DNA"], "R-XTR-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-XTR-2559580": ["r", "Oxidative Stress Induced Senescence"], "PWY-6936": ["t", "seleno-amino acid biosynthesis (plants)"], "R-CFA-72649": ["r", "Translation initiation complex formation"], "R-SSC-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-SSC-2024096": ["r", "HS-GAG degradation"], "R-BTA-2022928": ["r", "HS-GAG biosynthesis"], "R-DDI-170660": ["r", "Adenylate cyclase activating pathway"], "R-DDI-418597": ["r", "G alpha (z) signalling events"], "R-BTA-170660": ["r", "Adenylate cyclase activating pathway"], "R-PFA-936837": ["r", "Ion transport by P-type ATPases"], "R-HSA-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-DDI-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-BTA-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-HSA-5660489": ["r", "MTF1 activates gene expression"], "PWY-5408": ["t", "9-lipoxygenase and 9-hydroperoxide lyase pathway"], "PWY-5407": ["t", "9-lipoxygenase and 9-allene oxide synthase pathway"], "PWY-6917": ["t", "vernolate biosynthesis III"], "PWY-5406": ["t", "divinyl ether biosynthesis I"], "R-BTA-450385": ["r", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "R-CEL-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-BTA-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-DDI-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-XTR-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-BTA-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "R-DRE-450604": ["r", "KSRP (KHSRP) binds and destabilizes mRNA"], "R-DRE-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-DDI-450513": ["r", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "PWY-5659": ["t", "GDP-mannose biosynthesis"], "PWY-3861": ["t", "mannitol degradation II"], "PWY-6992": ["t", "1,5-anhydrofructose degradation"], "PWY-7586": ["t", "beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation"], "PWY-3881": ["t", "mannitol biosynthesis"], "R-HSA-4043916": ["r", "Defective MPI causes MPI-CDG"], "R-HSA-446205": ["r", "Synthesis of GDP-mannose"], "R-RNO-446205": ["r", "Synthesis of GDP-mannose"], "R-SPO-446205": ["r", "Synthesis of GDP-mannose"], "R-DDI-446205": ["r", "Synthesis of GDP-mannose"], "R-MMU-446205": ["r", "Synthesis of GDP-mannose"], "R-BTA-446205": ["r", "Synthesis of GDP-mannose"], "R-CEL-446205": ["r", "Synthesis of GDP-mannose"], "R-SCE-446205": ["r", "Synthesis of GDP-mannose"], "R-MMU-8877627": ["r", "Vitamin E transport"], "R-DDI-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-HSA-8877627": ["r", "Vitamin E transport"], "R-GGA-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-RNO-8877627": ["r", "Vitamin E transport"], "R-DDI-2453902": ["r", "The canonical retinoid cycle in rods (twilight vision)"], "R-XTR-5419276": ["r", "Mitochondrial translation termination"], "R-XTR-5389840": ["r", "Mitochondrial translation elongation"], "R-XTR-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-HSA-9679509": ["r", "Virion Assembly and Release"], "R-HSA-9694635": ["r", "Translation of Structural Proteins"], "R-HSA-9683701": ["r", "Translation of Structural Proteins"], "R-HSA-9694322": ["r", "Virion Assembly and Release"], "R-SSC-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-SSC-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-SSC-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-SSC-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-SSC-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-SSC-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-SSC-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-SSC-72086": ["r", "mRNA Capping"], "R-SSC-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-SSC-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-SSC-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-HSA-9918438": ["r", "Defective visual phototransduction due to RDH5 loss of function"], "R-DDI-8877627": ["r", "Vitamin E transport"], "R-DME-8877627": ["r", "Vitamin E transport"], "PWY-6728": ["t", "methylaspartate cycle"], "PWY-561": ["t", "superpathway of glyoxylate cycle and fatty acid degradation"], "PWY-5690": ["t", "TCA cycle II (plants and fungi)"], "PWY-5392": ["t", "reductive TCA cycle II"], "PWY-6969": ["t", "TCA cycle V (2-oxoglutarate synthase)"], "R-XTR-9856872": ["r", "Malate-aspartate shuttle"], "R-HSA-9663199": ["r", "Defective DNA double strand break response due to BRCA1 loss of function"], "R-XTR-171306": ["r", "Packaging Of Telomere Ends"], "R-BTA-174430": ["r", "Telomere C-strand synthesis initiation"], "R-XTR-110331": ["r", "Cleavage of the damaged purine"], "PWY-8314": ["t", "inulin degradation"], "PWY-6611": ["t", "adenine and adenosine salvage V"], "PWY-7179": ["t", "purine deoxyribonucleosides degradation I"], "PWY-6609": ["t", "adenine and adenosine salvage III"], "R-DRE-5683826": ["r", "Surfactant metabolism"], "R-DDI-9755088": ["r", "Ribavirin ADME"], "R-DRE-74217": ["r", "Purine salvage"], "R-MMU-2161541": ["r", "Abacavir metabolism"], "R-DME-2161541": ["r", "Abacavir metabolism"], "R-DRE-2161541": ["r", "Abacavir metabolism"], "R-HSA-2161541": ["r", "Abacavir metabolism"], "R-PFA-9755088": ["r", "Ribavirin ADME"], "R-XTR-9755088": ["r", "Ribavirin ADME"], "R-XTR-74217": ["r", "Purine salvage"], "R-CEL-2161541": ["r", "Abacavir metabolism"], "R-HSA-9734735": ["r", "Defective ADA disrupts (deoxy)adenosine deamination"], "R-DRE-5173105": ["r", "O-linked glycosylation"], "R-DRE-2129379": ["r", "Molecules associated with elastic fibres"], "R-BTA-173623": ["r", "Classical antibody-mediated complement activation"], "R-DDI-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-BTA-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-HSA-451927": ["r", "Interleukin-2 family signaling"], "R-RNO-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "R-HSA-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "R-MMU-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "PWY-3661": ["t", "glycine betaine degradation I"], "PWY-8363": ["t", "photorespiration III"], "PWY-181": ["t", "photorespiration I"], "PWY-8325": ["t", "glycine betaine degradation III"], "PWY-8362": ["t", "photorespiration II"], "R-SCE-71262": ["r", "Carnitine synthesis"], "R-MMU-71262": ["r", "Carnitine synthesis"], "R-SPO-71262": ["r", "Carnitine synthesis"], "R-CEL-71262": ["r", "Carnitine synthesis"], "R-HSA-71262": ["r", "Carnitine synthesis"], "R-CEL-196757": ["r", "Metabolism of folate and pterines"], "PWY-7432": ["t", "L-phenylalanine biosynthesis III (cytosolic, plants)"], "PWY-6848": ["t", "rutin degradation"], "PWY-7367": ["t", "phosphatidylcholine resynthesis via glycerophosphocholine"], "PWY-1921": ["t", "indole-3-acetate activation II"], "PWY-6558": ["t", "heparan sulfate biosynthesis"], "PWY-8391": ["t", "D-galacturonate degradation III"], "PWY-8390": ["t", "D-glucuronate degradation III"], "PWY-6308": ["t", "L-cysteine biosynthesis II (tRNA-dependent)"], "PWY-8384": ["t", "vitamin B6 degradation II"], "PWY-7002": ["t", "4-hydroxyacetophenone degradation"], "PWY-8455": ["t", "misacylated tRNA editing"], "PWY-6415": ["t", "L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)"], "PWY-8247": ["t", "(Kdo)2-lipid A biosynthesis (P. gingivalis)"], "PWY-5835": ["t", "geranyl acetate biosynthesis"], "PWY-7982": ["t", "pinoresinol degradation"], "PWY-7712": ["t", "deoxynivalenol biosynthesis"], "PWY-6190": ["t", "2,4-dichlorotoluene degradation"], "PWY-8143": ["t", "L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)"], "PWY-7521": ["t", "3-(4-sulfophenyl)butanoate degradation"], "R-SSC-113418": ["r", "Formation of the Early Elongation Complex"], "R-PFA-189085": ["r", "Digestion of dietary carbohydrate"], "R-CEL-189085": ["r", "Digestion of dietary carbohydrate"], "R-SCE-189085": ["r", "Digestion of dietary carbohydrate"], "R-DME-189085": ["r", "Digestion of dietary carbohydrate"], "R-CFA-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-XTR-173736": ["r", "Alternative complement activation"], "R-CFA-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-XTR-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-RNO-72764": ["r", "Eukaryotic Translation Termination"], "R-BTA-72764": ["r", "Eukaryotic Translation Termination"], "R-SPO-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-CEL-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-BTA-400511": ["r", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "R-SCE-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-HSA-9854909": ["r", "Regulation of MITF-M dependent genes involved in invasion"], "R-MMU-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-RNO-203754": ["r", "NOSIP mediated eNOS trafficking"], "R-SPO-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-SSC-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-HSA-211897": ["r", "Cytochrome P450 - arranged by substrate type"], "R-SCE-5578775": ["r", "Ion homeostasis"], "R-HSA-203754": ["r", "NOSIP mediated eNOS trafficking"], "R-MMU-203754": ["r", "NOSIP mediated eNOS trafficking"], "R-DME-203754": ["r", "NOSIP mediated eNOS trafficking"], "R-HSA-6782861": ["r", "Synthesis of wybutosine at G37 of tRNA(Phe)"], "R-DDI-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-SCE-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-RNO-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-SPO-5578775": ["r", "Ion homeostasis"], "R-DME-392154": ["r", "Nitric oxide stimulates guanylate cyclase"], "R-DDI-203754": ["r", "NOSIP mediated eNOS trafficking"], "R-MMU-162791": ["r", "Attachment of GPI anchor to uPAR"], "R-BTA-162791": ["r", "Attachment of GPI anchor to uPAR"], "R-HSA-162791": ["r", "Attachment of GPI anchor to uPAR"], "PWY-7397": ["t", "naringenin biosynthesis (engineered)"], "PWY-6515": ["t", "phloridzin biosynthesis"], "PWY-7897": ["t", "flavonoid di-C-glucosylation"], "PWY-5135": ["t", "xanthohumol biosynthesis"], "PWY-6787": ["t", "flavonoid biosynthesis (in equisetum)"], "R-DDI-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "PWY-7560": ["t", "methylerythritol phosphate pathway II"], "R-BTA-1170546": ["r", "Prolactin receptor signaling"], "R-DDI-9673163": ["r", "Oleoyl-phe metabolism"], "R-SCE-9673163": ["r", "Oleoyl-phe metabolism"], "R-HSA-5579007": ["r", "Defective ACY1 causes encephalopathy"], "R-DDI-5423646": ["r", "Aflatoxin activation and detoxification"], "R-DRE-9912633": ["r", "Antigen processing: Ub, ATP-independent proteasomal degradation"], "R-DME-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-HSA-9764790": ["r", "Positive Regulation of CDH1 Gene Transcription"], "R-CEL-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-HSA-210746": ["r", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "R-DRE-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-HSA-8866906": ["r", "TFAP2 (AP-2) family regulates transcription of other transcription factors"], "R-HSA-9761174": ["r", "Formation of intermediate mesoderm"], "R-XTR-171319": ["r", "Telomere Extension By Telomerase"], "R-XTR-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "R-CEL-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-CEL-6783984": ["r", "Glycine degradation"], "R-CEL-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-HSA-2408550": ["r", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se"], "R-CEL-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-RNO-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "R-MTU-870331": ["r", "Mycothiol metabolism"], "R-DDI-9859138": ["r", "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV"], "R-BTA-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "R-BTA-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-BTA-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-CEL-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-DME-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "R-RNO-9859138": ["r", "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV"], "R-DRE-9696273": ["r", "RND1 GTPase cycle"], "R-DRE-193048": ["r", "Androgen biosynthesis"], "R-DME-193048": ["r", "Androgen biosynthesis"], "R-XTR-193048": ["r", "Androgen biosynthesis"], "R-XTR-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-SCE-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-CEL-193048": ["r", "Androgen biosynthesis"], "R-SPO-193048": ["r", "Androgen biosynthesis"], "R-RNO-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-DME-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-CEL-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-HSA-4755579": ["r", "Defective SRD5A3 causes SRD5A3-CDG, KHRZ"], "R-SCE-193048": ["r", "Androgen biosynthesis"], "R-DRE-446199": ["r", "Synthesis of dolichyl-phosphate"], "PWY-5028": ["t", "L-histidine degradation II"], "R-MMU-70921": ["r", "Histidine catabolism"], "R-RNO-70921": ["r", "Histidine catabolism"], "R-CEL-70921": ["r", "Histidine catabolism"], "R-BTA-70921": ["r", "Histidine catabolism"], "R-HSA-70921": ["r", "Histidine catabolism"], "R-DDI-70921": ["r", "Histidine catabolism"], "PWY-7803": ["t", "tRNA splicing II"], "R-GGA-373920": ["r", "Pyruvate metabolism"], "R-GGA-70268": ["r", "Pyruvate metabolism"], "R-DME-70268": ["r", "Pyruvate metabolism"], "R-DRE-70268": ["r", "Pyruvate metabolism"], "PWY-6309": ["t", "L-tryptophan degradation XI (mammalian, via kynurenine)"], "PWY-8382": ["t", "diazepinomicin biosynthesis"], "PWY-7096": ["t", "triclosan resistance"], "PWY-7300": ["t", "ecdysone and 20-hydroxyecdysone biosynthesis"], "R-DRE-9755088": ["r", "Ribavirin ADME"], "R-PFA-74217": ["r", "Purine salvage"], "R-SSC-5676594": ["r", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "R-BTA-5676594": ["r", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "R-SSC-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-SSC-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-MMU-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-CFA-5676594": ["r", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "R-SPO-111469": ["r", "SMAC, XIAP-regulated apoptotic response"], "R-HSA-111463": ["r", "SMAC (DIABLO) binds to IAPs"], "R-HSA-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-CFA-5357786": ["r", "TNFR1-induced proapoptotic signaling"], "R-RNO-111463": ["r", "SMAC (DIABLO) binds to IAPs"], "R-HSA-111469": ["r", "SMAC, XIAP-regulated apoptotic response"], "R-DME-111469": ["r", "SMAC, XIAP-regulated apoptotic response"], "R-MMU-111464": ["r", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"], "R-DME-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-RNO-111464": ["r", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"], "R-MMU-111463": ["r", "SMAC (DIABLO) binds to IAPs"], "R-HSA-111464": ["r", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"], "R-RNO-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-RNO-111469": ["r", "SMAC, XIAP-regulated apoptotic response"], "R-XTR-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-DRE-9931269": ["r", "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)"], "R-SSC-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-SSC-8849932": ["r", "Synaptic adhesion-like molecules"], "R-BTA-5213460": ["r", "RIPK1-mediated regulated necrosis"], "R-SSC-193692": ["r", "Regulated proteolysis of p75NTR"], "R-BTA-9839383": ["r", "TGFBR3 PTM regulation"], "R-DRE-193692": ["r", "Regulated proteolysis of p75NTR"], "R-DRE-9839383": ["r", "TGFBR3 PTM regulation"], "R-SSC-9839383": ["r", "TGFBR3 PTM regulation"], "R-BTA-193692": ["r", "Regulated proteolysis of p75NTR"], "R-HSA-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-SSC-9839389": ["r", "TGFBR3 regulates TGF-beta signaling"], "R-RNO-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-HSA-168277": ["r", "Influenza Virus Induced Apoptosis"], "R-SSC-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-SSC-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "PWY-5956": ["t", "sterigmatocystin biosynthesis"], "PWY-6302": ["t", "dihydroconiferyl alcohol biosynthesis"], "PWY-6996": ["t", "daidzin and daidzein degradation"], "PWY-7881": ["t", "virginiae butanolide type gamma-butyrolactones biosynthesis"], "PWY-7154": ["t", "ergosterol biosynthesis II"], "PWY-5367": ["t", "petroselinate biosynthesis"], "PWY-5393": ["t", "raspberry ketone biosynthesis"], "PWY-5972": ["t", "stearate biosynthesis I (animals)"], "PWY-7770": ["t", "indolmycin biosynthesis"], "PWY-6332": ["t", "coumestrol biosynthesis"], "PWY-7846": ["t", "heme degradation V"], "PWY-6088": ["t", "3-chlorobenzoate degradation I (via chlorocatechol)"], "PWY-8044": ["t", "cyclohexane-1-carboxyl-CoA biosynthesis"], "PWY-6786": ["t", "detoxification of reactive carbonyls in chloroplasts"], "PWY-2541": ["t", "phytosterol biosynthesis (plants)"], "PWY-5818": ["t", "validamycin biosynthesis"], "R-HSA-2160456": ["r", "Phenylketonuria"], "R-DDI-8964208": ["r", "Phenylalanine metabolism"], "R-CEL-8964208": ["r", "Phenylalanine metabolism"], "R-DDI-209905": ["r", "Catecholamine biosynthesis"], "R-BTA-1614517": ["r", "Sulfide oxidation to sulfate"], "R-HSA-2466712": ["r", "Biosynthesis of A2E, implicated in retinal degradation"], "R-DDI-70268": ["r", "Pyruvate metabolism"], "PWY-8270": ["t", "cyclic electron flow"], "PWY-7268": ["t", "cytosolic NADPH production (yeast)"], "R-DDI-71336": ["r", "Pentose phosphate pathway"], "R-PFA-71336": ["r", "Pentose phosphate pathway"], "R-RNO-71336": ["r", "Pentose phosphate pathway"], "R-DME-71336": ["r", "Pentose phosphate pathway"], "R-PFA-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-CEL-71336": ["r", "Pentose phosphate pathway"], "R-CEL-9840310": ["r", "Glycosphingolipid catabolism"], "PWY-7084": ["t", "nitrifier denitrification"], "PWY-6748": ["t", "nitrate reduction VII (denitrification)"], "PWY-6523": ["t", "nitrite-dependent anaerobic methane oxidation"], "R-HSA-381183": ["r", "ATF6 (ATF6-alpha) activates chaperone genes"], "R-SSC-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-XTR-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-SSC-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-PFA-73817": ["r", "Purine ribonucleoside monophosphate biosynthesis"], "R-HSA-5619060": ["r", "Defective CP causes aceruloplasminemia (ACERULOP)"], "R-HSA-5619049": ["r", "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)"], "R-DDI-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-CEL-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-MMU-166020": ["r", "Transfer of LPS from LBP carrier to CD14"], "R-HSA-166020": ["r", "Transfer of LPS from LBP carrier to CD14"], "R-DDI-6803157": ["r", "Antimicrobial peptides"], "R-CEL-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-RNO-166020": ["r", "Transfer of LPS from LBP carrier to CD14"], "R-DDI-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-GGA-353503": ["r", "Translesion synthesis by Pol kappa"], "R-SSC-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-DRE-211979": ["r", "Eicosanoids"], "R-RNO-211957": ["r", "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2"], "R-DRE-211916": ["r", "Vitamins"], "R-HSA-211979": ["r", "Eicosanoids"], "R-SSC-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-CFA-211945": ["r", "Phase I - Functionalization of compounds"], "R-HSA-211994": ["r", "Sterols are 12-hydroxylated by CYP8B1"], "R-DDI-211976": ["r", "Endogenous sterols"], "R-CFA-9757110": ["r", "Prednisone ADME"], "R-BTA-211999": ["r", "CYP2E1 reactions"], "R-CEL-193144": ["r", "Estrogen biosynthesis"], "R-RNO-193144": ["r", "Estrogen biosynthesis"], "R-MMU-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-SSC-193144": ["r", "Estrogen biosynthesis"], "R-RNO-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-BTA-166058": ["r", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "R-XTR-450321": ["r", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"], "R-DRE-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-XTR-937042": ["r", "IRAK2 mediated activation of TAK1 complex"], "R-BTA-975871": ["r", "MyD88 cascade initiated on plasma membrane"], "R-BTA-975138": ["r", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"], "R-XTR-166058": ["r", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "R-XTR-450302": ["r", "activated TAK1 mediates p38 MAPK activation"], "R-XTR-975871": ["r", "MyD88 cascade initiated on plasma membrane"], "R-SSC-975138": ["r", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"], "R-XTR-209560": ["r", "NF-kB is activated and signals survival"], "R-SSC-166058": ["r", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "R-XTR-975138": ["r", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"], "R-XTR-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-DRE-937072": ["r", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "R-SSC-975871": ["r", "MyD88 cascade initiated on plasma membrane"], "R-RNO-174430": ["r", "Telomere C-strand synthesis initiation"], "R-RNO-5649702": ["r", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "R-DRE-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-BTA-9818564": ["r", "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "R-HSA-192814": ["r", "vRNA Synthesis"], "R-DME-5696397": ["r", "Gap-filling DNA repair synthesis and ligation in GG-NER"], "R-DRE-174430": ["r", "Telomere C-strand synthesis initiation"], "R-XTR-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-DRE-171319": ["r", "Telomere Extension By Telomerase"], "R-HSA-9699150": ["r", "Defective DNA double strand break response due to BARD1 loss of function"], "R-RNO-110381": ["r", "Resolution of AP sites via the single-nucleotide replacement pathway"], "R-HSA-5579032": ["r", "Defective TBXAS1 causes GHDD"], "R-DME-193144": ["r", "Estrogen biosynthesis"], "R-CEL-211916": ["r", "Vitamins"], "R-HSA-211999": ["r", "CYP2E1 reactions"], "R-SSC-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-DRE-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-SSC-211935": ["r", "Fatty acids"], "R-MMU-211999": ["r", "CYP2E1 reactions"], "R-DRE-5365859": ["r", "RA biosynthesis pathway"], "R-CEL-5423646": ["r", "Aflatoxin activation and detoxification"], "R-DDI-9749641": ["r", "Aspirin ADME"], "R-CEL-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-MMU-211935": ["r", "Fatty acids"], "R-DDI-2142670": ["r", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "R-BTA-211979": ["r", "Eicosanoids"], "R-HSA-5579013": ["r", "Defective CYP7B1 causes SPG5A and CBAS3"], "R-DDI-211981": ["r", "Xenobiotics"], "R-DME-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-HSA-5579011": ["r", "Defective CYP2U1 causes SPG56"], "R-HSA-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-RNO-211958": ["r", "Miscellaneous substrates"], "R-SSC-194002": ["r", "Glucocorticoid biosynthesis"], "R-MMU-211994": ["r", "Sterols are 12-hydroxylated by CYP8B1"], "R-RNO-211935": ["r", "Fatty acids"], "R-CFA-9754706": ["r", "Atorvastatin ADME"], "R-DME-211958": ["r", "Miscellaneous substrates"], "R-SSC-211958": ["r", "Miscellaneous substrates"], "R-BTA-211958": ["r", "Miscellaneous substrates"], "R-RNO-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-MMU-211979": ["r", "Eicosanoids"], "R-HSA-5579028": ["r", "Defective CYP17A1 causes AH5"], "R-HSA-211958": ["r", "Miscellaneous substrates"], "R-BTA-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-HSA-5579030": ["r", "Defective CYP19A1 causes AEXS"], "R-HSA-193144": ["r", "Estrogen biosynthesis"], "R-SSC-192105": ["r", "Synthesis of bile acids and bile salts"], "R-DDI-211999": ["r", "CYP2E1 reactions"], "R-HSA-5579005": ["r", "Defective CYP4F22 causes ARCI5"], "R-HSA-5579027": ["r", "Defective CYP27B1 causes VDDR1B"], "R-DDI-196791": ["r", "Vitamin D (calciferol) metabolism"], "R-HSA-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-CEL-2142670": ["r", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "R-SSC-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-XTR-211916": ["r", "Vitamins"], "R-DRE-193144": ["r", "Estrogen biosynthesis"], "R-DME-211916": ["r", "Vitamins"], "R-DDI-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-DDI-211958": ["r", "Miscellaneous substrates"], "R-HSA-5579009": ["r", "Defective CYP11B2 causes CMO-1 deficiency"], "R-SPO-211976": ["r", "Endogenous sterols"], "R-DME-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-BTA-211935": ["r", "Fatty acids"], "R-CEL-211935": ["r", "Fatty acids"], "R-SSC-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-SCE-211976": ["r", "Endogenous sterols"], "R-HSA-211957": ["r", "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2"], "R-DDI-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-CEL-211958": ["r", "Miscellaneous substrates"], "R-CFA-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-HSA-5579010": ["r", "Defective CYP24A1 causes HCAI"], "R-HSA-5579004": ["r", "Defective CYP26C1 causes FFDD4"], "R-HSA-9754706": ["r", "Atorvastatin ADME"], "R-MMU-9754706": ["r", "Atorvastatin ADME"], "R-MMU-211957": ["r", "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2"], "R-DDI-211916": ["r", "Vitamins"], "R-CFA-211958": ["r", "Miscellaneous substrates"], "R-MMU-9027307": ["r", "Biosynthesis of maresin-like SPMs"], "R-DME-211979": ["r", "Eicosanoids"], "R-RNO-211999": ["r", "CYP2E1 reactions"], "R-HSA-5579021": ["r", "Defective CYP21A2 causes AH3"], "R-DME-211976": ["r", "Endogenous sterols"], "R-DDI-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-CEL-211999": ["r", "CYP2E1 reactions"], "R-BTA-211916": ["r", "Vitamins"], "R-RNO-211916": ["r", "Vitamins"], "R-CFA-211999": ["r", "CYP2E1 reactions"], "R-RNO-211979": ["r", "Eicosanoids"], "R-CFA-5423646": ["r", "Aflatoxin activation and detoxification"], "R-HSA-5579015": ["r", "Defective CYP26B1 causes RHFCA"], "R-RNO-9754706": ["r", "Atorvastatin ADME"], "R-HSA-5579017": ["r", "Defective CYP11B1 causes AH4"], "R-HSA-5579000": ["r", "Defective CYP1B1 causes Glaucoma"], "R-HSA-5578996": ["r", "Defective CYP27A1 causes CTX"], "R-CEL-2142816": ["r", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "R-MMU-211958": ["r", "Miscellaneous substrates"], "R-DDI-211945": ["r", "Phase I - Functionalization of compounds"], "R-HSA-211916": ["r", "Vitamins"], "R-HSA-5579014": ["r", "Defective CYP27B1 causes VDDR1A"], "R-CEL-211981": ["r", "Xenobiotics"], "R-CEL-211976": ["r", "Endogenous sterols"], "R-BTA-211981": ["r", "Xenobiotics"], "R-DDI-211935": ["r", "Fatty acids"], "R-XTR-5365859": ["r", "RA biosynthesis pathway"], "R-DME-211935": ["r", "Fatty acids"], "R-CFA-211981": ["r", "Xenobiotics"], "R-CFA-9749641": ["r", "Aspirin ADME"], "R-SSC-211979": ["r", "Eicosanoids"], "R-MMU-211916": ["r", "Vitamins"], "R-MMU-193144": ["r", "Estrogen biosynthesis"], "R-HSA-211935": ["r", "Fatty acids"], "R-HSA-9026766": ["r", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "R-BTA-9026762": ["r", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "R-DDI-156590": ["r", "Glutathione conjugation"], "R-DDI-2142688": ["r", "Synthesis of 5-eicosatetraenoic acids"], "R-RNO-9026766": ["r", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "R-DDI-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-DDI-2142700": ["r", "Biosynthesis of Lipoxins (LX)"], "R-BTA-2142700": ["r", "Biosynthesis of Lipoxins (LX)"], "R-RNO-9026762": ["r", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "R-BTA-9026766": ["r", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "R-DDI-9026762": ["r", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "R-DDI-9026766": ["r", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "R-MMU-9026762": ["r", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "R-DRE-975163": ["r", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "R-DRE-209560": ["r", "NF-kB is activated and signals survival"], "R-XTR-5689896": ["r", "Ovarian tumor domain proteases"], "PWY-5686": ["t", "UMP biosynthesis I"], "R-PFA-500753": ["r", "Pyrimidine biosynthesis"], "R-RNO-500753": ["r", "Pyrimidine biosynthesis"], "R-SPO-500753": ["r", "Pyrimidine biosynthesis"], "R-SPO-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-HSA-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-HSA-4551295": ["r", "Defective ALG11 causes CDG-1p"], "R-MMU-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-HSA-4549349": ["r", "Defective ALG2 causes CDG-1i"], "R-HSA-4549380": ["r", "Defective ALG1 causes CDG-1k"], "R-RNO-446353": ["r", "Cell-extracellular matrix interactions"], "R-XTR-9627069": ["r", "Regulation of the apoptosome activity"], "R-DRE-111458": ["r", "Formation of apoptosome"], "R-XTR-111458": ["r", "Formation of apoptosome"], "R-HSA-111458": ["r", "Formation of apoptosome"], "R-MMU-111458": ["r", "Formation of apoptosome"], "R-DRE-9627069": ["r", "Regulation of the apoptosome activity"], "R-GGA-9627069": ["r", "Regulation of the apoptosome activity"], "R-DME-5223345": ["r", "Miscellaneous transport and binding events"], "R-CEL-5223345": ["r", "Miscellaneous transport and binding events"], "R-DME-111458": ["r", "Formation of apoptosome"], "R-DME-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "R-BTA-111458": ["r", "Formation of apoptosome"], "R-GGA-111458": ["r", "Formation of apoptosome"], "R-DME-1482788": ["r", "Acyl chain remodelling of PC"], "R-GGA-2132270": ["r", "Lectin-mediated initiation of complement cascade"], "R-CEL-1482801": ["r", "Acyl chain remodelling of PS"], "R-CEL-1482922": ["r", "Acyl chain remodelling of PI"], "R-BTA-166662": ["r", "Lectin pathway of complement activation"], "R-CFA-2172127": ["r", "DAP12 interactions"], "R-RNO-2172127": ["r", "DAP12 interactions"], "R-BTA-3000480": ["r", "Scavenging by Class A Receptors"], "R-MMU-2172127": ["r", "DAP12 interactions"], "R-DME-1483166": ["r", "Synthesis of PA"], "R-MMU-111469": ["r", "SMAC, XIAP-regulated apoptotic response"], "R-BTA-139910": ["r", "Activation of BMF and translocation to mitochondria"], "R-BTA-111446": ["r", "Activation of BIM and translocation to mitochondria"], "R-SPO-917937": ["r", "Iron uptake and transport"], "R-XTR-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-DDI-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-MMU-9026766": ["r", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "R-HSA-9026762": ["r", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "R-BTA-2142688": ["r", "Synthesis of 5-eicosatetraenoic acids"], "R-GGA-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-HSA-3311021": ["r", "SMAD4 MH2 Domain Mutants in Cancer"], "R-GGA-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-DRE-2173795": ["r", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "R-DRE-2173789": ["r", "TGF-beta receptor signaling activates SMADs"], "R-HSA-3315487": ["r", "SMAD2/3 MH2 Domain Mutants in Cancer"], "R-CEL-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-SSC-1181150": ["r", "Signaling by NODAL"], "R-DME-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-GGA-1181150": ["r", "Signaling by NODAL"], "R-MMU-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-SSC-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-BTA-8941326": ["r", "RUNX2 regulates bone development"], "R-DRE-1502540": ["r", "Signaling by Activin"], "R-RNO-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-SSC-8941326": ["r", "RUNX2 regulates bone development"], "R-CFA-9839383": ["r", "TGFBR3 PTM regulation"], "R-HSA-376172": ["r", "DSCAM interactions"], "R-DRE-166662": ["r", "Lectin pathway of complement activation"], "R-DME-1482922": ["r", "Acyl chain remodelling of PI"], "R-HSA-5687868": ["r", "Defective SFTPA2 causes IPF"], "R-HSA-5688849": ["r", "Defective CSF2RB causes SMDP5"], "R-CFA-2424491": ["r", "DAP12 signaling"], "R-SSC-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-BTA-391160": ["r", "Signal regulatory protein family interactions"], "R-SSC-166016": ["r", "Toll Like Receptor 4 (TLR4) Cascade"], "R-HSA-5688890": ["r", "Defective CSF2RA causes SMDP4"], "R-SSC-391160": ["r", "Signal regulatory protein family interactions"], "R-DME-1482839": ["r", "Acyl chain remodelling of PE"], "R-CEL-6803157": ["r", "Antimicrobial peptides"], "R-BTA-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-DME-1482801": ["r", "Acyl chain remodelling of PS"], "R-CEL-1482788": ["r", "Acyl chain remodelling of PC"], "R-SPO-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-SCE-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-DDI-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "PWY-7927": ["t", "sulfide oxidation IV (mitochondria)"], "PWY-5350": ["t", "thiosulfate disproportionation IV (rhodanese)"], "R-MMU-418889": ["r", "Caspase activation via Dependence Receptors in the absence of ligand"], "R-CEL-9948001": ["r", "CASP4 inflammasome assembly"], "R-DME-9948011": ["r", "CASP5 inflammasome assembly"], "R-RNO-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-MMU-9948011": ["r", "CASP5 inflammasome assembly"], "R-DRE-9948001": ["r", "CASP4 inflammasome assembly"], "R-DRE-9960519": ["r", "CASP4-mediated substrate cleavage"], "R-HSA-8869496": ["r", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "R-GGA-418124": ["r", "Telomere maintenance"], "PWY-7894": ["t", "procollagen hydroxylation and glycosylation"], "R-CEL-6799198": ["r", "Complex I biogenesis"], "R-BTA-381033": ["r", "ATF6 (ATF6-alpha) activates chaperones"], "R-BTA-8874211": ["r", "CREB3 factors activate genes"], "R-BTA-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "R-BTA-8874177": ["r", "ATF6B (ATF6-beta) activates chaperones"], "R-CEL-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-HSA-9948011": ["r", "CASP5 inflammasome assembly"], "R-HSA-844615": ["r", "The AIM2 inflammasome"], "R-BTA-9948011": ["r", "CASP5 inflammasome assembly"], "R-DRE-9960525": ["r", "CASP5-mediated substrate cleavage"], "R-RNO-75158": ["r", "TRAIL signaling"], "R-CEL-9948011": ["r", "CASP5 inflammasome assembly"], "R-DME-418889": ["r", "Caspase activation via Dependence Receptors in the absence of ligand"], "R-DRE-9948011": ["r", "CASP5 inflammasome assembly"], "R-RNO-418889": ["r", "Caspase activation via Dependence Receptors in the absence of ligand"], "R-DME-75153": ["r", "Apoptotic execution phase"], "R-DME-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-CEL-9824594": ["r", "Regulation of MITF-M-dependent genes involved in apoptosis"], "R-DME-446205": ["r", "Synthesis of GDP-mannose"], "R-HSA-5619073": ["r", "Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)"], "R-DME-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-SCE-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-SPO-170822": ["r", "Regulation of Glucokinase by Glucokinase Regulatory Protein"], "R-HSA-5619056": ["r", "Defective HK1 causes hexokinase deficiency (HK deficiency)"], "R-GGA-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-HSA-192869": ["r", "cRNA Synthesis"], "PWY-6348": ["t", "phosphate acquisition"], "R-GGA-9013407": ["r", "RHOH GTPase cycle"], "R-XTR-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-DRE-532668": ["r", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "R-SCE-9755511": ["r", "KEAP1-NFE2L2 pathway"], "R-SPO-9755511": ["r", "KEAP1-NFE2L2 pathway"], "PWY-241": ["t", "C4 photosynthetic carbon assimilation cycle, NADP-ME type"], "R-GGA-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-BTA-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-DRE-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-HSA-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-MMU-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-CEL-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-DRE-1237044": ["r", "Erythrocytes take up carbon dioxide and release oxygen"], "R-CEL-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-DRE-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-CEL-1247673": ["r", "Erythrocytes take up oxygen and release carbon dioxide"], "R-RNO-1475029": ["r", "Reversible hydration of carbon dioxide"], "R-HSA-1222449": ["r", "Mtb iron assimilation by chelation"], "R-BTA-6799990": ["r", "Metal sequestration by antimicrobial proteins"], "R-DME-6799990": ["r", "Metal sequestration by antimicrobial proteins"], "R-GGA-421984": ["r", "Heme synthesis"], "R-SSC-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-SSC-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-CFA-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-DRE-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-SSC-5362517": ["r", "Signaling by Retinoic Acid"], "R-DME-9858328": ["r", "OADH complex synthesizes glutaryl-CoA from 2-OA"], "R-CFA-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-SSC-9853506": ["r", "OGDH complex synthesizes succinyl-CoA from 2-OG"], "R-SSC-6783984": ["r", "Glycine degradation"], "R-BTA-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-CFA-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-DDI-2485179": ["r", "Activation of the phototransduction cascade"], "R-CEL-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-BTA-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-CFA-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-GGA-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-CEL-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-DRE-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-SCE-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-BTA-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-HSA-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-DME-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-SSC-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-SSC-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-BTA-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-DRE-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-RNO-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-MMU-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-SPO-9707616": ["r", "Heme signaling"], "R-GGA-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-SPO-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-BTA-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-DME-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-DRE-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-CFA-2028269": ["r", "Signaling by Hippo"], "R-CFA-9860927": ["r", "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells"], "R-DRE-9968551": ["r", "Regulation of GBP-mediated host defense"], "R-HSA-844455": ["r", "The NLRP1 inflammasome"], "R-DRE-9953170": ["r", "GBP-mediated host defense"], "R-RNO-844455": ["r", "The NLRP1 inflammasome"], "R-DRE-844456": ["r", "The NLRP3 inflammasome"], "R-MMU-844455": ["r", "The NLRP1 inflammasome"], "R-RNO-111458": ["r", "Formation of apoptosome"], "R-DRE-844455": ["r", "The NLRP1 inflammasome"], "R-DRE-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-DME-399710": ["r", "Activation of AMPA receptors"], "R-RNO-451307": ["r", "Activation of Na-permeable kainate receptors"], "R-MMU-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-MMU-9609736": ["r", "Assembly and cell surface presentation of NMDA receptors"], "R-MMU-399710": ["r", "Activation of AMPA receptors"], "R-CEL-451307": ["r", "Activation of Na-permeable kainate receptors"], "R-CFA-8849932": ["r", "Synaptic adhesion-like molecules"], "R-CEL-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-DME-500657": ["r", "Presynaptic function of Kainate receptors"], "R-DME-451307": ["r", "Activation of Na-permeable kainate receptors"], "R-HSA-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-RNO-399710": ["r", "Activation of AMPA receptors"], "R-CFA-3928662": ["r", "EPHB-mediated forward signaling"], "R-RNO-500657": ["r", "Presynaptic function of Kainate receptors"], "R-CEL-399710": ["r", "Activation of AMPA receptors"], "R-DME-9609736": ["r", "Assembly and cell surface presentation of NMDA receptors"], "R-CFA-9609736": ["r", "Assembly and cell surface presentation of NMDA receptors"], "R-HSA-451307": ["r", "Activation of Na-permeable kainate receptors"], "R-HSA-399710": ["r", "Activation of AMPA receptors"], "R-CEL-500657": ["r", "Presynaptic function of Kainate receptors"], "R-RNO-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-RNO-9609736": ["r", "Assembly and cell surface presentation of NMDA receptors"], "R-DME-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-DDI-202040": ["r", "G-protein activation"], "R-DDI-416482": ["r", "G alpha (12/13) signalling events"], "R-GGA-170670": ["r", "Adenylate cyclase inhibitory pathway"], "R-DDI-6787639": ["r", "GDP-fucose biosynthesis"], "R-CEL-70370": ["r", "Galactose catabolism"], "R-MMU-6787639": ["r", "GDP-fucose biosynthesis"], "R-DME-6787639": ["r", "GDP-fucose biosynthesis"], "R-HSA-6787639": ["r", "GDP-fucose biosynthesis"], "R-CEL-6787639": ["r", "GDP-fucose biosynthesis"], "PWY-7981": ["t", "alpha-dystroglycan glycosylation"], "PWY-6720": ["t", "toyocamycin biosynthesis"], "PWY-5381": ["t", "NAD salvage (plants)"], "PWY-7018": ["t", "paromomycin biosynthesis"], "PWY-5800": ["t", "xylan biosynthesis"], "R-SSC-70171": ["r", "Glycolysis"], "R-PFA-8866652": ["r", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "R-PFA-5689603": ["r", "UCH proteinases"], "R-PFA-8951664": ["r", "Neddylation"], "R-RNO-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-CEL-901042": ["r", "Calnexin/calreticulin cycle"], "R-SPO-901042": ["r", "Calnexin/calreticulin cycle"], "R-DME-901042": ["r", "Calnexin/calreticulin cycle"], "R-RNO-901042": ["r", "Calnexin/calreticulin cycle"], "R-SSC-901042": ["r", "Calnexin/calreticulin cycle"], "R-BTA-419812": ["r", "Calcitonin-like ligand receptors"], "R-SSC-419812": ["r", "Calcitonin-like ligand receptors"], "R-BTA-8937144": ["r", "Aryl hydrocarbon receptor signalling"], "R-RNO-168928": ["r", "DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "R-GGA-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-DDI-901042": ["r", "Calnexin/calreticulin cycle"], "R-MMU-901042": ["r", "Calnexin/calreticulin cycle"], "R-SCE-901042": ["r", "Calnexin/calreticulin cycle"], "R-SSC-3000480": ["r", "Scavenging by Class A Receptors"], "R-SSC-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-BTA-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-RNO-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-SPO-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-SSC-71336": ["r", "Pentose phosphate pathway"], "R-HSA-6791055": ["r", "TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P"], "R-DDI-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-MMU-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-SSC-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-HSA-6791462": ["r", "TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P"], "R-SCE-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-DME-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-HSA-163754": ["r", "Insulin effects increased synthesis of Xylulose-5-Phosphate"], "R-BTA-5223345": ["r", "Miscellaneous transport and binding events"], "R-RNO-445095": ["r", "Interaction between L1 and Ankyrins"], "R-GGA-9035034": ["r", "RHOF GTPase cycle"], "R-DME-445095": ["r", "Interaction between L1 and Ankyrins"], "R-GGA-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-BTA-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "PWY-7800": ["t", "Ac/N-end rule pathway"], "PWY-7799": ["t", "Arg/N-end rule pathway (eukaryotic)"], "R-CEL-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-XTR-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-DRE-6803157": ["r", "Antimicrobial peptides"], "R-MMU-418346": ["r", "Platelet homeostasis"], "R-BTA-418346": ["r", "Platelet homeostasis"], "R-RNO-418346": ["r", "Platelet homeostasis"], "R-DRE-418346": ["r", "Platelet homeostasis"], "R-BTA-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-DRE-139853": ["r", "Elevation of cytosolic Ca2+ levels"], "R-HSA-418346": ["r", "Platelet homeostasis"], "R-CEL-9865881": ["r", "Complex III assembly"], "R-BTA-9865881": ["r", "Complex III assembly"], "R-SCE-9865878": ["r", "Complex III assembly"], "R-CFA-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-CFA-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-DDI-1834941": ["r", "STING mediated induction of host immune responses"], "R-CFA-72187": ["r", "mRNA 3'-end processing"], "R-CFA-73856": ["r", "RNA Polymerase II Transcription Termination"], "R-GGA-3371571": ["r", "HSF1-dependent transactivation"], "R-HSA-4755609": ["r", "Defective DHDDS causes RP59"], "R-CEL-2022090": ["r", "Assembly of collagen fibrils and other multimeric structures"], "R-DME-419037": ["r", "NCAM1 interactions"], "R-CEL-3000157": ["r", "Laminin interactions"], "R-DME-8948216": ["r", "Collagen chain trimerization"], "R-CEL-8948216": ["r", "Collagen chain trimerization"], "R-GGA-9753281": ["r", "Paracetamol ADME"], "R-HSA-156582": ["r", "Acetylation"], "R-GGA-156582": ["r", "Acetylation"], "R-MMU-156582": ["r", "Acetylation"], "R-BTA-156582": ["r", "Acetylation"], "R-RNO-156582": ["r", "Acetylation"], "R-BTA-203615": ["r", "eNOS activation"], "R-MMU-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-DRE-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-HSA-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-DRE-3214842": ["r", "HDMs demethylate histones"], "R-DME-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-MMU-1834941": ["r", "STING mediated induction of host immune responses"], "R-HSA-112126": ["r", "ALKBH3 mediated reversal of alkylation damage"], "R-DME-1834941": ["r", "STING mediated induction of host immune responses"], "R-HSA-5619050": ["r", "Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)"], "R-DRE-425381": ["r", "Bicarbonate transporters"], "R-RNO-425381": ["r", "Bicarbonate transporters"], "R-XTR-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-CFA-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-BTA-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-CEL-3134963": ["r", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production"], "R-SSC-9013418": ["r", "RHOBTB2 GTPase cycle"], "R-HSA-5688354": ["r", "Defective pro-SFTPC causes SMDP2 and RDS"], "PWY-7346": ["t", "UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)"], "PWY-7820": ["t", "teichuronic acid biosynthesis (B. subtilis 168)"], "R-BTA-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-HSA-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-CEL-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-RNO-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-MMU-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-DME-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-CFA-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-MMU-9958517": ["r", "SLC-mediated bile acid transport"], "R-CEL-9958517": ["r", "SLC-mediated bile acid transport"], "R-HSA-5656364": ["r", "Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)"], "R-RNO-9958517": ["r", "SLC-mediated bile acid transport"], "R-SSC-8981373": ["r", "Intestinal hexose absorption"], "R-DME-9958517": ["r", "SLC-mediated bile acid transport"], "R-MMU-429593": ["r", "Inositol transporters"], "R-BTA-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-CFA-429593": ["r", "Inositol transporters"], "R-HSA-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-HSA-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-RNO-8981373": ["r", "Intestinal hexose absorption"], "R-MMU-189200": ["r", "Cellular hexose transport"], "R-RNO-189200": ["r", "Cellular hexose transport"], "R-XTR-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-DRE-189200": ["r", "Cellular hexose transport"], "R-DRE-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-MMU-8981373": ["r", "Intestinal hexose absorption"], "R-HSA-5619114": ["r", "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)"], "R-DRE-9958790": ["r", "SLC-mediated transport of inorganic anions"], "R-MMU-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-HSA-5658208": ["r", "Defective SLC5A2 causes renal glucosuria (GLYS1)"], "R-XTR-9958790": ["r", "SLC-mediated transport of inorganic anions"], "R-HSA-9958790": ["r", "SLC-mediated transport of inorganic anions"], "R-MMU-9958790": ["r", "SLC-mediated transport of inorganic anions"], "R-HSA-8981373": ["r", "Intestinal hexose absorption"], "R-HSA-189200": ["r", "Cellular hexose transport"], "R-BTA-189200": ["r", "Cellular hexose transport"], "R-SSC-189200": ["r", "Cellular hexose transport"], "R-MMU-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-RNO-429593": ["r", "Inositol transporters"], "R-HSA-9958517": ["r", "SLC-mediated bile acid transport"], "R-XTR-196807": ["r", "Nicotinate metabolism"], "R-RNO-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-HSA-5658471": ["r", "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)"], "R-RNO-9958790": ["r", "SLC-mediated transport of inorganic anions"], "R-HSA-429593": ["r", "Inositol transporters"], "R-HSA-5619096": ["r", "Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)"], "R-SPO-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-CEL-6803207": ["r", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "R-DDI-446388": ["r", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "R-HSA-8956319": ["r", "Nucleotide catabolism"], "R-MMU-8956319": ["r", "Nucleotide catabolism"], "PWY-7790": ["t", "UMP biosynthesis II"], "R-GGA-936837": ["r", "Ion transport by P-type ATPases"], "R-XTR-936837": ["r", "Ion transport by P-type ATPases"], "R-DME-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-MMU-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-CFA-5578775": ["r", "Ion homeostasis"], "R-CFA-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-DDI-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-SCE-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-DDI-936837": ["r", "Ion transport by P-type ATPases"], "R-HSA-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-CEL-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-GGA-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-GGA-5578775": ["r", "Ion homeostasis"], "R-RNO-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-SPO-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-SPO-936837": ["r", "Ion transport by P-type ATPases"], "R-SCE-936837": ["r", "Ion transport by P-type ATPases"], "R-SSC-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-BTA-418359": ["r", "Reduction of cytosolic Ca++ levels"], "R-SSC-173623": ["r", "Classical antibody-mediated complement activation"], "R-XTR-8849932": ["r", "Synaptic adhesion-like molecules"], "R-BTA-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-XTR-438066": ["r", "Unblocking of NMDA receptors, glutamate binding and activation"], "R-SCE-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-CEL-5625900": ["r", "RHO GTPases activate CIT"], "R-DRE-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-DRE-450520": ["r", "HuR (ELAVL1) binds and stabilizes mRNA"], "R-DRE-917937": ["r", "Iron uptake and transport"], "R-BTA-450520": ["r", "HuR (ELAVL1) binds and stabilizes mRNA"], "R-BTA-844456": ["r", "The NLRP3 inflammasome"], "R-HSA-139915": ["r", "Activation of PUMA and translocation to mitochondria"], "R-HSA-5545619": ["r", "XAV939 stabilizes AXIN"], "R-DME-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-DRE-8956319": ["r", "Nucleotide catabolism"], "R-BTA-1483196": ["r", "PI and PC transport between ER and Golgi membranes"], "R-DDI-1483226": ["r", "Synthesis of PI"], "R-RNO-1483196": ["r", "PI and PC transport between ER and Golgi membranes"], "R-HSA-1483196": ["r", "PI and PC transport between ER and Golgi membranes"], "R-DDI-1483196": ["r", "PI and PC transport between ER and Golgi membranes"], "R-MMU-1483196": ["r", "PI and PC transport between ER and Golgi membranes"], "PWY-7807": ["t", "glyphosate degradation III"], "PWY-7805": ["t", "(aminomethyl)phosphonate degradation"], "R-CEL-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-DME-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-HSA-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-BTA-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-RNO-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-MMU-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-DDI-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "PWY-5514": ["t", "UDP-N-acetyl-D-galactosamine biosynthesis II"], "PWY-622": ["t", "starch biosynthesis"], "PWY-621": ["t", "sucrose degradation III (sucrose invertase)"], "PWY-7347": ["t", "sucrose biosynthesis III"], "PWY-6981": ["t", "chitin biosynthesis"], "PWY-5384": ["t", "sucrose degradation IV (sucrose phosphorylase)"], "PWY-8013": ["t", "UDP-N-acetyl-D-galactosamine biosynthesis III"], "PWY-5054": ["t", "D-sorbitol biosynthesis I"], "PWY-7221": ["t", "guanosine ribonucleotides de novo biosynthesis"], "R-BTA-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-DME-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-DME-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-CFA-500657": ["r", "Presynaptic function of Kainate receptors"], "R-CFA-9634597": ["r", "GPER1 signaling"], "R-CFA-400042": ["r", "Adrenaline,noradrenaline inhibits insulin secretion"], "R-CFA-420092": ["r", "Glucagon-type ligand receptors"], "R-BTA-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-BTA-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-CFA-8964315": ["r", "G beta:gamma signalling through BTK"], "R-CFA-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-BTA-1299308": ["r", "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"], "R-BTA-5576886": ["r", "Phase 4 - resting membrane potential"], "R-HSA-5576886": ["r", "Phase 4 - resting membrane potential"], "R-MMU-1299308": ["r", "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"], "R-MMU-5576886": ["r", "Phase 4 - resting membrane potential"], "R-HSA-1299308": ["r", "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"], "R-RNO-1299308": ["r", "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"], "R-RNO-5576886": ["r", "Phase 4 - resting membrane potential"], "R-DDI-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-HSA-9692912": ["r", "SARS-CoV-1 targets PDZ proteins in cell-cell junction"], "R-DME-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-DRE-8941237": ["r", "Invadopodia formation"], "R-CEL-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-DDI-5223345": ["r", "Miscellaneous transport and binding events"], "R-GGA-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-CFA-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-CFA-9013407": ["r", "RHOH GTPase cycle"], "R-PFA-9748787": ["r", "Azathioprine ADME"], "R-GGA-975577": ["r", "N-Glycan antennae elongation"], "R-RNO-9037629": ["r", "Lewis blood group biosynthesis"], "R-GGA-4085001": ["r", "Sialic acid metabolism"], "R-DRE-4085001": ["r", "Sialic acid metabolism"], "R-GGA-977068": ["r", "Termination of O-glycan biosynthesis"], "R-XTR-4085001": ["r", "Sialic acid metabolism"], "R-BTA-4085001": ["r", "Sialic acid metabolism"], "R-BTA-9037629": ["r", "Lewis blood group biosynthesis"], "R-MMU-975577": ["r", "N-Glycan antennae elongation"], "R-RNO-975577": ["r", "N-Glycan antennae elongation"], "R-HSA-975577": ["r", "N-Glycan antennae elongation"], "R-XTR-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-SSC-159231": ["r", "Transport of Mature mRNA Derived from an Intronless Transcript"], "R-CFA-392851": ["r", "Prostacyclin signalling through prostacyclin receptor"], "R-SSC-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-SSC-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-SPO-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-DRE-428930": ["r", "Thromboxane signalling through TP receptor"], "R-XTR-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-MMU-163282": ["r", "Mitochondrial transcription initiation"], "R-SPO-163282": ["r", "Mitochondrial transcription initiation"], "R-BTA-163282": ["r", "Mitochondrial transcription initiation"], "R-DME-163282": ["r", "Mitochondrial transcription initiation"], "R-SCE-163282": ["r", "Mitochondrial transcription initiation"], "R-HSA-163282": ["r", "Mitochondrial transcription initiation"], "R-RNO-163282": ["r", "Mitochondrial transcription initiation"], "R-DME-6803205": ["r", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "R-HSA-9022534": ["r", "Loss of MECP2 binding ability to 5hmC-DNA"], "R-HSA-9022927": ["r", "MECP2 regulates transcription of genes involved in GABA signaling"], "R-HSA-8866423": ["r", "VLDL assembly"], "R-RNO-3000497": ["r", "Scavenging by Class H Receptors"], "R-DME-8964041": ["r", "LDL remodeling"], "R-SSC-8964041": ["r", "LDL remodeling"], "R-MMU-8866423": ["r", "VLDL assembly"], "R-SSC-8963888": ["r", "Chylomicron assembly"], "R-MMU-8964041": ["r", "LDL remodeling"], "R-DRE-8964041": ["r", "LDL remodeling"], "R-RNO-8866423": ["r", "VLDL assembly"], "R-RNO-8964041": ["r", "LDL remodeling"], "R-SSC-8866423": ["r", "VLDL assembly"], "R-CFA-399719": ["r", "Trafficking of AMPA receptors"], "R-CFA-203641": ["r", "NOSTRIN mediated eNOS trafficking"], "R-CFA-9035034": ["r", "RHOF GTPase cycle"], "R-CFA-209968": ["r", "Thyroxine biosynthesis"], "R-DDI-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-DDI-380612": ["r", "Metabolism of serotonin"], "R-DRE-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-DDI-379401": ["r", "Dopamine clearance from the synaptic cleft"], "R-HSA-141333": ["r", "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "R-RNO-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-RNO-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-DRE-141333": ["r", "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "R-MMU-141333": ["r", "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "R-HSA-5579012": ["r", "Defective MAOA causes BRUNS"], "R-MMU-380612": ["r", "Metabolism of serotonin"], "R-RNO-380612": ["r", "Metabolism of serotonin"], "R-RNO-141333": ["r", "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "R-BTA-380612": ["r", "Metabolism of serotonin"], "R-MMU-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-MMU-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-HSA-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-DRE-379401": ["r", "Dopamine clearance from the synaptic cleft"], "R-HSA-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-DDI-141333": ["r", "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "R-BTA-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-BTA-141333": ["r", "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "R-BTA-379401": ["r", "Dopamine clearance from the synaptic cleft"], "R-BTA-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-DRE-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-DDI-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-DDI-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-DRE-380612": ["r", "Metabolism of serotonin"], "R-HSA-380612": ["r", "Metabolism of serotonin"], "R-DRE-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-DDI-449836": ["r", "Other interleukin signaling"], "R-RNO-425561": ["r", "Sodium/Calcium exchangers"], "R-XTR-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-DRE-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-MMU-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-CFA-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-DRE-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-XTR-3214847": ["r", "HATs acetylate histones"], "R-SSC-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-SCE-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-DRE-8943724": ["r", "Regulation of PTEN gene transcription"], "R-XTR-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-SCE-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-SCE-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-XTR-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-DRE-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-MMU-9615017": ["r", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "R-DME-5625900": ["r", "RHO GTPases activate CIT"], "R-XTR-9013424": ["r", "RHOV GTPase cycle"], "R-DRE-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-CEL-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-SPO-2132295": ["r", "MHC class II antigen presentation"], "R-HSA-425561": ["r", "Sodium/Calcium exchangers"], "R-MMU-425561": ["r", "Sodium/Calcium exchangers"], "R-DRE-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-DRE-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-BTA-381753": ["r", "Olfactory Signaling Pathway"], "R-DME-9037629": ["r", "Lewis blood group biosynthesis"], "R-DRE-9646399": ["r", "Aggrephagy"], "R-DRE-2565942": ["r", "Regulation of PLK1 Activity at G2/M Transition"], "R-SSC-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-BTA-9615933": ["r", "Postmitotic nuclear pore complex (NPC) reformation"], "R-BTA-177929": ["r", "Signaling by EGFR"], "R-CFA-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-CFA-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-SSC-191859": ["r", "snRNP Assembly"], "R-BTA-8964315": ["r", "G beta:gamma signalling through BTK"], "R-DDI-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-BTA-5626978": ["r", "TNFR1-mediated ceramide production"], "R-DDI-418457": ["r", "cGMP effects"], "R-DDI-418555": ["r", "G alpha (s) signalling events"], "R-DDI-111957": ["r", "Cam-PDE 1 activation"], "R-GGA-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-CFA-77387": ["r", "Insulin receptor recycling"], "R-GGA-77387": ["r", "Insulin receptor recycling"], "R-GGA-2132295": ["r", "MHC class II antigen presentation"], "R-SCE-2132295": ["r", "MHC class II antigen presentation"], "R-GGA-75205": ["r", "Dissolution of Fibrin Clot"], "PWY-7854": ["t", "crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered)"], "PWY-7295": ["t", "L-arabinose degradation IV"], "PWY-7118": ["t", "chitin deacetylation"], "PWY-7294": ["t", "D-xylose degradation IV"], "PWY-6703": ["t", "preQ0 biosynthesis"], "PWY-5663": ["t", "erythro-tetrahydrobiopterin biosynthesis I"], "PWY-6983": ["t", "threo-tetrahydrobiopterin biosynthesis"], "PWY-7442": ["t", "drosopterin and aurodrosopterin biosynthesis"], "R-MMU-9839397": ["r", "TGFBR3 regulates FGF2 signaling"], "R-HSA-9839397": ["r", "TGFBR3 regulates FGF2 signaling"], "R-RNO-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-DRE-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-RNO-9839397": ["r", "TGFBR3 regulates FGF2 signaling"], "R-BTA-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-HSA-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-XTR-8936459": ["r", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "R-DRE-9717207": ["r", "Sensory perception of sweet, bitter, and umami (glutamate) taste"], "R-RNO-430039": ["r", "mRNA decay by 5' to 3' exoribonuclease"], "R-XTR-110314": ["r", "Recognition of DNA damage by PCNA-containing replication complex"], "R-SPO-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-SPO-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-SSC-176417": ["r", "Phosphorylation of Emi1"], "R-SSC-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-DME-209441": ["r", "WG ligand not bound to FZ receptors"], "R-GGA-141444": ["r", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"], "R-DRE-392170": ["r", "ADP signalling through P2Y purinoceptor 12"], "R-BTA-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-RNO-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-SSC-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-CFA-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-SSC-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-GGA-5668599": ["r", "RHO GTPases Activate NADPH Oxidases"], "R-RNO-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-BTA-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-SSC-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-MMU-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-SSC-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-RNO-5625970": ["r", "RHO GTPases activate KTN1"], "R-BTA-983189": ["r", "Kinesins"], "R-CEL-983189": ["r", "Kinesins"], "R-DRE-983189": ["r", "Kinesins"], "R-DME-983189": ["r", "Kinesins"], "R-SCE-983189": ["r", "Kinesins"], "R-DDI-983189": ["r", "Kinesins"], "R-MMU-5625970": ["r", "RHO GTPases activate KTN1"], "R-SPO-983189": ["r", "Kinesins"], "R-HSA-5625970": ["r", "RHO GTPases activate KTN1"], "PWY-8182": ["t", "valproate beta-oxidation"], "PWY-6458": ["t", "benzoyl-CoA biosynthesis"], "PWY-7007": ["t", "methyl ketone biosynthesis (engineered)"], "PWY-8354": ["t", "adipate degradation"], "PWY-8347": ["t", "adipate biosynthesis"], "PWY-7654": ["t", "(8E,10E)-dodeca-8,10-dienol biosynthesis"], "PWY-5138": ["t", "fatty acid beta-oxidation IV (unsaturated, even number)"], "PWY-6446": ["t", "benzoate biosynthesis III (CoA-dependent, non-beta-oxidative)"], "PWY-5136": ["t", "fatty acid beta-oxidation II (plant peroxisome)"], "PWY-8181": ["t", "2-methyl-branched fatty acid beta-oxidation"], "PWY-1361": ["t", "benzoyl-CoA degradation I (aerobic)"], "PWY-6443": ["t", "benzoate biosynthesis I (CoA-dependent, beta-oxidative)"], "R-RNO-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-RNO-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-CEL-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-HSA-77288": ["r", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "R-DRE-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-CEL-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-RNO-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-HSA-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-HSA-77285": ["r", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "R-HSA-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-MMU-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-SSC-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-RNO-77305": ["r", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "R-SSC-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-MMU-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-RNO-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-RNO-77285": ["r", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "R-RNO-77288": ["r", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "R-CEL-70895": ["r", "Branched-chain amino acid catabolism"], "R-MMU-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-RNO-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-BTA-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-HSA-77305": ["r", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "R-SSC-77305": ["r", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "R-CEL-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-SSC-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-HSA-9914274": ["r", "3-methylglutaconic aciduria"], "R-HSA-9916720": ["r", "Mitochondrial short-chain enoyl-CoA hydratase deficiency 1"], "R-SSC-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-CEL-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-MMU-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-SCE-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-SSC-1482798": ["r", "Acyl chain remodeling of CL"], "R-BTA-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-HSA-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-CEL-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-DDI-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-DDI-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-DDI-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-DDI-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-BTA-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-MMU-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-MMU-77285": ["r", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "R-BTA-77350": ["r", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "R-MMU-77305": ["r", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "R-HSA-77310": ["r", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "R-BTA-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-SSC-77285": ["r", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "R-DDI-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-MMU-77288": ["r", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "PWY-7791": ["t", "UMP biosynthesis III"], "R-DRE-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-SSC-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-DRE-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-BTA-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-DRE-196780": ["r", "Biotin transport and metabolism"], "R-SSC-196780": ["r", "Biotin transport and metabolism"], "R-BTA-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-RNO-447043": ["r", "Neurofascin interactions"], "R-BTA-199920": ["r", "CREB phosphorylation"], "R-DME-442742": ["r", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"], "R-CFA-418597": ["r", "G alpha (z) signalling events"], "R-CFA-381676": ["r", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "R-DRE-381771": ["r", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "R-DRE-202040": ["r", "G-protein activation"], "R-CFA-418217": ["r", "G beta:gamma signalling through PLC beta"], "R-DRE-204005": ["r", "COPII-mediated vesicle transport"], "R-DDI-3247509": ["r", "Chromatin modifying enzymes"], "R-XTR-1632852": ["r", "Macroautophagy"], "R-DRE-1632852": ["r", "Macroautophagy"], "R-BTA-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-HSA-9673766": ["r", "Signaling by cytosolic PDGFRA and PDGFRB fusion proteins"], "R-BTA-165159": ["r", "MTOR signalling"], "R-CEL-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-SSC-5626978": ["r", "TNFR1-mediated ceramide production"], "R-SCE-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-DRE-4641265": ["r", "Repression of WNT target genes"], "R-DME-9617629": ["r", "Regulation of FOXO transcriptional activity by acetylation"], "R-DRE-211163": ["r", "AKT-mediated inactivation of FOXO1A"], "R-DRE-198693": ["r", "AKT phosphorylates targets in the nucleus"], "R-CEL-9615017": ["r", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "R-XTR-9617828": ["r", "FOXO-mediated transcription of cell cycle genes"], "R-BTA-392851": ["r", "Prostacyclin signalling through prostacyclin receptor"], "R-SSC-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-MMU-5627083": ["r", "RHO GTPases regulate CFTR trafficking"], "R-MMU-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-DRE-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-HSA-5627083": ["r", "RHO GTPases regulate CFTR trafficking"], "R-SSC-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-BTA-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-DRE-420092": ["r", "Glucagon-type ligand receptors"], "R-DRE-381753": ["r", "Olfactory Signaling Pathway"], "R-DDI-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "PWY-6123": ["t", "inosine-5'-phosphate biosynthesis I"], "PWY-7234": ["t", "inosine-5'-phosphate biosynthesis III"], "PWY-6124": ["t", "inosine-5'-phosphate biosynthesis II"], "PWY-6964": ["t", "ammonia assimilation cycle II"], "PWY-8294": ["t", "L-aspartate degradation III (anaerobic)"], "PWY-8291": ["t", "L-aspartate degradation II (aerobic)"], "PWY-6963": ["t", "ammonia assimilation cycle I"], "R-DDI-196757": ["r", "Metabolism of folate and pterines"], "R-SSC-9937383": ["r", "Mitochondrial ribosome-associated quality control"], "R-SSC-5389840": ["r", "Mitochondrial translation elongation"], "R-CFA-72163": ["r", "mRNA Splicing - Major Pathway"], "R-BTA-3232142": ["r", "SUMOylation of ubiquitinylation proteins"], "R-DRE-1538133": ["r", "G0 and Early G1"], "R-CEL-4641265": ["r", "Repression of WNT target genes"], "R-DRE-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-RNO-4641265": ["r", "Repression of WNT target genes"], "R-GGA-5663220": ["r", "RHO GTPases Activate Formins"], "R-XTR-8943724": ["r", "Regulation of PTEN gene transcription"], "R-SSC-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-MMU-4641265": ["r", "Repression of WNT target genes"], "R-XTR-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-DRE-5626978": ["r", "TNFR1-mediated ceramide production"], "PWY-6707": ["t", "gallate biosynthesis"], "PWY-6416": ["t", "quinate degradation II"], "PWY-7919": ["t", "protein N-glycosylation processing phase (plants and animals)"], "R-HSA-4793950": ["r", "Defective MAN1B1 causes MRT15"], "R-CEL-964827": ["r", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "R-MMU-964827": ["r", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "R-DME-964827": ["r", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "R-HSA-964827": ["r", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "R-DDI-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-BTA-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-CEL-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-DDI-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-BTA-977443": ["r", "GABA receptor activation"], "R-GGA-977443": ["r", "GABA receptor activation"], "R-DDI-1266695": ["r", "Interleukin-7 signaling"], "R-XTR-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-XTR-70635": ["r", "Urea cycle"], "R-HSA-9956520": ["r", "ASS1 variants cause citrullinemia"], "R-GGA-917937": ["r", "Iron uptake and transport"], "R-CFA-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "PWY-5996": ["t", "oleate biosynthesis II (animals and fungi)"], "R-BTA-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-DRE-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-DRE-2132295": ["r", "MHC class II antigen presentation"], "R-CFA-177929": ["r", "Signaling by EGFR"], "R-DRE-8964038": ["r", "LDL clearance"], "R-GGA-437239": ["r", "Recycling pathway of L1"], "R-GGA-8964038": ["r", "LDL clearance"], "R-XTR-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-GGA-196025": ["r", "Formation of annular gap junctions"], "R-XTR-8866427": ["r", "VLDLR internalisation and degradation"], "R-GGA-5140745": ["r", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "R-HSA-164939": ["r", "Nef mediated downregulation of CD28 cell surface expression"], "R-GGA-416993": ["r", "Trafficking of GluR2-containing AMPA receptors"], "R-XTR-437239": ["r", "Recycling pathway of L1"], "R-XTR-196025": ["r", "Formation of annular gap junctions"], "R-DRE-177504": ["r", "Retrograde neurotrophin signalling"], "R-GGA-190873": ["r", "Gap junction degradation"], "R-GGA-177504": ["r", "Retrograde neurotrophin signalling"], "R-XTR-8964038": ["r", "LDL clearance"], "R-DRE-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-DME-9707616": ["r", "Heme signaling"], "R-SPO-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-MMU-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-DME-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "PWY-7782": ["t", "plasmalogen biosynthesis I (aerobic)"], "PWY-7158": ["t", "L-phenylalanine degradation V"], "PWY-8099": ["t", "tetrahydropteridine recycling"], "R-SPO-8964208": ["r", "Phenylalanine metabolism"], "R-SCE-8964208": ["r", "Phenylalanine metabolism"], "R-SPO-70895": ["r", "Branched-chain amino acid catabolism"], "R-SCE-70895": ["r", "Branched-chain amino acid catabolism"], "R-GGA-209968": ["r", "Thyroxine biosynthesis"], "R-GGA-209822": ["r", "Glycoprotein hormones"], "R-GGA-375281": ["r", "Hormone ligand-binding receptors"], "R-SSC-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-XTR-196757": ["r", "Metabolism of folate and pterines"], "R-HSA-141405": ["r", "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"], "R-XTR-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "R-DME-4641265": ["r", "Repression of WNT target genes"], "R-DRE-3214858": ["r", "RMTs methylate histone arginines"], "PWY-6498": ["t", "eumelanin biosynthesis"], "R-CFA-982772": ["r", "Growth hormone receptor signaling"], "R-GGA-1170546": ["r", "Prolactin receptor signaling"], "R-CFA-1170546": ["r", "Prolactin receptor signaling"], "R-GGA-982772": ["r", "Growth hormone receptor signaling"], "R-DRE-169911": ["r", "Regulation of Apoptosis"], "R-RNO-169911": ["r", "Regulation of Apoptosis"], "R-MMU-169911": ["r", "Regulation of Apoptosis"], "R-HSA-169911": ["r", "Regulation of Apoptosis"], "R-DRE-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-CEL-8939211": ["r", "ESR-mediated signaling"], "R-SSC-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-SSC-3371568": ["r", "Attenuation phase"], "R-SPO-844456": ["r", "The NLRP3 inflammasome"], "R-HSA-5657655": ["r", "MGMT-mediated DNA damage reversal"], "R-RNO-5173105": ["r", "O-linked glycosylation"], "R-CFA-9037629": ["r", "Lewis blood group biosynthesis"], "R-CFA-5173105": ["r", "O-linked glycosylation"], "R-CEL-9037629": ["r", "Lewis blood group biosynthesis"], "R-GGA-9864848": ["r", "Complex IV assembly"], "R-RNO-9864848": ["r", "Complex IV assembly"], "R-HSA-4341670": ["r", "Defective NEU1 causes sialidosis"], "PWY-7205": ["t", "CMP phosphorylation"], "PWY-7176": ["t", "UTP and CTP de novo biosynthesis"], "PWY-7224": ["t", "purine deoxyribonucleosides salvage"], "PWY-7197": ["t", "pyrimidine deoxyribonucleotide phosphorylation"], "R-CFA-499943": ["r", "Interconversion of nucleotide di- and triphosphates"], "R-GGA-9755088": ["r", "Ribavirin ADME"], "R-BTA-9755088": ["r", "Ribavirin ADME"], "R-DME-9755088": ["r", "Ribavirin ADME"], "R-SSC-9755088": ["r", "Ribavirin ADME"], "R-CFA-9748787": ["r", "Azathioprine ADME"], "R-CFA-9755088": ["r", "Ribavirin ADME"], "PWY-6157": ["t", "autoinducer AI-1 biosynthesis"], "R-CFA-70171": ["r", "Glycolysis"], "R-CFA-70268": ["r", "Pyruvate metabolism"], "R-DDI-844456": ["r", "The NLRP3 inflammasome"], "R-BTA-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-CFA-3000480": ["r", "Scavenging by Class A Receptors"], "R-SCE-8939211": ["r", "ESR-mediated signaling"], "R-CEL-5675482": ["r", "Regulation of necroptotic cell death"], "R-SCE-844456": ["r", "The NLRP3 inflammasome"], "R-DRE-3371568": ["r", "Attenuation phase"], "R-SSC-3371511": ["r", "HSF1 activation"], "R-DDI-8939211": ["r", "ESR-mediated signaling"], "R-DRE-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-BTA-9652282": ["r", "Drug-mediated inhibition of ERBB2 signaling"], "R-SSC-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-DRE-3371511": ["r", "HSF1 activation"], "R-MMU-264876": ["r", "Insulin processing"], "R-BTA-9845576": ["r", "Glycosphingolipid transport"], "R-DRE-8851805": ["r", "MET activates RAS signaling"], "R-BTA-9730628": ["r", "Sensory perception of salty taste"], "R-CFA-9730628": ["r", "Sensory perception of salty taste"], "R-CEL-9730628": ["r", "Sensory perception of salty taste"], "R-MMU-9730628": ["r", "Sensory perception of salty taste"], "R-HSA-9730628": ["r", "Sensory perception of salty taste"], "R-DRE-2672351": ["r", "Stimuli-sensing channels"], "R-RNO-9730628": ["r", "Sensory perception of salty taste"], "R-DRE-2559585": ["r", "Oncogene Induced Senescence"], "R-SCE-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-CEL-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-BTA-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-SSC-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-GGA-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-CFA-204005": ["r", "COPII-mediated vesicle transport"], "R-CFA-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-GGA-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-BTA-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-DRE-392451": ["r", "G beta:gamma signalling through PI3Kgamma"], "R-BTA-5625900": ["r", "RHO GTPases activate CIT"], "R-CFA-114604": ["r", "GPVI-mediated activation cascade"], "R-DRE-9607240": ["r", "FLT3 Signaling"], "R-SSC-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-DRE-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-BTA-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-GGA-9607240": ["r", "FLT3 Signaling"], "R-BTA-4086400": ["r", "PCP/CE pathway"], "R-CFA-9013424": ["r", "RHOV GTPase cycle"], "R-CFA-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-RNO-5627083": ["r", "RHO GTPases regulate CFTR trafficking"], "R-SSC-1169092": ["r", "Activation of RAS in B cells"], "R-CFA-418885": ["r", "DCC mediated attractive signaling"], "R-GGA-9648002": ["r", "RAS processing"], "R-SSC-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-GGA-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-DRE-2179392": ["r", "EGFR Transactivation by Gastrin"], "R-BTA-372708": ["r", "p130Cas linkage to MAPK signaling for integrins"], "R-DDI-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-BTA-5625970": ["r", "RHO GTPases activate KTN1"], "R-HSA-9753510": ["r", "Signaling by RAS GAP mutants"], "R-SSC-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-DRE-8873719": ["r", "RAB geranylgeranylation"], "R-BTA-8875555": ["r", "MET activates RAP1 and RAC1"], "R-SPO-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-DRE-69541": ["r", "Stabilization of p53"], "R-CEL-5578768": ["r", "Physiological factors"], "R-DDI-112311": ["r", "Neurotransmitter clearance"], "R-DDI-5578768": ["r", "Physiological factors"], "R-CEL-192456": ["r", "Digestion of dietary lipid"], "R-DDI-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "R-CEL-2022377": ["r", "Metabolism of Angiotensinogen to Angiotensins"], "PWY-5704": ["t", "urea degradation II"], "R-XTR-9837999": ["r", "Mitochondrial protein degradation"], "R-CEL-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-GGA-9013419": ["r", "RHOT2 GTPase cycle"], "R-GGA-389359": ["r", "CD28 dependent Vav1 pathway"], "R-DRE-180336": ["r", "SHC1 events in EGFR signaling"], "R-SSC-8854214": ["r", "TBC/RABGAPs"], "R-SSC-5627123": ["r", "RHO GTPases activate PAKs"], "R-GGA-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-SSC-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-DME-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-CFA-5627123": ["r", "RHO GTPases activate PAKs"], "R-CFA-3928664": ["r", "Ephrin signaling"], "R-CFA-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-DME-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-CFA-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-SSC-9013420": ["r", "RHOU GTPase cycle"], "R-DRE-209563": ["r", "Axonal growth stimulation"], "R-CEL-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-CFA-5663220": ["r", "RHO GTPases Activate Formins"], "R-GGA-1169092": ["r", "Activation of RAS in B cells"], "R-SPO-165159": ["r", "MTOR signalling"], "R-DRE-9013425": ["r", "RHOT1 GTPase cycle"], "R-SSC-171007": ["r", "p38MAPK events"], "R-CFA-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-GGA-2424491": ["r", "DAP12 signaling"], "R-CFA-389359": ["r", "CD28 dependent Vav1 pathway"], "R-GGA-171007": ["r", "p38MAPK events"], "R-DME-9013419": ["r", "RHOT2 GTPase cycle"], "R-DME-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-GGA-5654688": ["r", "SHC-mediated cascade:FGFR1"], "R-XTR-9013419": ["r", "RHOT2 GTPase cycle"], "R-CFA-3928663": ["r", "EPHA-mediated growth cone collapse"], "R-CFA-8854214": ["r", "TBC/RABGAPs"], "R-SPO-9696270": ["r", "RND2 GTPase cycle"], "R-CFA-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "R-BTA-9013425": ["r", "RHOT1 GTPase cycle"], "R-GGA-9013424": ["r", "RHOV GTPase cycle"], "R-BTA-416572": ["r", "Sema4D induced cell migration and growth-cone collapse"], "R-DRE-5625970": ["r", "RHO GTPases activate KTN1"], "R-CFA-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-DRE-179812": ["r", "GRB2 events in EGFR signaling"], "R-SSC-3214841": ["r", "PKMTs methylate histone lysines"], "R-DME-3214842": ["r", "HDMs demethylate histones"], "R-SCE-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-GGA-3214842": ["r", "HDMs demethylate histones"], "R-SSC-5693607": ["r", "Processing of DNA double-strand break ends"], "R-GGA-3214841": ["r", "PKMTs methylate histone lysines"], "R-SSC-110331": ["r", "Cleavage of the damaged purine"], "R-SPO-3214842": ["r", "HDMs demethylate histones"], "R-SSC-171306": ["r", "Packaging Of Telomere Ends"], "R-SSC-3214842": ["r", "HDMs demethylate histones"], "R-CEL-5576892": ["r", "Phase 0 - rapid depolarisation"], "R-CEL-5576893": ["r", "Phase 2 - plateau phase"], "R-CEL-422356": ["r", "Regulation of insulin secretion"], "R-GGA-6807505": ["r", "RNA polymerase II transcribes snRNA genes"], "R-CFA-209563": ["r", "Axonal growth stimulation"], "R-SSC-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-CFA-8873719": ["r", "RAB geranylgeranylation"], "R-CFA-193634": ["r", "Axonal growth inhibition (RHOA activation)"], "R-SSC-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-GGA-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-SSC-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-GGA-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-SPO-198203": ["r", "PI3K/AKT activation"], "R-GGA-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-SCE-9696264": ["r", "RND3 GTPase cycle"], "R-CEL-198203": ["r", "PI3K/AKT activation"], "R-CFA-4086400": ["r", "PCP/CE pathway"], "R-SSC-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-CFA-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-SCE-198203": ["r", "PI3K/AKT activation"], "R-CFA-5218920": ["r", "VEGFR2 mediated vascular permeability"], "R-CFA-9013420": ["r", "RHOU GTPase cycle"], "R-DME-198203": ["r", "PI3K/AKT activation"], "R-DME-2672351": ["r", "Stimuli-sensing channels"], "R-SSC-3214847": ["r", "HATs acetylate histones"], "R-SSC-69473": ["r", "G2/M DNA damage checkpoint"], "R-SPO-2299718": ["r", "Condensation of Prophase Chromosomes"], "R-SSC-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-GGA-3214858": ["r", "RMTs methylate histone arginines"], "R-SCE-3214842": ["r", "HDMs demethylate histones"], "PWY-5491": ["t", "diethylphosphate degradation"], "R-DME-8935690": ["r", "Digestion"], "R-SCE-8935690": ["r", "Digestion"], "R-SPO-8935690": ["r", "Digestion"], "R-BTA-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-RNO-425986": ["r", "Sodium/Proton exchangers"], "R-HSA-425986": ["r", "Sodium/Proton exchangers"], "R-MMU-425986": ["r", "Sodium/Proton exchangers"], "R-HSA-5619066": ["r", "Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)"], "R-CEL-112308": ["r", "Presynaptic depolarization and calcium channel opening"], "R-GGA-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "R-DRE-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "R-CEL-1655829": ["r", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "PWY-5691": ["t", "urate conversion to allantoin I"], "R-DDI-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-DRE-174113": ["r", "SCF-beta-TrCP mediated degradation of Emi1"], "R-DRE-176417": ["r", "Phosphorylation of Emi1"], "R-DRE-68881": ["r", "Mitotic Metaphase/Anaphase Transition"], "R-RNO-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-MMU-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-HSA-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-CEL-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-DRE-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-DDI-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-DME-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-SCE-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-GGA-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "R-BTA-204626": ["r", "Hypusine synthesis from eIF5A-lysine"], "PWY-6069": ["t", "indigo biosynthesis"], "PWY-5642": ["t", "2,4-dinitrotoluene degradation"], "R-BTA-425986": ["r", "Sodium/Proton exchangers"], "R-DDI-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-SCE-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-HSA-1483152": ["r", "Hydrolysis of LPE"], "R-CEL-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-HSA-111997": ["r", "CaM pathway"], "R-PFA-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-DME-425561": ["r", "Sodium/Calcium exchangers"], "R-CEL-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-DME-9856872": ["r", "Malate-aspartate shuttle"], "R-CEL-9013425": ["r", "RHOT1 GTPase cycle"], "R-RNO-9013419": ["r", "RHOT2 GTPase cycle"], "R-BTA-8949215": ["r", "Mitochondrial calcium ion transport"], "R-RNO-5607763": ["r", "CLEC7A (Dectin-1) induces NFAT activation"], "R-HSA-111957": ["r", "Cam-PDE 1 activation"], "R-RNO-8949215": ["r", "Mitochondrial calcium ion transport"], "PWY-6094": ["t", "3,4,6-trichlorocatechol degradation"], "PWY-7557": ["t", "(-)-dehydrodiconiferyl alcohol degradation"], "PWY-6089": ["t", "3-chlorocatechol degradation I (ortho)"], "PWY-8019": ["t", "2-hydroxyparaconate and itatartarate biosynthesis"], "PWY-7734": ["t", "quinoxaline-2-carboxylate biosynthesis"], "PWY-7682": ["t", "arabidopyrone biosynthesis"], "PWY-6193": ["t", "3-chlorocatechol degradation II (ortho)"], "PWY-5163": ["t", "p-cumate degradation to 2-hydroxypentadienoate"], "PWY-6102": ["t", "5-chloro-3-methyl-catechol degradation"], "PWY-6093": ["t", "4,5-dichlorocatechol degradation"], "PWY-6068": ["t", "indican biosynthesis"], "PWY-6667": ["t", "resveratrol degradation"], "PWY-8432": ["t", "4-hydroxypyridine degradation"], "PWY-7006": ["t", "4-amino-3-hydroxybenzoate degradation"], "PWY-6178": ["t", "2,4,6-trichlorophenol degradation"], "PWY-7733": ["t", "3-hydroxyquinaldate biosynthesis"], "PWY-7010": ["t", "2-propylphenol degradation"], "PWY-7582": ["t", "mercaptosuccinate degradation"], "PWY-6084": ["t", "3,5-dichlorocatechol degradation"], "PWY-6087": ["t", "4-chlorocatechol degradation"], "PWY-7009": ["t", "2,2'-dihydroxybiphenyl degradation"], "PWY-6107": ["t", "chlorosalicylate degradation"], "PWY-7011": ["t", "2-isopropylphenol degradation"], "PWY-8431": ["t", "L-mimosine degradation"], "PWY-8260": ["t", "roxarsone degradation I"], "PWY-721": ["t", "3-methylquinoline degradation"], "PWY-8269": ["t", "methylarsonous acid detoxification III"], "PWY-6336": ["t", "protocatechuate degradation III (para-cleavage pathway)"], "PWY-3641": ["t", "L-carnitine degradation II"], "PWY-7384": ["t", "anaerobic energy metabolism (invertebrates, mitochondrial)"], "PWY-7686": ["t", "L-malate degradation II"], "R-HSA-9818025": ["r", "NFE2L2 regulating TCA cycle genes"], "R-DME-350416": ["r", "Regulation of non-muscle Myosin II"], "R-RNO-111957": ["r", "Cam-PDE 1 activation"], "R-MMU-5607763": ["r", "CLEC7A (Dectin-1) induces NFAT activation"], "R-DME-5607763": ["r", "CLEC7A (Dectin-1) induces NFAT activation"], "R-XTR-8949215": ["r", "Mitochondrial calcium ion transport"], "R-SCE-445355": ["r", "Smooth Muscle Contraction"], "PWY-5874": ["t", "heme degradation I"], "R-MMU-9707587": ["r", "Regulation of HMOX1 expression and activity"], "R-SSC-9707587": ["r", "Regulation of HMOX1 expression and activity"], "R-SSC-189483": ["r", "Heme degradation"], "R-BTA-9707587": ["r", "Regulation of HMOX1 expression and activity"], "R-MTU-868688": ["r", "Trehalose biosynthesis"], "R-MMU-165160": ["r", "PDE3B signalling"], "R-RNO-165160": ["r", "PDE3B signalling"], "R-MMU-111957": ["r", "Cam-PDE 1 activation"], "R-PFA-418457": ["r", "cGMP effects"], "R-DME-418457": ["r", "cGMP effects"], "R-DDI-165160": ["r", "PDE3B signalling"], "R-DME-111957": ["r", "Cam-PDE 1 activation"], "R-CEL-418457": ["r", "cGMP effects"], "R-PFA-445355": ["r", "Smooth Muscle Contraction"], "R-CFA-445355": ["r", "Smooth Muscle Contraction"], "R-BTA-111957": ["r", "Cam-PDE 1 activation"], "R-PFA-418555": ["r", "G alpha (s) signalling events"], "R-CFA-418457": ["r", "cGMP effects"], "R-CFA-9013422": ["r", "RHOBTB1 GTPase cycle"], "R-DDI-445355": ["r", "Smooth Muscle Contraction"], "R-SCE-165160": ["r", "PDE3B signalling"], "R-SCE-418555": ["r", "G alpha (s) signalling events"], "R-PFA-165160": ["r", "PDE3B signalling"], "PWY-7619": ["t", "juniperonate biosynthesis"], "PWY-5080": ["t", "very long chain fatty acid biosynthesis I"], "PWY-7725": ["t", "arachidonate biosynthesis V (8-detaturase, mammals)"], "PWY-8041": ["t", "ultra-long-chain fatty acid biosynthesis"], "PWY-7724": ["t", "icosapentaenoate biosynthesis III (8-desaturase, mammals)"], "PWY-7036": ["t", "very long chain fatty acid biosynthesis II"], "PWY-7035": ["t", "(9Z)-tricosene biosynthesis"], "PWY-6598": ["t", "sciadonate biosynthesis"], "PWY-6433": ["t", "hydroxylated fatty acid biosynthesis (plants)"], "R-XTR-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-DME-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-XTR-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-DRE-75876": ["r", "Synthesis of very long-chain fatty acyl-CoAs"], "R-DME-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-CEL-2046106": ["r", "alpha-linolenic acid (ALA) metabolism"], "R-CEL-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-XTR-2046105": ["r", "Linoleic acid (LA) metabolism"], "R-DME-5576893": ["r", "Phase 2 - plateau phase"], "R-GGA-422356": ["r", "Regulation of insulin secretion"], "R-SPO-445355": ["r", "Smooth Muscle Contraction"], "R-DME-5576892": ["r", "Phase 0 - rapid depolarisation"], "R-SCE-500753": ["r", "Pyrimidine biosynthesis"], "R-RNO-9955298": ["r", "SLC-mediated transport of organic anions"], "R-DME-433137": ["r", "Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "R-CEL-433137": ["r", "Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "R-RNO-433137": ["r", "Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "R-CEL-9955298": ["r", "SLC-mediated transport of organic anions"], "R-HSA-433137": ["r", "Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "R-DME-9955298": ["r", "SLC-mediated transport of organic anions"], "R-HSA-9955298": ["r", "SLC-mediated transport of organic anions"], "R-MMU-9955298": ["r", "SLC-mediated transport of organic anions"], "R-MMU-433137": ["r", "Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "R-CFA-9609523": ["r", "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"], "R-SCE-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-CEL-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-HSA-3560792": ["r", "Defective SLC26A2 causes chondrodysplasias"], "R-SPO-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-BTA-174362": ["r", "Transport and metabolism of PAPS"], "R-SCE-174362": ["r", "Transport and metabolism of PAPS"], "R-HSA-5619085": ["r", "Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)"], "R-BTA-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-HSA-5619046": ["r", "Defective SLC26A4 causes Pendred syndrome (PDS)"], "R-RNO-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-SPO-174362": ["r", "Transport and metabolism of PAPS"], "R-CEL-174362": ["r", "Transport and metabolism of PAPS"], "R-HSA-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-DRE-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-MMU-174362": ["r", "Transport and metabolism of PAPS"], "R-HSA-174362": ["r", "Transport and metabolism of PAPS"], "R-MMU-427601": ["r", "Inorganic anion exchange by SLC26 transporters"], "R-RNO-174362": ["r", "Transport and metabolism of PAPS"], "R-HSA-948021": ["r", "Transport to the Golgi and subsequent modification"], "R-DME-8949215": ["r", "Mitochondrial calcium ion transport"], "R-HSA-8949215": ["r", "Mitochondrial calcium ion transport"], "R-DDI-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-CEL-425561": ["r", "Sodium/Calcium exchangers"], "R-DME-9619229": ["r", "Activation of RAC1 downstream of NMDARs"], "R-CEL-9013419": ["r", "RHOT2 GTPase cycle"], "R-CEL-111957": ["r", "Cam-PDE 1 activation"], "R-DRE-8949215": ["r", "Mitochondrial calcium ion transport"], "R-PFA-6811558": ["r", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "R-DME-8963693": ["r", "Aspartate and asparagine metabolism"], "R-DRE-1358803": ["r", "Downregulation of ERBB2:ERBB3 signaling"], "R-CFA-8953750": ["r", "Transcriptional Regulation by E2F6"], "R-BTA-212436": ["r", "Generic Transcription Pathway"], "R-BTA-169911": ["r", "Regulation of Apoptosis"], "R-RNO-9707587": ["r", "Regulation of HMOX1 expression and activity"], "R-BTA-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-DRE-110381": ["r", "Resolution of AP sites via the single-nucleotide replacement pathway"], "R-DRE-5649702": ["r", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "R-DRE-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-BTA-73930": ["r", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "R-HSA-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-BTA-110381": ["r", "Resolution of AP sites via the single-nucleotide replacement pathway"], "R-BTA-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-MMU-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-RNO-73930": ["r", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "R-MMU-73930": ["r", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "R-DRE-73930": ["r", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "R-HSA-73930": ["r", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "R-RNO-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-XTR-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-DRE-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-SCE-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "PWY-5629": ["t", "isopenicillin N biosynthesis"], "R-RNO-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-HSA-167826": ["r", "The fatty acid cycling model"], "R-SSC-1268020": ["r", "Mitochondrial protein import"], "R-RNO-166187": ["r", "Mitochondrial Uncoupling"], "R-CEL-1614517": ["r", "Sulfide oxidation to sulfate"], "R-DDI-71064": ["r", "Lysine catabolism"], "R-DDI-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-MMU-166187": ["r", "Mitochondrial Uncoupling"], "R-SCE-166187": ["r", "Mitochondrial Uncoupling"], "R-HSA-71064": ["r", "Lysine catabolism"], "R-SPO-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-SCE-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-SSC-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-SCE-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-RNO-167826": ["r", "The fatty acid cycling model"], "R-SCE-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-DDI-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-SPO-1268020": ["r", "Mitochondrial protein import"], "R-HSA-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-RNO-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-DDI-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-HSA-166187": ["r", "Mitochondrial Uncoupling"], "R-BTA-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-BTA-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-DME-167826": ["r", "The fatty acid cycling model"], "R-DDI-166187": ["r", "Mitochondrial Uncoupling"], "R-SSC-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-BTA-549127": ["r", "SLC-mediated transport of organic cations"], "R-SSC-5205685": ["r", "PINK1-PRKN Mediated Mitophagy"], "R-SSC-70268": ["r", "Pyruvate metabolism"], "R-SCE-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-SCE-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-CEL-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-CEL-9018681": ["r", "Biosynthesis of protectins"], "R-CEL-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-SPO-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-DDI-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-RNO-1236977": ["r", "Endosomal/Vacuolar pathway"], "R-SPO-9020265": ["r", "Biosynthesis of aspirin-triggered D-series resolvins"], "R-DDI-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-CFA-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-CEL-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-DDI-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-CEL-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-SPO-9018681": ["r", "Biosynthesis of protectins"], "R-CEL-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-SCE-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-SCE-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-SCE-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-CEL-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-DDI-9018681": ["r", "Biosynthesis of protectins"], "R-SPO-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-DDI-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-SPO-9023661": ["r", "Biosynthesis of E-series 18(R)-resolvins"], "R-SCE-9018681": ["r", "Biosynthesis of protectins"], "R-CEL-8949215": ["r", "Mitochondrial calcium ion transport"], "R-CEL-5607763": ["r", "CLEC7A (Dectin-1) induces NFAT activation"], "R-BTA-9013419": ["r", "RHOT2 GTPase cycle"], "R-PFA-8856828": ["r", "Clathrin-mediated endocytosis"], "R-BTA-451308": ["r", "Activation of Ca-permeable Kainate Receptor"], "R-MMU-8949215": ["r", "Mitochondrial calcium ion transport"], "R-PFA-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-BTA-5607763": ["r", "CLEC7A (Dectin-1) induces NFAT activation"], "R-XTR-8957275": ["r", "Post-translational protein phosphorylation"], "R-DRE-9013419": ["r", "RHOT2 GTPase cycle"], "R-DME-9013425": ["r", "RHOT1 GTPase cycle"], "R-PFA-1660499": ["r", "Synthesis of PIPs at the plasma membrane"], "R-CEL-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-CFA-8943724": ["r", "Regulation of PTEN gene transcription"], "R-RNO-70370": ["r", "Galactose catabolism"], "R-DME-70370": ["r", "Galactose catabolism"], "R-HSA-5609978": ["r", "Defective GALT can cause GALCT"], "R-BTA-209952": ["r", "Peptide hormone biosynthesis"], "R-SCE-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-MMU-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-SCE-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-DME-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-XTR-549127": ["r", "SLC-mediated transport of organic cations"], "R-MMU-167826": ["r", "The fatty acid cycling model"], "R-DRE-167826": ["r", "The fatty acid cycling model"], "R-RNO-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-XTR-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-BTA-71064": ["r", "Lysine catabolism"], "R-SSC-167826": ["r", "The fatty acid cycling model"], "R-CEL-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-HSA-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-SPO-549127": ["r", "SLC-mediated transport of organic cations"], "R-DDI-1614517": ["r", "Sulfide oxidation to sulfate"], "R-BTA-166187": ["r", "Mitochondrial Uncoupling"], "R-MMU-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-BTA-167826": ["r", "The fatty acid cycling model"], "R-SPO-166187": ["r", "Mitochondrial Uncoupling"], "R-SPO-428643": ["r", "Organic anion transport by SLC5/17/25 transporters"], "R-SPO-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-CFA-9732724": ["r", "IFNG signaling activates MAPKs"], "R-CFA-877312": ["r", "Regulation of IFNG signaling"], "R-CFA-877300": ["r", "Interferon gamma signaling"], "R-GGA-9032759": ["r", "NTRK2 activates RAC1"], "R-DRE-170984": ["r", "ARMS-mediated activation"], "R-DRE-167060": ["r", "NGF processing"], "R-BTA-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-SSC-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-DRE-198203": ["r", "PI3K/AKT activation"], "R-BTA-9603381": ["r", "Activated NTRK3 signals through PI3K"], "R-DRE-205017": ["r", "NFG and proNGF binds to p75NTR"], "R-BTA-9026527": ["r", "Activated NTRK2 signals through PLCG1"], "R-GGA-9028731": ["r", "Activated NTRK2 signals through FRS2 and FRS3"], "R-SSC-9026527": ["r", "Activated NTRK2 signals through PLCG1"], "R-BTA-9034793": ["r", "Activated NTRK3 signals through PLCG1"], "R-DRE-187042": ["r", "TRKA activation by NGF"], "R-BTA-9034013": ["r", "NTF3 activates NTRK3 signaling"], "R-GGA-9026527": ["r", "Activated NTRK2 signals through PLCG1"], "R-CEL-165160": ["r", "PDE3B signalling"], "R-GGA-1268020": ["r", "Mitochondrial protein import"], "R-BTA-111885": ["r", "Opioid Signalling"], "R-DDI-9840310": ["r", "Glycosphingolipid catabolism"], "R-HSA-9953111": ["r", "MPS IV - Morquio syndrome B (CS/DS degradation)"], "R-DDI-2022857": ["r", "Keratan sulfate degradation"], "R-DDI-2024101": ["r", "CS/DS degradation"], "R-HSA-2206308": ["r", "MPS IV - Morquio syndrome B (Keratin metabolism)"], "R-SSC-5693571": ["r", "Nonhomologous End-Joining (NHEJ)"], "R-SSC-606279": ["r", "Deposition of new CENPA-containing nucleosomes at the centromere"], "R-SSC-2559586": ["r", "DNA Damage/Telomere Stress Induced Senescence"], "PWY-7851": ["t", "coenzyme A biosynthesis II (eukaryotic)"], "R-SCE-196783": ["r", "Coenzyme A biosynthesis"], "R-CEL-196783": ["r", "Coenzyme A biosynthesis"], "R-SPO-196783": ["r", "Coenzyme A biosynthesis"], "R-XTR-196783": ["r", "Coenzyme A biosynthesis"], "R-MMU-196783": ["r", "Coenzyme A biosynthesis"], "R-DRE-196783": ["r", "Coenzyme A biosynthesis"], "R-HSA-196783": ["r", "Coenzyme A biosynthesis"], "R-RNO-196783": ["r", "Coenzyme A biosynthesis"], "R-CFA-390522": ["r", "Striated Muscle Contraction"], "PWY-8342": ["t", "coenzyme A biosynthesis III (archaea)"], "R-XTR-192456": ["r", "Digestion of dietary lipid"], "R-SSC-192456": ["r", "Digestion of dietary lipid"], "PWY-6834": ["t", "spermidine biosynthesis III"], "R-MMU-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-HSA-5619067": ["r", "Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)"], "R-MMU-9958863": ["r", "SLC-mediated transport of amino acids"], "R-RNO-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-BTA-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-HSA-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-HSA-5619062": ["r", "Defective SLC1A3 causes episodic ataxia 6 (EA6)"], "R-CFA-9845576": ["r", "Glycosphingolipid transport"], "R-DRE-9845576": ["r", "Glycosphingolipid transport"], "PWY-6466": ["t", "pyridoxal 5'-phosphate biosynthesis II"], "R-CEL-156590": ["r", "Glutathione conjugation"], "R-HSA-9958863": ["r", "SLC-mediated transport of amino acids"], "R-BTA-9958863": ["r", "SLC-mediated transport of amino acids"], "R-RNO-9958863": ["r", "SLC-mediated transport of amino acids"], "R-CEL-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-CEL-9958863": ["r", "SLC-mediated transport of amino acids"], "R-BTA-3000497": ["r", "Scavenging by Class H Receptors"], "R-SSC-3000497": ["r", "Scavenging by Class H Receptors"], "PWY-5397": ["t", "crocetin biosynthesis"], "R-BTA-2682334": ["r", "EPH-Ephrin signaling"], "PWY-6619": ["t", "adenine and adenosine salvage VI"], "R-DRE-1250347": ["r", "SHC1 events in ERBB4 signaling"], "R-CFA-3928665": ["r", "EPH-ephrin mediated repulsion of cells"], "R-CEL-1169092": ["r", "Activation of RAS in B cells"], "R-DRE-1169092": ["r", "Activation of RAS in B cells"], "R-BTA-416550": ["r", "Sema4D mediated inhibition of cell attachment and migration"], "R-DRE-8854214": ["r", "TBC/RABGAPs"], "R-BTA-6785631": ["r", "ERBB2 Regulates Cell Motility"], "R-CFA-5625740": ["r", "RHO GTPases activate PKNs"], "R-BTA-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-GGA-9013408": ["r", "RHOG GTPase cycle"], "R-SSC-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-GGA-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-CFA-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-SSC-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-DRE-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-BTA-209563": ["r", "Axonal growth stimulation"], "R-DME-112399": ["r", "IRS-mediated signalling"], "R-BTA-264876": ["r", "Insulin processing"], "R-BTA-8865999": ["r", "MET activates PTPN11"], "R-RNO-264876": ["r", "Insulin processing"], "R-DRE-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-BTA-1461973": ["r", "Defensins"], "R-GGA-1461973": ["r", "Defensins"], "R-SSC-1461957": ["r", "Beta defensins"], "R-RNO-1461973": ["r", "Defensins"], "R-BTA-1461957": ["r", "Beta defensins"], "R-MMU-1461973": ["r", "Defensins"], "R-RNO-1461957": ["r", "Beta defensins"], "R-HSA-1461973": ["r", "Defensins"], "R-XTR-1971475": ["r", "Glycosaminoglycan-protein linkage region biosynthesis"], "R-DRE-202733": ["r", "Cell surface interactions at the vascular wall"], "R-XTR-2024096": ["r", "HS-GAG degradation"], "R-DRE-2024096": ["r", "HS-GAG degradation"], "R-XTR-202733": ["r", "Cell surface interactions at the vascular wall"], "R-XTR-2022928": ["r", "HS-GAG biosynthesis"], "R-DRE-2022928": ["r", "HS-GAG biosynthesis"], "R-DME-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-BTA-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-DME-1483248": ["r", "Synthesis of PIPs at the ER membrane"], "R-CEL-5666185": ["r", "RHO GTPases Activate Rhotekin and Rhophilins"], "R-GGA-445989": ["r", "TAK1-dependent IKK and NF-kappa-B activation"], "R-CFA-9032759": ["r", "NTRK2 activates RAC1"], "R-SSC-5654719": ["r", "SHC-mediated cascade:FGFR4"], "R-CFA-399954": ["r", "Sema3A PAK dependent Axon repulsion"], "R-DRE-8875656": ["r", "MET receptor recycling"], "R-DRE-5627117": ["r", "RHO GTPases Activate ROCKs"], "R-DRE-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-CFA-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-SSC-2871796": ["r", "FCERI mediated MAPK activation"], "R-CEL-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-SSC-5654704": ["r", "SHC-mediated cascade:FGFR3"], "R-CFA-5625900": ["r", "RHO GTPases activate CIT"], "R-SCE-165159": ["r", "MTOR signalling"], "R-SSC-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-CFA-198203": ["r", "PI3K/AKT activation"], "R-DRE-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-CFA-8985586": ["r", "SLIT2:ROBO1 increases RHOA activity"], "R-CFA-2871796": ["r", "FCERI mediated MAPK activation"], "R-SSC-9634635": ["r", "Estrogen-stimulated signaling through PRKCZ"], "R-CFA-6811434": ["r", "COPI-dependent Golgi-to-ER retrograde traffic"], "R-CFA-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-DRE-1963640": ["r", "GRB2 events in ERBB2 signaling"], "R-SPO-9696264": ["r", "RND3 GTPase cycle"], "R-SSC-525793": ["r", "Myogenesis"], "R-SPO-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-SSC-8849471": ["r", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "R-GGA-5654699": ["r", "SHC-mediated cascade:FGFR2"], "R-BTA-354194": ["r", "GRB2:SOS provides linkage to MAPK signaling for Integrins"], "R-BTA-8875656": ["r", "MET receptor recycling"], "R-DRE-446353": ["r", "Cell-extracellular matrix interactions"], "R-DME-373760": ["r", "L1CAM interactions"], "R-GGA-5625970": ["r", "RHO GTPases activate KTN1"], "R-SSC-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-GGA-5218921": ["r", "VEGFR2 mediated cell proliferation"], "R-SCE-9696270": ["r", "RND2 GTPase cycle"], "R-SSC-210993": ["r", "Tie2 Signaling"], "R-SSC-5625970": ["r", "RHO GTPases activate KTN1"], "R-SSC-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-GGA-8854214": ["r", "TBC/RABGAPs"], "R-DRE-9648002": ["r", "RAS processing"], "R-SSC-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-SSC-114604": ["r", "GPVI-mediated activation cascade"], "R-BTA-170984": ["r", "ARMS-mediated activation"], "R-SSC-8964616": ["r", "G beta:gamma signalling through CDC42"], "R-GGA-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "R-CFA-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-GGA-8851805": ["r", "MET activates RAS signaling"], "R-CFA-6807878": ["r", "COPI-mediated anterograde transport"], "R-CFA-5625970": ["r", "RHO GTPases activate KTN1"], "R-DRE-4086400": ["r", "PCP/CE pathway"], "R-SCE-5620912": ["r", "Anchoring of the basal body to the plasma membrane"], "R-CEL-5627083": ["r", "RHO GTPases regulate CFTR trafficking"], "R-HSA-9753512": ["r", "Signaling by RAS GTPase mutants"], "R-SSC-4085001": ["r", "Sialic acid metabolism"], "R-DRE-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-SSC-9627069": ["r", "Regulation of the apoptosome activity"], "R-CEL-5620971": ["r", "Pyroptosis"], "R-XTR-611105": ["r", "Respiratory electron transport"], "R-XTR-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-DME-5620971": ["r", "Pyroptosis"], "R-SPO-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-DME-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-CFA-3299685": ["r", "Detoxification of Reactive Oxygen Species"], "R-CFA-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-SSC-111458": ["r", "Formation of apoptosome"], "R-GGA-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-BTA-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-DRE-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-DDI-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-XTR-5620971": ["r", "Pyroptosis"], "R-HSA-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-BTA-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-XTR-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-SCE-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-DRE-5620971": ["r", "Pyroptosis"], "R-SSC-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-GGA-5620971": ["r", "Pyroptosis"], "R-SSC-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-GGA-5365859": ["r", "RA biosynthesis pathway"], "R-GGA-71384": ["r", "Ethanol oxidation"], "R-RNO-2161541": ["r", "Abacavir metabolism"], "R-DDI-2161541": ["r", "Abacavir metabolism"], "R-DME-5365859": ["r", "RA biosynthesis pathway"], "R-CEL-71384": ["r", "Ethanol oxidation"], "R-SPO-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-SCE-5652227": ["r", "Fructose biosynthesis"], "R-BTA-71384": ["r", "Ethanol oxidation"], "R-MMU-5652227": ["r", "Fructose biosynthesis"], "R-SPO-5365859": ["r", "RA biosynthesis pathway"], "R-SCE-5365859": ["r", "RA biosynthesis pathway"], "R-SPO-5652227": ["r", "Fructose biosynthesis"], "R-DDI-5365859": ["r", "RA biosynthesis pathway"], "R-GGA-2161541": ["r", "Abacavir metabolism"], "R-SPO-2161541": ["r", "Abacavir metabolism"], "R-BTA-5652227": ["r", "Fructose biosynthesis"], "R-SCE-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-RNO-5652227": ["r", "Fructose biosynthesis"], "R-RNO-71384": ["r", "Ethanol oxidation"], "R-HSA-5652227": ["r", "Fructose biosynthesis"], "R-SCE-2161541": ["r", "Abacavir metabolism"], "PWY-6857": ["t", "retinol biosynthesis"], "R-HSA-9661070": ["r", "Defective translocation of RB1 mutants to the nucleus"], "R-CEL-2299718": ["r", "Condensation of Prophase Chromosomes"], "PWY-40": ["t", "putrescine biosynthesis I"], "PWY-43": ["t", "putrescine biosynthesis II"], "PWY-8365": ["t", "C25,25 CDP-archaeol biosynthesis"], "PWY-6349": ["t", "C20,20 CDP-archaeol biosynthesis"], "R-CEL-9840373": ["r", "Cellular response to mitochondrial stress"], "PWY-5796": ["t", "malonate decarboxylase activation"], "R-DRE-6785631": ["r", "ERBB2 Regulates Cell Motility"], "PWY-8394": ["t", "ribitol degradation II"], "PWY-5129": ["t", "sphingolipid biosynthesis (plants)"], "PWY-6369": ["t", "inositol diphosphates biosynthesis"], "PWY-7077": ["t", "N-acetyl-D-galactosamine degradation"], "PWY-7740": ["t", "beta-D-mannosyl phosphomycoketide biosynthesis"], "PWY-8129": ["t", "cell-surface glycoconjugate-linked phosphonate biosynthesis"], "PWY-8392": ["t", "D-arabinitol degradation II"], "PWY-7948": ["t", "4-oxopentanoate degradation"], "PWY-7321": ["t", "ecdysteroid metabolism (arthropods)"], "PWY-8393": ["t", "xylitol degradation II"], "PWY-8324": ["t", "D-tagatose degradation"], "PWY-7975": ["t", "adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II"], "PWY-7886": ["t", "cell-surface glycoconjugate-linked phosphocholine biosynthesis"], "PWY-8402": ["t", "N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation"], "PWY-7377": ["t", "cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)"], "R-BTA-69541": ["r", "Stabilization of p53"], "R-BTA-69895": ["r", "Transcriptional activation of cell cycle inhibitor p21"], "R-DRE-6804754": ["r", "Regulation of TP53 Expression"], "R-SSC-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-SSC-69541": ["r", "Stabilization of p53"], "R-SSC-6804758": ["r", "Regulation of TP53 Activity through Acetylation"], "R-BTA-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-HSA-69895": ["r", "Transcriptional activation of cell cycle inhibitor p21"], "R-BTA-6804754": ["r", "Regulation of TP53 Expression"], "R-DRE-8941855": ["r", "RUNX3 regulates CDKN1A transcription"], "R-BTA-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-RNO-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-SSC-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-DRE-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-RNO-6804754": ["r", "Regulation of TP53 Expression"], "R-MMU-6804754": ["r", "Regulation of TP53 Expression"], "R-SSC-69895": ["r", "Transcriptional activation of cell cycle inhibitor p21"], "R-SSC-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-SSC-6804754": ["r", "Regulation of TP53 Expression"], "R-RNO-69895": ["r", "Transcriptional activation of cell cycle inhibitor p21"], "R-HSA-111448": ["r", "Activation of NOXA and translocation to mitochondria"], "R-SSC-432720": ["r", "Lysosome Vesicle Biogenesis"], "R-CFA-193048": ["r", "Androgen biosynthesis"], "R-BTA-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-CFA-194002": ["r", "Glucocorticoid biosynthesis"], "R-RNO-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-CFA-193993": ["r", "Mineralocorticoid biosynthesis"], "R-SSC-5662702": ["r", "Melanin biosynthesis"], "R-HSA-5662702": ["r", "Melanin biosynthesis"], "R-CEL-5662702": ["r", "Melanin biosynthesis"], "R-MMU-5662702": ["r", "Melanin biosynthesis"], "R-RNO-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-HSA-5619042": ["r", "Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)"], "R-HSA-9037628": ["r", "Rhesus blood group biosynthesis"], "R-MMU-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-BTA-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-HSA-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-DRE-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-DDI-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-GGA-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-CFA-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-XTR-444411": ["r", "Rhesus glycoproteins mediate ammonium transport"], "R-HSA-8964572": ["r", "Lipid particle organization"], "R-HSA-8868766": ["r", "rRNA processing in the mitochondrion"], "R-DME-9018896": ["r", "Biosynthesis of E-series 18(S)-resolvins"], "R-BTA-193144": ["r", "Estrogen biosynthesis"], "R-HSA-5662853": ["r", "Essential pentosuria"], "R-SSC-5365859": ["r", "RA biosynthesis pathway"], "R-CEL-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-DRE-194002": ["r", "Glucocorticoid biosynthesis"], "R-CEL-77288": ["r", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "R-SCE-2187335": ["r", "The retinoid cycle in cones (daylight vision)"], "R-RNO-75896": ["r", "Plasmalogen biosynthesis"], "R-HSA-9918440": ["r", "Defective visual phototransduction due to RDH12 loss of function"], "R-DRE-9757110": ["r", "Prednisone ADME"], "R-DME-75896": ["r", "Plasmalogen biosynthesis"], "R-MMU-77108": ["r", "Utilization of Ketone Bodies"], "R-SCE-8964572": ["r", "Lipid particle organization"], "R-CFA-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-DME-9018676": ["r", "Biosynthesis of D-series resolvins"], "R-HSA-9033500": ["r", "TYSND1 cleaves peroxisomal proteins"], "R-RNO-8964572": ["r", "Lipid particle organization"], "R-DME-2142700": ["r", "Biosynthesis of Lipoxins (LX)"], "R-DME-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-DME-70895": ["r", "Branched-chain amino acid catabolism"], "R-RNO-77108": ["r", "Utilization of Ketone Bodies"], "R-SCE-193144": ["r", "Estrogen biosynthesis"], "R-DRE-75896": ["r", "Plasmalogen biosynthesis"], "R-GGA-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-HSA-6785470": ["r", "tRNA processing in the mitochondrion"], "R-SPO-193144": ["r", "Estrogen biosynthesis"], "R-XTR-75896": ["r", "Plasmalogen biosynthesis"], "R-DRE-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-MMU-75896": ["r", "Plasmalogen biosynthesis"], "R-BTA-77108": ["r", "Utilization of Ketone Bodies"], "R-CEL-8964572": ["r", "Lipid particle organization"], "R-DME-68952": ["r", "DNA replication initiation"], "R-SCE-68952": ["r", "DNA replication initiation"], "R-PFA-68952": ["r", "DNA replication initiation"], "R-HSA-68952": ["r", "DNA replication initiation"], "R-PFA-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-SCE-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-MMU-68952": ["r", "DNA replication initiation"], "R-SPO-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-SPO-68952": ["r", "DNA replication initiation"], "R-CEL-68952": ["r", "DNA replication initiation"], "R-PFA-68962": ["r", "Activation of the pre-replicative complex"], "PWY-7546": ["t", "diphthamide biosynthesis II (eukaryotes)"], "PWY-6482": ["t", "diphthamide biosynthesis I (archaea)"], "PWY-5209": ["t", "methyl-coenzyme M oxidation to CO2 I"], "PWY-7784": ["t", "reductive acetyl coenzyme A pathway II (autotrophic methanogens)"], "PWY-8305": ["t", "methoxylated aromatic compound degradation II"], "PWY-3121": ["t", "linamarin degradation"], "PWY-7091": ["t", "linustatin bioactivation"], "PWY-7913": ["t", "firefly bioluminescence"], "PWY-7092": ["t", "neolinustatin bioactivation"], "PWY-5176": ["t", "coumarin biosynthesis (via 2-coumarate)"], "PWY-6002": ["t", "lotaustralin degradation"], "PWY-6686": ["t", "mannosylglucosylglycerate biosynthesis I"], "PWY-6366": ["t", "D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"], "PWY-6575": ["t", "juvenile hormone III biosynthesis I"], "PWY-8176": ["t", "geraniol biosynthesis (cytosol)"], "PWY-8430": ["t", "1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis"], "PWY-7863": ["t", "roseoflavin biosynthesis"], "PWY-7882": ["t", "IM-2 type gamma-butyrolactones biosynthesis"], "PWY-8372": ["t", "erythritol biosynthesis I"], "PWY-6365": ["t", "D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis"], "PWY-6991": ["t", "(-)-camphor biosynthesis"], "PWY-7878": ["t", "A-factor gamma-butyrolactone biosynthesis"], "PWY-7531": ["t", "mannojirimycin biosynthesis"], "PWY-8373": ["t", "erythritol biosynthesis II"], "PWY-4702": ["t", "phytate degradation I"], "PWY-7119": ["t", "ceramide and sphingolipid recycling and degradation (yeast)"], "PWY-6990": ["t", "(+)-camphor biosynthesis"], "PWY-8282": ["t", "adenosylcobinamide-GDP salvage from assorted adenosylcobamides"], "PWY-8429": ["t", "1-(sn-glycero-1-phospho)-1D-myo-inositol biosynthesis"], "PWY-6456": ["t", "serinol biosynthesis"], "R-HSA-75896": ["r", "Plasmalogen biosynthesis"], "R-DME-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-DME-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-MMU-8964572": ["r", "Lipid particle organization"], "R-HSA-77108": ["r", "Utilization of Ketone Bodies"], "R-HSA-5619058": ["r", "Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)"], "R-DRE-2473224": ["r", "Antagonism of Activin by Follistatin"], "R-HSA-5619110": ["r", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)"], "R-DME-879518": ["r", "Organic anion transport by SLCO transporters"], "R-BTA-879518": ["r", "Organic anion transport by SLCO transporters"], "R-HSA-5619095": ["r", "Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"], "R-HSA-5655799": ["r", "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)"], "R-CEL-75102": ["r", "C6 deamination of adenosine"], "R-RNO-77042": ["r", "Formation of editosomes by ADAR proteins"], "R-DME-75102": ["r", "C6 deamination of adenosine"], "R-RNO-75102": ["r", "C6 deamination of adenosine"], "R-CEL-77042": ["r", "Formation of editosomes by ADAR proteins"], "R-DME-77042": ["r", "Formation of editosomes by ADAR proteins"], "R-MMU-75102": ["r", "C6 deamination of adenosine"], "R-HSA-75102": ["r", "C6 deamination of adenosine"], "R-MMU-77042": ["r", "Formation of editosomes by ADAR proteins"], "R-HSA-77042": ["r", "Formation of editosomes by ADAR proteins"], "PWY-7723": ["t", "bacterial bioluminescence"], "PWY-6733": ["t", "sporopollenin precursors biosynthesis"], "PWY-1121": ["t", "suberin monomers biosynthesis"], "PWY-321": ["t", "cutin biosynthesis"], "R-DME-75105": ["r", "Fatty acyl-CoA biosynthesis"], "R-HSA-9955542": ["r", "CPS1 variants cause CPS1 deficiency"], "R-HSA-114294": ["r", "Activation, translocation and oligomerization of BAX"], "PWY-7771": ["t", "butachlor degradation"], "PWY-6664": ["t", "di-myo-inositol phosphate biosynthesis"], "PWY-5912": ["t", "2'-deoxymugineic acid phytosiderophore biosynthesis"], "PWY-6151": ["t", "S-adenosyl-L-methionine salvage I"], "PWY-6890": ["t", "4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I"], "R-HSA-5578998": ["r", "Defective OPLAH causes OPLAHD"], "R-DDI-174403": ["r", "Glutathione synthesis and recycling"], "PWY-6596": ["t", "adenosine nucleotides degradation I"], "PWY-5695": ["t", "inosine 5'-phosphate degradation"], "PWY-6607": ["t", "guanosine nucleotides degradation I"], "PWY-6608": ["t", "guanosine nucleotides degradation III"], "PWY-6606": ["t", "guanosine nucleotides degradation II"], "PWY-5856": ["t", "ubiquinol-9 biosynthesis (early decarboxylation)"], "PWY-6708": ["t", "ubiquinol-8 biosynthesis (early decarboxylation)"], "PWY-5857": ["t", "ubiquinol-10 biosynthesis (early decarboxylation)"], "PWY-5855": ["t", "ubiquinol-7 biosynthesis (early decarboxylation)"], "R-XTR-77387": ["r", "Insulin receptor recycling"], "R-GGA-917977": ["r", "Transferrin endocytosis and recycling"], "R-DRE-983712": ["r", "Ion channel transport"], "R-XTR-1222556": ["r", "ROS and RNS production in phagocytes"], "R-XTR-917977": ["r", "Transferrin endocytosis and recycling"], "R-DRE-1222556": ["r", "ROS and RNS production in phagocytes"], "R-GGA-9639288": ["r", "Amino acids regulate mTORC1"], "R-XTR-983712": ["r", "Ion channel transport"], "R-DRE-917977": ["r", "Transferrin endocytosis and recycling"], "R-DRE-77387": ["r", "Insulin receptor recycling"], "PWY-8113": ["t", "3PG-factor 420 biosynthesis"], "PWY-8112": ["t", "factor 420 biosynthesis I (archaea)"], "PWY-5198": ["t", "factor 420 biosynthesis II (mycobacteria)"], "PWY-5199": ["t", "factor 420 polyglutamylation"], "R-RNO-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-BTA-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "R-SPO-426486": ["r", "Small interfering RNA (siRNA) biogenesis"], "PWY-6654": ["t", "phosphopantothenate biosynthesis III (archaea)"], "R-SPO-1482798": ["r", "Acyl chain remodeling of CL"], "R-SSC-75109": ["r", "Triglyceride biosynthesis"], "R-SSC-1483166": ["r", "Synthesis of PA"], "R-DME-446343": ["r", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "R-MMU-111452": ["r", "Activation and oligomerization of BAK protein"], "R-MMU-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-RNO-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-BTA-114294": ["r", "Activation, translocation and oligomerization of BAX"], "R-MMU-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-BTA-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-GGA-844455": ["r", "The NLRP1 inflammasome"], "R-RNO-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-HSA-111452": ["r", "Activation and oligomerization of BAK protein"], "R-RNO-114294": ["r", "Activation, translocation and oligomerization of BAX"], "R-GGA-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-CEL-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-MMU-114294": ["r", "Activation, translocation and oligomerization of BAX"], "R-CEL-171319": ["r", "Telomere Extension By Telomerase"], "R-SPO-171319": ["r", "Telomere Extension By Telomerase"], "R-GGA-417076": ["r", "Assembly of telomerase and telomere extension"], "R-DME-171319": ["r", "Telomere Extension By Telomerase"], "R-SCE-171319": ["r", "Telomere Extension By Telomerase"], "R-DDI-171319": ["r", "Telomere Extension By Telomerase"], "PWY-6164": ["t", "3-dehydroquinate biosynthesis I"], "R-CEL-3322077": ["r", "Glycogen synthesis"], "R-MMU-3322077": ["r", "Glycogen synthesis"], "R-MMU-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-SCE-3322077": ["r", "Glycogen synthesis"], "R-DRE-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-HSA-3858516": ["r", "Glycogen storage disease type 0 (liver GYS2)"], "R-HSA-5083627": ["r", "Defective LARGE causes MDDGA6 and MDDGB6"], "R-HSA-3878781": ["r", "Glycogen storage disease type IV (GBE1)"], "R-HSA-3814836": ["r", "Glycogen storage disease type XV (GYG1)"], "R-HSA-3828062": ["r", "Glycogen storage disease type 0 (muscle GYS1)"], "R-HSA-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-RNO-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-RNO-3322077": ["r", "Glycogen synthesis"], "R-MMU-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-HSA-5221030": ["r", "TET1,2,3 and TDG demethylate DNA"], "PWY-5737": ["t", "(5R)-carbapenem carboxylate biosynthesis"], "R-SPO-70688": ["r", "Proline catabolism"], "R-CEL-70688": ["r", "Proline catabolism"], "R-HSA-70688": ["r", "Proline catabolism"], "R-SCE-70688": ["r", "Proline catabolism"], "R-DDI-70688": ["r", "Proline catabolism"], "R-DME-70688": ["r", "Proline catabolism"], "R-MMU-70688": ["r", "Proline catabolism"], "R-CEL-389661": ["r", "Glyoxylate metabolism and glycine degradation"], "R-RNO-70688": ["r", "Proline catabolism"], "R-MMU-888568": ["r", "GABA synthesis"], "R-BTA-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-HSA-888568": ["r", "GABA synthesis"], "R-CFA-888568": ["r", "GABA synthesis"], "R-RNO-888568": ["r", "GABA synthesis"], "R-SSC-888568": ["r", "GABA synthesis"], "R-DME-209931": ["r", "Serotonin and melatonin biosynthesis"], "R-XTR-1614558": ["r", "Degradation of cysteine and homocysteine"], "R-DME-70921": ["r", "Histidine catabolism"], "R-BTA-888568": ["r", "GABA synthesis"], "R-DME-888568": ["r", "GABA synthesis"], "R-DDI-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-SCE-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-SPO-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-DRE-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-DME-399955": ["r", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "R-HSA-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-RNO-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-DDI-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-BTA-8847453": ["r", "Synthesis of PIPs in the nucleus"], "R-DRE-6811555": ["r", "PI5P Regulates TP53 Acetylation"], "R-SCE-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-SPO-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "PWY-7883": ["t", "peptidoglycan recycling II"], "R-DME-209266": ["r", "Peptidoglycan bound PGRP-LC/LE oligomerises"], "R-DME-209171": ["r", "Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE"], "PWY-7269": ["t", "mitochondrial NADPH production (yeast)"], "PWY-8148": ["t", "NADP biosynthesis"], "PWY-1281": ["t", "sulfoacetaldehyde degradation I"], "PWY-6637": ["t", "sulfolactate degradation II"], "PWY-7839": ["t", "lacto-series glycosphingolipids biosynthesis"], "PWY-7832": ["t", "ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide"], "PWY-7831": ["t", "ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide"], "PWY-7833": ["t", "biosynthesis of Lewis epitopes (H. pylori)"], "PWY-8459": ["t", "human milk oligisaccharides biosynthesis"], "R-MMU-9033807": ["r", "ABO blood group biosynthesis"], "R-RNO-9033807": ["r", "ABO blood group biosynthesis"], "R-SSC-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-BTA-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-SSC-9037629": ["r", "Lewis blood group biosynthesis"], "R-SSC-9033807": ["r", "ABO blood group biosynthesis"], "R-BTA-9033807": ["r", "ABO blood group biosynthesis"], "R-HSA-9033807": ["r", "ABO blood group biosynthesis"], "R-SCE-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-SPO-264876": ["r", "Insulin processing"], "R-XTR-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-RNO-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-SPO-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-SCE-425410": ["r", "Metal ion SLC transporters"], "R-MMU-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-CEL-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-XTR-264876": ["r", "Insulin processing"], "R-DDI-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-DRE-264876": ["r", "Insulin processing"], "R-SPO-425410": ["r", "Metal ion SLC transporters"], "R-DRE-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-SCE-264876": ["r", "Insulin processing"], "R-HSA-435368": ["r", "Zinc efflux and compartmentalization by the SLC30 family"], "R-SCE-549127": ["r", "SLC-mediated transport of organic cations"], "R-DRE-549127": ["r", "SLC-mediated transport of organic cations"], "PWY-5340": ["t", "sulfate activation for sulfonation"], "R-HSA-3560796": ["r", "Defective PAPSS2 causes SEMD-PA"], "PWY-6829": ["t", "tRNA methylation (yeast)"], "R-SCE-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-DME-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-SPO-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-CEL-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-HSA-5579024": ["r", "Defective MAT1A causes MATD"], "R-DDI-2408508": ["r", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "R-BTA-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-HSA-9667769": ["r", "Acetylcholine inhibits contraction of outer hair cells"], "R-DME-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-DRE-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-BTA-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-CEL-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-HSA-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-MMU-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-RNO-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-DME-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-GGA-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-RNO-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-DRE-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-RNO-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-GGA-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-HSA-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-CEL-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-GGA-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-CEL-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-DME-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-MMU-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-BTA-629594": ["r", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "R-MMU-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "R-CEL-629587": ["r", "Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"], "R-HSA-629597": ["r", "Highly calcium permeable nicotinic acetylcholine receptors"], "PWY-8202": ["t", "11-oxyandrogens biosynthesis"], "R-DDI-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-DDI-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-BTA-5676934": ["r", "Protein repair"], "R-HSA-9683612": ["r", "Maturation of protein M"], "R-HSA-9694594": ["r", "Maturation of protein M"], "R-MMU-71064": ["r", "Lysine catabolism"], "R-DRE-71064": ["r", "Lysine catabolism"], "PWY-6012": ["t", "acyl carrier protein metabolism"], "PWY-6289": ["t", "petrobactin biosynthesis"], "PWY-7545": ["t", "pyruvate to cytochrome bd oxidase electron transfer"], "PWY-6580": ["t", "phosphatidylinositol biosynthesis I (bacteria)"], "PWY-2301": ["t", "myo-inositol biosynthesis"], "PWY-6372": ["t", "1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"], "PWY-4661": ["t", "1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)"], "R-DME-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-PFA-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-DME-264876": ["r", "Insulin processing"], "R-CEL-264876": ["r", "Insulin processing"], "R-BTA-159418": ["r", "Recycling of bile acids and salts"], "R-DME-3295583": ["r", "TRP channels"], "R-CEL-3295583": ["r", "TRP channels"], "R-DRE-3295583": ["r", "TRP channels"], "R-BTA-3295583": ["r", "TRP channels"], "R-RNO-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-BTA-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-GGA-8866911": ["r", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "R-RNO-6814848": ["r", "Glycerophospholipid catabolism"], "R-BTA-6814848": ["r", "Glycerophospholipid catabolism"], "R-DRE-6814848": ["r", "Glycerophospholipid catabolism"], "R-SCE-9840310": ["r", "Glycosphingolipid catabolism"], "PWY-5523": ["t", "5,6-dimethylbenzimidazole biosynthesis I (aerobic)"], "PWY-6700": ["t", "queuosine biosynthesis I (de novo)"], "PWY-8106": ["t", "queuosine biosynthesis III (queuosine salvage)"], "R-DDI-3322077": ["r", "Glycogen synthesis"], "R-SPO-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-SPO-3322077": ["r", "Glycogen synthesis"], "R-SCE-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-DDI-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-BTA-3322077": ["r", "Glycogen synthesis"], "PWY-7339": ["t", "10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)"], "PWY-735": ["t", "jasmonic acid biosynthesis"], "PWY-7338": ["t", "10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)"], "PWY-6435": ["t", "4-hydroxybenzoate biosynthesis III (plants)"], "PWY-481": ["t", "ethylbenzene degradation (anaerobic)"], "PWY-7340": ["t", "9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)"], "PWY-7288": ["t", "fatty acid beta-oxidation VII (yeast peroxisome)"], "PWY-5109": ["t", "propanoate fermentation to 2-methylbutanoate"], "PWY-7337": ["t", "10-cis-heptadecenoyl-CoA degradation (yeast)"], "PWY-7094": ["t", "fatty acid salvage"], "PWY-6080": ["t", "4-ethylphenol degradation (anaerobic)"], "R-DRE-70895": ["r", "Branched-chain amino acid catabolism"], "R-DRE-77108": ["r", "Utilization of Ketone Bodies"], "R-HSA-9915355": ["r", "Beta-ketothiolase deficiency"], "R-BTA-77285": ["r", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "R-BTA-77305": ["r", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "R-CEL-77285": ["r", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "R-CEL-77108": ["r", "Utilization of Ketone Bodies"], "R-CEL-77305": ["r", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "R-CEL-1482798": ["r", "Acyl chain remodeling of CL"], "R-DDI-77108": ["r", "Utilization of Ketone Bodies"], "R-HSA-3359454": ["r", "Defective TCN2 causes TCN2 deficiency"], "R-HSA-3359485": ["r", "Defective CD320 causes MMATC"], "R-BTA-9758890": ["r", "Transport of RCbl within the body"], "R-DME-9758890": ["r", "Transport of RCbl within the body"], "R-HSA-3359457": ["r", "Defective CBLIF causes IFD"], "R-MMU-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-DME-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "PWY-5316": ["t", "nicotine biosynthesis"], "PWY-7342": ["t", "superpathway of nicotine biosynthesis"], "PWY-2681": ["t", "trans-zeatin biosynthesis"], "R-BTA-73614": ["r", "Pyrimidine salvage"], "R-GGA-74259": ["r", "Purine catabolism"], "R-CEL-74259": ["r", "Purine catabolism"], "R-CEL-9755088": ["r", "Ribavirin ADME"], "R-BTA-74259": ["r", "Purine catabolism"], "R-DRE-74259": ["r", "Purine catabolism"], "R-PFA-74259": ["r", "Purine catabolism"], "PWY-8277": ["t", "NAD de novo biosynthesis IV (anaerobic)"], "PWY-5653": ["t", "NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"], "PWY-8352": ["t", "NAD de novo biosynthesis III"], "R-SSC-196807": ["r", "Nicotinate metabolism"], "PWY-5489": ["t", "methyl parathion degradation"], "PWY-8065": ["t", "chlorpyrifos degradation"], "PWY-5490": ["t", "paraoxon degradation"], "R-CEL-9754706": ["r", "Atorvastatin ADME"], "R-CEL-2142688": ["r", "Synthesis of 5-eicosatetraenoic acids"], "R-SSC-8964011": ["r", "HDL clearance"], "R-BTA-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-DME-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-DDI-434313": ["r", "Intracellular metabolism of fatty acids regulates insulin secretion"], "R-SSC-3000471": ["r", "Scavenging by Class B Receptors"], "PWY-5921": ["t", "glutaminyl-tRNAgln biosynthesis via transamidation"], "R-GGA-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-XTR-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-GGA-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-GGA-69166": ["r", "Removal of the Flap Intermediate"], "R-GGA-5651801": ["r", "PCNA-Dependent Long Patch Base Excision Repair"], "R-GGA-174437": ["r", "Removal of the Flap Intermediate from the C-strand"], "R-XTR-110362": ["r", "POLB-Dependent Long Patch Base Excision Repair"], "R-BTA-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-DME-390471": ["r", "Association of TriC/CCT with target proteins during biosynthesis"], "R-PFA-6814122": ["r", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "R-BTA-5620922": ["r", "BBSome-mediated cargo-targeting to cilium"], "R-HSA-390450": ["r", "Folding of actin by CCT/TriC"], "PWY-6313": ["t", "serotonin degradation"], "PWY-5751": ["t", "phenylethanol biosynthesis"], "PWY-5082": ["t", "L-methionine degradation III"], "PWY-5486": ["t", "pyruvate fermentation to ethanol II"], "PWY-5480": ["t", "pyruvate fermentation to ethanol I"], "PWY-6587": ["t", "pyruvate fermentation to ethanol III"], "PWY-5078": ["t", "L-isoleucine degradation II"], "PWY-7396": ["t", "butanol and isobutanol biosynthesis (engineered)"], "PWY-3162": ["t", "L-tryptophan degradation V (side chain pathway)"], "PWY-6802": ["t", "salidroside biosynthesis"], "PWY-5076": ["t", "L-leucine degradation III"], "PWY-6333": ["t", "acetaldehyde biosynthesis I"], "PWY-7013": ["t", "(S)-propane-1,2-diol degradation"], "PWY-5057": ["t", "L-valine degradation II"], "PWY-6342": ["t", "noradrenaline and adrenaline degradation"], "PWY-5079": ["t", "L-phenylalanine degradation III"], "PWY-46": ["t", "putrescine biosynthesis III"], "R-CEL-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-SPO-2142753": ["r", "Arachidonate metabolism"], "R-SPO-1483152": ["r", "Hydrolysis of LPE"], "R-SCE-111995": ["r", "phospho-PLA2 pathway"], "R-SPO-111995": ["r", "phospho-PLA2 pathway"], "R-SCE-2142753": ["r", "Arachidonate metabolism"], "R-SCE-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-SCE-1483115": ["r", "Hydrolysis of LPC"], "R-SPO-1482922": ["r", "Acyl chain remodelling of PI"], "R-SCE-1482922": ["r", "Acyl chain remodelling of PI"], "R-MMU-1483152": ["r", "Hydrolysis of LPE"], "R-SPO-6811436": ["r", "COPI-independent Golgi-to-ER retrograde traffic"], "R-SPO-1483115": ["r", "Hydrolysis of LPC"], "R-SCE-1482788": ["r", "Acyl chain remodelling of PC"], "R-SCE-1483152": ["r", "Hydrolysis of LPE"], "R-SPO-1482788": ["r", "Acyl chain remodelling of PC"], "PWY-7286": ["t", "7-(3-amino-3-carboxypropyl)-wyosine biosynthesis"], "PWY-6683": ["t", "assimilatory sulfate reduction III"], "PWY-5278": ["t", "sulfite oxidation III"], "PWY-6932": ["t", "selenate reduction"], "PWY-7858": ["t", "(5Z)-dodecenoate biosynthesis II"], "PWY-7291": ["t", "oleate beta-oxidation (isomerase-dependent, yeast)"], "PWY-7574": ["t", "propanoyl-CoA degradation II"], "PWY-7180": ["t", "2-deoxy-alpha-D-ribose 1-phosphate degradation"], "PWY-8060": ["t", "2-deoxy-D-ribose degradation I"], "R-BTA-71336": ["r", "Pentose phosphate pathway"], "R-XTR-211945": ["r", "Phase I - Functionalization of compounds"], "R-XTR-2173791": ["r", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "R-XTR-9673163": ["r", "Oleoyl-phe metabolism"], "R-MMU-9673163": ["r", "Oleoyl-phe metabolism"], "R-SPO-9673163": ["r", "Oleoyl-phe metabolism"], "R-HSA-9673163": ["r", "Oleoyl-phe metabolism"], "R-DRE-9673163": ["r", "Oleoyl-phe metabolism"], "PWY-6689": ["t", "tRNA splicing I"], "PWY-6129": ["t", "dolichol and dolichyl phosphate biosynthesis"], "PWY-7366": ["t", "phosphatidylglycerol degradation"], "PWY-5978": ["t", "kanosamine biosynthesis I"], "R-SPO-379398": ["r", "Enzymatic degradation of Dopamine by monoamine oxidase"], "R-SPO-379397": ["r", "Enzymatic degradation of dopamine by COMT"], "R-DRE-156581": ["r", "Methylation"], "R-HSA-5619043": ["r", "Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"], "R-RNO-5653890": ["r", "Lactose synthesis"], "R-SSC-422356": ["r", "Regulation of insulin secretion"], "R-BTA-5653890": ["r", "Lactose synthesis"], "R-GGA-352832": ["r", "Glucose transport"], "R-BTA-8981373": ["r", "Intestinal hexose absorption"], "R-HSA-5619098": ["r", "Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)"], "R-DRE-426117": ["r", "Cation-coupled Chloride cotransporters"], "R-HSA-5619104": ["r", "Defective SLC12A1 causes Bartter syndrome 1 (BS1)"], "PWY-6837": ["t", "fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)"], "R-CEL-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-CEL-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-BTA-390247": ["r", "Beta-oxidation of very long chain fatty acids"], "R-CEL-389887": ["r", "Beta-oxidation of pristanoyl-CoA"], "R-DRE-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-XTR-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-XTR-8932505": ["r", "DAG1 core M3 glycosylations"], "R-DME-2022854": ["r", "Keratan sulfate biosynthesis"], "R-SSC-913709": ["r", "O-linked glycosylation of mucins"], "R-DME-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-CFA-9840309": ["r", "Glycosphingolipid biosynthesis"], "R-CEL-196819": ["r", "Vitamin B1 (thiamin) metabolism"], "R-SSC-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "R-CFA-210993": ["r", "Tie2 Signaling"], "R-BTA-2855086": ["r", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "R-GGA-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-CEL-1362409": ["r", "Mitochondrial iron-sulfur cluster biogenesis"], "R-DME-9854311": ["r", "Maturation of TCA enzymes and regulation of TCA cycle"], "R-SSC-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-RNO-190371": ["r", "FGFR3b ligand binding and activation"], "R-BTA-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-SSC-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-GGA-190375": ["r", "FGFR2c ligand binding and activation"], "R-GGA-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-GGA-190322": ["r", "FGFR4 ligand binding and activation"], "R-BTA-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-BTA-190375": ["r", "FGFR2c ligand binding and activation"], "R-RNO-190375": ["r", "FGFR2c ligand binding and activation"], "R-GGA-190377": ["r", "FGFR2b ligand binding and activation"], "R-BTA-5654700": ["r", "FRS-mediated FGFR2 signaling"], "R-RNO-190377": ["r", "FGFR2b ligand binding and activation"], "R-BTA-190371": ["r", "FGFR3b ligand binding and activation"], "R-HSA-5619052": ["r", "Defective SLC9A9 causes autism 16 (AUTS16)"], "R-HSA-5619092": ["r", "Defective SLC9A6 causes X-linked, syndromic mental retardation, Christianson type (MRXSCH)"], "R-HSA-9709275": ["r", "Impaired BRCA2 translocation to the nucleus"], "R-HSA-9763198": ["r", "Impaired BRCA2 binding to SEM1 (DSS1)"], "R-GGA-5358565": ["r", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "R-HSA-5545483": ["r", "Defective Mismatch Repair Associated With MLH1"], "R-HSA-5632987": ["r", "Defective Mismatch Repair Associated With PMS2"], "R-HSA-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "R-BTA-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-BTA-5654228": ["r", "Phospholipase C-mediated cascade, FGFR4"], "R-RNO-190372": ["r", "FGFR3c ligand binding and activation"], "R-BTA-5654706": ["r", "FRS-mediated FGFR3 signaling"], "R-GGA-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-GGA-190373": ["r", "FGFR1c ligand binding and activation"], "R-GGA-190370": ["r", "FGFR1b ligand binding and activation"], "R-BTA-5654712": ["r", "FRS-mediated FGFR4 signaling"], "R-SSC-190373": ["r", "FGFR1c ligand binding and activation"], "R-BTA-9839397": ["r", "TGFBR3 regulates FGF2 signaling"], "R-BTA-190377": ["r", "FGFR2b ligand binding and activation"], "R-GGA-190371": ["r", "FGFR3b ligand binding and activation"], "R-GGA-9839397": ["r", "TGFBR3 regulates FGF2 signaling"], "R-BTA-5654693": ["r", "FRS-mediated FGFR1 signaling"], "R-SSC-5654689": ["r", "PI-3K cascade:FGFR1"], "R-BTA-190370": ["r", "FGFR1b ligand binding and activation"], "R-CEL-5658623": ["r", "FGFRL1 modulation of FGFR1 signaling"], "R-SSC-190322": ["r", "FGFR4 ligand binding and activation"], "R-BTA-190373": ["r", "FGFR1c ligand binding and activation"], "R-GGA-5654227": ["r", "Phospholipase C-mediated cascade, FGFR3"], "R-BTA-190322": ["r", "FGFR4 ligand binding and activation"], "R-SSC-5654687": ["r", "Downstream signaling of activated FGFR1"], "R-SSC-5654720": ["r", "PI-3K cascade:FGFR4"], "R-BTA-190372": ["r", "FGFR3c ligand binding and activation"], "R-GGA-190372": ["r", "FGFR3c ligand binding and activation"], "R-GGA-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-GGA-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-BTA-5654219": ["r", "Phospholipase C-mediated cascade: FGFR1"], "R-BTA-5654221": ["r", "Phospholipase C-mediated cascade, FGFR2"], "R-HSA-5579016": ["r", "Defective UGT1A4 causes hyperbilirubinemia"], "R-HSA-5579002": ["r", "Defective UGT1A1 causes hyperbilirubinemia"], "R-CEL-9757110": ["r", "Prednisone ADME"], "PWY-8292": ["t", "trimethylamine N-oxide biosynthesis"], "PWY-7850": ["t", "taurine biosynthesis II"], "PWY-6968": ["t", "trimethylamine degradation"], "PWY-5331": ["t", "taurine biosynthesis I"], "PWY-5882": ["t", "epoxypseudoisoeugenol-2-methylbutanoate biosynthesis"], "PWY-6526": ["t", "limonene degradation III (to perillate)"], "PWY-5871": ["t", "ubiquinol-9 biosynthesis (late decarboxylation)"], "PWY-7626": ["t", "bacilysin biosynthesis"], "PWY-5421": ["t", "dehydroabietic acid biosynthesis"], "PWY-6495": ["t", "ergotamine biosynthesis"], "PWY-6340": ["t", "5,5'-dehydrodivanillate degradation"], "PWY-2467": ["t", "(+)-pisatin biosynthesis"], "PWY-7615": ["t", "pterocarpan phytoalexins modification (maackiain, medicarpin, pisatin, phaseollin)"], "PWY-7757": ["t", "bisphenol A degradation"], "PWY-5706": ["t", "alliin metabolism"], "PWY-7604": ["t", "notoamide C and D biosynthesis"], "PWY-7212": ["t", "baicalein metabolism"], "PWY-7895": ["t", "ethionamide activation"], "PWY-5873": ["t", "ubiquinol-7 biosynthesis (late decarboxylation)"], "PWY-7230": ["t", "ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)"], "PWY-6831": ["t", "pyrrolnitrin biosynthesis"], "PWY-7861": ["t", "N-hydroxy-L-pipecolate biosynthesis"], "PWY-2724": ["t", "alkane oxidation"], "PWY-581": ["t", "indole-3-acetate biosynthesis II"], "PWY-8158": ["t", "ibotenate and muscimol biosynthesis"], "PWY-6503": ["t", "superpathway of ergotamine biosynthesis"], "PWY-7175": ["t", "nostoxanthin biosynthesis"], "PWY-7603": ["t", "stephacidin A biosynthesis"], "PWY-7650": ["t", "echinocandin B biosynthesis"], "PWY-7779": ["t", "methyl tert-butyl ether degradation"], "PWY-7430": ["t", "indole degradation to anthranil and anthranilate"], "PWY-5412": ["t", "levopimaric acid biosynthesis"], "PWY-8087": ["t", "indole-3-acetate degradation II"], "PWY-7698": ["t", "2,5-xylenol and 3,5-xylenol degradation"], "PWY-2421": ["t", "indole-3-acetate degradation I"], "PWY-7513": ["t", "flaviolin dimer and mompain biosynthesis"], "PWY-8111": ["t", "carbaryl degradation"], "PWY-5321": ["t", "quercetin glycoside biosynthesis (Arabidopsis)"], "PWY-8211": ["t", "Escherichia coli serotype O:7 O antigen biosynthesis"], "PWY-7487": ["t", "(+)-secoisolariciresinol diglucoside biosynthesis"], "PWY-6655": ["t", "xanthan biosynthesis"], "PWY-7137": ["t", "quercetin gentiotetraside biosynthesis"], "PWY-7885": ["t", "phosphatidylinositol mannoside biosynthesis"], "PWY-5666": ["t", "alpha-solanine/alpha-chaconine biosynthesis"], "PWY-8209": ["t", "Escherichia coli serotype O:15 O antigen biosynthesis"], "PWY-4421": ["t", "curcumin glucoside biosynthesis"], "PWY-7824": ["t", "prunasin and amygdalin biosynthesis"], "PWY-6024": ["t", "isovitexin glycosides biosynthesis"], "PWY-8322": ["t", "protein N-glycosylation processing of proteins targeted for retention in cellular organelles (cis-Golgi, yeast)"], "PWY-7921": ["t", "protein O-mannosylation I (yeast)"], "PWY-5797": ["t", "indole-3-acetate inactivation VI"], "PWY-8232": ["t", "Shigella boydii serotype 6 O antigen biosynthesis"], "PWY-6658": ["t", "acetan biosynthesis"], "PWY-7166": ["t", "kaempferide triglycoside biosynthesis"], "PWY-8233": ["t", "Escherichia coli serotype O:169 O antigen biosynthesis"], "PWY-8221": ["t", "Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis"], "PWY-6239": ["t", "luteolin glycosides biosynthesis"], "PWY-7449": ["t", "acylated cyanidin galactoside biosynthesis"], "PWY-8218": ["t", "Escherichia coli serotype O:56 O antigen biosynthesis"], "PWY-5399": ["t", "betacyanin biosynthesis"], "PWY-8206": ["t", "Salmonella enterica serotype O:18 O antigen biosynthesis"], "PWY-641": ["t", "proanthocyanidins biosynthesis from flavanols"], "PWY-8461": ["t", "Streptococcus pneumoniae serotype 4 capsular polysaccharide biosynthesis"], "PWY-7922": ["t", "protein O-mannosylation II (mammals, core M1 and core M2)"], "PWY-5774": ["t", "saponin biosynthesis IV"], "PWY-8236": ["t", "Salmonella enterica serotype O:39 O antigen biosynthesis"], "PWY-8226": ["t", "Escherichia coli serotype O:152 O antigen biosynthesis"], "PWY-7491": ["t", "podophyllotoxin glucosides metabolism"], "PWY-7658": ["t", "protein N-glycosylation (Methanococcus voltae)"], "PWY-8220": ["t", "Escherichia coli serotype O:117 O antigen biosynthesis"], "PWY-6525": ["t", "stellariose and mediose biosynthesis"], "PWY-8217": ["t", "Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis"], "PWY-7071": ["t", "steviol glucoside biosynthesis (rebaudioside A biosynthesis)"], "PWY-6279": ["t", "myxol-2' fucoside biosynthesis"], "PWY-8081": ["t", "leucine-derived hydroxynitrile glucoside biosynthesis"], "PWY-8251": ["t", "Escherichia coli serotype O:2 O antigen biosynthesis"], "PWY-8204": ["t", "Salmonella enterica serotype O:54 O antigen biosynthesis"], "PWY-8234": ["t", "Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"], "PWY-8235": ["t", "Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"], "PWY-7819": ["t", "poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis"], "PWY-7191": ["t", "kaempferol diglycoside biosynthesis (pollen-specific)"], "PWY-8241": ["t", "Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"], "PWY-1901": ["t", "aurone biosynthesis"], "PWY-7143": ["t", "kaempferol gentiobioside biosynthesis"], "PWY-5936": ["t", "xyloglucan biosynthesis"], "PWY-7623": ["t", "astaxanthin dirhamnoside biosynthesis"], "PWY-5338": ["t", "galactosylcyclitol biosynthesis"], "PWY-5759": ["t", "saponin biosynthesis III"], "PWY-6972": ["t", "oleandomycin activation/inactivation"], "PWY-8252": ["t", "Escherichia coli serotype O:50 O antigen biosynthesis"], "PWY-5339": ["t", "chalcone 2'-O-glucoside biosynthesis"], "PWY-5310": ["t", "superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)"], "PWY-8253": ["t", "Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"], "PWY-5286": ["t", "anthocyanidin sophoroside metabolism"], "PWY-7139": ["t", "sesaminol glucoside biosynthesis"], "PWY-8250": ["t", "Escherichia coli serotype O:9 O antigen biosynthesis"], "PWY-7192": ["t", "quercetin diglycoside biosynthesis (pollen-specific)"], "PWY-8219": ["t", "Escherichia coli serotype O:107 O antigen biosynthesis"], "PWY-7140": ["t", "myricetin gentiobioside biosynthesis"], "PWY-7463": ["t", "N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"], "PWY-5784": ["t", "indole-3-acetate inactivation VIII"], "PWY-6546": ["t", "brassinosteroids inactivation"], "PWY-6297": ["t", "tuberonate glucoside biosynthesis"], "PWY-8224": ["t", "Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis"], "PWY-6624": ["t", "salicylate glucosides biosynthesis III"], "PWY-8205": ["t", "Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"], "PWY-8323": ["t", "protein N-glycosylation processing of mannoproteins (cis-Golgi, yeast)"], "PWY-7960": ["t", "rhabduscin biosynthesis"], "PWY-7838": ["t", "globo-series glycosphingolipids biosynthesis"], "PWY-1961": ["t", "indole-3-acetate inactivation I"], "PWY-8207": ["t", "Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis"], "PWY-822": ["t", "fructan biosynthesis"], "PWY-6657": ["t", "polyhydroxydecanoate biosynthesis"], "PWY-8230": ["t", "Salmonella enterica serotype O:13 O antigen biosynthesis"], "PWY-5822": ["t", "trichloroethene degradation"], "PWY-5756": ["t", "saponin biosynthesis II"], "PWY-7859": ["t", "jasmonoyl-L-isoleucine inactivation"], "PWY-7145": ["t", "genistin gentiobioside biosynthesis"], "PWY-1981": ["t", "indole-3-acetate inactivation III"], "PWY-8460": ["t", "Streptococcus pneumoniae serotype 2 capsular polysaccharide biosynthesis"], "PWY-5793": ["t", "maysin biosynthesis"], "PWY-5320": ["t", "kaempferol glycoside biosynthesis (Arabidopsis)"], "PWY-6010": ["t", "apigenin glycosides biosynthesis"], "PWY-8244": ["t", "Escherichia coli serotype O:177 O antigen biosynthesis"], "PWY-6762": ["t", "salicylate glucosides biosynthesis IV"], "PWY-5342": ["t", "ajugose biosynthesis I (galactinol-dependent)"], "PWY-6051": ["t", "2,4,6-trinitrotoluene degradation"], "PWY-2881": ["t", "cytokinins 7-N-glucoside biosynthesis"], "PWY-5160": ["t", "rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)"], "PWY-7946": ["t", "sarcinaxanthin diglucoside biosynthesis"], "PWY-7945": ["t", "2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis"], "PWY-8208": ["t", "Salmonella enterica serotype O:6,7 O antigen biosynthesis"], "PWY-7213": ["t", "wogonin metabolism"], "PWY-83": ["t", "monolignol glucosides biosynthesis"], "PWY-8237": ["t", "Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"], "PWY-5094": ["t", "naringenin glycoside biosynthesis"], "PWY-5312": ["t", "superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)"], "PWY-6401": ["t", "hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis"], "PWY-8248": ["t", "lipid A-core biosynthesis (P. gingivalis)"], "PWY-5343": ["t", "ajugose biosynthesis II (galactinol-independent)"], "PWY-5380": ["t", "A series fagopyritols biosynthesis"], "PWY-7109": ["t", "megalomicin A biosynthesis"], "PWY-7633": ["t", "calycosin 7-O-glucoside biosynthesis"], "PWY-6623": ["t", "salicylate glucosides biosynthesis II"], "PWY-2902": ["t", "cytokinin-O-glucosides biosynthesis"], "PWY-5379": ["t", "B series fagopyritols biosynthesis"], "PWY-5672": ["t", "ginsenosides biosynthesis"], "PWY-7074": ["t", "phenylethanol glycoconjugate biosynthesis"], "PWY-8000": ["t", "vitamin K degradation"], "PWY-7129": ["t", "quercetin glucoside biosynthesis (Allium)"], "PWY-7253": ["t", "apigeninidin 5-O-glucoside biosynthesis"], "PWY-8039": ["t", "mitomycin biosynthesis"], "PWY-8242": ["t", "Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"], "PWY-7252": ["t", "luteolinidin 5-O-glucoside biosynthesis"], "PWY-8340": ["t", "isoorientin biosynthesis II"], "PWY-8228": ["t", "Porphyromonas gingivalis O-LPS antigen biosynthesis"], "PWY-2901": ["t", "cytokinins 9-N-glucoside biosynthesis"], "PWY-2021": ["t", "indole-3-acetate inactivation IV"], "PWY-7468": ["t", "benzoyl-beta-D-glucopyranose biosynthesis"], "PWY-5926": ["t", "afrormosin conjugates interconversion"], "PWY-7037": ["t", "protein O-glycosylation (Neisseria)"], "PWY-8222": ["t", "Escherichia coli serotype O:128 O antigen biosynthesis"], "PWY-5434": ["t", "(3E)-4,8-dimethylnona-1,3,7-triene biosynthesis I"], "PWY-6552": ["t", "caffeine degradation I (main, plants)"], "PWY-7937": ["t", "fungal bioluminescence"], "PWY-5870": ["t", "ubiquinol-8 biosynthesis (late decarboxylation)"], "PWY-7638": ["t", "echinenone and zeaxanthin biosynthesis (Synechocystis)"], "PWY-5413": ["t", "neoabietic acid biosynthesis"], "PWY-5414": ["t", "palustric acid biosynthesis"], "PWY-7949": ["t", "diadinoxanthin and diatoxanthin interconversion"], "PWY-7749": ["t", "(-)-4'-demethyl-epipodophyllotoxin biosynthesis"], "PWY-1381": ["t", "fluorene degradation II"], "PWY-7085": ["t", "triethylamine degradation"], "PWY-7304": ["t", "3-amino-4,7-dihydroxy-coumarin biosynthesis"], "PWY-7492": ["t", "paspaline biosynthesis"], "PWY-5422": ["t", "isopimaric acid biosynthesis"], "PWY-6710": ["t", "poly-hydroxy fatty acids biosynthesis"], "PWY-7481": ["t", "oryzalide A biosynthesis"], "PWY-5872": ["t", "ubiquinol-10 biosynthesis (late decarboxylation)"], "PWY-7648": ["t", "3-hydroxy-4-methyl-proline biosynthesis"], "PWY-7637": ["t", "2,2'-dihydroxyketocarotenoids biosynthesis"], "PWY-7775": ["t", "propane degradation II"], "PWY-8085": ["t", "picolinate degradation"], "PWY-7780": ["t", "butane degradation"], "PWY-7703": ["t", "2,4-xylenol degradation to protocatechuate"], "R-DRE-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-PFA-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-HSA-5619063": ["r", "Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)"], "PWY-5161": ["t", "6'-deoxychalcone metabolism"], "PWY-6015": ["t", "vitexin and derivatives biosynthesis"], "PWY-7697": ["t", "geranyl beta-primeveroside biosynthesis"], "PWY-3462": ["t", "L-phenylalanine biosynthesis II"], "PWY-6120": ["t", "L-tyrosine biosynthesis III"], "PWY-3461": ["t", "L-tyrosine biosynthesis II"], "R-CFA-3295583": ["r", "TRP channels"], "R-SCE-3295583": ["r", "TRP channels"], "R-SSC-1810476": ["r", "RIP-mediated NFkB activation via ZBP1"], "R-DME-977443": ["r", "GABA receptor activation"], "R-CEL-977443": ["r", "GABA receptor activation"], "PWY-6344": ["t", "L-arginine degradation XIV (oxidative Stickland reaction)"], "R-HSA-9956553": ["r", "OTC main chain variants cause OTC deficiency"], "R-GGA-70635": ["r", "Urea cycle"], "R-HSA-9956551": ["r", "OTC leader sequence variants cause OTC deficiency"], "R-HSA-5619113": ["r", "Defective SLC3A1 causes cystinuria (CSNU)"], "R-XTR-210991": ["r", "Basigin interactions"], "R-HSA-5660862": ["r", "Defective SLC7A7 causes lysinuric protein intolerance (LPI)"], "R-HSA-5660883": ["r", "Defective SLC7A9 causes cystinuria (CSNU)"], "R-XTR-352230": ["r", "Amino acid transport across the plasma membrane"], "R-DRE-210991": ["r", "Basigin interactions"], "R-DRE-352230": ["r", "Amino acid transport across the plasma membrane"], "R-SCE-352230": ["r", "Amino acid transport across the plasma membrane"], "R-SPO-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "PWY-6281": ["t", "L-selenocysteine biosynthesis II (archaea and eukaryotes)"], "R-SPO-5620971": ["r", "Pyroptosis"], "R-GGA-111459": ["r", "Activation of caspases through apoptosome-mediated cleavage"], "R-GGA-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-CFA-611105": ["r", "Respiratory electron transport"], "R-SCE-5620971": ["r", "Pyroptosis"], "R-DDI-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-CFA-5628897": ["r", "TP53 Regulates Metabolic Genes"], "R-CFA-5620971": ["r", "Pyroptosis"], "R-CEL-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-CFA-9627069": ["r", "Regulation of the apoptosome activity"], "R-CFA-111458": ["r", "Formation of apoptosome"], "R-DDI-5620971": ["r", "Pyroptosis"], "R-CFA-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-DRE-111457": ["r", "Release of apoptotic factors from the mitochondria"], "R-SSC-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-CEL-200425": ["r", "Carnitine shuttle"], "R-MMU-69895": ["r", "Transcriptional activation of cell cycle inhibitor p21"], "R-HSA-9723905": ["r", "Loss of function of TP53 in cancer due to loss of tetramerization ability"], "R-CEL-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-SSC-917977": ["r", "Transferrin endocytosis and recycling"], "R-SSC-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-SSC-9696273": ["r", "RND1 GTPase cycle"], "R-MMU-1300642": ["r", "Sperm Motility And Taxes"], "R-RNO-1300642": ["r", "Sperm Motility And Taxes"], "R-DME-1300642": ["r", "Sperm Motility And Taxes"], "R-PFA-5576890": ["r", "Phase 3 - rapid repolarisation"], "R-HSA-1300642": ["r", "Sperm Motility And Taxes"], "R-CEL-1300642": ["r", "Sperm Motility And Taxes"], "R-HSA-1296052": ["r", "Ca2+ activated K+ channels"], "R-DRE-1296052": ["r", "Ca2+ activated K+ channels"], "R-MMU-1296052": ["r", "Ca2+ activated K+ channels"], "R-DRE-1300642": ["r", "Sperm Motility And Taxes"], "R-BTA-1296052": ["r", "Ca2+ activated K+ channels"], "R-RNO-1296052": ["r", "Ca2+ activated K+ channels"], "R-SSC-8964038": ["r", "LDL clearance"], "R-SSC-9907900": ["r", "Proteasome assembly"], "PWY-5155": ["t", "beta-alanine biosynthesis III"], "R-DME-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-GGA-1236977": ["r", "Endosomal/Vacuolar pathway"], "R-CFA-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-DME-196780": ["r", "Biotin transport and metabolism"], "R-DDI-73621": ["r", "Pyrimidine catabolism"], "R-CFA-199220": ["r", "Vitamin B5 (pantothenate) metabolism"], "R-CFA-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "R-HSA-3371598": ["r", "Defective BTD causes biotidinase deficiency"], "PWY-7970": ["t", "benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-7969": ["t", "5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-5509": ["t", "adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I"], "PWY-7964": ["t", "adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-7968": ["t", "5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-7966": ["t", "5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-7965": ["t", "2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-7967": ["t", "5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-6269": ["t", "superpathway of adenosylcobalamin salvage from cobinamide II"], "PWY-7962": ["t", "adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide"], "PWY-7972": ["t", "adenosylcobinamide-GDP salvage from cobinamide II"], "PWY-7971": ["t", "adenosylcobinamide-GDP salvage from cobinamide I"], "PWY-1723": ["t", "formaldehyde oxidation VI (H4MPT pathway)"], "R-SSC-2730905": ["r", "Role of LAT2/NTAL/LAB on calcium mobilization"], "R-SSC-5690714": ["r", "CD22 mediated BCR regulation"], "R-GGA-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-SSC-1236977": ["r", "Endosomal/Vacuolar pathway"], "R-HSA-5619054": ["r", "Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)"], "R-GGA-381042": ["r", "PERK regulates gene expression"], "R-XTR-9840373": ["r", "Cellular response to mitochondrial stress"], "R-PFA-72731": ["r", "Recycling of eIF2:GDP"], "R-GGA-9840373": ["r", "Cellular response to mitochondrial stress"], "R-CFA-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-RNO-5676594": ["r", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "R-HSA-9656256": ["r", "Defective OGG1 Substrate Processing"], "R-DME-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-HSA-9657050": ["r", "Defective OGG1 Localization"], "R-DME-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-HSA-9656255": ["r", "Defective OGG1 Substrate Binding"], "R-SCE-110330": ["r", "Recognition and association of DNA glycosylase with site containing an affected purine"], "R-DME-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-DME-110331": ["r", "Cleavage of the damaged purine"], "R-SCE-110331": ["r", "Cleavage of the damaged purine"], "R-RNO-110329": ["r", "Cleavage of the damaged pyrimidine"], "R-MMU-1296067": ["r", "Potassium transport channels"], "R-HSA-1296067": ["r", "Potassium transport channels"], "R-RNO-1296067": ["r", "Potassium transport channels"], "R-SSC-5576886": ["r", "Phase 4 - resting membrane potential"], "R-HSA-1296053": ["r", "Classical Kir channels"], "R-SSC-1296053": ["r", "Classical Kir channels"], "R-RNO-1296053": ["r", "Classical Kir channels"], "R-CFA-5576886": ["r", "Phase 4 - resting membrane potential"], "R-BTA-1296053": ["r", "Classical Kir channels"], "R-MMU-1296053": ["r", "Classical Kir channels"], "R-HSA-9729555": ["r", "Sensory perception of sour taste"], "R-CFA-1296053": ["r", "Classical Kir channels"], "R-SSC-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-SSC-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-GGA-5576886": ["r", "Phase 4 - resting membrane potential"], "R-GGA-1296053": ["r", "Classical Kir channels"], "R-GGA-997272": ["r", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "R-GGA-1296041": ["r", "Activation of G protein gated Potassium channels"], "R-CFA-6788467": ["r", "IL-6-type cytokine receptor ligand interactions"], "R-BTA-1236977": ["r", "Endosomal/Vacuolar pathway"], "R-SSC-1236974": ["r", "ER-Phagosome pathway"], "R-SSC-2871809": ["r", "FCERI mediated Ca+2 mobilization"], "R-GGA-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-SSC-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-SSC-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-GGA-1236974": ["r", "ER-Phagosome pathway"], "R-SSC-2029485": ["r", "Role of phospholipids in phagocytosis"], "R-GGA-2132286": ["r", "Classical antibody-mediated complement activation"], "R-DME-3000178": ["r", "ECM proteoglycans"], "R-XTR-418990": ["r", "Adherens junctions interactions"], "R-CFA-202427": ["r", "Phosphorylation of CD3 and TCR zeta chains"], "R-GGA-72731": ["r", "Recycling of eIF2:GDP"], "R-PFA-9840373": ["r", "Cellular response to mitochondrial stress"], "R-XTR-381042": ["r", "PERK regulates gene expression"], "R-RNO-1299344": ["r", "TWIK-related spinal cord K+ channel (TRESK)"], "R-DME-1299503": ["r", "TWIK related potassium channel (TREK)"], "R-HSA-1299287": ["r", "Tandem pore domain halothane-inhibited K+ channel (THIK)"], "R-MMU-1299287": ["r", "Tandem pore domain halothane-inhibited K+ channel (THIK)"], "R-SCE-1299503": ["r", "TWIK related potassium channel (TREK)"], "R-MMU-1299316": ["r", "TWIK-releated acid-sensitive K+ channel (TASK)"], "R-SCE-5576886": ["r", "Phase 4 - resting membrane potential"], "R-HSA-1299316": ["r", "TWIK-releated acid-sensitive K+ channel (TASK)"], "R-CEL-1299316": ["r", "TWIK-releated acid-sensitive K+ channel (TASK)"], "R-HSA-1299503": ["r", "TWIK related potassium channel (TREK)"], "R-RNO-1299287": ["r", "Tandem pore domain halothane-inhibited K+ channel (THIK)"], "R-MMU-1299503": ["r", "TWIK related potassium channel (TREK)"], "R-SCE-1299361": ["r", "TWIK-related alkaline pH activated K+ channel (TALK)"], "R-DME-5576886": ["r", "Phase 4 - resting membrane potential"], "R-CEL-5576886": ["r", "Phase 4 - resting membrane potential"], "R-MMU-1299361": ["r", "TWIK-related alkaline pH activated K+ channel (TALK)"], "R-SCE-1299316": ["r", "TWIK-releated acid-sensitive K+ channel (TASK)"], "R-HSA-1299361": ["r", "TWIK-related alkaline pH activated K+ channel (TALK)"], "R-HSA-1299344": ["r", "TWIK-related spinal cord K+ channel (TRESK)"], "R-CEL-1299344": ["r", "TWIK-related spinal cord K+ channel (TRESK)"], "R-CEL-1299503": ["r", "TWIK related potassium channel (TREK)"], "R-DME-1299344": ["r", "TWIK-related spinal cord K+ channel (TRESK)"], "R-MMU-1299344": ["r", "TWIK-related spinal cord K+ channel (TRESK)"], "R-RNO-1299316": ["r", "TWIK-releated acid-sensitive K+ channel (TASK)"], "R-SCE-1299344": ["r", "TWIK-related spinal cord K+ channel (TRESK)"], "R-RNO-1299503": ["r", "TWIK related potassium channel (TREK)"], "R-SCE-1299308": ["r", "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"], "R-SCE-1299287": ["r", "Tandem pore domain halothane-inhibited K+ channel (THIK)"], "PWY-7761": ["t", "NAD salvage pathway II (PNC IV cycle)"], "PWY-6350": ["t", "archaetidylinositol biosynthesis"], "PWY-6804": ["t", "diacylglycerol biosynthesis (PUFA enrichment in oilseed)"], "PWY-5901": ["t", "2,3-dihydroxybenzoate biosynthesis"], "PWY-6502": ["t", "8-oxo-(d)GTP detoxification I"], "R-DME-373753": ["r", "Nephrin family interactions"], "R-DRE-420597": ["r", "Nectin/Necl trans heterodimerization"], "R-DME-447043": ["r", "Neurofascin interactions"], "R-CEL-447043": ["r", "Neurofascin interactions"], "R-BTA-420029": ["r", "Tight junction interactions"], "R-HSA-433692": ["r", "Proton-coupled monocarboxylate transport"], "R-GGA-210991": ["r", "Basigin interactions"], "R-CFA-202433": ["r", "Generation of second messenger molecules"], "R-RNO-8864260": ["r", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "R-MMU-8864260": ["r", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "R-GGA-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "PWY-5196": ["t", "factor 430 biosynthesis"], "PWY-5194": ["t", "siroheme biosynthesis"], "R-MMU-5221030": ["r", "TET1,2,3 and TDG demethylate DNA"], "R-SPO-5221030": ["r", "TET1,2,3 and TDG demethylate DNA"], "R-DRE-6804116": ["r", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "PWY-5674": ["t", "nitrate reduction IV (dissimilatory)"], "R-SCE-5689896": ["r", "Ovarian tumor domain proteases"], "R-HSA-5633231": ["r", "Defective ALG14 causes ALG14-CMS"], "R-RNO-420597": ["r", "Nectin/Necl trans heterodimerization"], "R-HSA-5619070": ["r", "Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)"], "R-GGA-156590": ["r", "Glutathione conjugation"], "R-GGA-9748787": ["r", "Azathioprine ADME"], "R-SPO-5689896": ["r", "Ovarian tumor domain proteases"], "PWY-1269": ["t", "CMP-3-deoxy-D-manno-octulosonate biosynthesis"], "PWY-7900": ["t", "glycogen biosynthesis III (from alpha-maltose 1-phosphate)"], "PWY-881": ["t", "trehalose biosynthesis II"], "R-XTR-9013407": ["r", "RHOH GTPase cycle"], "R-DRE-5689877": ["r", "Josephin domain DUBs"], "R-XTR-8876725": ["r", "Protein methylation"], "R-XTR-110320": ["r", "Translesion Synthesis by POLH"], "R-DRE-8932506": ["r", "DAG1 core M1 glycosylations"], "R-RNO-8932506": ["r", "DAG1 core M1 glycosylations"], "R-HSA-8932504": ["r", "DAG1 core M2 glycosylations"], "R-HSA-5083633": ["r", "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"], "R-RNO-8932504": ["r", "DAG1 core M2 glycosylations"], "R-DME-8932506": ["r", "DAG1 core M1 glycosylations"], "R-DME-8932504": ["r", "DAG1 core M2 glycosylations"], "R-DRE-8932504": ["r", "DAG1 core M2 glycosylations"], "R-HSA-8932506": ["r", "DAG1 core M1 glycosylations"], "R-DME-8932505": ["r", "DAG1 core M3 glycosylations"], "R-MMU-8932504": ["r", "DAG1 core M2 glycosylations"], "R-HSA-5083629": ["r", "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2"], "R-MMU-8932506": ["r", "DAG1 core M1 glycosylations"], "R-MMU-420597": ["r", "Nectin/Necl trans heterodimerization"], "R-RNO-376172": ["r", "DSCAM interactions"], "R-HSA-373756": ["r", "SDK interactions"], "R-DRE-1300645": ["r", "Acrosome Reaction and Sperm:Oocyte Membrane Binding"], "R-CFA-983695": ["r", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "R-GGA-9749641": ["r", "Aspirin ADME"], "R-XTR-202433": ["r", "Generation of second messenger molecules"], "R-GGA-433692": ["r", "Proton-coupled monocarboxylate transport"], "R-CEL-433692": ["r", "Proton-coupled monocarboxylate transport"], "PWY-7403": ["t", "tetramethylpyrazine degradation"], "PWY-8229": ["t", "UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis"], "R-SPO-9629569": ["r", "Protein hydroxylation"], "R-GGA-9629569": ["r", "Protein hydroxylation"], "R-DRE-1234174": ["r", "Cellular response to hypoxia"], "R-HSA-420597": ["r", "Nectin/Necl trans heterodimerization"], "R-BTA-5690714": ["r", "CD22 mediated BCR regulation"], "R-DME-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-DME-376172": ["r", "DSCAM interactions"], "R-DME-3000171": ["r", "Non-integrin membrane-ECM interactions"], "R-MMU-433692": ["r", "Proton-coupled monocarboxylate transport"], "R-DRE-198933": ["r", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "R-CEL-428542": ["r", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "R-DRE-216083": ["r", "Integrin cell surface interactions"], "R-MMU-373756": ["r", "SDK interactions"], "PWY-8418": ["t", "S-benzyl-L-cysteine degradation"], "PWY-7496": ["t", "linuron degradation"], "PWY-8453": ["t", "D-glutamate degradation"], "PWY-8293": ["t", "alazopeptin biosynthesis"], "PWY-1822": ["t", "indole-3-acetate activation I"], "PWY-6409": ["t", "pyoverdine I biosynthesis"], "PWY-6899": ["t", "base-degraded thiamine salvage"], "PWY-7652": ["t", "echinocandin B degradation"], "PWY-5436": ["t", "L-threonine degradation IV"], "PWY-5162": ["t", "2-hydroxypenta-2,4-dienoate degradation"], "PWY-8062": ["t", "sulfoacetaldehyde degradation IV"], "R-DRE-5694530": ["r", "Cargo concentration in the ER"], "R-GGA-913709": ["r", "O-linked glycosylation of mucins"], "PWY-6146": ["t", "Methanobacterium thermoautotrophicum biosynthetic metabolism"], "R-DDI-196783": ["r", "Coenzyme A biosynthesis"], "R-SCE-8964058": ["r", "HDL remodeling"], "R-HSA-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-SPO-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-BTA-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-RNO-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-DDI-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-RNO-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-DDI-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-BTA-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-SCE-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-CEL-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-HSA-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-CEL-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-MMU-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-MMU-2470946": ["r", "Cohesin Loading onto Chromatin"], "PWY-8138": ["t", "polyphosphate metabolism"], "PWY-7303": ["t", "4-hydroxy-3-prenylbenzoate biosynthesis"], "R-SPO-426496": ["r", "Post-transcriptional silencing by small RNAs"], "R-XTR-426496": ["r", "Post-transcriptional silencing by small RNAs"], "R-DRE-426496": ["r", "Post-transcriptional silencing by small RNAs"], "R-XTR-5578749": ["r", "Transcriptional regulation by small RNAs"], "R-DME-426496": ["r", "Post-transcriptional silencing by small RNAs"], "R-RNO-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-RNO-426496": ["r", "Post-transcriptional silencing by small RNAs"], "PWY-6966": ["t", "methanol oxidation to formaldehyde I"], "PWY-6173": ["t", "histamine biosynthesis"], "R-HSA-111471": ["r", "Apoptotic factor-mediated response"], "R-HSA-9645722": ["r", "Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function"], "R-SPO-189483": ["r", "Heme degradation"], "R-CFA-5627083": ["r", "RHO GTPases regulate CFTR trafficking"], "R-SPO-9754706": ["r", "Atorvastatin ADME"], "R-SSC-9793528": ["r", "Ciprofloxacin ADME"], "R-HSA-5679090": ["r", "Defective ABCG8 causes GBD4 and sitosterolemia"], "R-SSC-9753281": ["r", "Paracetamol ADME"], "R-RNO-1369007": ["r", "Mitochondrial ABC transporters"], "R-SPO-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-DDI-1369007": ["r", "Mitochondrial ABC transporters"], "R-HSA-5678771": ["r", "Defective ABCB4 causes PFIC3, ICP3 and GBD1"], "R-PFA-9754706": ["r", "Atorvastatin ADME"], "R-DME-9753281": ["r", "Paracetamol ADME"], "R-SPO-1369007": ["r", "Mitochondrial ABC transporters"], "R-SPO-9749641": ["r", "Aspirin ADME"], "R-HSA-5690338": ["r", "Defective ABCC6 causes PXE"], "R-PFA-9757110": ["r", "Prednisone ADME"], "R-DDI-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-SCE-189483": ["r", "Heme degradation"], "R-DDI-9707564": ["r", "Cytoprotection by HMOX1"], "R-DDI-2142845": ["r", "Hyaluronan metabolism"], "R-PFA-382556": ["r", "ABC-family proteins mediated transport"], "R-SCE-9707564": ["r", "Cytoprotection by HMOX1"], "R-SSC-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-HSA-2161517": ["r", "Abacavir transmembrane transport"], "R-SPO-9758890": ["r", "Transport of RCbl within the body"], "R-CFA-2142691": ["r", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "R-DDI-9758890": ["r", "Transport of RCbl within the body"], "R-CFA-189483": ["r", "Heme degradation"], "R-HSA-5679096": ["r", "Defective ABCG5 causes sitosterolemia"], "R-SSC-189451": ["r", "Heme biosynthesis"], "R-SCE-159418": ["r", "Recycling of bile acids and salts"], "R-CFA-9758890": ["r", "Transport of RCbl within the body"], "R-HSA-5683678": ["r", "Defective ABCA3 causes SMDP3"], "R-DRE-5627083": ["r", "RHO GTPases regulate CFTR trafficking"], "R-CFA-159418": ["r", "Recycling of bile acids and salts"], "R-MMU-376172": ["r", "DSCAM interactions"], "R-RNO-433692": ["r", "Proton-coupled monocarboxylate transport"], "R-CFA-5690714": ["r", "CD22 mediated BCR regulation"], "R-SCE-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-DME-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-HSA-1369007": ["r", "Mitochondrial ABC transporters"], "R-SCE-9754706": ["r", "Atorvastatin ADME"], "R-CEL-2142845": ["r", "Hyaluronan metabolism"], "R-HSA-5683371": ["r", "Defective ABCB6 causes MCOPCB7"], "R-DME-9603798": ["r", "Class I peroxisomal membrane protein import"], "R-SCE-1369007": ["r", "Mitochondrial ABC transporters"], "R-CFA-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-SPO-159418": ["r", "Recycling of bile acids and salts"], "R-MMU-1369007": ["r", "Mitochondrial ABC transporters"], "R-DRE-1369007": ["r", "Mitochondrial ABC transporters"], "R-HSA-9918454": ["r", "Defective visual phototransduction due to ABCA4 loss of function"], "R-HSA-5678520": ["r", "Defective ABCB11 causes PFIC2 and BRIC2"], "R-CEL-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-DME-1296025": ["r", "ATP sensitive Potassium channels"], "R-CEL-1369007": ["r", "Mitochondrial ABC transporters"], "R-HSA-5682294": ["r", "Defective ABCA12 causes ARCI4B"], "R-HSA-5679001": ["r", "Defective ABCC2 causes DJS"], "R-PFA-159418": ["r", "Recycling of bile acids and salts"], "R-SCE-9758890": ["r", "Transport of RCbl within the body"], "R-CFA-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-HSA-5683329": ["r", "Defective ABCD4 causes MAHCJ"], "R-HSA-5684045": ["r", "Defective ABCD1 causes ALD"], "R-DRE-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-PFA-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-SPO-9757110": ["r", "Prednisone ADME"], "R-SPO-983170": ["r", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "R-SPO-9707564": ["r", "Cytoprotection by HMOX1"], "R-SCE-9749641": ["r", "Aspirin ADME"], "R-HSA-5688399": ["r", "Defective ABCA3 causes SMDP3"], "R-DME-189483": ["r", "Heme degradation"], "R-DME-9793528": ["r", "Ciprofloxacin ADME"], "R-PFA-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "PWY-6773": ["t", "1,3-beta-D-glucan biosynthesis"], "R-CFA-9020958": ["r", "Interleukin-21 signaling"], "PWY-7887": ["t", "protein SAMPylation and SAMP-mediated thiolation"], "R-SCE-71064": ["r", "Lysine catabolism"], "R-RNO-71064": ["r", "Lysine catabolism"], "R-CFA-912446": ["r", "Meiotic recombination"], "R-PFA-68949": ["r", "Orc1 removal from chromatin"], "R-GGA-69091": ["r", "Polymerase switching"], "R-BTA-202430": ["r", "Translocation of ZAP-70 to Immunological synapse"], "R-CFA-202430": ["r", "Translocation of ZAP-70 to Immunological synapse"], "R-CFA-389948": ["r", "Co-inhibition by PD-1"], "R-SPO-71064": ["r", "Lysine catabolism"], "PWY-6185": ["t", "4-methylcatechol degradation (ortho cleavage)"], "R-SPO-9845576": ["r", "Glycosphingolipid transport"], "R-DME-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-GGA-912446": ["r", "Meiotic recombination"], "R-SCE-69017": ["r", "CDK-mediated phosphorylation and removal of Cdc6"], "R-GGA-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-CFA-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-BTA-2454202": ["r", "Fc epsilon receptor (FCERI) signaling"], "R-SCE-9845576": ["r", "Glycosphingolipid transport"], "PWY-5707": ["t", "propanethial S-oxide biosynthesis"], "R-DDI-110312": ["r", "Translesion synthesis by REV1"], "R-XTR-110312": ["r", "Translesion synthesis by REV1"], "R-GGA-353473": ["r", "Translesion synthesis by Pol zeta"], "R-XTR-5656121": ["r", "Translesion synthesis by POLI"], "R-SCE-110312": ["r", "Translesion synthesis by REV1"], "PWY-6254": ["t", "santalene biosynthesis I"], "PWY-6653": ["t", "ent -kaurene biosynthesis II"], "PWY-5725": ["t", "farnesene biosynthesis"], "PWY-5197": ["t", "lactate biosynthesis (archaea)"], "PWY-7721": ["t", "methyl phomopsenoate biosynthesis"], "PWY-3041": ["t", "monoterpene biosynthesis"], "PWY-6275": ["t", "beta-caryophyllene biosynthesis"], "PWY-6257": ["t", "curcumene biosynthesis"], "PWY-6258": ["t", "patchoulol biosynthesis"], "R-CFA-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-BTA-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-CFA-5693616": ["r", "Presynaptic phase of homologous DNA pairing and strand exchange"], "R-DDI-68689": ["r", "CDC6 association with the ORC:origin complex"], "R-MMU-141334": ["r", "PAOs oxidise polyamines to amines"], "R-DME-141334": ["r", "PAOs oxidise polyamines to amines"], "R-HSA-141334": ["r", "PAOs oxidise polyamines to amines"], "R-DME-351200": ["r", "Interconversion of polyamines"], "R-CEL-71240": ["r", "Tryptophan catabolism"], "R-DDI-71240": ["r", "Tryptophan catabolism"], "R-DME-71240": ["r", "Tryptophan catabolism"], "R-DRE-71240": ["r", "Tryptophan catabolism"], "R-XTR-71240": ["r", "Tryptophan catabolism"], "R-PFA-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-CEL-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-BTA-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-HSA-5619087": ["r", "Defective SLC12A3 causes Gitelman syndrome (GS)"], "R-SSC-75893": ["r", "TNF signaling"], "R-CFA-75893": ["r", "TNF signaling"], "R-CFA-5626978": ["r", "TNFR1-mediated ceramide production"], "R-CFA-5669034": ["r", "TNFs bind their physiological receptors"], "R-SSC-5669034": ["r", "TNFs bind their physiological receptors"], "R-HSA-5688031": ["r", "Defective pro-SFTPB causes SMDP1 and RDS"], "R-DDI-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-GGA-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-GGA-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-GGA-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-GGA-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-BTA-912446": ["r", "Meiotic recombination"], "R-CFA-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-SCE-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-BTA-5693579": ["r", "Homologous DNA Pairing and Strand Exchange"], "R-MMU-912446": ["r", "Meiotic recombination"], "R-DRE-351202": ["r", "Metabolism of polyamines"], "R-DDI-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-DDI-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-DRE-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-BTA-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-SPO-9668328": ["r", "Sealing of the nuclear envelope (NE) by ESCRT-III"], "R-RNO-912446": ["r", "Meiotic recombination"], "R-CEL-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-PFA-2151201": ["r", "Transcriptional activation of mitochondrial biogenesis"], "R-CEL-5693607": ["r", "Processing of DNA double-strand break ends"], "PWY-8174": ["t", "odd iso-branched-chain fatty acid biosynthesis"], "PWY-5147": ["t", "oleate biosynthesis I (plants)"], "PWY-5142": ["t", "acyl-[acyl-carrier protein] thioesterase pathway"], "PWY-8427": ["t", "2-allylmalonyl-CoA biosynthesis"], "PWY-8280": ["t", "stearate biosynthesis IV"], "PWY-6519": ["t", "8-amino-7-oxononanoate biosynthesis I"], "PWY-8203": ["t", "8-amino-7-oxononanoate biosynthesis IV"], "PWY-7663": ["t", "gondoate biosynthesis (anaerobic)"], "PWY-5989": ["t", "stearate biosynthesis II (bacteria and plants)"], "PWY-5966": ["t", "fatty acid biosynthesis initiation (type I)"], "PWY-5971": ["t", "palmitate biosynthesis II (type II fatty acid synthase)"], "PWY-8173": ["t", "anteiso-branched-chain fatty acid biosynthesis"], "PWY-6113": ["t", "superpathway of mycolate biosynthesis"], "PWY-5366": ["t", "palmitoleate biosynthesis II (plants and bacteria)"], "PWY-7664": ["t", "oleate biosynthesis IV (anaerobic)"], "PWY-8175": ["t", "even iso-branched-chain fatty acid biosynthesis"], "PWY-7388": ["t", "octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)"], "PWY-5973": ["t", "cis-vaccenate biosynthesis"], "PWY-8279": ["t", "palmitate biosynthesis III"], "PWY-6282": ["t", "palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"], "PWY-7892": ["t", "tRNA-uridine 2-thiolation and selenation (bacteria)"], "PWY-6574": ["t", "achromobactin biosynthesis"], "PWY-7549": ["t", "asperlicin E biosynthesis"], "PWY-7665": ["t", "aureobasidin A biosynthesis"], "PWY-7842": ["t", "UDP-yelosamine biosynthesis"], "PWY-7600": ["t", "peramine biosynthesis"], "PWY-6374": ["t", "vibriobactin biosynthesis"], "PWY-7556": ["t", "(-)-microperfuranone biosynthesis"], "PWY-7510": ["t", "rhizocticin A and B biosynthesis"], "PWY-7797": ["t", "nocardicin A biosynthesis"], "PWY-7605": ["t", "roquefortine C biosynthesis"], "PWY-7542": ["t", "fumiquinazoline D biosynthesis"], "PWY-5669": ["t", "phosphatidylserine and phosphatidylethanolamine biosynthesis I"], "R-SSC-2408557": ["r", "Selenocysteine synthesis"], "R-MMU-2408557": ["r", "Selenocysteine synthesis"], "R-DRE-2408557": ["r", "Selenocysteine synthesis"], "R-DDI-2408557": ["r", "Selenocysteine synthesis"], "R-DME-2408557": ["r", "Selenocysteine synthesis"], "R-CEL-2408557": ["r", "Selenocysteine synthesis"], "PWY-6906": ["t", "chitin derivatives degradation"], "R-PFA-189200": ["r", "Cellular hexose transport"], "R-DME-5653890": ["r", "Lactose synthesis"], "R-PFA-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-DME-8981373": ["r", "Intestinal hexose absorption"], "R-SCE-189200": ["r", "Cellular hexose transport"], "R-PFA-5653890": ["r", "Lactose synthesis"], "R-CEL-8981373": ["r", "Intestinal hexose absorption"], "R-HSA-5619047": ["r", "Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"], "R-DME-189200": ["r", "Cellular hexose transport"], "R-SCE-5653890": ["r", "Lactose synthesis"], "R-SPO-429593": ["r", "Inositol transporters"], "PWY-6370": ["t", "ascorbate recycling (cytosolic)"], "PWY-2261": ["t", "ascorbate glutathione cycle"], "R-DDI-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-HSA-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-DME-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-XTR-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-SCE-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-DRE-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-PFA-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-MMU-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-HSA-5619088": ["r", "Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)"], "R-SPO-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-SSC-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-BTA-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-CEL-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-RNO-442380": ["r", "Zinc influx into cells by the SLC39 gene family"], "R-HSA-163316": ["r", "Mitochondrial transcription termination"], "R-MMU-163316": ["r", "Mitochondrial transcription termination"], "R-RNO-163316": ["r", "Mitochondrial transcription termination"], "R-DME-163316": ["r", "Mitochondrial transcription termination"], "PWY-8344": ["t", "ansamitocin P biosynthesis"], "R-PFA-9857492": ["r", "Protein lipoylation"], "R-MMU-1834949": ["r", "Cytosolic sensors of pathogen-associated DNA"], "R-CEL-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-CEL-1834949": ["r", "Cytosolic sensors of pathogen-associated DNA"], "R-CEL-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-RNO-1834949": ["r", "Cytosolic sensors of pathogen-associated DNA"], "PWY-7587": ["t", "oleate biosynthesis III (cyanobacteria)"], "PWY-7589": ["t", "palmitoleate biosynthesis III (cyanobacteria)"], "PWY-7411": ["t", "phosphatidate biosynthesis (yeast)"], "PWY-6961": ["t", "L-ascorbate degradation II (bacterial, aerobic)"], "PWY-8321": ["t", "salicylate biosynthesis II"], "PWY-6406": ["t", "salicylate biosynthesis I"], "PWY-5837": ["t", "2-carboxy-1,4-naphthoquinol biosynthesis"], "PWY-3961": ["t", "phosphopantothenate biosynthesis II"], "R-BTA-196783": ["r", "Coenzyme A biosynthesis"], "PWY-5668": ["t", "cardiolipin biosynthesis I"], "PWY-5269": ["t", "cardiolipin biosynthesis II"], "R-SCE-1834949": ["r", "Cytosolic sensors of pathogen-associated DNA"], "R-SPO-1834949": ["r", "Cytosolic sensors of pathogen-associated DNA"], "R-SCE-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-DRE-1614635": ["r", "Sulfur amino acid metabolism"], "R-DRE-6798163": ["r", "Choline catabolism"], "PWY-6997": ["t", "furfural degradation"], "PWY-6585": ["t", "2-methylketone biosynthesis"], "PWY-8184": ["t", "L-isoleucine degradation III (oxidative Stickland reaction)"], "PWY-981": ["t", "salicylate biosynthesis III"], "PWY-7402": ["t", "benzoate fermentation (to acetate and cyclohexane carboxylate)"], "PWY-7931": ["t", "brominated pyrroles biosynthesis"], "PWY-6995": ["t", "5-hydroxymethylfurfural degradation"], "PWY-8042": ["t", "acylceramide biosynthesis and processing"], "PWY-7216": ["t", "(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)"], "PWY-7292": ["t", "oleate beta-oxidation (thioesterase-dependent, yeast)"], "PWY-8339": ["t", "gamma-butyrobetaine degradation III"], "R-RNO-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-MTU-879325": ["r", "Mycothiol catabolism"], "R-BTA-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-MTU-879235": ["r", "Mycothiol-dependent detoxification"], "R-DDI-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-CFA-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-GGA-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-GGA-9953170": ["r", "GBP-mediated host defense"], "R-SSC-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-SSC-196025": ["r", "Formation of annular gap junctions"], "R-CFA-380284": ["r", "Loss of proteins required for interphase microtubule organization from the centrosome"], "R-SSC-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-XTR-2029482": ["r", "Regulation of actin dynamics for phagocytic cup formation"], "R-GGA-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-GGA-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-XTR-9953170": ["r", "GBP-mediated host defense"], "R-SSC-9933939": ["r", "Formation of the polybromo-BAF (pBAF) complex"], "R-CEL-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "PWY-7645": ["t", "hyaluronan degradation"], "PWY-7237": ["t", "myo-, chiro- and scyllo-inositol degradation"], "PWY-5940": ["t", "streptomycin biosynthesis"], "PWY-7241": ["t", "myo-inositol degradation II"], "R-DME-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "R-SCE-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-SPO-5685938": ["r", "HDR through Single Strand Annealing (SSA)"], "R-GGA-351468": ["r", "Processing of DNA double-strand break ends"], "PWY-5107": ["t", "phytol salvage pathway"], "PWY-8245": ["t", "lipid IVA biosynthesis (P. gingivalis)"], "PWY-8073": ["t", "lipid IVA biosynthesis (P. putida)"], "PWY-8283": ["t", "lipid IVA biosynthesis (generic)"], "PWY-7395": ["t", "D-galactosamine and N-acetyl-D-galactosamine degradation"], "R-BTA-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "R-DRE-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "PWY-7247": ["t", "beta-D-glucuronide and D-glucuronate degradation"], "PWY-7371": ["t", "1,4-dihydroxy-6-naphthoate biosynthesis II"], "PWY-7374": ["t", "1,4-dihydroxy-6-naphthoate biosynthesis I"], "R-XTR-6799198": ["r", "Complex I biogenesis"], "PWY-5297": ["t", "siroheme amide biosynthesis"], "PWY-7134": ["t", "rutin degradation (plants)"], "PWY-8435": ["t", "yeast mannan degradation"], "PWY-7133": ["t", "quercetin glucoside degradation (Allium)"], "PWY-6784": ["t", "cellulose and hemicellulose degradation (cellulolosome)"], "PWY-8436": ["t", "mammalian high-mannose N-glycan degradation"], "PWY-6717": ["t", "(1,4)-beta-D-xylan degradation"], "PWY-7647": ["t", "ulvan degradation"], "PWY-5976": ["t", "dhurrin degradation"], "PWY-6821": ["t", "kappa-carrageenan degradation"], "PWY-6735": ["t", "starch degradation IV"], "PWY-7057": ["t", "cichoriin interconversion"], "PWY-862": ["t", "fructan degradation"], "PWY-5821": ["t", "dalcochinin biosynthesis"], "PWY-7056": ["t", "daphnin interconversion"], "PWY-7256": ["t", "cyanidin diglucoside biosynthesis (acyl-glucose dependent)"], "PWY-7963": ["t", "4-methylphenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "PWY-7961": ["t", "phenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP"], "R-RNO-71262": ["r", "Carnitine synthesis"], "R-GGA-71262": ["r", "Carnitine synthesis"], "R-BTA-71262": ["r", "Carnitine synthesis"], "PWY-5785": ["t", "di-trans,poly-cis-undecaprenyl phosphate biosynthesis"], "PWY-5661": ["t", "GDP-alpha-D-glucose biosynthesis"], "PWY-2722": ["t", "trehalose degradation IV"], "PWY-2723": ["t", "trehalose degradation V"], "R-DRE-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-SSC-446353": ["r", "Cell-extracellular matrix interactions"], "R-XTR-9764561": ["r", "Regulation of CDH1 Function"], "R-XTR-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-GGA-9933947": ["r", "Formation of the non-canonical BAF (ncBAF) complex"], "R-XTR-446353": ["r", "Cell-extracellular matrix interactions"], "R-CFA-380320": ["r", "Recruitment of NuMA to mitotic centrosomes"], "R-CFA-380259": ["r", "Loss of Nlp from mitotic centrosomes"], "R-SSC-9953170": ["r", "GBP-mediated host defense"], "R-CFA-380270": ["r", "Recruitment of mitotic centrosome proteins and complexes"], "R-SSC-190873": ["r", "Gap junction degradation"], "R-XTR-5626467": ["r", "RHO GTPases activate IQGAPs"], "R-GGA-9934037": ["r", "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)"], "R-XTR-5663213": ["r", "RHO GTPases Activate WASPs and WAVEs"], "R-SSC-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-SSC-9933946": ["r", "Formation of the embryonic stem cell BAF (esBAF) complex"], "R-XTR-9933937": ["r", "Formation of the canonical BAF (cBAF) complex"], "R-DRE-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-CEL-75896": ["r", "Plasmalogen biosynthesis"], "R-SCE-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-SPO-880009": ["r", "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "R-XTR-201451": ["r", "Signaling by BMP"], "PWY-6806": ["t", "carotenoid cleavage"], "PWY-7898": ["t", "4,4'-disulfanediyldibutanoate degradation"], "R-CEL-964739": ["r", "N-glycan trimming and elongation in the cis-Golgi"], "R-RNO-964739": ["r", "N-glycan trimming and elongation in the cis-Golgi"], "R-HSA-964739": ["r", "N-glycan trimming and elongation in the cis-Golgi"], "R-HSA-5083628": ["r", "Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"], "R-MMU-964739": ["r", "N-glycan trimming and elongation in the cis-Golgi"], "R-DRE-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-DRE-176187": ["r", "Activation of ATR in response to replication stress"], "R-GGA-5358606": ["r", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "R-DRE-68962": ["r", "Activation of the pre-replicative complex"], "R-HSA-5619040": ["r", "Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)"], "R-HSA-427589": ["r", "Type II Na+/Pi cotransporters"], "R-HSA-5619097": ["r", "Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)"], "R-HSA-5619045": ["r", "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)"], "R-MMU-427589": ["r", "Type II Na+/Pi cotransporters"], "R-RNO-427589": ["r", "Type II Na+/Pi cotransporters"], "R-HSA-5687583": ["r", "Defective SLC34A2 causes PALM"], "R-SSC-9035034": ["r", "RHOF GTPase cycle"], "R-BTA-9913635": ["r", "Strand-asynchronous mitochondrial DNA replication"], "R-HSA-4793953": ["r", "Defective B4GALT1 causes CDG-2d"], "R-CEL-975577": ["r", "N-Glycan antennae elongation"], "R-DRE-975577": ["r", "N-Glycan antennae elongation"], "R-DME-975577": ["r", "N-Glycan antennae elongation"], "R-BTA-975577": ["r", "N-Glycan antennae elongation"], "R-SSC-975577": ["r", "N-Glycan antennae elongation"], "R-SCE-70350": ["r", "Fructose catabolism"], "R-SPO-70350": ["r", "Fructose catabolism"], "PWY-8440": ["t", "nucleoside and nucleotide degradation (halobacteria)"], "R-HSA-6791461": ["r", "RPIA deficiency: failed conversion of RU5P to R5P"], "R-HSA-5659996": ["r", "RPIA deficiency: failed conversion of R5P to RU5P"], "PWY-6389": ["t", "pyruvate fermentation to (S)-acetoin"], "PWY-5938": ["t", "pyruvate fermentation to (R)-acetoin I"], "PWY-5939": ["t", "pyruvate fermentation to (R)-acetoin II"], "PWY-6549": ["t", "nitrogen remobilization from senescing leaves"], "PWY-7254": ["t", "TCA cycle VII (acetate-producers)"], "PWY-5913": ["t", "partial TCA cycle (obligate autotrophs)"], "R-HSA-2978092": ["r", "Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate"], "R-SPO-389542": ["r", "NADPH regeneration"], "R-SCE-389542": ["r", "NADPH regeneration"], "PWY-7674": ["t", "CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis"], "PWY-6711": ["t", "archaeosine biosynthesis I"], "PWY-7923": ["t", "archaeosine biosynthesis II"], "R-HSA-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-RNO-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-MMU-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-DRE-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-PFA-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-DDI-73930": ["r", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "R-DDI-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-DME-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-DRE-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-PFA-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-DDI-110373": ["r", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway"], "R-DME-73933": ["r", "Resolution of Abasic Sites (AP sites)"], "R-PFA-110357": ["r", "Displacement of DNA glycosylase by APEX1"], "R-BTA-8941856": ["r", "RUNX3 regulates NOTCH signaling"], "R-MMU-844615": ["r", "The AIM2 inflammasome"], "R-SSC-77108": ["r", "Utilization of Ketone Bodies"], "R-DME-77108": ["r", "Utilization of Ketone Bodies"], "R-DME-9759194": ["r", "Nuclear events mediated by NFE2L2"], "R-GGA-9708530": ["r", "Regulation of BACH1 activity"], "R-CEL-8874211": ["r", "CREB3 factors activate genes"], "R-DRE-8874211": ["r", "CREB3 factors activate genes"], "R-CEL-381033": ["r", "ATF6 (ATF6-alpha) activates chaperones"], "R-CEL-8874177": ["r", "ATF6B (ATF6-beta) activates chaperones"], "R-DDI-381033": ["r", "ATF6 (ATF6-alpha) activates chaperones"], "R-GGA-112382": ["r", "Formation of RNA Pol II elongation complex"], "R-GGA-159227": ["r", "Transport of the SLBP independent Mature mRNA"], "R-GGA-72086": ["r", "mRNA Capping"], "R-GGA-159230": ["r", "Transport of the SLBP Dependant Mature mRNA"], "R-GGA-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-GGA-9930044": ["r", "Nuclear RNA decay"], "PWY-5895": ["t", "menaquinol-13 biosynthesis"], "PWY-5849": ["t", "menaquinol-6 biosynthesis"], "PWY-5839": ["t", "menaquinol-7 biosynthesis"], "PWY-5891": ["t", "menaquinol-11 biosynthesis"], "PWY-5892": ["t", "menaquinol-12 biosynthesis"], "PWY-5844": ["t", "menaquinol-9 biosynthesis"], "PWY-5890": ["t", "menaquinol-10 biosynthesis"], "PWY-7996": ["t", "menaquinol-4 biosynthesis I"], "R-DME-1296052": ["r", "Ca2+ activated K+ channels"], "R-CEL-1296052": ["r", "Ca2+ activated K+ channels"], "R-SSC-1296052": ["r", "Ca2+ activated K+ channels"], "PWY-6462": ["t", "peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)"], "PWY-6463": ["t", "peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)"], "PWY-6841": ["t", "homophytochelatin biosynthesis"], "PWY-6690": ["t", "cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate"], "R-DRE-9865881": ["r", "Complex III assembly"], "R-GGA-9865881": ["r", "Complex III assembly"], "R-SSC-9865881": ["r", "Complex III assembly"], "PWY-8171": ["t", "molybdenum cofactor biosynthesis"], "PWY-7801": ["t", "N-end rule pathway I (prokaryotic)"], "PWY-7378": ["t", "aminopropanol phosphate biosynthesis II"], "PWY-6535": ["t", "4-aminobutanoate degradation I"], "PWY-6537": ["t", "4-aminobutanoate degradation II"], "PWY-5022": ["t", "4-aminobutanoate degradation V"], "PWY-8346": ["t", "GABA shunt II"], "PWY-6536": ["t", "4-aminobutanoate degradation III"], "R-RNO-916853": ["r", "Degradation of GABA"], "R-SSC-916853": ["r", "Degradation of GABA"], "R-CEL-916853": ["r", "Degradation of GABA"], "R-DDI-916853": ["r", "Degradation of GABA"], "R-SPO-916853": ["r", "Degradation of GABA"], "R-HSA-916853": ["r", "Degradation of GABA"], "R-SCE-916853": ["r", "Degradation of GABA"], "R-MMU-916853": ["r", "Degradation of GABA"], "PWY-7855": ["t", "ectoine degradation"], "PWY-5853": ["t", "demethylmenaquinol-6 biosynthesis I"], "PWY-7997": ["t", "demethylmenaquinol-4 biosynthesis"], "PWY-5852": ["t", "demethylmenaquinol-8 biosynthesis I"], "PWY-5851": ["t", "demethylmenaquinol-9 biosynthesis"], "R-GGA-77595": ["r", "Processing of Intronless Pre-mRNAs"], "PWY-5067": ["t", "glycogen biosynthesis II (from UDP-D-Glucose)"], "R-HSA-5619077": ["r", "Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)"], "R-RNO-9615017": ["r", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "R-GGA-9615017": ["r", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "R-HSA-8963684": ["r", "Tyrosine catabolism"], "PWY-8043": ["t", "ophthalmate biosynthesis"], "PWY-6967": ["t", "methylamine degradation I"], "PWY-5025": ["t", "indole-3-acetate biosynthesis IV (bacteria)"], "PWY-7308": ["t", "acrylonitrile degradation I"], "PWY-8319": ["t", "NiFe(CO)(CN)2 cofactor biosynthesis"], "PWY-7130": ["t", "L-glucose degradation"], "PWY-7188": ["t", "orientin and isoorientin biosynthesis I"], "PWY-5780": ["t", "hypericin biosynthesis"], "PWY-7275": ["t", "L-homophenylalanine biosynthesis"], "PWY-8029": ["t", "limonene degradation IV (anaerobic)"], "PWY-8134": ["t", "bile acid 7beta-dehydroxylation"], "PWY-7610": ["t", "GDP-6-deoxy-D-altro-heptose biosynthesis"], "PWY-8335": ["t", "plasmalogen biosynthesis II (anaerobic)"], "PWY-2229": ["t", "superpathway of pterocarpan biosynthesis (via formononetin)"], "PWY-6602": ["t", "naringenin C-glucosylation"], "PWY-5979": ["t", "3-amino-5-hydroxybenzoate biosynthesis"], "PWY-5644": ["t", "4-nitrotoluene degradation II"], "PWY-7189": ["t", "pinocembrin C-glucosylation"], "PWY-5410": ["t", "traumatin and (Z)-3-hexen-1-yl acetate biosynthesis"], "PWY-7613": ["t", "GDP-6-deoxy-D-manno-heptose biosynthesis"], "PWY-5061": ["t", "6,7,4'-trihydroxyisoflavone biosynthesis"], "PWY-6721": ["t", "sangivamycin biosynthesis"], "PWY-5409": ["t", "divinyl ether biosynthesis II"], "PWY-7428": ["t", "2-chloroacrylate degradation II"], "R-PFA-1632852": ["r", "Macroautophagy"], "R-DDI-8874177": ["r", "ATF6B (ATF6-beta) activates chaperones"], "R-HSA-5619036": ["r", "Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)"], "R-SPO-8949215": ["r", "Mitochondrial calcium ion transport"], "R-SCE-425561": ["r", "Sodium/Calcium exchangers"], "R-SPO-425561": ["r", "Sodium/Calcium exchangers"], "R-SCE-8949215": ["r", "Mitochondrial calcium ion transport"], "R-HSA-5619055": ["r", "Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)"], "R-RNO-8963684": ["r", "Tyrosine catabolism"], "R-MMU-8963684": ["r", "Tyrosine catabolism"], "R-BTA-8963684": ["r", "Tyrosine catabolism"], "R-DDI-8963684": ["r", "Tyrosine catabolism"], "R-RNO-8964540": ["r", "Alanine metabolism"], "R-SPO-71240": ["r", "Tryptophan catabolism"], "R-XTR-8964540": ["r", "Alanine metabolism"], "R-DDI-8964540": ["r", "Alanine metabolism"], "R-SPO-8964540": ["r", "Alanine metabolism"], "R-DRE-8964540": ["r", "Alanine metabolism"], "R-XTR-70268": ["r", "Pyruvate metabolism"], "R-CEL-8963684": ["r", "Tyrosine catabolism"], "R-HSA-8964540": ["r", "Alanine metabolism"], "R-SCE-8964540": ["r", "Alanine metabolism"], "R-MMU-8964540": ["r", "Alanine metabolism"], "R-SCE-426117": ["r", "Cation-coupled Chloride cotransporters"], "R-CEL-426117": ["r", "Cation-coupled Chloride cotransporters"], "R-SPO-426117": ["r", "Cation-coupled Chloride cotransporters"], "PWY-1001": ["t", "cellulose biosynthesis"], "R-PFA-1300642": ["r", "Sperm Motility And Taxes"], "R-DME-8963684": ["r", "Tyrosine catabolism"], "R-DME-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-PFA-156590": ["r", "Glutathione conjugation"], "R-PFA-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-DDI-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-DDI-204174": ["r", "Regulation of pyruvate dehydrogenase (PDH) complex"], "R-CEL-196836": ["r", "Vitamin C (ascorbate) metabolism"], "R-DME-156590": ["r", "Glutathione conjugation"], "R-SSC-156581": ["r", "Methylation"], "PWY-7506": ["t", "phosphatidylserine biosynthesis II"], "PWY-7501": ["t", "phosphatidylserine biosynthesis I"], "PWY-6273": ["t", "phosphatidylethanolamine biosynthesis III"], "R-MMU-1483101": ["r", "Synthesis of PS"], "R-BTA-1483101": ["r", "Synthesis of PS"], "R-XTR-1483101": ["r", "Synthesis of PS"], "R-HSA-1483101": ["r", "Synthesis of PS"], "R-GGA-1483101": ["r", "Synthesis of PS"], "R-DME-1483101": ["r", "Synthesis of PS"], "R-DRE-1483101": ["r", "Synthesis of PS"], "R-RNO-1483101": ["r", "Synthesis of PS"], "R-BTA-8984722": ["r", "Interleukin-35 Signalling"], "R-BTA-9020591": ["r", "Interleukin-12 signaling"], "R-DME-975634": ["r", "Retinoid metabolism and transport"], "PWY-5957": ["t", "L-nicotianamine biosynthesis"], "R-HSA-5340573": ["r", "LGK974 inhibits PORCN"], "R-DDI-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-DRE-422085": ["r", "Synthesis, secretion, and deacylation of Ghrelin"], "R-MMU-8869496": ["r", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "R-RNO-8869496": ["r", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "R-DME-8869496": ["r", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "PWY-8419": ["t", "L-canavanine degradation II"], "R-SPO-425986": ["r", "Sodium/Proton exchangers"], "R-CEL-425986": ["r", "Sodium/Proton exchangers"], "R-SCE-425986": ["r", "Sodium/Proton exchangers"], "R-DDI-425986": ["r", "Sodium/Proton exchangers"], "PWY-6578": ["t", "8-amino-7-oxononanoate biosynthesis III"], "PWY-7147": ["t", "8-amino-7-oxononanoate biosynthesis II"], "R-DME-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-SSC-9749641": ["r", "Aspirin ADME"], "R-SSC-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-HSA-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-SSC-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-RNO-112311": ["r", "Neurotransmitter clearance"], "R-SSC-112311": ["r", "Neurotransmitter clearance"], "R-SSC-2161517": ["r", "Abacavir transmembrane transport"], "R-BTA-112311": ["r", "Neurotransmitter clearance"], "R-BTA-9793528": ["r", "Ciprofloxacin ADME"], "R-MMU-2161517": ["r", "Abacavir transmembrane transport"], "R-RNO-2161517": ["r", "Abacavir transmembrane transport"], "R-MMU-112311": ["r", "Neurotransmitter clearance"], "R-MMU-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-RNO-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-HSA-5619053": ["r", "Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"], "R-BTA-2161517": ["r", "Abacavir transmembrane transport"], "R-SSC-549127": ["r", "SLC-mediated transport of organic cations"], "R-SPO-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-SCE-425397": ["r", "Transport of vitamins, nucleosides, and related molecules"], "R-HSA-5619061": ["r", "Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"], "R-RNO-8849468": ["r", "PTK6 Regulates Proteins Involved in RNA Processing"], "R-XTR-8849468": ["r", "PTK6 Regulates Proteins Involved in RNA Processing"], "PWY-4921": ["t", "protein citrullination"], "PWY-6840": ["t", "homoglutathione biosynthesis"], "PWY-7255": ["t", "ergothioneine biosynthesis I (bacteria)"], "R-HSA-5578999": ["r", "Defective GCLC causes HAGGSD"], "R-DME-174403": ["r", "Glutathione synthesis and recycling"], "R-CEL-174403": ["r", "Glutathione synthesis and recycling"], "PWY-5389": ["t", "3-methylthiopropanoate biosynthesis"], "R-GGA-1237112": ["r", "Methionine salvage pathway"], "R-DDI-1237112": ["r", "Methionine salvage pathway"], "R-DDI-189200": ["r", "Cellular hexose transport"], "PWY-7893": ["t", "protein Pupylation and dePupylation"], "PWY-5386": ["t", "methylglyoxal degradation I"], "R-DRE-74749": ["r", "Signal attenuation"], "R-GGA-264876": ["r", "Insulin processing"], "R-CFA-74751": ["r", "Insulin receptor signalling cascade"], "R-CFA-264876": ["r", "Insulin processing"], "R-CFA-74752": ["r", "Signaling by Insulin receptor"], "R-DRE-74713": ["r", "IRS activation"], "R-GGA-74713": ["r", "IRS activation"], "R-SSC-264876": ["r", "Insulin processing"], "R-CFA-74749": ["r", "Signal attenuation"], "R-SSC-74752": ["r", "Signaling by Insulin receptor"], "R-GGA-74751": ["r", "Insulin receptor signalling cascade"], "R-SSC-77387": ["r", "Insulin receptor recycling"], "R-DRE-74752": ["r", "Signaling by Insulin receptor"], "R-CFA-74713": ["r", "IRS activation"], "R-GGA-74752": ["r", "Signaling by Insulin receptor"], "R-GGA-74749": ["r", "Signal attenuation"], "R-DDI-68952": ["r", "DNA replication initiation"], "R-RNO-68952": ["r", "DNA replication initiation"], "R-BTA-68952": ["r", "DNA replication initiation"], "R-DRE-8849468": ["r", "PTK6 Regulates Proteins Involved in RNA Processing"], "R-MMU-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "R-PFA-5263617": ["r", "Metabolism of ingested MeSeO2H into MeSeH"], "R-GGA-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-DRE-8951936": ["r", "RUNX3 regulates p14-ARF"], "R-DRE-69202": ["r", "Cyclin E associated events during G1/S transition"], "R-DRE-9706019": ["r", "RHOBTB3 ATPase cycle"], "R-DRE-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-DRE-69563": ["r", "p53-Dependent G1 DNA Damage Response"], "R-XTR-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-XTR-6782135": ["r", "Dual incision in TC-NER"], "R-GGA-8956319": ["r", "Nucleotide catabolism"], "R-DDI-8956319": ["r", "Nucleotide catabolism"], "R-BTA-8956319": ["r", "Nucleotide catabolism"], "R-CEL-8956319": ["r", "Nucleotide catabolism"], "R-SSC-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-GGA-3301854": ["r", "Nuclear Pore Complex (NPC) Disassembly"], "R-BTA-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-GGA-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "R-DRE-8934593": ["r", "Regulation of RUNX1 Expression and Activity"], "R-GGA-2995383": ["r", "Initiation of Nuclear Envelope (NE) Reformation"], "R-DRE-9754119": ["r", "Drug-mediated inhibition of CDK4/CDK6 activity"], "R-DRE-8849470": ["r", "PTK6 Regulates Cell Cycle"], "R-DRE-69200": ["r", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"], "R-GGA-2980767": ["r", "Activation of NIMA Kinases NEK9, NEK6, NEK7"], "PWY-6550": ["t", "carbazole degradation"], "R-BTA-8932505": ["r", "DAG1 core M3 glycosylations"], "R-BTA-912694": ["r", "Regulation of IFNA/IFNB signaling"], "R-GGA-8932505": ["r", "DAG1 core M3 glycosylations"], "PWY-5923": ["t", "limonene degradation I (D-limonene)"], "PWY-5927": ["t", "(4S)-carveol and (4S)-dihydrocarveol degradation"], "PWY-5922": ["t", "(4R)-carveol and (4R)-dihydrocarveol degradation"], "PWY-5924": ["t", "limonene degradation II (L-limonene)"], "PWY-8445": ["t", "puerarin degradation"], "PWY-7328": ["t", "superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis"], "PWY-7622": ["t", "UDP-alpha-D-galactofuranose biosynthesis"], "PWY-6910": ["t", "hydroxymethylpyrimidine salvage"], "PWY-6620": ["t", "guanine and guanosine salvage I"], "PWY-6644": ["t", "fluoroacetate and fluorothreonine biosynthesis"], "R-CEL-72764": ["r", "Eukaryotic Translation Termination"], "R-DME-72764": ["r", "Eukaryotic Translation Termination"], "R-XTR-72764": ["r", "Eukaryotic Translation Termination"], "PWY-5747": ["t", "2-methylcitrate cycle II"], "PWY-3081": ["t", "L-lysine biosynthesis V"], "PWY-6938": ["t", "NADH repair (eukaryotes)"], "PWY-8137": ["t", "NADPH repair (eukaryotes)"], "PWY-8136": ["t", "NADPH repair (prokaryotes)"], "R-PFA-196807": ["r", "Nicotinate metabolism"], "R-SSC-380095": ["r", "Tachykinin receptors bind tachykinins"], "PWY-5372": ["t", "carbon tetrachloride degradation II"], "PWY-6780": ["t", "hydrogen production VI"], "PWY-7177": ["t", "UTP and CTP dephosphorylation II"], "PWY-7380": ["t", "biotin biosynthesis from 8-amino-7-oxononanoate II"], "PWY-6649": ["t", "glycolate and glyoxylate degradation III"], "R-DDI-3065679": ["r", "SUMO is proteolytically processed"], "R-SCE-8981373": ["r", "Intestinal hexose absorption"], "R-HSA-5619068": ["r", "Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"], "R-XTR-189200": ["r", "Cellular hexose transport"], "R-SCE-422356": ["r", "Regulation of insulin secretion"], "R-PFA-422356": ["r", "Regulation of insulin secretion"], "R-CEL-5653890": ["r", "Lactose synthesis"], "R-PFA-8981373": ["r", "Intestinal hexose absorption"], "R-SCE-429593": ["r", "Inositol transporters"], "R-CEL-429593": ["r", "Inositol transporters"], "R-CEL-189200": ["r", "Cellular hexose transport"], "R-PFA-199992": ["r", "trans-Golgi Network Vesicle Budding"], "R-SSC-204005": ["r", "COPII-mediated vesicle transport"], "R-PFA-6811438": ["r", "Intra-Golgi traffic"], "PWY-5848": ["t", "cinchona alkaloids biosynthesis"], "PWY-7825": ["t", "juglone degradation"], "PWY-7788": ["t", "erythritol degradation II"], "PWY-6392": ["t", "meso-butanediol biosynthesis II"], "PWY-1186": ["t", "L-homomethionine biosynthesis"], "PWY-8370": ["t", "leporin B biosynthesis"], "PWY-7489": ["t", "oryzalexin A, B, and C biosynthesis"], "PWY-6883": ["t", "pyruvate fermentation to butanol II (engineered)"], "PWY-7568": ["t", "L-galactose degradation"], "PWY-7787": ["t", "L-threitol degradation"], "PWY-6926": ["t", "pyrethrin I biosynthesis"], "PWY-6539": ["t", "(Z)-phenylmethanethial S-oxide biosynthesis"], "PWY-6634": ["t", "3-sulfopropanediol degradation I"], "PWY-5830": ["t", "CDP-ascarylose biosynthesis"], "PWY-8383": ["t", "myxochelin A and B biosynthesis"], "PWY-6704": ["t", "L-ascorbate degradation IV"], "PWY-6583": ["t", "pyruvate fermentation to butanol I"], "PWY-8139": ["t", "CDP-6-deoxy-D-gulose biosynthesis"], "PWY-5652": ["t", "2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA"], "PWY-7774": ["t", "propane degradation I"], "PWY-6693": ["t", "D-galactose degradation IV"], "PWY-6738": ["t", "pinitol biosynthesis I"], "PWY-7331": ["t", "UDP-N-acetyl-beta-L-quinovosamine biosynthesis"], "PWY-7490": ["t", "patulin biosynthesis"], "PWY-7657": ["t", "dTDP-beta-L-digitoxose biosynthesis"], "PWY-5271": ["t", "abscisic acid degradation to phaseic acid"], "PWY-7541": ["t", "1,2-propanediol biosynthesis from lactate (engineered)"], "PWY-6391": ["t", "meso-butanediol biosynthesis I"], "PWY-3261": ["t", "UDP-beta-L-rhamnose biosynthesis"], "PWY-6659": ["t", "fusicoccin A biosynthesis"], "R-GGA-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-GGA-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-GGA-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-XTR-1300642": ["r", "Sperm Motility And Taxes"], "R-HSA-5579006": ["r", "Defective GSS causes GSS deficiency"], "R-HSA-4793954": ["r", "Defective MOGS causes CDG-2b"], "R-GGA-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-HSA-9636467": ["r", "Blockage of phagosome acidification"], "R-RNO-5624138": ["r", "Trafficking of myristoylated proteins to the cilium"], "PWY-4981": ["t", "L-proline biosynthesis II (from arginine)"], "PWY-6661": ["t", "4-hydroxy-2(1H)-quinolone biosynthesis"], "PWY-5958": ["t", "acridone alkaloid biosynthesis"], "PWY-7581": ["t", "N-acetylneuraminate and N-acetylmannosamine degradation II"], "PWY-7552": ["t", "heme b biosynthesis III (from siroheme)"], "PWY-8155": ["t", "testosterone degradation (anaerobic)"], "PWY-6061": ["t", "bile acid biosynthesis, neutral pathway"], "PWY-7636": ["t", "astaxanthin biosynthesis (flowering plants)"], "R-SCE-9959399": ["r", "SLC-mediated transport of oligopeptides"], "R-DDI-9959399": ["r", "SLC-mediated transport of oligopeptides"], "R-BTA-9959399": ["r", "SLC-mediated transport of oligopeptides"], "R-MMU-9959399": ["r", "SLC-mediated transport of oligopeptides"], "R-DME-9959399": ["r", "SLC-mediated transport of oligopeptides"], "R-SCE-5223345": ["r", "Miscellaneous transport and binding events"], "R-HSA-9959399": ["r", "SLC-mediated transport of oligopeptides"], "R-CEL-9959399": ["r", "SLC-mediated transport of oligopeptides"], "PWY-6053": ["t", "dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)"], "PWY-7042": ["t", "the visual cycle (insects)"], "PWY-5867": ["t", "t-anethole biosynthesis"], "PWY-8214": ["t", "3-sulfopropanediol degradation II"], "PWY-7554": ["t", "heme d1 biosynthesis"], "PWY-8409": ["t", "cyathin biosynthesis"], "PWY-8297": ["t", "6-diazo-5-oxo-L-norleucine biosynthesis"], "PWY-6974": ["t", "dTDP-beta-L-olivose biosynthesis"], "PWY-2601": ["t", "isethionate degradation"], "PWY-7043": ["t", "11-cis-3-hydroxyretinal biosynthesis"], "PWY-7520": ["t", "terrequinone A biosynthesis"], "PWY-6863": ["t", "pyruvate fermentation to hexanol (engineered)"], "PWY-3722": ["t", "glycine betaine biosynthesis II (Gram-positive bacteria)"], "PWY-6989": ["t", "(S)-camphor degradation"], "PWY-7649": ["t", "3-hydroxy-L-homotyrosine biosynthesis"], "PWY-5782": ["t", "2-keto-L-gulonate biosynthesis"], "PWY-741": ["t", "p-cymene degradation to p-cumate"], "PWY-7333": ["t", "UDP-N-acetyl-alpha-D-fucosamine biosynthesis"], "R-GGA-75955": ["r", "RNA Polymerase II Transcription Elongation"], "R-DME-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-HSA-4720454": ["r", "Defective ALG9 causes CDG-1l"], "R-CEL-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-DME-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-HSA-4720489": ["r", "Defective ALG12 causes CDG-1g"], "R-DRE-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-GGA-6796648": ["r", "TP53 Regulates Transcription of DNA Repair Genes"], "R-CEL-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-DME-2161517": ["r", "Abacavir transmembrane transport"], "R-XTR-380972": ["r", "Energy dependent regulation of mTOR by LKB1-AMPK"], "R-XTR-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "PWY-4621": ["t", "arsenic detoxification (bacteria)"], "PWY-8264": ["t", "arsenate detoxification I"], "R-CEL-9793528": ["r", "Ciprofloxacin ADME"], "R-DME-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-CEL-2161517": ["r", "Abacavir transmembrane transport"], "R-DRE-561048": ["r", "Organic anion transport by SLC22 transporters"], "R-XTR-446205": ["r", "Synthesis of GDP-mannose"], "R-DRE-446205": ["r", "Synthesis of GDP-mannose"], "PWY-7902": ["t", "glucosylglycerol biosynthesis"], "R-CFA-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-BTA-8869496": ["r", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "R-BTA-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-CEL-9834899": ["r", "Specification of the neural plate border"], "R-CFA-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-CEL-8866907": ["r", "Activation of the TFAP2 (AP-2) family of transcription factors"], "R-RNO-9834899": ["r", "Specification of the neural plate border"], "R-BTA-9834899": ["r", "Specification of the neural plate border"], "R-MMU-9834899": ["r", "Specification of the neural plate border"], "R-BTA-8864260": ["r", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "R-CFA-9834899": ["r", "Specification of the neural plate border"], "R-BTA-8866904": ["r", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "R-BTA-71240": ["r", "Tryptophan catabolism"], "PWY-6892": ["t", "thiazole component of thiamine diphosphate biosynthesis I"], "PWY-6891": ["t", "thiazole component of thiamine diphosphate biosynthesis II"], "R-DME-9861559": ["r", "PDH complex synthesizes acetyl-CoA from PYR"], "R-SCE-9629569": ["r", "Protein hydroxylation"], "PWY-5437": ["t", "L-threonine degradation I"], "PWY-5493": ["t", "reductive monocarboxylic acid cycle"], "PWY-1422": ["t", "vitamin E biosynthesis (tocopherols)"], "PWY-6318": ["t", "L-phenylalanine degradation IV (mammalian, via side chain)"], "PWY-1581": ["t", "plastoquinol-9 biosynthesis I"], "PWY-6134": ["t", "L-tyrosine biosynthesis IV"], "PWY-5049": ["t", "rosmarinic acid biosynthesis II"], "PWY-3581": ["t", "(S)-reticuline biosynthesis I"], "PWY-5394": ["t", "betalamic acid biosynthesis"], "PWY-6133": ["t", "(S)-reticuline biosynthesis II"], "PWY-6030": ["t", "serotonin and melatonin biosynthesis"], "R-PFA-446205": ["r", "Synthesis of GDP-mannose"], "R-HSA-4043911": ["r", "Defective PMM2 causes PMM2-CDG"], "R-DRE-977347": ["r", "Serine metabolism"], "R-XTR-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-DRE-917729": ["r", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "R-XTR-432720": ["r", "Lysosome Vesicle Biogenesis"], "PWY-7999": ["t", "vitamin K-epoxide cycle"], "PWY-7731": ["t", "superpathway of photosynthetic hydrogen production"], "R-DRE-3322077": ["r", "Glycogen synthesis"], "R-DME-3322077": ["r", "Glycogen synthesis"], "R-CFA-1632852": ["r", "Macroautophagy"], "PWY-5630": ["t", "penicillin K biosynthesis"], "R-SPO-1855191": ["r", "Synthesis of IPs in the nucleus"], "R-RNO-1855191": ["r", "Synthesis of IPs in the nucleus"], "R-MMU-1855191": ["r", "Synthesis of IPs in the nucleus"], "R-HSA-1855191": ["r", "Synthesis of IPs in the nucleus"], "R-SCE-1855191": ["r", "Synthesis of IPs in the nucleus"], "R-SPO-70370": ["r", "Galactose catabolism"], "R-SCE-70370": ["r", "Galactose catabolism"], "R-DDI-70370": ["r", "Galactose catabolism"], "R-HSA-5609974": ["r", "Defective PGM1 causes PGM1-CDG"], "R-SSC-446210": ["r", "Synthesis of UDP-N-acetyl-glucosamine"], "PWY-8359": ["t", "taurine biosynthesis III"], "PWY-801": ["t", "homocysteine and cysteine interconversion"], "PWY-5443": ["t", "aminopropanol phosphate biosynthesis I"], "PWY-7274": ["t", "D-cycloserine biosynthesis"], "PWY-7870": ["t", "L-cysteine biosynthesis VII (from S-sulfo-L-cysteine)"], "PWY-8071": ["t", "N-3-oxalyl-L-2,3-diaminopropanoate biosynthesis"], "PWY-7344": ["t", "UDP-alpha-D-galactose biosynthesis"], "R-HSA-5609977": ["r", "Defective GALE causes EDG"], "R-HSA-112122": ["r", "ALKBH2 mediated reversal of alkylation damage"], "R-SSC-983712": ["r", "Ion channel transport"], "R-SSC-9639288": ["r", "Amino acids regulate mTORC1"], "R-HSA-3359478": ["r", "Defective MUT causes MMAM"], "R-HSA-3359475": ["r", "Defective MMAA causes MMA, cblA type"], "R-DME-9840310": ["r", "Glycosphingolipid catabolism"], "R-BTA-8983711": ["r", "OAS antiviral response"], "PWY-5697": ["t", "allantoin degradation to ureidoglycolate I (urea producing)"], "R-DRE-73621": ["r", "Pyrimidine catabolism"], "PWY-7316": ["t", "dTDP-N-acetylviosamine biosynthesis"], "PWY-6942": ["t", "dTDP-D-desosamine biosynthesis"], "PWY-7413": ["t", "dTDP-6-deoxy-alpha-D-allose biosynthesis"], "PWY-7414": ["t", "dTDP-alpha-D-mycaminose biosynthesis"], "PWY-6808": ["t", "dTDP-alpha-D-forosamine biosynthesis"], "PWY-7312": ["t", "dTDP-beta-D-fucofuranose biosynthesis"], "PWY-6953": ["t", "dTDP-3-acetamido-alpha-D-fucose biosynthesis"], "PWY-7315": ["t", "dTDP-N-acetylthomosamine biosynthesis"], "PWY-6610": ["t", "adenine salvage"], "PWY-6599": ["t", "guanine and guanosine salvage II"], "R-XTR-156581": ["r", "Methylation"], "R-SSC-9969896": ["r", "Lanosterol biosynthesis"], "R-DRE-70921": ["r", "Histidine catabolism"], "R-XTR-70921": ["r", "Histidine catabolism"], "PWY-6444": ["t", "benzoate biosynthesis II (CoA-independent, non-beta-oxidative)"], "PWY-6457": ["t", "cinnamoyl-CoA biosynthesis"], "PWY-6853": ["t", "ethene biosynthesis II (microbes)"], "R-DRE-70688": ["r", "Proline catabolism"], "R-BTA-70688": ["r", "Proline catabolism"], "R-BTA-446199": ["r", "Synthesis of dolichyl-phosphate"], "R-PFA-9845576": ["r", "Glycosphingolipid transport"], "R-SCE-75109": ["r", "Triglyceride biosynthesis"], "PWY-5530": ["t", "sorbitol biosynthesis II"], "PWY-8334": ["t", "D-arabinose degradation V"], "R-HSA-5624138": ["r", "Trafficking of myristoylated proteins to the cilium"], "R-DRE-5624138": ["r", "Trafficking of myristoylated proteins to the cilium"], "R-DRE-73762": ["r", "RNA Polymerase I Transcription Initiation"], "PWY-7089": ["t", "taxiphyllin bioactivation"], "R-DME-844456": ["r", "The NLRP3 inflammasome"], "R-CEL-844456": ["r", "The NLRP3 inflammasome"], "R-GGA-844456": ["r", "The NLRP3 inflammasome"], "R-GGA-5676934": ["r", "Protein repair"], "R-XTR-5625740": ["r", "RHO GTPases activate PKNs"], "R-PFA-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-XTR-2393930": ["r", "Phosphate bond hydrolysis by NUDT proteins"], "R-BTA-113501": ["r", "Inhibition of replication initiation of damaged DNA by RB1/E2F1"], "R-MMU-5624138": ["r", "Trafficking of myristoylated proteins to the cilium"], "R-DME-9845576": ["r", "Glycosphingolipid transport"], "PWY-8259": ["t", "arsenic detoxification (plants)"], "PWY-5963": ["t", "molybdenum cofactor sulfulylation (eukaryotes)"], "PWY-6605": ["t", "adenine and adenosine salvage II"], "PWY-7183": ["t", "pyrimidine nucleobases salvage I"], "PWY-7343": ["t", "UDP-alpha-D-glucose biosynthesis"], "PWY-8448": ["t", "D-alanine degradation"], "PWY-8185": ["t", "L-leucine degradation V (oxidative Stickland reaction)"], "PWY-5108": ["t", "L-isoleucine biosynthesis V"], "PWY-8183": ["t", "L-valine degradation III (oxidative Stickland reaction)"], "PWY-7767": ["t", "L-leucine degradation IV (reductive Stickland reaction)"], "R-XTR-5627123": ["r", "RHO GTPases activate PAKs"], "R-XTR-180024": ["r", "DARPP-32 events"], "R-CFA-180024": ["r", "DARPP-32 events"], "R-SPO-727802": ["r", "Transport of nucleotide sugars"], "R-HSA-5579020": ["r", "Defective SLC35D1 causes SCHBCKD"], "R-BTA-727802": ["r", "Transport of nucleotide sugars"], "R-DME-727802": ["r", "Transport of nucleotide sugars"], "R-HSA-727802": ["r", "Transport of nucleotide sugars"], "R-SPO-6787639": ["r", "GDP-fucose biosynthesis"], "R-DDI-727802": ["r", "Transport of nucleotide sugars"], "R-CEL-2022854": ["r", "Keratan sulfate biosynthesis"], "R-HSA-5619078": ["r", "Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)"], "R-MMU-727802": ["r", "Transport of nucleotide sugars"], "R-PFA-1660514": ["r", "Synthesis of PIPs at the Golgi membrane"], "R-DDI-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-CEL-9845576": ["r", "Glycosphingolipid transport"], "R-CEL-5624138": ["r", "Trafficking of myristoylated proteins to the cilium"], "R-SPO-2467813": ["r", "Separation of Sister Chromatids"], "R-SCE-2467813": ["r", "Separation of Sister Chromatids"], "R-CEL-2467813": ["r", "Separation of Sister Chromatids"], "R-GGA-901042": ["r", "Calnexin/calreticulin cycle"], "R-CEL-8964041": ["r", "LDL remodeling"], "PWY-6543": ["t", "4-aminobenzoate biosynthesis I"], "R-BTA-6787639": ["r", "GDP-fucose biosynthesis"], "R-CEL-727802": ["r", "Transport of nucleotide sugars"], "R-HSA-4724289": ["r", "Defective ALG6 causes CDG-1c"], "R-RNO-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-HSA-4724325": ["r", "Defective ALG8 causes CDG-1h"], "R-GGA-446193": ["r", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "R-PFA-5620916": ["r", "VxPx cargo-targeting to cilium"], "R-SSC-5694530": ["r", "Cargo concentration in the ER"], "R-PFA-6807878": ["r", "COPI-mediated anterograde transport"], "R-DDI-5694530": ["r", "Cargo concentration in the ER"], "PWY-6568": ["t", "dermatan sulfate biosynthesis"], "PWY-6567": ["t", "chondroitin sulfate biosynthesis"], "PWY-8358": ["t", "curacin A biosynthesis"], "R-DRE-2022870": ["r", "CS-GAG biosynthesis"], "R-GGA-2022928": ["r", "HS-GAG biosynthesis"], "R-DME-2022923": ["r", "DS-GAG biosynthesis"], "R-DRE-975578": ["r", "Reactions specific to the complex N-glycan synthesis pathway"], "R-DME-2022870": ["r", "CS-GAG biosynthesis"], "R-DRE-2022923": ["r", "DS-GAG biosynthesis"], "R-BTA-176974": ["r", "Unwinding of DNA"], "R-SCE-176974": ["r", "Unwinding of DNA"], "R-SPO-176974": ["r", "Unwinding of DNA"], "R-DDI-176974": ["r", "Unwinding of DNA"], "R-MMU-176974": ["r", "Unwinding of DNA"], "R-CEL-176974": ["r", "Unwinding of DNA"], "R-GGA-1660661": ["r", "Sphingolipid de novo biosynthesis"], "R-GGA-433584": ["r", "Sphingolipid metabolism"], "R-XTR-1660661": ["r", "Sphingolipid de novo biosynthesis"], "PWY-5537": ["t", "pyruvate fermentation to acetate V"], "PWY-5538": ["t", "pyruvate fermentation to acetate VI"], "R-CEL-71064": ["r", "Lysine catabolism"], "R-SPO-1442490": ["r", "Collagen degradation"], "R-DRE-1483213": ["r", "Synthesis of PE"], "R-DME-71064": ["r", "Lysine catabolism"], "R-PFA-8964539": ["r", "Glutamate and glutamine metabolism"], "R-CEL-1483213": ["r", "Synthesis of PE"], "R-DME-1483213": ["r", "Synthesis of PE"], "R-DME-8964539": ["r", "Glutamate and glutamine metabolism"], "R-XTR-4086398": ["r", "Ca2+ pathway"], "R-CEL-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-DME-3238698": ["r", "WNT ligand biogenesis and trafficking"], "R-GGA-4641262": ["r", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "R-CFA-6783984": ["r", "Glycine degradation"], "PWY-1187": ["t", "glucosinolate biosynthesis from homomethionine"], "PWY-7901": ["t", "glucosinolate biosynthesis from tyrosine"], "PWY-2821": ["t", "glucosinolate biosynthesis from phenylalanine"], "PWY-8302": ["t", "S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation"], "PWY-4681": ["t", "kievitone biosynthesis"], "PWY-8389": ["t", "penigequinolone biosynthesis"], "PWY-7998": ["t", "menaquinol-4 biosynthesis II"], "PWY-6262": ["t", "demethylmenaquinol-8 biosynthesis II"], "PWY-8442": ["t", "hyperxanthone E biosynthesis"], "PWY-5802": ["t", "alizarin biosynthesis"], "PWY-7493": ["t", "paxilline and diprenylpaxilline biosynthesis"], "PWY-5815": ["t", "rubber biosynthesis"], "PWY-5817": ["t", "dodecaprenyl diphosphate biosynthesis"], "PWY-7540": ["t", "aflatrem biosynthesis"], "PWY-8388": ["t", "aspoquinolone biosynthesis"], "R-RNO-71737": ["r", "Pyrophosphate hydrolysis"], "R-DRE-71737": ["r", "Pyrophosphate hydrolysis"], "R-BTA-71737": ["r", "Pyrophosphate hydrolysis"], "R-MMU-71737": ["r", "Pyrophosphate hydrolysis"], "R-HSA-71737": ["r", "Pyrophosphate hydrolysis"], "PWY-7376": ["t", "cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)"], "PWY-7573": ["t", "GDP-mycosamine biosynthesis"], "PWY-5739": ["t", "GDP-D-perosamine biosynthesis"], "PWY-8225": ["t", "GDP-N-acetyl-alpha-D-perosamine biosynthesis"], "PWY-5738": ["t", "GDP-6-deoxy-D-talose biosynthesis"], "PWY-5740": ["t", "GDP-L-colitose biosynthesis"], "PWY-66": ["t", "GDP-L-fucose biosynthesis I (from GDP-D-mannose)"], "PWY-7856": ["t", "heme a biosynthesis"], "R-GGA-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "PWY-5708": ["t", "ethiin metabolism"], "PWY-6900": ["t", "(Z)-butanethial-S-oxide biosynthesis"], "R-BTA-5685939": ["r", "HDR through MMEJ (alt-NHEJ)"], "PWY-5656": ["t", "mannosylglycerate biosynthesis I"], "PWY-5087": ["t", "L-glutamate degradation VI (to pyruvate)"], "R-DME-73621": ["r", "Pyrimidine catabolism"], "R-GGA-73621": ["r", "Pyrimidine catabolism"], "PWY-6696": ["t", "oxalate degradation III"], "PWY-7985": ["t", "oxalate degradation VI"], "PWY-1881": ["t", "formate oxidation to CO2"], "PWY-6038": ["t", "citrate degradation"], "R-XTR-432722": ["r", "Golgi Associated Vesicle Biogenesis"], "R-XTR-2672351": ["r", "Stimuli-sensing channels"], "R-DDI-1483115": ["r", "Hydrolysis of LPC"], "R-DDI-1482922": ["r", "Acyl chain remodelling of PI"], "R-DDI-1482839": ["r", "Acyl chain remodelling of PE"], "R-DDI-1482788": ["r", "Acyl chain remodelling of PC"], "R-XTR-5423646": ["r", "Aflatoxin activation and detoxification"], "R-DRE-5423646": ["r", "Aflatoxin activation and detoxification"], "R-DME-77288": ["r", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "R-BTA-77288": ["r", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "R-DME-77348": ["r", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "R-DME-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-HSA-9914355": ["r", "Isovaleric acidemia"], "R-CEL-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-CEL-6807047": ["r", "Cholesterol biosynthesis via desmosterol (Bloch pathway)"], "R-DRE-425410": ["r", "Metal ion SLC transporters"], "R-SCE-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-SPO-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-CEL-2162123": ["r", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "R-CEL-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-SSC-2160916": ["r", "Hyaluronan degradation"], "R-HSA-9953080": ["r", "MPS VII - Sly syndrome (CS/DS degradation)"], "R-SSC-2024101": ["r", "CS/DS degradation"], "R-HSA-2206292": ["r", "MPS VII - Sly syndrome (Hyaluronan metabolism)"], "R-CEL-8853383": ["r", "Lysosomal oligosaccharide catabolism"], "PWY-7778": ["t", "2-methylpropene degradation"], "PWY-5177": ["t", "glutaryl-CoA degradation"], "R-SSC-77352": ["r", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "R-XTR-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-XTR-76042": ["r", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "R-XTR-73779": ["r", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"], "R-XTR-75953": ["r", "RNA Polymerase II Transcription Initiation"], "R-XTR-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-SCE-9770562": ["r", "mRNA Polyadenylation"], "R-XTR-399956": ["r", "CRMPs in Sema3A signaling"], "R-GGA-399956": ["r", "CRMPs in Sema3A signaling"], "R-CFA-6803544": ["r", "Ion influx/efflux at host-pathogen interface"], "R-DRE-75109": ["r", "Triglyceride biosynthesis"], "R-XTR-75109": ["r", "Triglyceride biosynthesis"], "R-CEL-192105": ["r", "Synthesis of bile acids and bile salts"], "R-BTA-1369062": ["r", "ABC transporters in lipid homeostasis"], "R-DRE-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-GGA-204005": ["r", "COPII-mediated vesicle transport"], "PWY-7426": ["t", "complex N-linked glycan biosynthesis (vertebrates)"], "R-GGA-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-BTA-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-RNO-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-SSC-2465910": ["r", "MASTL Facilitates Mitotic Progression"], "R-BTA-4641265": ["r", "Repression of WNT target genes"], "R-SSC-977347": ["r", "Serine metabolism"], "R-HSA-5339700": ["r", "Signaling by TCF7L2 mutants"], "R-XTR-917937": ["r", "Iron uptake and transport"], "R-DDI-8949215": ["r", "Mitochondrial calcium ion transport"], "R-SCE-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-SPO-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-XTR-5693568": ["r", "Resolution of D-loop Structures through Holliday Junction Intermediates"], "R-DME-420597": ["r", "Nectin/Necl trans heterodimerization"], "R-BTA-8849175": ["r", "Threonine catabolism"], "R-DME-8849175": ["r", "Threonine catabolism"], "R-CEL-8849175": ["r", "Threonine catabolism"], "R-GGA-5223345": ["r", "Miscellaneous transport and binding events"], "R-HSA-4687000": ["r", "Defective MPDU1 causes CDG-1f"], "PWY-6915": ["t", "pentalenolactone biosynthesis"], "PWY-6086": ["t", "4-chloro-2-methylphenoxyacetate degradation"], "PWY-8080": ["t", "kainate biosynthesis"], "PWY-7398": ["t", "coumarins biosynthesis (engineered)"], "PWY-6085": ["t", "2,4-dichlorophenoxyacetate degradation"], "PWY-7232": ["t", "gibberellin biosynthesis V"], "PWY-6919": ["t", "neopentalenoketolactone and pentalenate biosynthesis"], "PWY-5349": ["t", "esculetin biosynthesis"], "PWY-5036": ["t", "gibberellin biosynthesis II (early C-3 hydroxylation)"], "PWY-5070": ["t", "gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)"], "PWY-8360": ["t", "hectochlorin biosynthesis"], "PWY-8083": ["t", "domoic acid biosynthesis"], "PWY-5035": ["t", "gibberellin biosynthesis III (early C-13 hydroxylation)"], "PWY-102": ["t", "gibberellin inactivation I (2beta-hydroxylation)"], "PWY-5047": ["t", "gibberellin biosynthesis IV (Gibberella fujikuroi)"], "PWY-5283": ["t", "L-lysine degradation V"], "R-CFA-8866423": ["r", "VLDL assembly"], "R-CFA-8964046": ["r", "VLDL clearance"], "R-SPO-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-DDI-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-SCE-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-BTA-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "R-CFA-8963888": ["r", "Chylomicron assembly"], "R-CFA-975634": ["r", "Retinoid metabolism and transport"], "R-CFA-8963901": ["r", "Chylomicron remodeling"], "R-GGA-353248": ["r", "DNA damage recognition in global genomic repair"], "R-CFA-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-CFA-9913351": ["r", "Formation of the dystrophin-glycoprotein complex (DGC)"], "R-CFA-9010553": ["r", "Regulation of expression of SLITs and ROBOs"], "R-CFA-8932506": ["r", "DAG1 core M1 glycosylations"], "R-CFA-8932504": ["r", "DAG1 core M2 glycosylations"], "R-CFA-8932505": ["r", "DAG1 core M3 glycosylations"], "PWY-8263": ["t", "arsenate detoxification III"], "R-MMU-975574": ["r", "Reactions specific to the hybrid N-glycan synthesis pathway"], "R-HSA-975574": ["r", "Reactions specific to the hybrid N-glycan synthesis pathway"], "R-RNO-975574": ["r", "Reactions specific to the hybrid N-glycan synthesis pathway"], "R-BTA-2559584": ["r", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "R-CFA-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "R-BTA-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "R-SSC-264870": ["r", "Caspase-mediated cleavage of cytoskeletal proteins"], "PWY-6483": ["t", "ceramide degradation (generic)"], "R-BTA-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-DME-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-DRE-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-RNO-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-MMU-112314": ["r", "Neurotransmitter receptors and postsynaptic signal transmission"], "R-DME-4085001": ["r", "Sialic acid metabolism"], "PWY-6681": ["t", "neurosporaxanthin biosynthesis"], "PWY-7906": ["t", "rhizobitoxine biosynthesis"], "PWY-7372": ["t", "demethylmenaquinol-6 biosynthesis II"], "PWY-5893": ["t", "tridecaprenyl diphosphate biosynthesis"], "PWY-6403": ["t", "carrageenan biosynthesis"], "PWY-5816": ["t", "all trans undecaprenyl diphosphate biosynthesis"], "PWY-4502": ["t", "wighteone and luteone biosynthesis"], "PWY-7572": ["t", "lolitrem B biosynthesis"], "PWY-8010": ["t", "L-cysteine biosynthesis IX (Trichomonas vaginalis)"], "PWY-8190": ["t", "L-glutamate degradation XI (reductive Stickland reaction)"], "PWY-6931": ["t", "seleno-amino acid detoxification and volatilization I"], "PWY-6933": ["t", "seleno-amino acid detoxification and volatilization III"], "PWY-7793": ["t", "dimethyl sulfide biosynthesis from methionine"], "PWY-5084": ["t", "2-oxoglutarate decarboxylation to succinyl-CoA"], "PWY-5046": ["t", "2-oxoisovalerate decarboxylation to isobutanoyl-CoA"], "R-DRE-174403": ["r", "Glutathione synthesis and recycling"], "R-DRE-70635": ["r", "Urea cycle"], "R-XTR-9758890": ["r", "Transport of RCbl within the body"], "R-XTR-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-DRE-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-GGA-9758881": ["r", "Uptake of dietary cobalamins into enterocytes"], "R-GGA-9758890": ["r", "Transport of RCbl within the body"], "R-DRE-9758890": ["r", "Transport of RCbl within the body"], "R-XTR-204005": ["r", "COPII-mediated vesicle transport"], "R-XTR-5694530": ["r", "Cargo concentration in the ER"], "R-HSA-9956514": ["r", "ARG1 variants cause hyperargininemia"], "R-PFA-70635": ["r", "Urea cycle"], "R-SSC-70635": ["r", "Urea cycle"], "R-XTR-196836": ["r", "Vitamin C (ascorbate) metabolism"], "PWY-6556": ["t", "pyrimidine ribonucleosides salvage II"], "PWY-4722": ["t", "creatinine degradation II"], "PWY-6898": ["t", "thiamine diphosphate salvage III"], "PWY-6908": ["t", "thiamine diphosphate biosynthesis IV (eukaryotes)"], "PWY-6907": ["t", "thiamine diphosphate biosynthesis III (Staphylococcus)"], "PWY-6894": ["t", "thiamine diphosphate biosynthesis I (E. coli)"], "PWY-6893": ["t", "thiamine diphosphate biosynthesis II (Bacillus)"], "PWY-6896": ["t", "thiamine diphosphate salvage I"], "PWY-1801": ["t", "formaldehyde oxidation II (glutathione-dependent)"], "R-XTR-444473": ["r", "Formyl peptide receptors bind formyl peptides and many other ligands"], "R-XTR-418594": ["r", "G alpha (i) signalling events"], "PWY-8465": ["t", "(1R)-(2-amino-1-hydroxyethyl)phosphonate degradation"], "PWY-7425": ["t", "2-chloroacrylate degradation I"], "PWY-5787": ["t", "oligomeric urushiol biosynthesis"], "PWY-5476": ["t", "cornusiin E biosynthesis"], "PWY-5439": ["t", "betacyanin biosynthesis (via dopamine)"], "R-XTR-3214858": ["r", "RMTs methylate histone arginines"], "R-XTR-8939243": ["r", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "R-MMU-6787450": ["r", "tRNA modification in the mitochondrion"], "R-RNO-6787450": ["r", "tRNA modification in the mitochondrion"], "R-BTA-6787450": ["r", "tRNA modification in the mitochondrion"], "PWY-8074": ["t", "Kdo transfer to lipid IVA (P. putida)"], "PWY-8246": ["t", "Kdo transfer to lipid IVA (P. gingivalis)"], "PWY-8284": ["t", "Kdo transfer to lipid IVA (Vibrio cholerae serogroup O1 El Tor)"], "PWY-7675": ["t", "Kdo transfer to lipid IVA (Haemophilus)"], "R-GGA-212436": ["r", "Generic Transcription Pathway"], "PWY-5254": ["t", "methanofuran biosynthesis"], "R-BTA-1234158": ["r", "Regulation of gene expression by Hypoxia-inducible Factor"], "R-HSA-4570571": ["r", "Defective RFT1 causes CDG-1n"], "R-DME-6798163": ["r", "Choline catabolism"], "R-DDI-9958517": ["r", "SLC-mediated bile acid transport"], "R-XTR-9958517": ["r", "SLC-mediated bile acid transport"], "R-DDI-6798163": ["r", "Choline catabolism"], "R-BTA-9958517": ["r", "SLC-mediated bile acid transport"], "R-XTR-1483191": ["r", "Synthesis of PC"], "R-SSC-9958517": ["r", "SLC-mediated bile acid transport"], "R-DRE-9958517": ["r", "SLC-mediated bile acid transport"], "PWY-5247": ["t", "methanogenesis from methylamine"], "R-DDI-2142753": ["r", "Arachidonate metabolism"], "R-SPO-9640463": ["r", "Wax biosynthesis"], "R-XTR-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-DDI-9640463": ["r", "Wax biosynthesis"], "R-SPO-75109": ["r", "Triglyceride biosynthesis"], "R-HSA-9640463": ["r", "Wax biosynthesis"], "R-SCE-9640463": ["r", "Wax biosynthesis"], "R-MMU-9640463": ["r", "Wax biosynthesis"], "R-DRE-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "R-SCE-1482883": ["r", "Acyl chain remodeling of DAG and TAG"], "PWY-8341": ["t", "N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis"], "PWY-7466": ["t", "acetone degradation III (to propane-1,2-diol)"], "PWY-5451": ["t", "acetone degradation I (to methylglyoxal)"], "PWY-6398": ["t", "melatonin degradation I"], "R-XTR-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "R-XTR-2142789": ["r", "Ubiquinol biosynthesis"], "PWY-6745": ["t", "phytochelatins biosynthesis"], "R-DRE-6787639": ["r", "GDP-fucose biosynthesis"], "R-PFA-204005": ["r", "COPII-mediated vesicle transport"], "R-PFA-8876198": ["r", "RAB GEFs exchange GTP for GDP on RABs"], "R-XTR-6804115": ["r", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "R-CFA-9864848": ["r", "Complex IV assembly"], "R-CFA-9772755": ["r", "Formation of WDR5-containing histone-modifying complexes"], "R-CFA-201722": ["r", "Formation of the beta-catenin:TCF transactivating complex"], "PWY-7920": ["t", "complex N-linked glycan biosynthesis (plants)"], "R-HSA-4793952": ["r", "Defective MGAT2 causes CDG-2a"], "PWY-7126": ["t", "ethene biosynthesis IV (engineered)"], "R-HSA-2206282": ["r", "MPS IIIB - Sanfilippo syndrome B"], "PWY-4841": ["t", "UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)"], "PWY-8142": ["t", "L-ascorbate biosynthesis VI (plants, myo-inositol pathway)"], "R-DRE-1855183": ["r", "Synthesis of IP2, IP, and Ins in the cytosol"], "R-SCE-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-DME-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-SPO-210455": ["r", "Astrocytic Glutamate-Glutamine Uptake And Metabolism"], "R-CEL-68616": ["r", "Assembly of the ORC complex at the origin of replication"], "R-BTA-70350": ["r", "Fructose catabolism"], "R-XTR-1268020": ["r", "Mitochondrial protein import"], "R-HSA-4720475": ["r", "Defective ALG3 causes CDG-1d"], "R-DME-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-SPO-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-PFA-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-PFA-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-CEL-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-SCE-71737": ["r", "Pyrophosphate hydrolysis"], "R-DDI-71737": ["r", "Pyrophosphate hydrolysis"], "R-MMU-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-SPO-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-CEL-71737": ["r", "Pyrophosphate hydrolysis"], "R-PFA-71737": ["r", "Pyrophosphate hydrolysis"], "R-DDI-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-DME-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-DDI-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-SCE-379726": ["r", "Mitochondrial tRNA aminoacylation"], "R-BTA-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-DME-71737": ["r", "Pyrophosphate hydrolysis"], "R-MMU-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-CEL-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-SCE-379716": ["r", "Cytosolic tRNA aminoacylation"], "R-SPO-71737": ["r", "Pyrophosphate hydrolysis"], "PWY-5705": ["t", "allantoin degradation to glyoxylate III"], "PWY-5694": ["t", "allantoin degradation to glyoxylate I"], "R-DDI-9969901": ["r", "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)"], "R-HSA-9931929": ["r", "Defective GALM causes GALAC4"], "R-SSC-70370": ["r", "Galactose catabolism"], "R-DME-176974": ["r", "Unwinding of DNA"], "R-SCE-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-RNO-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-DDI-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-SPO-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-SPO-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-HSA-5619037": ["r", "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)"], "R-CEL-4085001": ["r", "Sialic acid metabolism"], "R-HSA-5663020": ["r", "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)"], "R-CFA-727802": ["r", "Transport of nucleotide sugars"], "R-SPO-4085001": ["r", "Sialic acid metabolism"], "R-CEL-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-RNO-727802": ["r", "Transport of nucleotide sugars"], "R-HSA-5619083": ["r", "Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)"], "R-HSA-5619072": ["r", "Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)"], "R-SSC-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-SSC-425410": ["r", "Metal ion SLC transporters"], "R-GGA-71403": ["r", "Citric acid cycle (TCA cycle)"], "R-XTR-9865881": ["r", "Complex III assembly"], "R-BTA-5624958": ["r", "ARL13B-mediated ciliary trafficking of INPP5E"], "R-CFA-5624958": ["r", "ARL13B-mediated ciliary trafficking of INPP5E"], "R-PFA-6782210": ["r", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "R-PFA-6781823": ["r", "Formation of TC-NER Pre-Incision Complex"], "R-PFA-73776": ["r", "RNA Polymerase II Promoter Escape"], "R-PFA-77075": ["r", "RNA Pol II CTD phosphorylation and interaction with CE"], "R-PFA-72086": ["r", "mRNA Capping"], "R-PFA-674695": ["r", "RNA Polymerase II Pre-transcription Events"], "R-PFA-113418": ["r", "Formation of the Early Elongation Complex"], "R-PFA-72203": ["r", "Processing of Capped Intron-Containing Pre-mRNA"], "R-HSA-191273": ["r", "Cholesterol biosynthesis"], "R-DDI-191273": ["r", "Cholesterol biosynthesis"], "R-SPO-191273": ["r", "Cholesterol biosynthesis"], "R-SCE-191273": ["r", "Cholesterol biosynthesis"], "R-MMU-191273": ["r", "Cholesterol biosynthesis"], "R-CEL-162710": ["r", "Synthesis of glycosylphosphatidylinositol (GPI)"], "PWY-6825": ["t", "phosphatidylcholine biosynthesis V"], "PWY-5651": ["t", "L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde"], "PWY-6019": ["t", "pseudouridine degradation"], "R-DME-418990": ["r", "Adherens junctions interactions"], "PWY-7934": ["t", "polybrominated dihydroxylated diphenyl ethers biosynthesis"], "PWY-5755": ["t", "4-hydroxybenzoate biosynthesis II (bacteria)"], "PWY-7935": ["t", "spongiadioxin C biosynthesis"], "PWY-7929": ["t", "polybrominated phenols biosynthesis"], "PWY-7889": ["t", "tRNA-uridine 2-thiolation (mammalian mitochondria)"], "PWY-5303": ["t", "thiosulfate oxidation II (via tetrathionate)"], "PWY-8164": ["t", "bis(guanylyl molybdopterin) cofactor sulfurylation"], "PWY-6675": ["t", "sulfur oxidation IV (intracellular sulfur)"], "PWY-7891": ["t", "tRNA-uridine 2-thiolation (yeast mitochondria)"], "PWY-7802": ["t", "N-end rule pathway II (prokaryotic)"], "R-GGA-389357": ["r", "CD28 dependent PI3K/Akt signaling"], "R-HSA-5578995": ["r", "Defective TPMT causes TPMT deficiency"], "R-CFA-156581": ["r", "Methylation"], "R-DRE-9845614": ["r", "Sphingolipid catabolism"], "R-SSC-163282": ["r", "Mitochondrial transcription initiation"], "R-SSC-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-SPO-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-XTR-9856649": ["r", "Transcriptional and post-translational regulation of MITF-M expression and activity"], "R-XTR-4641265": ["r", "Repression of WNT target genes"], "R-CFA-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-XTR-8878166": ["r", "Transcriptional regulation by RUNX2"], "R-CFA-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-CEL-163282": ["r", "Mitochondrial transcription initiation"], "R-CFA-3000471": ["r", "Scavenging by Class B Receptors"], "R-CEL-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-DDI-879415": ["r", "Advanced glycosylation endproduct receptor signaling"], "R-SPO-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-XTR-9825892": ["r", "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation"], "R-CFA-933542": ["r", "TRAF6 mediated NF-kB activation"], "R-GGA-8878166": ["r", "Transcriptional regulation by RUNX2"], "PWY-7165": ["t", "L-ascorbate biosynthesis VIII (engineered pathway)"], "R-BTA-2161541": ["r", "Abacavir metabolism"], "R-XTR-74259": ["r", "Purine catabolism"], "R-XTR-2161541": ["r", "Abacavir metabolism"], "PWY-6986": ["t", "alginate degradation"], "R-MMU-9033500": ["r", "TYSND1 cleaves peroxisomal proteins"], "R-SSC-8963901": ["r", "Chylomicron remodeling"], "R-SSC-8964058": ["r", "HDL remodeling"], "PWY-5947": ["t", "lutein biosynthesis"], "PWY-7938": ["t", "isorenieratene biosynthesis I (actinobacteria)"], "PWY-7947": ["t", "flexixanthin biosynthesis"], "PWY-5946": ["t", "alpha-carotene biosynthesis"], "PWY-7939": ["t", "chlorobactene biosynthesis"], "PWY-5943": ["t", "beta-carotene biosynthesis"], "R-SCE-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-SCE-5686938": ["r", "Regulation of TLR by endogenous ligand"], "R-CFA-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-DDI-163282": ["r", "Mitochondrial transcription initiation"], "R-DDI-140342": ["r", "Apoptosis induced DNA fragmentation"], "R-DME-1483255": ["r", "PI Metabolism"], "R-XTR-1483255": ["r", "PI Metabolism"], "R-BTA-1483255": ["r", "PI Metabolism"], "R-DRE-1483255": ["r", "PI Metabolism"], "R-RNO-1483255": ["r", "PI Metabolism"], "R-MMU-1483255": ["r", "PI Metabolism"], "R-GGA-1483255": ["r", "PI Metabolism"], "R-HSA-1483255": ["r", "PI Metabolism"], "R-RNO-176974": ["r", "Unwinding of DNA"], "R-SSC-429958": ["r", "mRNA decay by 3' to 5' exoribonuclease"], "R-BTA-72662": ["r", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "PWY-6554": ["t", "1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)"], "PWY-6362": ["t", "1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)"], "R-GGA-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-BTA-389599": ["r", "Alpha-oxidation of phytanate"], "R-CEL-389599": ["r", "Alpha-oxidation of phytanate"], "PWY-5337": ["t", "stachyose biosynthesis"], "PWY-6524": ["t", "lychnose and isolychnose biosynthesis"], "PWY-6047": ["t", "dimethyl sulfide degradation I"], "R-GGA-5218920": ["r", "VEGFR2 mediated vascular permeability"], "PWY-8165": ["t", "cytidylyl molybdenum cofactor sulfurylation"], "PWY-8452": ["t", "L-cysteine degradation IV"], "PWY-5526": ["t", "bacteriochlorophyll a biosynthesis"], "R-MMU-8941413": ["r", "Events associated with phagocytolytic activity of PMN cells"], "R-BTA-8941413": ["r", "Events associated with phagocytolytic activity of PMN cells"], "R-HSA-8941413": ["r", "Events associated with phagocytolytic activity of PMN cells"], "R-DDI-8941413": ["r", "Events associated with phagocytolytic activity of PMN cells"], "R-SSC-75108": ["r", "Activation, myristolyation of BID and translocation to mitochondria"], "R-RNO-111452": ["r", "Activation and oligomerization of BAK protein"], "R-SSC-111447": ["r", "Activation of BAD and translocation to mitochondria"], "R-SSC-114294": ["r", "Activation, translocation and oligomerization of BAX"], "R-SSC-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-SSC-111452": ["r", "Activation and oligomerization of BAK protein"], "PWY-8454": ["t", "aspartame degradation"], "PWY-6303": ["t", "methyl indole-3-acetate interconversion"], "R-XTR-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "R-DRE-1474151": ["r", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "PWY-5279": ["t", "sulfite oxidation II"], "PWY-6754": ["t", "S-methyl-5'-thioadenosine degradation I"], "R-HSA-9837092": ["r", "FASTK family proteins regulate processing and stability of mitochondrial RNAs"], "PWY-6361": ["t", "1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)"], "R-DRE-1855191": ["r", "Synthesis of IPs in the nucleus"], "R-DRE-1855167": ["r", "Synthesis of pyrophosphates in the cytosol"], "R-BTA-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-XTR-6811438": ["r", "Intra-Golgi traffic"], "PWY-5098": ["t", "chlorophyll a degradation I"], "PWY-6927": ["t", "chlorophyll a degradation II"], "PWY-7873": ["t", "D-erythronate degradation II"], "PWY-7874": ["t", "L-threonate degradation"], "R-HSA-9646304": ["r", "Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects"], "R-HSA-9646303": ["r", "Evasion of Oncogene Induced Senescence Due to p14ARF Defects"], "R-XTR-9696273": ["r", "RND1 GTPase cycle"], "R-XTR-9768727": ["r", "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane"], "R-RNO-162791": ["r", "Attachment of GPI anchor to uPAR"], "R-SSC-844456": ["r", "The NLRP3 inflammasome"], "R-XTR-8963889": ["r", "Assembly of active LPL and LIPC lipase complexes"], "PWY-7536": ["t", "2-amino-3-hydroxycyclopent-2-enone biosynthesis"], "R-CFA-425410": ["r", "Metal ion SLC transporters"], "PWY-6055": ["t", "dimethylsulfoniopropanoate biosynthesis II (Spartina)"], "PWY-8037": ["t", "saliniketal A biosynthesis"], "PWY-8376": ["t", "benzene degradation III (anaerobic)"], "PWY-7620": ["t", "naphthalene degradation (anaerobic)"], "PWY-6633": ["t", "caffeine degradation V (bacteria, via trimethylurate)"], "PWY-6959": ["t", "L-ascorbate degradation V"], "PWY-5113": ["t", "UDP-D-apiose biosynthesis (from UDP-D-glucuronate)"], "PWY-6935": ["t", "seleno-amino acid detoxification and volatilization II"], "PWY-3385": ["t", "choline biosynthesis I"], "PWY-7480": ["t", "2,3-dihydroxybenzoate degradation"], "PWY-8387": ["t", "microcin C biosynthesis"], "PWY-2721": ["t", "trehalose degradation III"], "PWY-7459": ["t", "kojibiose degradation"], "R-DRE-5223345": ["r", "Miscellaneous transport and binding events"], "R-RNO-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-HSA-9616334": ["r", "Defective Base Excision Repair Associated with NEIL1"], "R-MMU-110328": ["r", "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"], "R-SSC-449836": ["r", "Other interleukin signaling"], "PWY-882": ["t", "L-ascorbate biosynthesis I (plants, L-galactose pathway)"], "R-GGA-9674555": ["r", "Signaling by CSF3 (G-CSF)"], "PWY-6756": ["t", "S-methyl-5'-thioadenosine degradation II"], "PWY-6505": ["t", "L-tryptophan degradation XII (Geobacillus)"], "PWY-5647": ["t", "2-nitrobenzoate degradation I"], "R-HSA-448424": ["r", "Interleukin-17 signaling"], "PWY-5250": ["t", "methanogenesis from trimethylamine"], "PWY-6876": ["t", "isopropanol biosynthesis (engineered)"], "PWY-6588": ["t", "pyruvate fermentation to acetone"], "PWY-7420": ["t", "monoacylglycerol metabolism (yeast)"], "R-SCE-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-DRE-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-XTR-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-SPO-77346": ["r", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "R-DME-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-SSC-9840310": ["r", "Glycosphingolipid catabolism"], "R-DRE-6811440": ["r", "Retrograde transport at the Trans-Golgi-Network"], "PWY-3561": ["t", "choline biosynthesis III"], "PWY-7437": ["t", "protein O-[N-acetyl]-glucosylation"], "R-SPO-181430": ["r", "Norepinephrine Neurotransmitter Release Cycle"], "R-SCE-9707616": ["r", "Heme signaling"], "R-HSA-5619035": ["r", "Defective SLC17A5 causes Salla disease (SD) and ISSD"], "R-HSA-5619071": ["r", "Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"], "R-SPO-212676": ["r", "Dopamine Neurotransmitter Release Cycle"], "R-SCE-879518": ["r", "Organic anion transport by SLCO transporters"], "R-HSA-5619076": ["r", "Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)"], "R-CEL-427652": ["r", "Sodium-coupled phosphate cotransporters"], "R-SPO-181429": ["r", "Serotonin Neurotransmitter Release Cycle"], "R-XTR-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-DRE-442660": ["r", "SLC-mediated transport of neurotransmitters"], "R-CEL-189451": ["r", "Heme biosynthesis"], "R-DRE-196757": ["r", "Metabolism of folate and pterines"], "R-DRE-9707616": ["r", "Heme signaling"], "R-XTR-442660": ["r", "SLC-mediated transport of neurotransmitters"], "PWY-5760": ["t", "beta-alanine biosynthesis IV"], "PWY-6054": ["t", "dimethylsulfoniopropanoate biosynthesis I (Wollastonia)"], "PWY-7494": ["t", "choline degradation IV"], "PWY-3981": ["t", "beta-alanine biosynthesis I"], "PWY-7836": ["t", "ganglio-series glycosphingolipids biosynthesis"], "PWY-7277": ["t", "sphingolipid biosynthesis (mammals)"], "R-SPO-389599": ["r", "Alpha-oxidation of phytanate"], "PWY-5064": ["t", "chlorophyll a biosynthesis II"], "PWY-8127": ["t", "chlorophyll b2 biosynthesis"], "PWY-8126": ["t", "chlorophyll a2 biosynthesis"], "PWY-7764": ["t", "chlorophyll a biosynthesis III"], "PWY-5086": ["t", "chlorophyll a biosynthesis I"], "PWY-5068": ["t", "chlorophyll cycle"], "PWY-7052": ["t", "cyanophycin metabolism"], "PWY-7469": ["t", "gentisate degradation II"], "PWY-6420": ["t", "pyrroloquinoline quinone biosynthesis"], "PWY-7102": ["t", "bisabolene biosynthesis (engineered)"], "PWY-6859": ["t", "all-trans-farnesol biosynthesis"], "PWY-7710": ["t", "FeMo cofactor biosynthesis"], "PWY-1341": ["t", "phenylacetate degradation II (anaerobic)"], "PWY-8275": ["t", "pyruvate decarboxylation to acetyl CoA III"], "PWY-5600": ["t", "pyruvate fermentation to acetate VII"], "PWY-8189": ["t", "L-alanine degradation V (oxidative Stickland reaction)"], "PWY-5483": ["t", "pyruvate fermentation to acetate III"], "PWY-7857": ["t", "adlupulone and adhumulone biosynthesis"], "PWY-8328": ["t", "acetate and ATP formation from acetyl-CoA III"], "PWY-5133": ["t", "colupulone and cohumulone biosynthesis"], "PWY-5132": ["t", "lupulone and humulone biosynthesis"], "PWY-8285": ["t", "(Kdo)2-lipid A biosynthesis (generic)"], "PWY-8378": ["t", "Kdo-lipid A biosynthesis (Vibrio cholerae serogroup O1 El Tor)"], "R-GGA-174417": ["r", "Telomere C-strand (Lagging Strand) Synthesis"], "R-GGA-174414": ["r", "Processive synthesis on the C-strand of the telomere"], "R-GGA-174430": ["r", "Telomere C-strand synthesis initiation"], "R-GGA-171319": ["r", "Telomere Extension By Telomerase"], "R-BTA-9824585": ["r", "Regulation of MITF-M-dependent genes involved in pigmentation"], "R-RNO-163358": ["r", "PKA-mediated phosphorylation of key metabolic factors"], "R-DRE-6807062": ["r", "Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)"], "R-CEL-163358": ["r", "PKA-mediated phosphorylation of key metabolic factors"], "R-DRE-2470946": ["r", "Cohesin Loading onto Chromatin"], "R-HSA-5657562": ["r", "Essential fructosuria"], "PWY-5676": ["t", "acetyl-CoA fermentation to butanoate"], "PWY-5741": ["t", "ethylmalonyl-CoA pathway"], "PWY-8425": ["t", "(2S)-ethylmalonyl-CoA biosynthesis"], "PWY-5031": ["t", "L-histidine degradation V"], "PWY-5481": ["t", "pyruvate fermentation to (S)-lactate"], "R-DRE-2468052": ["r", "Establishment of Sister Chromatid Cohesion"], "R-MMU-428559": ["r", "Proton-coupled neutral amino acid transporters"], "R-CEL-428559": ["r", "Proton-coupled neutral amino acid transporters"], "R-DME-428559": ["r", "Proton-coupled neutral amino acid transporters"], "PWY-7431": ["t", "aromatic biogenic amine degradation (bacteria)"], "PWY-6839": ["t", "2-aminoethylphosphonate biosynthesis"], "PWY-8067": ["t", "methylphosphonate biosynthesis"], "PWY-6832": ["t", "2-aminoethylphosphonate degradation II"], "R-RNO-428559": ["r", "Proton-coupled neutral amino acid transporters"], "R-HSA-5619041": ["r", "Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)"], "R-DRE-210500": ["r", "Glutamate Neurotransmitter Release Cycle"], "R-HSA-428559": ["r", "Proton-coupled neutral amino acid transporters"], "R-SCE-888590": ["r", "GABA synthesis, release, reuptake and degradation"], "R-CEL-9861718": ["r", "Regulation of pyruvate metabolism"], "PWY-6050": ["t", "dimethyl sulfoxide degradation"], "PWY-5336": ["t", "carbon disulfide oxidation II (aerobic)"], "PWY-7462": ["t", "3,3'-disulfanediyldipropannoate degradation"], "PWY-5768": ["t", "pyruvate fermentation to acetate VIII"], "PWY-6330": ["t", "acetaldehyde biosynthesis II"], "PWY-6873": ["t", "long chain fatty acid ester synthesis (engineered)"], "PWY-381": ["t", "nitrate reduction II (assimilatory)"], "PWY-3161": ["t", "indole-3-acetate biosynthesis III (bacteria)"], "R-SCE-211945": ["r", "Phase I - Functionalization of compounds"], "PWY-7806": ["t", "glyphosate degradation II"], "PWY-7700": ["t", "4-methylphenol degradation to protocatechuate"], "PWY-6215": ["t", "4-chlorobenzoate degradation"], "PWY-8002": ["t", "4-coumarate degradation (aerobic)"], "PWY-6131": ["t", "glycerol degradation II"], "PWY-8003": ["t", "trans-caffeate degradation (aerobic)"], "PWY-6432": ["t", "curcuminoid biosynthesis"], "PWY-6040": ["t", "chlorogenic acid biosynthesis II"], "PWY-7046": ["t", "4-coumarate degradation (anaerobic)"], "PWY-6982": ["t", "umbelliferone biosynthesis"], "PWY-723": ["t", "alkylnitronates degradation"], "PWY-5675": ["t", "nitrate reduction V (assimilatory)"], "PWY-7905": ["t", "Escherichia coli serotype O:9a O antigen biosynthesis"], "PWY-7290": ["t", "Escherichia coli serotype O:86 O antigen biosynthesis"], "PWY-2661": ["t", "trehalose biosynthesis V"], "PWY-3621": ["t", "gamma-butyrobetaine degradation II"], "PWY-6100": ["t", "L-carnitine biosynthesis"], "R-HSA-2206291": ["r", "MPS IIIC - Sanfilippo syndrome C"], "PWY-7434": ["t", "terminal O-glycans residues modification (via type 2 precursor disaccharide)"], "PWY-7841": ["t", "neolacto-series glycosphingolipids biosynthesis"], "R-SSC-1482788": ["r", "Acyl chain remodelling of PC"], "PWY-6041": ["t", "4-sulfocatechol degradation"], "PWY-2361": ["t", "3-oxoadipate degradation"], "PWY-7307": ["t", "oleate beta-oxidation (reductase-dependent, yeast)"], "PWY-5137": ["t", "fatty acid beta-oxidation III (unsaturated, odd number)"], "R-BTA-203754": ["r", "NOSIP mediated eNOS trafficking"], "R-DME-209446": ["r", "N-HH ligand not bound to PTC receptor complex"], "R-HSA-5635851": ["r", "GLI proteins bind promoters of Hh responsive genes to promote transcription"], "PWY-7369": ["t", "thiamine triphosphate metabolism"], "PWY-5248": ["t", "methanogenesis from dimethylamine"], "PWY-2622": ["t", "trehalose biosynthesis IV"], "PWY-6530": ["t", "perchlorate reduction"], "PWY-6": ["t", "GDP-L-fucose biosynthesis II (from L-fucose)"], "R-GGA-70921": ["r", "Histidine catabolism"], "R-SPO-70921": ["r", "Histidine catabolism"], "R-SCE-70921": ["r", "Histidine catabolism"], "R-SSC-9031628": ["r", "NGF-stimulated transcription"], "R-RNO-9762293": ["r", "Regulation of CDH11 gene transcription"], "R-DME-3232118": ["r", "SUMOylation of transcription factors"], "R-BTA-6806664": ["r", "Metabolism of vitamin K"], "R-HSA-3248023": ["r", "Regulation by TREX1"], "R-CEL-1296067": ["r", "Potassium transport channels"], "R-CEL-1296053": ["r", "Classical Kir channels"], "R-CFA-9927354": ["r", "Co-stimulation by ICOS"], "R-HSA-9953097": ["r", "MPS IX - Natowicz syndrome (CS/DS degradation)"], "R-HSA-2206280": ["r", "MPS IX - Natowicz syndrome (Hyaluronan metabolism)"], "R-SSC-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-BTA-2428928": ["r", "IRS-related events triggered by IGF1R"], "R-BTA-2404192": ["r", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "R-SSC-2404192": ["r", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "R-SSC-2428928": ["r", "IRS-related events triggered by IGF1R"], "R-DME-9640463": ["r", "Wax biosynthesis"], "R-BTA-9640463": ["r", "Wax biosynthesis"], "R-RNO-9640463": ["r", "Wax biosynthesis"], "R-CFA-9841251": ["r", "Mitochondrial unfolded protein response (UPRmt)"], "R-CFA-3371568": ["r", "Attenuation phase"], "R-CFA-3371453": ["r", "Regulation of HSF1-mediated heat shock response"], "R-CFA-9833482": ["r", "PKR-mediated signaling"], "R-GGA-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-CEL-3371497": ["r", "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"], "R-CFA-3371571": ["r", "HSF1-dependent transactivation"], "R-RNO-6803204": ["r", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "PWY-7979": ["t", "protein O-mannosylation III (mammals, core M3)"], "R-DDI-174362": ["r", "Transport and metabolism of PAPS"], "R-DRE-727802": ["r", "Transport of nucleotide sugars"], "R-SCE-727802": ["r", "Transport of nucleotide sugars"], "R-DME-174362": ["r", "Transport and metabolism of PAPS"], "PWY-5670": ["t", "epoxysqualene biosynthesis"], "R-BTA-162699": ["r", "Synthesis of dolichyl-phosphate mannose"], "R-SPO-211945": ["r", "Phase I - Functionalization of compounds"], "PWY-6785": ["t", "hydrogen production VIII"], "PWY-6759": ["t", "hydrogen production III"], "PWY-5833": ["t", "CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis"], "PWY-5964": ["t", "guanylyl molybdenum cofactor biosynthesis"], "PWY-8168": ["t", "bis(guanylyl tungstenpterin) cofactor biosynthesis"], "PWY-7798": ["t", "protein S-nitrosylation and denitrosylation"], "PWY-7616": ["t", "methanol oxidation to carbon dioxide"], "PWY-8180": ["t", "acrylate degradation II"], "PWY-7544": ["t", "pyruvate to cytochrome bo oxidase electron transfer"], "PWY-7899": ["t", "protein NEDDylation"], "R-SPO-194002": ["r", "Glucocorticoid biosynthesis"], "R-SPO-77108": ["r", "Utilization of Ketone Bodies"], "PWY-6014": ["t", "vernolate biosynthesis I"], "PWY-8191": ["t", "cholesterol biosynthesis (algae, late side-chain reductase)"], "PWY-7618": ["t", "ricinoleate biosynthesis"], "PWY-7625": ["t", "phosphatidylinositol biosynthesis II (eukaryotes)"], "PWY-5172": ["t", "acetyl-CoA biosynthesis from citrate"], "PWY-5525": ["t", "D-glucuronate degradation I"], "R-BTA-203927": ["r", "MicroRNA (miRNA) biogenesis"], "R-SCE-8943724": ["r", "Regulation of PTEN gene transcription"], "R-SPO-8943724": ["r", "Regulation of PTEN gene transcription"], "PWY-7646": ["t", "dermatan sulfate degradation I (bacterial)"], "PWY-6572": ["t", "chondroitin sulfate degradation I (bacterial)"], "PWY-6771": ["t", "rhamnogalacturonan type I degradation II (bacteria)"], "PWY-7796": ["t", "pentose phosphate pathway (oxidative branch) II"], "R-XTR-9845576": ["r", "Glycosphingolipid transport"], "PWY-31": ["t", "L-canavanine degradation I"], "PWY-7849": ["t", "urate conversion to allantoin III"], "PWY-7394": ["t", "urate conversion to allantoin II"], "PWY-6999": ["t", "theophylline degradation"], "PWY-6538": ["t", "caffeine degradation III (bacteria, via demethylation)"], "R-HSA-9727281": ["r", "Translation of Accessory Proteins"], "PWY-8101": ["t", "arsenate detoxification II"], "PWY-8025": ["t", "cyanuric acid degradation I"], "PWY-5169": ["t", "cyanuric acid degradation II"], "PWY-5535": ["t", "acetate and ATP formation from acetyl-CoA II"], "PWY-6475": ["t", "trans-lycopene biosynthesis II (oxygenic phototrophs and green sulfur bacteria)"], "PWY-7701": ["t", "4-hydroxy-4-methyl-L-glutamate biosynthesis"], "PWY-7512": ["t", "3,5,6-trichloro-2-pyridinol degradation"], "R-HSA-3656234": ["r", "Defective HEXA causes GM2G1 (Hyaluronan metabolism)"], "R-HSA-3656248": ["r", "Defective HEXB causes GM2G2 (Hyaluronan metabolism)"], "R-CEL-2022857": ["r", "Keratan sulfate degradation"], "R-DDI-2160916": ["r", "Hyaluronan degradation"], "R-DRE-912446": ["r", "Meiotic recombination"], "PWY-2002": ["t", "isoflavonoid biosynthesis I"], "PWY-6325": ["t", "echinatin biosynthesis"], "R-DRE-71262": ["r", "Carnitine synthesis"], "R-SSC-71262": ["r", "Carnitine synthesis"], "R-SSC-71384": ["r", "Ethanol oxidation"], "R-CEL-6798163": ["r", "Choline catabolism"], "R-DME-6783310": ["r", "Fanconi Anemia Pathway"], "R-SPO-380612": ["r", "Metabolism of serotonin"], "R-SSC-380612": ["r", "Metabolism of serotonin"], "R-SCE-380612": ["r", "Metabolism of serotonin"], "PWY-3": ["t", "putrescine degradation V"], "PWY-282": ["t", "cuticular wax biosynthesis"], "PWY-2": ["t", "putrescine degradation IV"], "PWY-7033": ["t", "alkane biosynthesis II"], "PWY-7523": ["t", "L-arginine degradation XII"], "PWY-5168": ["t", "ferulate and sinapate biosynthesis"], "PWY-7128": ["t", "nicotine degradation III (VPP pathway)"], "PWY-6713": ["t", "L-rhamnose degradation II"], "PWY-5885": ["t", "wax esters biosynthesis II"], "PWY-7423": ["t", "bombykol biosynthesis"], "PWY-6328": ["t", "L-lysine degradation X"], "R-HSA-3359471": ["r", "Defective MMAB causes MMA, cblB type"], "R-DME-196843": ["r", "Vitamin B2 (riboflavin) metabolism"], "R-DRE-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "R-XTR-173599": ["r", "Formation of the active cofactor, UDP-glucuronate"], "PWY-7446": ["t", "sulfoquinovose degradation I"], "PWY-8350": ["t", "sulfoquinovose degradation VI"], "R-CFA-2428933": ["r", "SHC-related events triggered by IGF1R"], "R-CFA-2404192": ["r", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "R-SSC-444821": ["r", "Relaxin receptors"], "R-BTA-444821": ["r", "Relaxin receptors"], "R-DME-444821": ["r", "Relaxin receptors"], "R-CFA-2428928": ["r", "IRS-related events triggered by IGF1R"], "PWY-6181": ["t", "histamine degradation"], "R-CEL-432047": ["r", "Passive transport by Aquaporins"], "R-CEL-112310": ["r", "Neurotransmitter release cycle"], "R-HSA-112310": ["r", "Neurotransmitter release cycle"], "R-RNO-112310": ["r", "Neurotransmitter release cycle"], "R-MMU-112310": ["r", "Neurotransmitter release cycle"], "R-SPO-418346": ["r", "Platelet homeostasis"], "R-CEL-418346": ["r", "Platelet homeostasis"], "R-DDI-1483148": ["r", "Synthesis of PG"], "PWY-7164": ["t", "chlorophyll a degradation III"], "R-DRE-71288": ["r", "Creatine metabolism"], "R-XTR-71288": ["r", "Creatine metabolism"], "PWY-8098": ["t", "cyclic 2,3-bisphosphoglycerate biosynthesis"], "PWY-8450": ["t", "pyruvate-derived opine biosynthesis I (bacteria)"], "PWY-8451": ["t", "2-oxoglutarate-derived opine biosynthesis"], "R-SPO-71288": ["r", "Creatine metabolism"], "R-SCE-71288": ["r", "Creatine metabolism"], "PWY-5884": ["t", "wax esters biosynthesis I"], "PWY-2582": ["t", "brassinolide biosynthesis II"], "PWY-8200": ["t", "backdoor pathway of androgen biosynthesis"], "PWY-7455": ["t", "allopregnanolone biosynthesis"], "PWY-699": ["t", "brassinolide biosynthesis I"], "R-GGA-418597": ["r", "G alpha (z) signalling events"], "PWY-6752": ["t", "ortho-quinones biosynthesis"], "PWY-7917": ["t", "pheomelanin biosynthesis"], "PWY-6481": ["t", "L-dopa and L-dopachrome biosynthesis"], "PWY-5426": ["t", "betaxanthin biosynthesis"], "PWY-6334": ["t", "L-dopa degradation I (mammalian)"], "PWY-6815": ["t", "porphyran degradation"], "PWY-6816": ["t", "agarose degradation"], "R-BTA-193368": ["r", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "R-DME-5652227": ["r", "Fructose biosynthesis"], "R-SPO-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DDI-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-DDI-193144": ["r", "Estrogen biosynthesis"], "R-SPO-156590": ["r", "Glutathione conjugation"], "R-DDI-5652227": ["r", "Fructose biosynthesis"], "R-XTR-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-SPO-196108": ["r", "Pregnenolone biosynthesis"], "R-XTR-156590": ["r", "Glutathione conjugation"], "R-SCE-9757110": ["r", "Prednisone ADME"], "R-BTA-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-DDI-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-DDI-196108": ["r", "Pregnenolone biosynthesis"], "R-BTA-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-SCE-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DDI-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DME-196108": ["r", "Pregnenolone biosynthesis"], "R-DME-193807": ["r", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "R-DME-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-DRE-5661270": ["r", "Formation of xylulose-5-phosphate"], "R-SSC-70221": ["r", "Glycogen breakdown (glycogenolysis)"], "R-SCE-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-SCE-196108": ["r", "Pregnenolone biosynthesis"], "R-SPO-193775": ["r", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "R-DRE-156590": ["r", "Glutathione conjugation"], "PWY-2781": ["t", "cis-zeatin biosynthesis"], "R-DDI-71032": ["r", "Propionyl-CoA catabolism"], "PWY-5698": ["t", "allantoin degradation to ureidoglycolate II (ammonia producing)"], "PWY-5641": ["t", "2-nitrotoluene degradation"], "PWY-5419": ["t", "catechol degradation to 2-hydroxypentadienoate II"], "PWY-7008": ["t", "2-hydroxybiphenyl degradation"], "PWY-7747": ["t", "diphenyl ethers degradation"], "PWY-5692": ["t", "allantoin degradation to glyoxylate II"], "PWY-6499": ["t", "D-glucarate degradation II"], "PWY-6497": ["t", "D-galactarate degradation II"], "PWY-6486": ["t", "D-galacturonate degradation II"], "PWY-6501": ["t", "D-glucuronate degradation II"], "PWY-5298": ["t", "L-lysine degradation VI"], "PWY-6695": ["t", "oxalate degradation II"], "PWY-5207": ["t", "coenzyme B/coenzyme M regeneration I (methanophenazine-dependent)"], "PWY-6698": ["t", "oxalate degradation V"], "PWY-6493": ["t", "chanoclavine I aldehyde biosynthesis"], "PWY-8276": ["t", "4-aminobenzoate biosynthesis II"], "R-SCE-1614517": ["r", "Sulfide oxidation to sulfate"], "R-HSA-9956508": ["r", "SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome"], "R-SPO-352230": ["r", "Amino acid transport across the plasma membrane"], "PWY-8239": ["t", "cholesterol biosynthesis (diatoms)"], "PWY-6074": ["t", "zymosterol biosynthesis"], "PWY-8026": ["t", "sterol biosynthesis (methylotrophs)"], "R-GGA-353416": ["r", "Resolution of Abasic Sites (AP sites)"], "R-DRE-174411": ["r", "Polymerase switching on the C-strand of the telomere"], "R-HSA-3359473": ["r", "Defective MMADHC causes MMAHCD"], "R-GGA-9759218": ["r", "Cobalamin (Cbl) metabolism"], "PWY-7424": ["t", "sterol:steryl ester interconversion (yeast)"], "R-SSC-8964572": ["r", "Lipid particle organization"], "R-SPO-8964572": ["r", "Lipid particle organization"], "R-BTA-8964572": ["r", "Lipid particle organization"], "R-DME-8964572": ["r", "Lipid particle organization"], "R-DRE-8964572": ["r", "Lipid particle organization"], "R-XTR-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "R-MMU-6782315": ["r", "tRNA modification in the nucleus and cytosol"], "R-DDI-6782315": ["r", "tRNA modification in the nucleus and cytosol"], "R-SPO-6782315": ["r", "tRNA modification in the nucleus and cytosol"], "R-XTR-6804759": ["r", "Regulation of TP53 Activity through Association with Co-factors"], "R-XTR-209968": ["r", "Thyroxine biosynthesis"], "PWY-6138": ["t", "CMP-N-acetylneuraminate biosynthesis I (eukaryotes)"], "PWY-6139": ["t", "CMP-N-acetylneuraminate biosynthesis II (bacteria)"], "PWY-7330": ["t", "UDP-N-acetyl-beta-L-fucosamine biosynthesis"], "PWY-7332": ["t", "superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis"], "PWY-6143": ["t", "CMP-pseudaminate biosynthesis"], "PWY-7467": ["t", "UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactose biosynthesis"], "PWY-6363": ["t", "D-myo-inositol (1,4,5)-trisphosphate degradation"], "R-CEL-2142753": ["r", "Arachidonate metabolism"], "R-SSC-2142753": ["r", "Arachidonate metabolism"], "PWY-681": ["t", "dibenzothiophene desulfurization"], "R-DDI-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "R-SPO-2395516": ["r", "Electron transport from NADPH to Ferredoxin"], "PWY-5474": ["t", "hydroxycinnamic acid tyramine amides biosynthesis"], "PWY-6789": ["t", "(1,3)-beta-D-xylan degradation"], "R-SSC-9909505": ["r", "Modulation of host responses by IFN-stimulated genes"], "R-SSC-9860276": ["r", "SLC15A4:TASL-dependent IRF5 activation"], "R-SSC-168638": ["r", "NOD1/2 Signaling Pathway"], "R-DRE-936964": ["r", "Activation of IRF3, IRF7 mediated by TBK1, IKKEpsilon (IKBKE)"], "R-DRE-9824878": ["r", "Regulation of TBK1, IKKEpsilon (IKBKE)-mediated activation of IRF3, IRF7"], "PWY-4821": ["t", "UDP-alpha-D-xylose biosynthesis"], "PWY-6617": ["t", "adenosine nucleotides degradation III"], "PWY-8320": ["t", "(3R)-N-[(2S)-1-hydroxy-6-[(3R)-3-isocyanobutanamido]hexan-2-yl]-3-isocyanobutanamide biosynthesis"], "PWY-7032": ["t", "alkane biosynthesis I"], "PWY-6622": ["t", "heptadecane biosynthesis"], "R-XTR-83936": ["r", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "R-DRE-69273": ["r", "Cyclin A/B1/B2 associated events during G2/M transition"], "PWY-7579": ["t", "phycourobilin biosynthesis"], "PWY-5915": ["t", "phycoerythrobilin biosynthesis I"], "R-XTR-9648002": ["r", "RAS processing"], "R-DDI-426048": ["r", "Arachidonate production from DAG"], "R-DRE-8949664": ["r", "Processing of SMDT1"], "PWY-7676": ["t", "Kdo8N transfer to lipid IVA"], "PWY-8308": ["t", "thiazole component of thiamine diphosphate biosynthesis IV"], "PWY-7142": ["t", "cyanide detoxification II"], "PWY-5917": ["t", "phycocyanobilin biosynthesis"], "PWY-7578": ["t", "phycoviolobilin biosynthesis"], "PWY-6828": ["t", "linezolid resistance"], "PWY-6714": ["t", "L-rhamnose degradation III"], "PWY-6517": ["t", "N-acetylglucosamine degradation II"], "PWY-6753": ["t", "S-methyl-5'-thioadenosine degradation III"], "PWY-8011": ["t", "L-serine biosynthesis II"], "PWY-8008": ["t", "staphyloferrin B biosynthesis"], "R-HSA-1606322": ["r", "ZBP1(DAI) mediated induction of type I IFNs"], "R-HSA-73943": ["r", "Reversal of alkylation damage by DNA dioxygenases"], "R-RNO-73943": ["r", "Reversal of alkylation damage by DNA dioxygenases"], "R-MMU-73943": ["r", "Reversal of alkylation damage by DNA dioxygenases"], "PWY-5441": ["t", "S-methyl-L-methionine cycle"], "R-DRE-162658": ["r", "Golgi Cisternae Pericentriolar Stack Reorganization"], "PWY-6994": ["t", "L-pyrrolysine biosynthesis"], "R-XTR-9009391": ["r", "Extra-nuclear estrogen signaling"], "PWY-5677": ["t", "succinate fermentation to butanoate"], "PWY-7433": ["t", "mucin core 1 and core 2 O-glycosylation"], "PWY-5315": ["t", "1-methylpyrrolinium biosynthesis"], "PWY-7101": ["t", "5-deoxystrigol biosynthesis"], "PWY-3941": ["t", "beta-alanine biosynthesis II"], "R-HSA-9637698": ["r", "Phagocyte cell death caused by cytosolic Mtb"], "PWY-6826": ["t", "phosphatidylcholine biosynthesis VI"], "R-CFA-111448": ["r", "Activation of NOXA and translocation to mitochondria"], "R-CFA-111453": ["r", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "R-MMU-111448": ["r", "Activation of NOXA and translocation to mitochondria"], "R-RNO-111448": ["r", "Activation of NOXA and translocation to mitochondria"], "PWY-8318": ["t", "L-fucose degradation III"], "PWY-8444": ["t", "L-fucose degradation II"], "PWY-6557": ["t", "glycosaminoglycan-protein linkage region biosynthesis"], "PWY-5148": ["t", "acyl-CoA hydrolysis"], "PWY-7823": ["t", "chlorzoxazone degradation"], "PWY-7978": ["t", "N-methylpyrrolidone degradation"], "PWY-5645": ["t", "4-chloronitrobenzene degradation"], "PWY-6677": ["t", "thiosulfate oxidation IV (multienzyme complex)"], "PWY-5296": ["t", "thiosulfate oxidation III (multienzyme complex)"], "PWY-6909": ["t", "thiazole component of thiamine diphosphate biosynthesis III"], "PWY-6509": ["t", "methanol oxidation to formaldehyde III"], "PWY-7472": ["t", "D-carnitine degradation II"], "PWY-5905": ["t", "hypusine biosynthesis"], "R-BTA-163841": ["r", "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation"], "R-PFA-5693548": ["r", "Sensing of DNA Double Strand Breaks"], "R-PFA-983231": ["r", "Factors involved in megakaryocyte development and platelet production"], "PWY-6421": ["t", "arsenate detoxification IV (mycothiol)"], "PWY-8281": ["t", "4-aminobenzoate biosynthesis III"], "PWY-6144": ["t", "CMP-N-glycoloylneuraminate biosynthesis"], "PWY-8121": ["t", "2-deoxy-D-glucose 6-phosphate degradation"], "R-CEL-8932504": ["r", "DAG1 core M2 glycosylations"], "R-XTR-174048": ["r", "APC/C:Cdc20 mediated degradation of Cyclin B"], "R-XTR-179409": ["r", "APC-Cdc20 mediated degradation of Nek2A"], "R-XTR-176408": ["r", "Regulation of APC/C activators between G1/S and early anaphase"], "R-XTR-141430": ["r", "Inactivation of APC/C via direct inhibition of the APC/C complex"], "R-XTR-2559582": ["r", "Senescence-Associated Secretory Phenotype (SASP)"], "R-XTR-176407": ["r", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"], "R-XTR-176409": ["r", "APC/C:Cdc20 mediated degradation of mitotic proteins"], "R-XTR-73943": ["r", "Reversal of alkylation damage by DNA dioxygenases"], "R-DRE-73943": ["r", "Reversal of alkylation damage by DNA dioxygenases"], "R-SSC-163125": ["r", "Post-translational modification: synthesis of GPI-anchored proteins"], "PWY-722": ["t", "nicotinate degradation I"], "PWY-6993": ["t", "nicotine degradation II (pyrrolidine pathway)"], "PWY-5033": ["t", "nicotinate degradation II"], "R-DRE-5620924": ["r", "Intraflagellar transport"], "R-RNO-9818564": ["r", "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes"], "PWY-6073": ["t", "alginate biosynthesis I (algal)"], "PWY-6082": ["t", "alginate biosynthesis II (bacterial)"], "PWY-7335": ["t", "UDP-N-acetyl-alpha-D-mannosaminouronate biosynthesis"], "R-BTA-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-DRE-1834941": ["r", "STING mediated induction of host immune responses"], "R-BTA-1834941": ["r", "STING mediated induction of host immune responses"], "R-RNO-1834941": ["r", "STING mediated induction of host immune responses"], "R-DRE-3134975": ["r", "Regulation of innate immune responses to cytosolic DNA"], "R-RNO-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-XTR-1834941": ["r", "STING mediated induction of host immune responses"], "R-HSA-9916722": ["r", "3-hydroxyisobutyryl-CoA hydrolase deficiency"], "R-DRE-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-RNO-3270619": ["r", "IRF3-mediated induction of type I IFN"], "R-XTR-3249367": ["r", "STAT6-mediated induction of chemokines"], "R-DRE-373080": ["r", "Class B/2 (Secretin family receptors)"], "R-CFA-1461973": ["r", "Defensins"], "R-XTR-5656169": ["r", "Termination of translesion DNA synthesis"], "R-CFA-9670095": ["r", "Inhibition of DNA recombination at telomere"], "PWY-7918": ["t", "protein N-glycosylation processing phase (endoplasmic reticulum, yeast)"], "PWY-7744": ["t", "dimycocerosyl phthiocerol biosynthesis"], "PWY-6111": ["t", "mitochondrial L-carnitine shuttle"], "PWY-8091": ["t", "D-apionate degradation I (xylose isomerase family decarboxylase)"], "PWY-8090": ["t", "D-apionate degradation II (RLP decarboxylase)"], "PWY-8092": ["t", "D-apionate degradation III (RLP transcarboxylase/hydrolase)"], "PWY-7651": ["t", "heparan sulfate degradation"], "PWY-6046": ["t", "dimethylsulfoniopropanoate degradation I (cleavage)"], "PWY-6049": ["t", "superpathway of dimethylsulfoniopropanoate degradation"], "PWY-6364": ["t", "D-myo-inositol (1,3,4)-trisphosphate biosynthesis"], "PWY-7974": ["t", "cobalamin salvage (eukaryotic)"], "R-DRE-9759218": ["r", "Cobalamin (Cbl) metabolism"], "R-HSA-3359474": ["r", "Defective MMACHC causes MAHCC"], "R-BTA-9759218": ["r", "Cobalamin (Cbl) metabolism"], "PWY-6241": ["t", "thyroid hormone biosynthesis"], "PWY-7436": ["t", "vitamin E biosynthesis (tocotrienols)"], "PWY-7031": ["t", "protein N-glycosylation (bacterial)"], "PWY-7789": ["t", "erythritol degradation I"], "PWY-8462": ["t", "UDP-N-acetyl-alpha-D-mannosamine biosynthesis"], "PWY-7550": ["t", "ergothioneine biosynthesis II (fungi)"], "PWY-5027": ["t", "phylloquinol biosynthesis"], "R-HSA-4755583": ["r", "Defective DOLK causes DOLK-CDG"], "PWY-8416": ["t", "CDP-ribitol biosynthesis"], "PWY-6200": ["t", "2,4,5-trichlorophenoxyacetate degradation"], "PWY-5488": ["t", "4-nitrophenol degradation II"], "PWY-7081": ["t", "4-aminophenol degradation"], "PWY-5487": ["t", "4-nitrophenol degradation I"], "PWY-7773": ["t", "gamma-resorcylate degradation I"], "PWY-7772": ["t", "gamma-resorcylate degradation II"], "PWY-5115": ["t", "GDP-L-galactose biosynthesis"], "PWY-5752": ["t", "piperine biosynthesis"], "PWY-6670": ["t", "citronellol degradation"], "PWY-5045": ["t", "pinosylvin metabolism"], "PWY-8336": ["t", "valinomycin biosynthesis"], "PWY-6593": ["t", "sulfoacetate degradation"], "PWY-5749": ["t", "itaconate degradation"], "PWY-301": ["t", "cyclohexane-1-carboxylate degradation (anaerobic)"], "PWY-8033": ["t", "aureothin biosynthesis"], "PWY-8034": ["t", "spectinabilin biosynthesis"], "PWY-2501": ["t", "fatty acid alpha-oxidation I (plants)"], "PWY-7516": ["t", "L-lyxonate degradation"], "PWY-7752": ["t", "gadusol biosynthesis"], "PWY-5267": ["t", "glucosinolate activation"], "PWY-6684": ["t", "aromatic glucosinolate activation"], "R-SPO-189200": ["r", "Cellular hexose transport"], "PWY-5458": ["t", "methylglyoxal degradation V"], "PWY-5122": ["t", "geranyl diphosphate biosynthesis"], "PWY-7709": ["t", "(3R)-linalool biosynthesis"], "PWY-7410": ["t", "ipsdienol biosynthesis"], "PWY-7182": ["t", "linalool biosynthesis I"], "PWY-7141": ["t", "(3S)-linalool biosynthesis"], "PWY-7736": ["t", "stellatic acid biosynthesis"], "PWY-5123": ["t", "trans, trans-farnesyl diphosphate biosynthesis"], "PWY-7251": ["t", "pentacyclic triterpene biosynthesis"], "PWY-8216": ["t", "strychnine biosynthesis"], "PWY-7514": ["t", "L-tyrosine degradation IV (to 4-methylphenol)"], "PWY-6861": ["t", "the visual cycle I (vertebrates)"], "PWY-7794": ["t", "polyethylene terephthalate degradation"], "PWY-6307": ["t", "L-tryptophan degradation X (mammalian, via tryptamine)"], "PWY-7387": ["t", "hypotaurine degradation"], "PWY-0": ["t", "putrescine degradation III"], "PWY-5427": ["t", "naphthalene degradation (aerobic)"], "PWY-401": ["t", "galactolipid biosynthesis I"], "PWY-7840": ["t", "gala-series glycosphingolipids biosynthesis"], "PWY-7666": ["t", "galactolipid biosynthesis II"], "PWY-8061": ["t", "8-oxo-(d)GTP detoxification II"], "PWY-7178": ["t", "D-xylose degradation to ethylene glycol (engineered)"], "PWY-8020": ["t", "D-xylose degradation V"], "PWY-5159": ["t", "trans-4-hydroxy-L-proline degradation II"], "PWY-5517": ["t", "L-arabinose degradation III"], "PWY-6760": ["t", "D-xylose degradation III"], "PWY-5519": ["t", "D-arabinose degradation III"], "PWY-7758": ["t", "bacteriochlorophyll d biosynthesis"], "PWY-7759": ["t", "bacteriochlorophyll c biosynthesis"], "PWY-7760": ["t", "bacteriochlorophyll e biosynthesis"], "PWY-5516": ["t", "D-xylose degradation II"], "PWY-7808": ["t", "tetracycline resistance"], "PWY-7910": ["t", "homofuraneol biosynthesis"], "R-BTA-9939291": ["r", "Matriglycan biosynthesis on DAG1"], "PWY-7435": ["t", "mucin core 3 and core 4 O-glycosylation"], "PWY-6001": ["t", "linoleate biosynthesis II (animals)"], "PWY-5143": ["t", "long-chain fatty acid activation"], "PWY-6000": ["t", "gamma-linolenate biosynthesis II (animals)"], "PWY-5288": ["t", "astaxanthin biosynthesis (bacteria, fungi, algae)"], "PWY-8188": ["t", "L-alanine degradation VI (reductive Stickland reaction)"], "PWY-6618": ["t", "guanine and guanosine salvage III"], "PWY-6640": ["t", "salicylate degradation IV"], "PWY-6223": ["t", "gentisate degradation I"], "PWY-7087": ["t", "2-methylisoborneol biosynthesis"], "PWY-7685": ["t", "L-malate degradation I"], "PWY-8135": ["t", "bile acids deconjugation"], "PWY-7872": ["t", "D-erythronate degradation I"], "PWY-7871": ["t", "D-threonate degradation"], "PWY-3181": ["t", "L-tryptophan degradation VI (via tryptamine)"], "PWY-6399": ["t", "melatonin degradation II"], "PWY-4341": ["t", "L-glutamate biosynthesis V"], "PWY-5140": ["t", "cannabinoid biosynthesis"], "PWY-7299": ["t", "progesterone biosynthesis"], "PWY-6794": ["t", "adenosine 5'-phosphoramidate biosynthesis"], "PWY-7781": ["t", "omega-sulfo-II-dihydromenaquinone-9 biosynthesis"], "PWY-4002": ["t", "L-asparagine degradation II"], "PWY-6818": ["t", "ornithine lipid biosynthesis"], "PWY-6691": ["t", "plaunotol biosynthesis"], "PWY-5120": ["t", "geranylgeranyl diphosphate biosynthesis"], "PWY-7720": ["t", "ophiobolin F biosynthesis"], "PWY-5175": ["t", "lactucaxanthin biosynthesis"], "PWY-5368": ["t", "dimorphecolate biosynthesis"], "PWY-2961": ["t", "sesquiterpenoid phytoalexins biosynthesis"], "PWY-7495": ["t", "gossypetin metabolism"], "PWY-5775": ["t", "rotenoid biosynthesis I"], "PWY-5795": ["t", "juglone biosynthesis"], "PWY-6280": ["t", "synechoxanthin biosynthesis"], "PWY-7941": ["t", "isorenieratene biosynthesis II (Chlorobiaceae)"], "PWY-8110": ["t", "L-dopa degradation II (bacterial)"], "PWY-5766": ["t", "L-glutamate degradation X"], "PWY-7515": ["t", "trans-3-hydroxy-L-proline degradation"], "PWY-8167": ["t", "bis(tungstenpterin) cofactor biosynthesis"], "PWY-8456": ["t", "tetrahydrosarcinapterin biosynthesis"], "PWY-5770": ["t", "phenazine-1-carboxylate biosynthesis"], "PWY-5983": ["t", "trehalose biosynthesis VI"], "PWY-4121": ["t", "glutathionylspermidine biosynthesis"], "PWY-7093": ["t", "vicianin bioactivation"], "PWY-6011": ["t", "amygdalin and prunasin degradation"], "PWY-5515": ["t", "L-arabinose degradation II"], "PWY-8274": ["t", "pyruvate fermentation to (R)-lactate"], "PWY-7993": ["t", "beta-dihydromenaquinone-9 biosynthesis"], "PWY-6141": ["t", "archaetidylserine and archaetidylethanolamine biosynthesis"], "R-DDI-418346": ["r", "Platelet homeostasis"], "PWY-1781": ["t", "beta-alanine degradation II"], "PWY-8007": ["t", "staphylopine biosynthesis"]} |