Reviewer #1:

1. The GWAS analysis lacks multiple-testing correction. Please re-run with FDR control and report q-values for all significant loci. In addition, the sample size justification is missing — please add a power analysis or at least discuss the detectable effect size.

2. Figure 3 is blurry and the axis labels are unreadable. As noted in Comment 3, the same issue applies to Figure S2. Please replace all figures with high-resolution versions.

3. Minor: please add the standard error estimates to Supplementary Table 2.

Reviewer #2:

1. The claim of novelty overstates the advance relative to Zhang et al. 2023. The introduction should more clearly delineate what is new.

2. How were the batch effects between the two sequencing centers corrected? This is essential to support the conclusions.
