diff --git a/deploy/toggle_bioflow_176.sh b/deploy/toggle_bioflow_176.sh
new file mode 100755
index 0000000..6904981
--- /dev/null
+++ b/deploy/toggle_bioflow_176.sh
@@ -0,0 +1,51 @@
+#!/bin/bash
+# deploy/toggle_bioflow_176.sh —— 176 生信模块快速开关(off/on)
+# 用法(在 176 上执行,或从 175 ssh 过去执行):
+#   bash /srv/plantai/toggle_bioflow_176.sh off   # 关生信:env=false + 重启 BFF → 生信 TAB/入口消失
+#   bash /srv/plantai/toggle_bioflow_176.sh on    # 开生信:env=true  + 重启 BFF → 生信 TAB 恢复
+# 原理:BFF main.py 按 BIOFLOW_ENABLED 决定是否注册 bioflow 反代路由;
+#       不注册时 /api/bioflow/health 返回 404,前端 probe 落 offline,生信 TAB 自动隐藏。
+set -uo pipefail
+
+ACTION="${1:-}"
+ENV_FILE="/srv/plantai/install/sdk/.env"
+PY="/srv/plantai/install/venv/bin/python"
+
+if [ "$ACTION" != "off" ] && [ "$ACTION" != "on" ]; then
+  echo "用法: $0 <off|on>" >&2
+  exit 2
+fi
+
+VAL="true"
+[ "$ACTION" = "off" ] && VAL="false"
+
+# 1. 改 env
+if grep -q "^BIOFLOW_ENABLED=" "$ENV_FILE"; then
+  sed -i "s/^BIOFLOW_ENABLED=.*/BIOFLOW_ENABLED=$VAL/" "$ENV_FILE"
+else
+  echo "BIOFLOW_ENABLED=$VAL" >> "$ENV_FILE"
+fi
+echo "BIOFLOW_ENABLED -> $VAL"
+
+# 2. 重启 BFF 8090(仅取 LISTEN 者;venv 必须绝对路径,cd sdk 后才能 import app.main)
+kill $(lsof -ti tcp:8090 -sTCP:LISTEN) 2>/dev/null
+sleep 2
+cd /srv/plantai/install && set -a && . sdk/.env && set +a
+( cd sdk && setsid "$PY" -m uvicorn app.main:app --host 127.0.0.1 --port 8090 \
+  > /tmp/plantai-sdk.log 2>&1 < /dev/null & ) && disown -a
+
+# 3. 自检
+for i in $(seq 1 20); do
+  sleep 2
+  curl -s -m 3 http://127.0.0.1:8090/api/health >/dev/null 2>&1 && break
+done
+curl -s -m 10 http://127.0.0.1:8090/api/health | head -c 150
+echo
+if [ "$ACTION" = "off" ]; then
+  CODE=$(curl -s -o /dev/null -w "%{http_code}" -m 8 http://127.0.0.1:8090/api/bioflow/health)
+  echo "bioflow/health HTTP $CODE (off 期望 404)"
+  [ "$CODE" = "404" ] && echo "OFF_OK" || echo "OFF_CHECK_FAIL"
+else
+  curl -s -m 8 http://127.0.0.1:8090/api/bioflow/health | head -c 150
+  echo
+fi
diff --git a/ui/src/components/layout/TopBar.vue b/ui/src/components/layout/TopBar.vue
index bbffc03..afdb3aa 100644
--- a/ui/src/components/layout/TopBar.vue
+++ b/ui/src/components/layout/TopBar.vue
@@ -13,6 +13,7 @@ import { computed, onMounted, ref } from 'vue';
 import { APP_NAME, STATUS_LABEL, T } from '../../i18n/labels.js';
 import { BF } from '../../i18n/bioflow.js';
 import { useThemeStore } from '../../stores/theme.js';
+import { useBioflowStore } from '../../stores/bioflow.js';
 
 const props = defineProps({
   /** 当前会话标题（无会话为 null → 显示「就绪」徽章） */
@@ -34,6 +35,11 @@ const emit = defineEmits(['menu', 'bench', 'close-bench', 'goto-extensions', 'go
 /* ---------- 主题 ---------- */
 const themeStore = useThemeStore();
 
+/* ---------- 生信可用性(右上角生信跳转按钮显隐;=== 'online' 避免 unknown 闪现) ---------- */
+const bioflowStore = useBioflowStore();
+const bioflowOnline = computed(() => bioflowStore.availability === 'online');
+const bioflowStatus = computed(() => bioflowStore.availability);
+
 /* ---------- B2/B3 store 数据（动态导入 + 空值守卫） ---------- */
 const chatStore = ref(null);
 const benchStore = ref(null);
@@ -134,6 +140,12 @@ function onMenu() {
 function onBench() {
   emit('bench');
 }
+/** 生信跳转(2026-09-16):开新窗口访问 PlantAI-dev(9017);主机名跟随当前访问地址自适应 */
+function openBioflowDev() {
+  const devUrl = window.location.protocol + '//' + window.location.hostname + ':9017/';
+  window.open(devUrl, '_blank', 'noopener');
+}
+
 function onToggleTheme() {
   themeStore.toggle();
 }
@@ -147,6 +159,7 @@ const iconClose = '<svg viewBox="0 0 24 24" fill="none" stroke="currentColor" st
 // 右上角快捷按钮图标(2026-09-15:会话/扩展/知识图谱/设置 自侧栏迁移)
 const iconRailExt = '<svg viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"><path d="M12 2l2.4 4.9 5.4.8-3.9 3.8.9 5.4-4.8-2.5-4.8 2.5.9-5.4L4.2 7.7l5.4-.8z"/><path d="M20 14v5a2 2 0 0 1-2 2H6a2 2 0 0 1-2-2v-5"/></svg>';
 const iconRailSettings = '<svg viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round"><circle cx="12" cy="12" r="3"/><path d="M19.4 15a1.7 1.7 0 0 0 .34 1.87l.06.06a2 2 0 1 1-2.83 2.83l-.06-.06a1.7 1.7 0 0 0-1.87-.34 1.7 1.7 0 0 0-1 1.55V21a2 2 0 1 1-4 0v-.09a1.7 1.7 0 0 0-1-1.55 1.7 1.7 0 0 0-1.87.34l-.06.06a2 2 0 1 1-2.83-2.83l.06-.06a1.7 1.7 0 0 0 .34-1.87 1.7 1.7 0 0 0-1.55-1H3a2 2 0 1 1 0-4h.09a1.7 1.7 0 0 0 1.55-1 1.7 1.7 0 0 0-.34-1.87l-.06-.06a2 2 0 1 1 2.83-2.83l.06.06a1.7 1.7 0 0 0 1.87.34h0a1.7 1.7 0 0 0 1-1.55V3a2 2 0 1 1 4 0v.09a1.7 1.7 0 0 0 1 1.55h0a1.7 1.7 0 0 0 1.87-.34l.06-.06a2 2 0 1 1 2.83 2.83l-.06.06a1.7 1.7 0 0 0-.34 1.87v0a1.7 1.7 0 0 0 1.55 1H21a2 2 0 1 1 0 4h-.09a1.7 1.7 0 0 0-1.55 1z"/></svg>';
+const iconRailBio = '<svg viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"><path d="M7 3c0 4-1.2 8.6-5 11"/><path d="M7 3c0 4 1.2 8.6 5 11"/><path d="M17 3c0 4 1.2 8.6 5 11"/><path d="M17 3c0 4-1.2 8.6-5 11"/><path d="M8.5 8h7"/><path d="M8 13.5h8"/><path d="M10.5 18h3"/></svg>';
 </script>
 
 <template>
@@ -197,21 +210,29 @@ const iconRailSettings = '<svg viewBox="0 0 24 24" fill="none" stroke="currentCo
       <span v-if="!benchOverlayOpen && sourceCount != null" class="bench-btn-count">{{ sourceCount }}</span>
     </button>
 
-    <!-- 右上角快捷按钮(2026-09-15 自侧栏迁移;仅 desktop/laptop;三按钮同行右对齐) -->
+    <!-- 右上角快捷按钮(2026-09-15 自侧栏迁移;仅 desktop/laptop;图标+文字同行右对齐) -->
     <template v-if="tier === 'desktop' || tier === 'laptop'">
       <button class="icon-btn top-rail-btn" type="button" :title="BF.extRailTitle" :aria-label="BF.extRailTitle"
               @click="$emit('goto-extensions')">
         <span v-html="iconRailExt"></span>
+        <span class="rail-label">{{ BF.extRailTitle }}</span>
+      </button>
+      <!-- 生信跳转(2026-09-16:仅无生信模块时显示,开新窗访问 PlantAI-dev 9017) -->
+      <button v-if="!bioflowOnline" class="icon-btn top-rail-btn" type="button" title="生信" aria-label="生信"
+              @click="openBioflowDev">
+        <span v-html="iconRailBio"></span>
+        <span class="rail-label">生信</span>
       </button>
       <button class="icon-btn top-rail-btn" type="button" :title="T.railSettings" :aria-label="T.railSettings"
               @click="$emit('goto-settings')">
         <span v-html="iconRailSettings"></span>
+        <span class="rail-label">{{ T.railSettings }}</span>
       </button>
     </template>
 
     <!-- 主题切换（日月 SVG + rotate 180° 400ms，FR-THEME-002） -->
     <button
-      class="icon-btn"
+      class="icon-btn top-rail-btn"
       type="button"
       :title="themeStore.theme === 'dark' ? '切换到浅色主题' : '切换到深色主题'"
       :aria-label="themeStore.theme === 'dark' ? '切换到浅色主题' : '切换到深色主题'"
@@ -220,6 +241,7 @@ const iconRailSettings = '<svg viewBox="0 0 24 24" fill="none" stroke="currentCo
       <span class="theme-toggle-anim" :class="{ flipped: themeStore.theme === 'dark' }">
         <span v-html="themeStore.theme === 'dark' ? iconSun : iconMoon"></span>
       </span>
+      <span class="rail-label">主题</span>
     </button>
   </header>
 </template>
diff --git a/ui/src/styles/base.css b/ui/src/styles/base.css
index 5ae0937..2aee2db 100644
--- a/ui/src/styles/base.css
+++ b/ui/src/styles/base.css
@@ -119,8 +119,18 @@ html.drawer-open { overflow: hidden; }
 }
 .icon-btn svg { width: 16px; height: 16px; }
 .icon-btn:disabled { opacity: .45; cursor: not-allowed; }
-.top-rail-btn { margin-left: 2px; }
+.top-rail-btn {
+  margin-left: 2px;
+  width: auto;
+  padding: 0 10px;
+  gap: 6px;
+}
 .top-rail-btn > span { display: flex; align-items: center; justify-content: center; }
+.top-rail-btn .rail-label {
+  font-size: 12px;
+  font-weight: 500;
+  white-space: nowrap;
+}
 
 /* 状态徽章（pill，三编码：颜色+图标+文字，UI_SPEC §4.1 / PRD §2.1） */
 .badge {